Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EGF_HUMAN
Description:epidermal growth factor [Source:HGNC Symbol;Acc:3229]
Location:chr4 q25
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S262DRIFYsTWKMKPhosphoSitePlus
Y1170FHMPSyGTQTLPhosphoSitePlus
S348EGYALsRDRKYEGFPhosphoSitePlus

Dephosphorylation site
EGF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265171E537QCOSMICHead and Neck Cancer21798893
ENSP00000265171W270*COSMICSkin Cancer21984974
ENSP00000265171S1187LCOSMICBreast Cancer20668451
ENSP00000424316Y1128HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265171P160SCOSMICMelanoma21499247
ENSP00000265171P29SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000265171Y1170HBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
EGF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EGF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EGF_HUMANEGFR_HUMANligand -> receptorHPMR
EGF_HUMANEGFR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05212Pancreatic cancer
hsa05214Glioma
hsa04060Cytokine-cytokine receptor interaction
hsa05213Endometrial cancer
hsa05160Hepatitis C
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa05219Bladder cancer
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
hsa05223Non-small cell lung cancer
hsa04012ErbB signaling pathway
hsa04540Gap junction
hsa04144Endocytosis
hsa04010MAPK signaling pathway
hsa05218Melanoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043388positive regulation of DNA bindingISSbiological_process
GO:2000060positive regulation of protein ubiquitination invoIEAbiological_process
GO:0007262STAT protein import into nucleusISSbiological_process
GO:0006260DNA replicationTASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0001525angiogenesisIDAbiological_process
GO:0007262STAT protein import into nucleusIEAbiological_process
GO:0005576extracellular regionICcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0005154epidermal growth factor receptor bindingTASmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:1900127positive regulation of hyaluronan biosynthetic proIDAbiological_process
GO:0090279regulation of calcium ion importIDAbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0030297transmembrane receptor protein tyrosine kinase actTASmolecular_function
GO:0043388positive regulation of DNA bindingIEAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0010800positive regulation of peptidyl-threonine phosphorIDAbiological_process
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0051048negative regulation of secretionIDAbiological_process
GO:0000186activation of MAPKK activityIEAbiological_process
GO:2000008regulation of protein localization to cell surfaceIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0042327positive regulation of phosphorylationIDAbiological_process
GO:0070371ERK1 and ERK2 cascadeIDAbiological_process
GO:0045741positive regulation of epidermal growth factor-actIDAbiological_process
GO:0007171activation of transmembrane receptor protein tyrosTASbiological_process
GO:0035413positive regulation of catenin import into nucleusIDAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005154epidermal growth factor receptor bindingIEAmolecular_function
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0090370negative regulation of cholesterol effluxIEAbiological_process
GO:0021940positive regulation of cerebellar granule cell preIEAbiological_process
GO:0008083growth factor activityIDAmolecular_function