Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CADH2_HUMAN
Description:cadherin 2, type 1, N-cadherin (neuronal) [Source:HGNC Symbol;Acc:1759]
Location:chr18 q12.1
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y773DNILKyDEEGGDUF2207; Bravo_FIGEY; CadPhosphoSitePlus
Y852PTAPPyDSLLVSrcRegPhos
T454PIDFEtNRMFVCadherinPhosphoSitePlus
Y884GGEQDyDYLNDCadherin_CPhosphoSitePlus
Y852PTAPPyDSLLVCadherin_CPhosphoSitePlus
Y852PTAPPyDSLLVSRCphosphoELM
S135ESVKEsAEVEEHPRD
S61LNVKFsNCNGKCadherin_proPhosphoSitePlus
Y860LLVFDyEGSGSCadherin_CPhosphoSitePlus
Y884GGEQDyDYLNDSrcRegPhos
S788QDYDLsQLQQPBravo_FIGEY; Cadherin_CPhosphoSitePlus
Y785EEDQDyDLSQLHPRD; phosphoELM; RegPhos; SysPTM
Y785EEDQDyDLSQLDUF2207; Bravo_FIGEY; CadPhosphoSitePlus; SysPTM
Y886EQDYDyLNDWGCadherin_CPhosphoSitePlus
Y884GGEQDyDYLNDSRCphosphoELM
S788QDYDLsQLQQPHPRD
Y496VNENPyFAPNPPhosphoSitePlus
Y820HAEPQyPVRSACadherin_CPhosphoSitePlus

Dephosphorylation site
CADH2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269141E614KBIOMARTBreast Cancer21930507, 21930502
ENSP00000269141I648VCOSMICOvarian Cancer21720365
ENSP00000269141W272RCOSMICOvarian Cancer21720365
ENSP00000269141E752QCOSMICOvarian Cancer21720365
ENSP00000269141Y860CCOSMICLung Cancer20668451
ENSP00000269141R339GBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CADH2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CADH2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCADH2_HUMANkinase -> substrateRegPhos
CADH2_HUMANCADH2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0005912adherens junctionIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0016477cell migrationIEAbiological_process
GO:0045216cell-cell junction organizationTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005916fascia adherensIEAcellular_component
GO:0008013beta-catenin bindingTASmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0007156homophilic cell adhesionIEAbiological_process
GO:0045294alpha-catenin bindingIPImolecular_function
GO:0016342catenin complexIDAcellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0045202synapseIEAcellular_component
GO:0042692muscle cell differentiationTASbiological_process
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0045295gamma-catenin bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0034329cell junction assemblyTASbiological_process
GO:0034332adherens junction organizationTASbiological_process
GO:0005913cell-cell adherens junctionIDAcellular_component
GO:0005911cell-cell junctionIDAcellular_component
GO:0014704intercalated discIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0014704intercalated discISScellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0016339calcium-dependent cell-cell adhesionIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007157heterophilic cell-cell adhesionIEAbiological_process