| UniProt/SwissProt ID: | CETN1_HUMAN |
| Description: | centrin, EF-hand protein, 1 [Source:HGNC Symbol;Acc:1866] |
| Location: | chr18 p11.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S170 | IMKKTsLY | PKA_group | RegPhos |
| S9 | GFKKPsAASTG | PhosphoSitePlus | |
| S170 | IMKKTsLY | PKACa | RegPhos |
| S170 | IMKKTs | PRKACA | HPRD |
| S170 | IMKKTs | PKA_group | phosphoELM |
| Dephosphorylation site |
| CETN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000319052 | E24fs*30 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000319052 | R34W | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000319052 | R164W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000319052 | R164W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319052 | R128C | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| CETN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CETN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | CETN1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CETN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032795 | heterotrimeric G-protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000922 | spindle pole | IDA | cellular_component |
| GO:0032391 | photoreceptor connecting cilium | IEA | cellular_component |
| GO:0034605 | cellular response to heat | IEA | biological_process |
| GO:0008017 | microtubule binding | IEA | molecular_function |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IEA | molecular_function |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005813 | centrosome | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |