| UniProt/SwissProt ID: | CP8B1_HUMAN |
| Description: | cytochrome P450, family 8, subfamily B, polypeptide 1 [Source:HGNC Symbol;Acc:2653] |
| Location: | chr3 p22.1 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S369 | YTLKMsSGQEY | p450 | PhosphoSitePlus |
| Y182 | LFTAGyLSLFG | PhosphoSitePlus | |
| T62 | LKRMRtKHGDV | p450 | PhosphoSitePlus |
| S326 | LETKQsFAFKL | p450 | PhosphoSitePlus |
| T78 | GGQYFtFVMDP | p450 | PhosphoSitePlus |
| T347 | SVVEEtLRLRA | p450 | PhosphoSitePlus |
| T69 | HGDVFtVQLGG | p450 | PhosphoSitePlus |
| S269 | EQGVPsAMQDK | PhosphoSitePlus | |
| Y76 | QLGGQyFTFVM | p450 | PhosphoSitePlus |
| S127 | MIHSAsTKHLR | PhosphoSitePlus; HPRD | |
| S370 | TLKMSsGQEYL | p450 | PhosphoSitePlus |
| Dephosphorylation site |
| CP8B1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318867 | G332S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318867 | R26* | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CP8B1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CP8B1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HNF4A_HUMAN | CP8B1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CP8B1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009055 | electron carrier activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0008397 | sterol 12-alpha-hydroxylase activity | TAS | molecular_function |
| GO:0005789 | endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006805 | xenobiotic metabolic process | TAS | biological_process |
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0020037 | heme binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0033778 | 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxyla | IEA | molecular_function |
| GO:0016705 | oxidoreductase activity, acting on paired donors, | IEA | molecular_function |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0008206 | bile acid metabolic process | TAS | biological_process |
| GO:0006699 | bile acid biosynthetic process | TAS | biological_process |
| GO:0019825 | oxygen binding | TAS | molecular_function |