| UniProt/SwissProt ID: | CSPG4_HUMAN |
| Description: | chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:2466] |
| Location: | chr15 q24.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2079 | ANRTGsVPRFR | PhosphoSitePlus | |
| Y743 | QGRVRyLSTDP | PhosphoSitePlus | |
| T2310 | LQFCRtPNPAL | PhosphoSitePlus | |
| S2036 | RGVNAsAVVNV | PhosphoSitePlus | |
| T2077 | ELANRtGSVPR | PhosphoSitePlus | |
| T2042 | AVVNVtVRALL | PhosphoSitePlus | |
| T2252 | RKRNKtGKHDV | PKCa | RegPhos |
| S163 | YLRGTsRPLRG | Laminin_G_1 | PhosphoSitePlus |
| T21 | LALTLtMLARL | PhosphoSitePlus; RegPhos | |
| S643 | LTFRVsDGLQA | PhosphoSitePlus | |
| Dephosphorylation site |
| CSPG4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000312506 | V1197I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000312506 | A445V | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000312506 | W406L | COSMIC | Skin Cancer | 21984974 | ENSP00000312506 | S1911N | COSMIC | Skin Cancer | 21984974 | ENSP00000312506 | G1502S | COSMIC | Pancreatic Cancer | 21252315 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000312506 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000312506 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 3.2 | 19800108 |
| Hyperphosphorylation site |
| CSPG4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | CSPG4_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| CSPG4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphory | IDA | biological_process |
| GO:0030208 | dermatan sulfate biosynthetic process | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0009986 | cell surface | TAS | cellular_component |
| GO:0030206 | chondroitin sulfate biosynthetic process | TAS | biological_process |
| GO:0043202 | lysosomal lumen | TAS | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0030203 | glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0000187 | activation of MAPK activity | IEA | biological_process |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0008347 | glial cell migration | IEA | biological_process |
| GO:0030207 | chondroitin sulfate catabolic process | TAS | biological_process |
| GO:0048771 | tissue remodeling | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0031258 | lamellipodium membrane | IEA | cellular_component |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0030204 | chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |