Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CP7A1_HUMAN
Description:cytochrome P450, family 7, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:2651]
Location:chr8 q12.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T269NDTLStFDDLEp450PhosphoSitePlus
T266MFLNDtLSTFDHPRD
S268LNDTLsTFDDLp450PhosphoSitePlus
Y432GLKLKyYYMPFp450PhosphoSitePlus
S439YMPFGsGATICp450PhosphoSitePlus
T269NDTLStFDDLEHPRD
T266MFLNDtLSTFDp450PhosphoSitePlus
S268LNDTLsTFDDLHPRD
T4__MMTtSLIWGPhosphoSitePlus
Y433LKLKYyYMPFGp450PhosphoSitePlus

Dephosphorylation site
CP7A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000301645T421IBIOMARTBreast Cancer21930507, 21930502
ENSP00000301645L467FCOSMICOvarian Cancer21720365

Differential expressed protein
CP7A1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CP7A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NR5A2_HUMANCP7A1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CP7A1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0070857regulation of bile acid biosynthetic processISSbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0020037heme bindingIEAmolecular_function
GO:0009055electron carrier activityIEAmolecular_function
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0043231intracellular membrane-bounded organelleISScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0016705oxidoreductase activity, acting on paired donors, IEAmolecular_function
GO:0008123cholesterol 7-alpha-monooxygenase activityISSmolecular_function
GO:0008123cholesterol 7-alpha-monooxygenase activityIEAmolecular_function
GO:0042632cholesterol homeostasisISSbiological_process
GO:0071397cellular response to cholesterolIEAbiological_process
GO:0006707cholesterol catabolic processIEAbiological_process
GO:0005506iron ion bindingIEAmolecular_function
GO:0006805xenobiotic metabolic processTASbiological_process
GO:0008206bile acid metabolic processTASbiological_process
GO:0006707cholesterol catabolic processISSbiological_process
GO:0070857regulation of bile acid biosynthetic processIEAbiological_process
GO:0071397cellular response to cholesterolISSbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0071333cellular response to glucose stimulusIDAbiological_process
GO:0006699bile acid biosynthetic processISSbiological_process


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