Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSPG4_HUMAN
Description:chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:2466]
Location:chr15 q24.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2079ANRTGsVPRFRPhosphoSitePlus
Y743QGRVRyLSTDPPhosphoSitePlus
T2310LQFCRtPNPALPhosphoSitePlus
S2036RGVNAsAVVNVPhosphoSitePlus
T2077ELANRtGSVPRPhosphoSitePlus
T2042AVVNVtVRALLPhosphoSitePlus
T2252RKRNKtGKHDVPKCa RegPhos
S163YLRGTsRPLRGLaminin_G_1PhosphoSitePlus
T21LALTLtMLARLPhosphoSitePlus; RegPhos
S643LTFRVsDGLQAPhosphoSitePlus

Dephosphorylation site
CSPG4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312506V1197ICOSMICOvarian Cancer21720365
ENSP00000312506A445VCOSMICHepatocellular Carcinoma21822264
ENSP00000312506W406LCOSMICSkin Cancer21984974
ENSP00000312506S1911NCOSMICSkin Cancer21984974
ENSP00000312506G1502SCOSMICPancreatic Cancer21252315

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000312506Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000312506Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp3.219800108

Hyperphosphorylation site
CSPG4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCSPG4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
CSPG4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0030208dermatan sulfate biosynthetic processTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0009986cell surfaceTAScellular_component
GO:0030206chondroitin sulfate biosynthetic processTASbiological_process
GO:0043202lysosomal lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0008283cell proliferationIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0008347glial cell migrationIEAbiological_process
GO:0030207chondroitin sulfate catabolic processTASbiological_process
GO:0048771tissue remodelingIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0031258lamellipodium membraneIEAcellular_component
GO:0016324apical plasma membraneIEAcellular_component
GO:0030204chondroitin sulfate metabolic processTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0035556intracellular signal transductionIDAbiological_process
GO:0005576extracellular regionTAScellular_component


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