Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CXA5_HUMAN
Description:gap junction protein, alpha 5, 40kDa [Source:HGNC Symbol;Acc:4279]
Location:chr1 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S120KEVRGsGSYEYConnexinPhosphoSitePlus
S122VRGSGsYEYPVConnexinPhosphoSitePlus
S345DKRRLsKASSKPRKACAHPRD
Y125SGSYEyPVAEKConnexinPhosphoSitePlus
Y123RGSGSyEYPVAConnexinPhosphoSitePlus
S120KEVRGsGSYEYPRKACAHPRD

Dephosphorylation site
CXA5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358240M34ICOSMICOvarian Cancer21720365
ENSP00000358240G176RBIOMARTBreast Cancer21930507, 21930502
ENSP00000271348T56MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000407645T56MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000358240T56MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000271348G176RBIOMARTBreast Cancer21930507, 21930502
ENSP00000358240R33CCOSMICSkin Cancer21984974
ENSP00000407645G176RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CXA5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CXA5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANCXA5_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
CXA5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003284septum primum developmentIEAbiological_process
GO:0086015regulation of SA node cell action potentialIEAbiological_process
GO:0055077gap junction hemi-channel activityIDAmolecular_function
GO:0014704intercalated discIDAcellular_component
GO:0035050embryonic heart tube developmentIEAbiological_process
GO:0005922connexon complexIEAcellular_component
GO:0001568blood vessel developmentIEAbiological_process
GO:1900133regulation of renin secretion into blood streamIEAbiological_process
GO:0005921gap junctionIDAcellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0060413atrial septum morphogenesisIEAbiological_process
GO:0003294atrial ventricular junction remodelingIEAbiological_process
GO:0060371regulation of atrial cardiac muscle cell membrane IMPbiological_process
GO:0086077gap junction channel activity involved in AV node IDAmolecular_function
GO:0003193pulmonary valve formationIMPbiological_process
GO:0060412ventricular septum morphogenesisIEAbiological_process
GO:0086091regulation of heart rate by cardiac conductionIEAbiological_process
GO:0055117regulation of cardiac muscle contractionIMPbiological_process
GO:0003283atrial septum developmentIMPbiological_process
GO:0086067AV node cell to bundle of His cell communicationIEAbiological_process
GO:0048844artery morphogenesisISSbiological_process
GO:0060371regulation of atrial cardiac muscle cell membrane IEAbiological_process
GO:0086075gap junction channel activity involved in cardiac IMPmolecular_function
GO:0003281ventricular septum developmentIMPbiological_process
GO:0060307regulation of ventricular cardiac muscle cell membIEAbiological_process
GO:0086053AV node cell to bundle of His cell communication bIMPbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:1900825regulation of membrane depolarization involved in IEAbiological_process
GO:0086069bundle of His cell to Purkinje myocyte communicatiIMPbiological_process
GO:0005243gap junction channel activityIEAmolecular_function
GO:0086064cell communication by electrical coupling involvedIDAbiological_process
GO:0003073regulation of systemic arterial blood pressureIEAbiological_process
GO:0061337cardiac conductionIEAbiological_process
GO:0086064cell communication by electrical coupling involvedIEAbiological_process
GO:0016264gap junction assemblyIMPbiological_process
GO:0060373regulation of ventricular cardiac muscle cell membIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0035922foramen ovale closureIEAbiological_process
GO:0003161cardiac conduction system developmentIEAbiological_process
GO:0086014regulation of atrial cardiac muscle cell action poIMPbiological_process
GO:0005922connexon complexIDAcellular_component
GO:0007267cell-cell signalingIEAbiological_process
GO:0003071renal system process involved in regulation of sysIEAbiological_process
GO:0086065cell communication involved in cardiac conductionIEAbiological_process
GO:0001525angiogenesisIEPbiological_process
GO:0003174mitral valve developmentIMPbiological_process
GO:0005921gap junctionIEAcellular_component
GO:0003151outflow tract morphogenesisIMPbiological_process
GO:0042312regulation of vasodilationIEAbiological_process
GO:0086005regulation of ventricular cardiac muscle cell actiIEAbiological_process