Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDB1_HUMAN
Description:damage-specific DNA binding protein 1, 127kDa [Source:HGNC Symbol;Acc:2717]
Location:chr11 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S720VPLYEsPRKICPhosphoSitePlus
S781APHETsFGEEVPhosphoSitePlus
Y346NEQGSyVVAMEPhosphoSitePlus
T8YNYVVtAQKPTHPRD
Y718RTVPLyESPRKPhosphoSitePlus
T636LGTQPtVLRTFPhosphoSitePlus; HPRD
Y91ACILEyKQSGEPhosphoSitePlus
Y42TRLEIyVVTAEPhosphoSitePlus
S645TFRSLsTTNVFPhosphoSitePlus
Y84ILTAKyNACILPhosphoSitePlus
S196KTYEVsLREKEPhosphoSitePlus
S764QALSSsVSSSKHPRD
Y660RPTVIySSNHKPhosphoSitePlus
T633KVTLGtQPTVLHPRD
T1137VVEELtRIH__PhosphoSitePlus
S116RIGRPsETGIIPhosphoSitePlus
T1125MKREAtADDLIPhosphoSitePlus
T640PTVLRtFRSLSPhosphoSitePlus
Y871VKGAVySMVEFCPSF_APhosphoSitePlus
Y193RHVKTyEVSLRPhosphoSitePlus
T646FRSLStTNVFAPhosphoSitePlus
T294EQMDGtVTLKDPhosphoSitePlus
T860DGKLQtVAEKECPSF_APhosphoSitePlus
S757LRPSAsTQALSHPRD
T296MDGTVtLKDLRPhosphoSitePlus
S763TQALSsSVSSSHPRD

Dephosphorylation site
DDB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000301764E525KCOSMICSkin Cancer21984974
ENSP00000301764K1067NCOSMICHead and Neck Cancer21798893
ENSP00000301764S345CBIOMARTBreast Cancer21930507, 21930502
ENSP00000301764G227RCOSMICLung Cancer20668451
ENSP00000301764P721LCOSMICOvarian Cancer21720365
ENSP00000301764E535QCOSMICOvarian Cancer21720365
ENSP00000301764P417LCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000301764Gastric CancerMetastasiscell lineUp2.317022644
ENSP00000301764Gastric CancerMetastasiscell lineUp2.317022644

Hyperphosphorylation site
DDB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMANDDB1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DDB1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042787protein ubiquitination involved in ubiquitin-depenIDAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0080008Cul4-RING ubiquitin ligase complexIDAcellular_component
GO:0000075cell cycle checkpointIMPbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031464Cul4A-RING ubiquitin ligase complexIDAcellular_component
GO:0031465Cul4B-RING ubiquitin ligase complexIDAcellular_component
GO:0003684damaged DNA bindingTASmolecular_function
GO:0043161proteasomal ubiquitin-dependent protein catabolic IMPbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006289nucleotide-excision repairTASbiological_process
GO:0006281DNA repairTASbiological_process


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