| UniProt/SwissProt ID: | DDB1_HUMAN |
| Description: | damage-specific DNA binding protein 1, 127kDa [Source:HGNC Symbol;Acc:2717] |
| Location: | chr11 q12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S720 | VPLYEsPRKIC | PhosphoSitePlus | |
| S781 | APHETsFGEEV | PhosphoSitePlus | |
| Y346 | NEQGSyVVAME | PhosphoSitePlus | |
| T8 | YNYVVtAQKPT | HPRD | |
| Y718 | RTVPLyESPRK | PhosphoSitePlus | |
| T636 | LGTQPtVLRTF | PhosphoSitePlus; HPRD | |
| Y91 | ACILEyKQSGE | PhosphoSitePlus | |
| Y42 | TRLEIyVVTAE | PhosphoSitePlus | |
| S645 | TFRSLsTTNVF | PhosphoSitePlus | |
| Y84 | ILTAKyNACIL | PhosphoSitePlus | |
| S196 | KTYEVsLREKE | PhosphoSitePlus | |
| S764 | QALSSsVSSSK | HPRD | |
| Y660 | RPTVIySSNHK | PhosphoSitePlus | |
| T633 | KVTLGtQPTVL | HPRD | |
| T1137 | VVEELtRIH__ | PhosphoSitePlus | |
| S116 | RIGRPsETGII | PhosphoSitePlus | |
| T1125 | MKREAtADDLI | PhosphoSitePlus | |
| T640 | PTVLRtFRSLS | PhosphoSitePlus | |
| Y871 | VKGAVySMVEF | CPSF_A | PhosphoSitePlus |
| Y193 | RHVKTyEVSLR | PhosphoSitePlus | |
| T646 | FRSLStTNVFA | PhosphoSitePlus | |
| T294 | EQMDGtVTLKD | PhosphoSitePlus | |
| T860 | DGKLQtVAEKE | CPSF_A | PhosphoSitePlus |
| S757 | LRPSAsTQALS | HPRD | |
| T296 | MDGTVtLKDLR | PhosphoSitePlus | |
| S763 | TQALSsSVSSS | HPRD | |
| Dephosphorylation site |
| DDB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000301764 | E525K | COSMIC | Skin Cancer | 21984974 | ENSP00000301764 | K1067N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000301764 | S345C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000301764 | G227R | COSMIC | Lung Cancer | 20668451 | ENSP00000301764 | P721L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000301764 | E535Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000301764 | P417L | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000301764 | Gastric Cancer | Metastasis | cell line | Up | 2.3 | 17022644 | ENSP00000301764 | Gastric Cancer | Metastasis | cell line | Up | 2.3 | 17022644 |
| Hyperphosphorylation site |
| DDB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCZ_HUMAN | DDB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DDB1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042787 | protein ubiquitination involved in ubiquitin-depen | IDA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0000718 | nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0080008 | Cul4-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0000075 | cell cycle checkpoint | IMP | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031465 | Cul4B-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0003684 | damaged DNA binding | TAS | molecular_function |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IMP | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006289 | nucleotide-excision repair | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |