| UniProt/SwissProt ID: | CDC6_HUMAN |
| Description: | cell division cycle 6 [Source:HGNC Symbol;Acc:1744] |
| Location: | chr17 q21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S381 | CARKVsAVSGD | PhosphoSitePlus; HPRD | |
| S20 | PKRKLsRALNK | PhosphoSitePlus | |
| S419 | LSECKsPSEPL | PhosphoSitePlus; HPRD | |
| T43 | NVQTVtCSPRV | PhosphoSitePlus; HPRD | |
| S106 | QLTIKsPSKRE | PhosphoSitePlus | |
| T481 | KIKEVtLGKLY | Cdc6_C | PhosphoSitePlus |
| T37 | AKLEPtNVQTV | PhosphoSitePlus | |
| S54 | KALPLsPRKRL | PhosphoSitePlus; SysPTM | |
| S421 | ECKSPsEPLIP | PhosphoSitePlus | |
| S106 | QLTIKsPSKRE | CDK2 | HPRD; phosphoELM; RegPhos |
| T67 | DNLCNtPHLPP | PhosphoSitePlus | |
| S384 | KVSAVsGDVRK | PhosphoSitePlus | |
| S45 | QTVTCsPRVKA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S127 | SSVRKsQEITT | PhosphoSitePlus; HPRD | |
| S74 | HLPPCsPPKQG | CDK2 | HPRD; phosphoELM; RegPhos |
| S54 | KALPLsPRKRL | CDK2 | HPRD; phosphoELM; RegPhos; SysPTM |
| T166 | KLVLNtAVPDR | PhosphoSitePlus; HPRD; RegPhos | |
| S74 | HLPPCsPPKQG | PhosphoSitePlus | |
| Dephosphorylation site |
| CDC6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000209728 | R445S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000209728 | R445S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000209728 | E153K | COSMIC | Breast Cancer | 19812674 |
| Differential expressed protein |
| CDC6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDC6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | CDC6_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | CDC6_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000076 | DNA replication checkpoint | TAS | biological_process |
| GO:0007089 | traversing start control point of mitotic cell cyc | TAS | biological_process |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0000083 | regulation of transcription involved in G1/S phase | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0008156 | negative regulation of DNA replication | TAS | biological_process |
| GO:0051233 | spindle midzone | IDA | cellular_component |
| GO:0071777 | positive regulation of cell cycle cytokinesis | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005819 | spindle | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0090007 | regulation of mitotic anaphase | IMP | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0000166 | nucleotide binding | TAS | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0000922 | spindle pole | IDA | cellular_component |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0051984 | positive regulation of chromosome segregation | IDA | biological_process |
| GO:0019900 | kinase binding | IPI | molecular_function |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | TAS | biological_process |