Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CACB2_HUMAN
Description:calcium channel, voltage-dependent, beta 2 subunit [Source:HGNC Symbol;Acc:1402]
Location:chr10 p12.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S510QHRSSsSAPHHPRKACAHPRD
S533SQHRSsSSAPHPKA_groupphosphoELM; RegPhos
S476PIRSAsQAEEEPRKACAHPRD
S534QHRSSsSAPHHPRKACAHPRD
T219SSRKStPPSSAPRKACAHPRD
S466PIRSAsQAEEEPRKACAHPRD
S480QHRSSsSAPHHPRKACAHPRD
T165SSRKStPPSSAPRKACAHPRD
S514PIRSAsQAEEEPRKACAHPRD
S484TLATSsLPLSPPhosphoSitePlus
S460PIRSAsQAEEEPRKACAHPRD
S485SQHRSsSSAPHPRKACAHPRD
T164SSRKStPPSSAPRKACAHPRD
S483RTLATsSLPLSPKACaRegPhos
S490PIRSAsQAEEEPRKACAHPRD
S479SQHRSsSSAPHPRKACAHPRD
S495TLASNsQGSQGPKACaRegPhos
S514PIRSAsQAEEEPKA_groupphosphoELM; RegPhos
S509SQHRSsSSAPHPRKACAHPRD
S534QHRSSsSAPHHPKACaRegPhos
S534QHRSSsSAPHHPKA_groupphosphoELM; RegPhos
S506QHRSSsSAPHHPRKACAHPRD
S533SQHRSsSSAPHPKACaRegPhos
T482SRTLAtSSLPLPhosphoSitePlus
S514PIRSAsQAEEEPKACaRegPhos
T191SSRKStPPSSAPRKACAHPRD
S482QHRSSsSAPHHPRKACAHPRD
S486QHRSSsSAPHHPRKACAHPRD
T219SSRKStPPSSAPKA_groupphosphoELM; RegPhos
S495SQHRSsSSAPHPRKACAHPRD
S479QHRSSsSAPHHPRKACAHPRD
T219SSRKStPPSSGPRKACAHPRD
T554LSRQEtFDSETPhosphoSitePlus
S505SQHRSsSSAPHPRKACAHPRD
T191SSRKStPPSSGPRKACAHPRD
T464AYWKAtHPPSSImpA-rel_NPhosphoSitePlus
T219SSRKStPPSSAPKACaRegPhos
S462PIRSAsQAEEEPRKACAHPRD
S486PIRSAsQAEEEPRKACAHPRD
S483HRSSSsAPHHNPRKACAHPRD
S459PIRSAsQAEEEPRKACAHPRD
S533SQHRSsSSAPHPRKACAHPRD
S478SQHRSsSSAPHPRKACAHPRD
S550TSRGLsRQETFPhosphoSitePlus
S496QHRSSsSAPHHPRKACAHPRD
T171SSRKStPPSSAPRKACAHPRD

Dephosphorylation site
CACB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366532*613WCOSMICOvarian Cancer21720365
ENSP00000366532*613YCOSMICRenal Cancer21248752
ENSP00000320025A99GBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000282343R450CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000320025A99GSjoblom2006Intestines Cancer16959974, 21930507, 21930502

Differential expressed protein
CACB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CACB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANCACB2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007411axon guidanceTASbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0006816calcium ion transportNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005891voltage-gated calcium channel complexIDAcellular_component
GO:0007601visual perceptionIEAbiological_process
GO:0005891voltage-gated calcium channel complexIEAcellular_component
GO:0070509calcium ion importIDAbiological_process
GO:0008331high voltage-gated calcium channel activityIDAmolecular_function
GO:0005262calcium channel activityNASmolecular_function
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0051928positive regulation of calcium ion transportIDAbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0007528neuromuscular junction developmentTASbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0005245voltage-gated calcium channel activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006810transportTASbiological_process


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