| UniProt/SwissProt ID: | DDX5_HUMAN |
| Description: | DEAD (Asp-Glu-Ala-Asp) box helicase 5 [Source:HGNC Symbol;Acc:2746] |
| Location: | chrHG183_PATCH q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S498 | RRDRYsAGKRG | HPRD | |
| Y297 | DFLKDyIHINI | PhosphoSitePlus; HPRD; RegPhos | |
| Y244 | LRRTTyLVLDE | DEAD | PhosphoSitePlus |
| Y514 | RDRENyDRGYS | P68HR | PhosphoSitePlus |
| Y244 | LRRTTyLVLDE | phosphoELM; RegPhos | |
| S520 | DRGYSsLLKRD | P68HR | PhosphoSitePlus; SysPTM |
| S498 | RRDRYsAGKRG | P68HR | PhosphoSitePlus |
| Y442 | KTGTAyTFFTP | PhosphoSitePlus | |
| S520 | DRGYSsLLKRD | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y97 | PVLNFyEANFP | PhosphoSitePlus | |
| T564 | RTGNPtGTYQN | P68HR | PhosphoSitePlus |
| S557 | AGIQTsFRTGN | PKCa | RegPhos |
| Y202 | KSTCIyGGAPK | phosphoELM | |
| T83 | RSKEItVRGHN | PhosphoSitePlus | |
| S519 | YDRGYsSLLKR | HPRD | |
| S24 | PRFGGsRAGPL | PhosphoSitePlus | |
| T507 | RGGFNtFRDRE | P68HR | PhosphoSitePlus; SysPTM |
| S557 | AGIQTsFRTGN | PRKCA | HPRD |
| Y535 | TQNGVySAANY | PhosphoSitePlus | |
| T224 | EICIAtPGRLI | DEAD | PhosphoSitePlus |
| T344 | EKENKtIVFVE | PhosphoSitePlus | |
| S480 | VEDRGsGRSRG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y595 | QQAYAyPATAA | PhosphoSitePlus | |
| S557 | AGIQTsFRTGN | PKC_group | phosphoELM; RegPhos |
| Y518 | NYDRGySSLLK | P68HR | PhosphoSitePlus |
| T446 | AYTFFtPNNIK | PhosphoSitePlus | |
| T224 | EICIAtPGRLI | HPRD | |
| S6 | MSGYSsDRDRG | PhosphoSitePlus | |
| Y416 | KFVINyDYPNS | Helicase_C | PhosphoSitePlus |
| S30 | RAGPLsGKKFG | PhosphoSitePlus; HPRD; RegPhos | |
| S6 | RDRG | HPRD | |
| Y593 | MNQQAyAYPAT | PhosphoSitePlus | |
| Y202 | KSTCIyGGAPK | DEAD | PhosphoSitePlus |
| T199 | CRLKStCIYGG | DEAD | PhosphoSitePlus |
| T507 | RGGFNtFRDRE | HPRD; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| DDX5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| DDX5_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000225792 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.46 | 18646787 | ENSP00000225792 | Leukemia | Normal vs. Cancer | cell line | Down | 0.38 | 17022645 | ENSP00000225792 | Leukemia | Normal vs. Cancer | cell line | Down | 0.39 | 17022645 | ENSP00000225792 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000225792 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000225792 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 | ENSP00000225792 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 | ENSP00000225792 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Down | 0.45 | 20625496 |
| Hyperphosphorylation site |
| DDX5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | DDX5_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | DDX5_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03040 | Spliceosome |
| hsa05202 | Transcriptional misregulation in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in | IEA | molecular_function |
| GO:0007623 | circadian rhythm | IEA | biological_process |
| GO:0048306 | calcium-dependent protein binding | IEA | molecular_function |
| GO:0072332 | intrinsic apoptotic signaling pathway by p53 class | IMP | biological_process |
| GO:0033148 | positive regulation of intracellular estrogen rece | IDA | biological_process |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:2001014 | regulation of skeletal muscle cell differentiation | ISS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | IEA | molecular_function |
| GO:0016049 | cell growth | NAS | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045667 | regulation of osteoblast differentiation | ISS | biological_process |
| GO:0071013 | catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0043517 | positive regulation of DNA damage response, signal | IMP | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0045069 | regulation of viral genome replication | IEA | biological_process |
| GO:0000381 | regulation of alternative mRNA splicing, via splic | IDA | biological_process |
| GO:0003724 | RNA helicase activity | NAS | molecular_function |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0003712 | transcription cofactor activity | IEA | molecular_function |
| GO:0019899 | enzyme binding | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0050681 | androgen receptor binding | IDA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0060765 | regulation of androgen receptor signaling pathway | IMP | biological_process |
| GO:0036002 | pre-mRNA binding | IDA | molecular_function |
| GO:0030331 | estrogen receptor binding | IDA | molecular_function |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |