Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDK12_HUMAN
Description:cyclin-dependent kinase 12 [Source:HGNC Symbol;Acc:24224]
Location:chr17 q12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T893ESRPYtNKVITPkinasePhosphoSitePlus
T770EGFPItAIREIPkinasePhosphoSitePlus
S18GSGGAsGTLQPHPRD
S420MDGKEsKGSPVPhosphoSitePlus; HPRD
S1236NSDKNsGPQGPHPRD
T82SSDSDtFSDDMHPRD
T1002LDHMLtLDPSKPkinasePhosphoSitePlus
S503QGTRDsKPIALHPRD
T893ESRPYtNKVITCDK12HPRD
S176SKESRsSKLHKPhosphoSitePlus
S320RSGSYsGRSPSPhosphoSitePlus; HPRD; phosphoELM
S238QDDSPsGASYGPhosphoSitePlus; HPRD
S332YGRRRsSSPFLPhosphoSitePlus; HPRD; phosphoELM
Y246SYGQDyDLSPSPhosphoSitePlus
S293STRSPsPYSRRPhosphoSitePlus; HPRD; phosphoELM
S359KSRSRsPAYSRPhosphoSitePlus; HPRD
S1082EPVKNsSPAPPPhosphoSitePlus; HPRD; phosphoELM
S434RKENSsVEAKDPhosphoSitePlus
S80DISSDsDTFSDPhosphoSitePlus; HPRD; phosphoELM
S84DSDTFsDDMAFPhosphoSitePlus; HPRD; phosphoELM
S276RRQSVsPPYKECDK12HPRD
S333GRRRSsSPFLSPhosphoSitePlus; HPRD; phosphoELM
S349RSPLPsRKSMKPhosphoSitePlus
S318YERSGsYSGRSPhosphoSitePlus; HPRD; phosphoELM
S32GGSSNsRERHRPhosphoSitePlus; HPRD; phosphoELM
S274TSRRQsVSPPYPhosphoSitePlus; phosphoELM
S423KESKGsPVFLPPhosphoSitePlus; HPRD; phosphoELM
T893ESRPYtNKVITHPRD; phosphoELM
Y327RSPSPyGRRRSPhosphoSitePlus; HPRD
S357SMKSRsRSPAYPhosphoSitePlus; HPRD
S886ARLYNsEESRPPkinasePhosphoSitePlus
S334RRRSSsPFLSKPhosphoSitePlus; HPRD; phosphoELM
Y892EESRPyTNKVIHPRD; phosphoELM
T65AASLGtVIKPLHPRD
S265DSYKKsPGSTSPhosphoSitePlus; HPRD; phosphoELM
S257RSHTSsNYDSYPhosphoSitePlus
S644DDDMDsPKETLPhosphoSitePlus
S276RRQSVsPPYKEPhosphoSitePlus; HPRD; phosphoELM
T57DMGLVtPEAASPhosphoSitePlus; HPRD
S261SSNYDsYKKSPPhosphoSitePlus
S383RSRHSsISPVRPhosphoSitePlus; phosphoELM
Y295RSPSPySRRQRHPRD
S1066PPSKTsRKETTPhosphoSitePlus
S385RHSSIsPVRLPCDK12HPRD
T770EGFPItAIREIHPRD
S382SRSRHsSISPVPhosphoSitePlus; HPRD; phosphoELM
S338SSPFLsKRSLSPhosphoSitePlus; HPRD; phosphoELM
S1083PVKNSsPAPPQPhosphoSitePlus; HPRD; phosphoELM
S253LSPSRsHTSSNHPRD
T1076TSGTStEPVKNHPRD
T158RSNEEtDDYGKPhosphoSitePlus
S236SKQDDsPSGASPhosphoSitePlus; HPRD; phosphoELM
S1063EEPPPsKTSRKPhosphoSitePlus
Y362SRSPAySRHSSPhosphoSitePlus
S681PGGDLsPPDSPPhosphoSitePlus; phosphoELM
S325SGRSPsPYGRRPhosphoSitePlus; HPRD; phosphoELM
T1246PRRTPtMPQEEHPRD
S1387HLGESsSYQGTPhosphoSitePlus
T1363SGPALtESLVQHPRD
S345RSLSRsPLPSRPhosphoSitePlus; HPRD; phosphoELM
Y73KPLVEyDDISSPhosphoSitePlus; HPRD
S400LGAELsRKKKEPhosphoSitePlus; HPRD; phosphoELM
S521KETETsEKETPPhosphoSitePlus
S256SRSHTsSNYDSPhosphoSitePlus
Y285KEPSAyQSSTRPhosphoSitePlus
S685LSPPDsPEPKAPhosphoSitePlus; phosphoELM
S385RHSSIsPVRLPPhosphoSitePlus; phosphoELM
S312RRRSSsYERSGPhosphoSitePlus
S301SRRQRsVSPYSPhosphoSitePlus; HPRD; phosphoELM
S14GKKDGsGGASGHPRD
S1075TTSGTsTEPVKHPRD
S215YKTVDsPKRRSPhosphoSitePlus; HPRD; phosphoELM
Y279SVSPPyKEPSAPhosphoSitePlus
T692EPKAItPPQQPPhosphoSitePlus; HPRD; phosphoELM
S249QDYDLsPSRSHPhosphoSitePlus; HPRD; phosphoELM
S316SSYERsGSYSGHPRD; phosphoELM
S681PGGDLsPPDSPCDK12HPRD
S29SSGGGsSNSREHPRD
S283PYKEPsAYQSSPhosphoSitePlus
S251YDLSPsRSHTSPhosphoSitePlus; HPRD; phosphoELM
T1071SRKETtSGTSTPhosphoSitePlus
S77EYDDIsSDSDTPhosphoSitePlus; HPRD; phosphoELM
S310YSRRRsSSYERPhosphoSitePlus
S177KESRSsKLHKEPhosphoSitePlus
S323SYSGRsPSPYGPhosphoSitePlus; HPRD; phosphoELM
T1375LVKNRtFSGSLPhosphoSitePlus
S62TPEAAsLGTVIHPRD
S25TLQPSsGGGSSPhosphoSitePlus; HPRD
S1053RRQRQsGVVVEPhosphoSitePlus
Y161EETDDyGKAQVPhosphoSitePlus
S889YNSEEsRPYTNHPRD
S287PSAYQsSTRSPPhosphoSitePlus
S363RSPAYsRHSSSPhosphoSitePlus
S889YNSEEsRPYTNPkinasePhosphoSitePlus
S379RSSSRsRHSSIHPRD
T1070TSRKEtTSGTSPhosphoSitePlus
S296SPSPYsRRQRSHPRD
Y305RSVSPySRRRSPhosphoSitePlus
S394LPLNSsLGAELPhosphoSitePlus; HPRD; phosphoELM
S383RSRHSsISPVRCDK12HPRD
S306SVSPYsRRRSSPhosphoSitePlus
S274TSRRQsVSPPYCDK12HPRD
S685LSPPDsPEPKACDK12HPRD
S393RLPLNsSLGAEPhosphoSitePlus; HPRD; phosphoELM
S303RQRSVsPYSRRPhosphoSitePlus; HPRD; phosphoELM
Y319ERSGSySGRSPPhosphoSitePlus; HPRD; phosphoELM
T1244QGPRRtPTMPQPhosphoSitePlus; HPRD
S355RKSMKsRSRSPPhosphoSitePlus; HPRD
T514KEEIVtPKETEPhosphoSitePlus; HPRD
S241SPSGAsYGQDYHPRD
S78YDDISsDSDTFPhosphoSitePlus; HPRD; phosphoELM
T520PKETEtSEKETPhosphoSitePlus
T255PSRSHtSSNYDPhosphoSitePlus
S291QSSTRsPSPYSPhosphoSitePlus; HPRD
S288SAYQSsTRSPSPhosphoSitePlus
S311SRRRSsSYERSPhosphoSitePlus
S1006LTLDPsKRCTAPkinasePhosphoSitePlus
S343SKRSLsRSPLPPhosphoSitePlus; HPRD; phosphoELM
S228PHRKWsDSSKQPhosphoSitePlus; HPRD
S24GTLQPsSGGGSPhosphoSitePlus; HPRD
S341FLSKRsLSRSPPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
CDK12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000398880E1198*BIOMARTBreast Cancer21930507, 21930502
ENSP00000398880L1179FBIOMARTBreast Cancer21930507, 21930502
ENSP00000398880E1171QBIOMARTBreast Cancer21930507, 21930502
ENSP00000407720E1198*BIOMARTBreast Cancer21930507, 21930502
ENSP00000407720Y901CTCGAOvarian Cancer21720365, 18772890
ENSP00000407720K975ETCGAOvarian Cancer21720365, 18772890
ENSP00000407720L1179FBIOMARTBreast Cancer21930507, 21930502
ENSP00000407720R882LTCGAOvarian Cancer21720365, 18772890
ENSP00000398880R912HHPIColorectal Cancer17344846
ENSP00000407720L996FTCGAOvarian Cancer21720365, 18772890
ENSP00000407720E1171QBIOMARTBreast Cancer21930507, 21930502
ENSP00000407720Q602*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CDK12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDK12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK12_HUMANCDK12_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
CDK12_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006397mRNA processingIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0002944cyclin K-CDK12 complexIPIcellular_component
GO:0019908nuclear cyclin-dependent protein kinase holoenzymeIEAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0008380RNA splicingIEAbiological_process
GO:0008353RNA polymerase II carboxy-terminal domain kinase aIMPmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043405regulation of MAP kinase activityIMPbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0030332cyclin bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0070816phosphorylation of RNA polymerase II C-terminal doIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030332cyclin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0019908nuclear cyclin-dependent protein kinase holoenzymeISScellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0008380RNA splicingISSbiological_process
GO:0016607nuclear speckIEAcellular_component