Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDC6_HUMAN
Description:cell division cycle 6 [Source:HGNC Symbol;Acc:1744]
Location:chr17 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S381CARKVsAVSGDPhosphoSitePlus; HPRD
S20PKRKLsRALNKPhosphoSitePlus
S419LSECKsPSEPLPhosphoSitePlus; HPRD
T43NVQTVtCSPRVPhosphoSitePlus; HPRD
S106QLTIKsPSKREPhosphoSitePlus
T481KIKEVtLGKLYCdc6_CPhosphoSitePlus
T37AKLEPtNVQTVPhosphoSitePlus
S54KALPLsPRKRLPhosphoSitePlus; SysPTM
S421ECKSPsEPLIPPhosphoSitePlus
S106QLTIKsPSKRECDK2HPRD; phosphoELM; RegPhos
T67DNLCNtPHLPPPhosphoSitePlus
S384KVSAVsGDVRKPhosphoSitePlus
S45QTVTCsPRVKAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S127SSVRKsQEITTPhosphoSitePlus; HPRD
S74HLPPCsPPKQGCDK2HPRD; phosphoELM; RegPhos
S54KALPLsPRKRLCDK2HPRD; phosphoELM; RegPhos; SysPTM
T166KLVLNtAVPDRPhosphoSitePlus; HPRD; RegPhos
S74HLPPCsPPKQGPhosphoSitePlus

Dephosphorylation site
CDC6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000209728R445STCGAOvarian Cancer21720365, 18772890
ENSP00000209728R445SCOSMICOvarian Cancer21720365
ENSP00000209728E153KCOSMICBreast Cancer19812674

Differential expressed protein
CDC6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDC6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANCDC6_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCDC6_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000076DNA replication checkpointTASbiological_process
GO:0007089traversing start control point of mitotic cell cycTASbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0000075cell cycle checkpointTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008156negative regulation of DNA replicationTASbiological_process
GO:0051233spindle midzoneIDAcellular_component
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005819spindleIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0090007regulation of mitotic anaphaseIMPbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0000166nucleotide bindingTASmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0007067mitosisIEAbiological_process
GO:0000922spindle poleIDAcellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0051984positive regulation of chromosome segregationIDAbiological_process
GO:0019900kinase bindingIPImolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process


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