Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CX3C1_HUMAN
Description:chemokine (C-X3-C motif) receptor 1 [Source:HGNC Symbol;Acc:2558]
Location:chr3 p22.2
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y128ISIDRyLAIVL7tm_1PhosphoSitePlus
S137VLAANsMNNRT7tm_1PhosphoSitePlus
Y303EKFRRyLYHLYPhosphoSitePlus

Dephosphorylation site
CX3C1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382166D15NCOSMICSkin Cancer21984974
ENSP00000444928D15NCOSMICSkin Cancer21984974
ENSP00000439140A82TCOSMICLung Cancer20668451
ENSP00000444928A82TCOSMICLung Cancer20668451
ENSP00000439140D15NCOSMICSkin Cancer21984974
ENSP00000382166A82TCOSMICLung Cancer20668451

Differential expressed protein
CX3C1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CX3C1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
X3CL1_HUMANCX3C1_HUMANligand -> receptorHPMR
X3CL1_HUMANCX3C1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016495C-X3-C chemokine receptor activityIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0002282microglial cell activation involved in immune respIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0070098chemokine-mediated signaling pathwayTASbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0004896cytokine receptor activityIEAmolecular_function
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0048246macrophage chemotaxisIEAbiological_process
GO:0016525negative regulation of angiogenesisIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0004950chemokine receptor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0006968cellular defense responseTASbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0032809neuronal cell body membraneIEAcellular_component
GO:0006935chemotaxisTASbiological_process
GO:0021795cerebral cortex cell migrationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0009611response to woundingTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process


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