Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDX5_HUMAN
Description:DEAD (Asp-Glu-Ala-Asp) box helicase 5 [Source:HGNC Symbol;Acc:2746]
Location:chrHG183_PATCH q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S498RRDRYsAGKRGHPRD
Y297DFLKDyIHINIPhosphoSitePlus; HPRD; RegPhos
Y244LRRTTyLVLDEDEADPhosphoSitePlus
Y514RDRENyDRGYSP68HRPhosphoSitePlus
Y244LRRTTyLVLDEphosphoELM; RegPhos
S520DRGYSsLLKRDP68HRPhosphoSitePlus; SysPTM
S498RRDRYsAGKRGP68HRPhosphoSitePlus
Y442KTGTAyTFFTPPhosphoSitePlus
S520DRGYSsLLKRDHPRD; phosphoELM; RegPhos; SysPTM
Y97PVLNFyEANFPPhosphoSitePlus
T564RTGNPtGTYQNP68HRPhosphoSitePlus
S557AGIQTsFRTGNPKCaRegPhos
Y202KSTCIyGGAPKphosphoELM
T83RSKEItVRGHNPhosphoSitePlus
S519YDRGYsSLLKRHPRD
S24PRFGGsRAGPLPhosphoSitePlus
T507RGGFNtFRDREP68HRPhosphoSitePlus; SysPTM
S557AGIQTsFRTGNPRKCAHPRD
Y535TQNGVySAANYPhosphoSitePlus
T224EICIAtPGRLIDEADPhosphoSitePlus
T344EKENKtIVFVEPhosphoSitePlus
S480VEDRGsGRSRGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y595QQAYAyPATAAPhosphoSitePlus
S557AGIQTsFRTGNPKC_groupphosphoELM; RegPhos
Y518NYDRGySSLLKP68HRPhosphoSitePlus
T446AYTFFtPNNIKPhosphoSitePlus
T224EICIAtPGRLIHPRD
S6MSGYSsDRDRGPhosphoSitePlus
Y416KFVINyDYPNSHelicase_CPhosphoSitePlus
S30RAGPLsGKKFGPhosphoSitePlus; HPRD; RegPhos
S6RDRGHPRD
Y593MNQQAyAYPATPhosphoSitePlus
Y202KSTCIyGGAPKDEADPhosphoSitePlus
T199CRLKStCIYGGDEADPhosphoSitePlus
T507RGGFNtFRDREHPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
DDX5_HUMAN do not have dephosphorylation site.

Mutation site
DDX5_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000225792Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4618646787
ENSP00000225792LeukemiaNormal vs. Cancercell lineDown0.3817022645
ENSP00000225792LeukemiaNormal vs. Cancercell lineDown0.3917022645
ENSP00000225792Breast CancerNormal vs. Cancercell lineUp1.420543960
ENSP00000225792Breast CancerNormal vs. Cancercell lineUp1.420543960
ENSP00000225792Breast CancerNormal vs. CancertissueUp0.6720739354
ENSP00000225792Breast CancerNormal vs. CancertissueUp0.6720739354
ENSP00000225792Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.4520625496

Hyperphosphorylation site
DDX5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANDDX5_HUMANkinase -> substrateRegPhos
KPCA_HUMANDDX5_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03040Spliceosome
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0016818hydrolase activity, acting on acid anhydrides, in IEAmolecular_function
GO:0007623circadian rhythmIEAbiological_process
GO:0048306calcium-dependent protein bindingIEAmolecular_function
GO:0072332intrinsic apoptotic signaling pathway by p53 classIMPbiological_process
GO:0033148positive regulation of intracellular estrogen receIDAbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:2001014regulation of skeletal muscle cell differentiationISSbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0004004ATP-dependent RNA helicase activityIEAmolecular_function
GO:0016049cell growthNASbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0045667regulation of osteoblast differentiationISSbiological_process
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0043517positive regulation of DNA damage response, signalIMPbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0045069regulation of viral genome replicationIEAbiological_process
GO:0000381regulation of alternative mRNA splicing, via splicIDAbiological_process
GO:0003724RNA helicase activityNASmolecular_function
GO:0004386helicase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0003712transcription cofactor activityIEAmolecular_function
GO:0019899enzyme bindingIEAmolecular_function
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0050681androgen receptor bindingIDAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0060765regulation of androgen receptor signaling pathwayIMPbiological_process
GO:0036002pre-mRNA bindingIDAmolecular_function
GO:0030331estrogen receptor bindingIDAmolecular_function
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process


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