| UniProt/SwissProt ID: | CXCL7_HUMAN |
| Description: | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) [Source:HGNC Symbol;Acc:9240] |
| Location: | chr4 q13.3 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y58 | LDSDLyAELRC | IL8 | PhosphoSitePlus |
| Dephosphorylation site |
| CXCL7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296028 | Q40K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000296028 | G39E | COSMIC | Melanoma | 21499247 | ENSP00000296028 | V92I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000296028 | K114N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000296028 | G48V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000296028 | acute lymphocytic leukemia | Normal vs. Cancer | tissue | Down | 19291297 | |
| Hyperphosphorylation site |
| CXCL7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CXCL7_HUMAN | CXCR2_HUMAN | ligand -> receptor | HPMR |
| CXCL7_HUMAN | CXCR2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04062 | Chemokine signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008009 | chemokine activity | IEA | molecular_function |
| GO:0005355 | glucose transmembrane transporter activity | TAS | molecular_function |
| GO:0015758 | glucose transport | TAS | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0031093 | platelet alpha granule lumen | TAS | cellular_component |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0051781 | positive regulation of cell division | IEA | biological_process |
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0006935 | chemotaxis | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0042742 | defense response to bacterium | IEA | biological_process |