Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CAC1C_HUMAN
Description:calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:HGNC Symbol;Acc:1390]
Location:chr12 p13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1739AVSAAsEDDIFPhosphoSitePlus
S1003SVSLIsFGIQSTM; Ion_transPhosphoSitePlus
S1898LGRRAsFHLECPRKACAHPRD
S1981LGRRAsFHLECPKA_group RegPhos
S1597IWKRTsMKLLDPRKACAHPRD
Y1076FKGKLyTCSDSIon_transPhosphoSitePlus
S1692LVGKPsQRNALPhosphoSitePlus
Y1920SQDETyEVKMNPhosphoSitePlus
S1973RGFLRsASLGRPKA_group RegPhos
S1535LTRDWsILGPHPKA_group RegPhos
S1404WTFIKsFQALPIon_transPhosphoSitePlus
S1981LGRRAsFHLECPhosphoSitePlus
T1919TSQDEtYEVKMPhosphoSitePlus
Y1832PRPAGyPSTVSPhosphoSitePlus
S2103SLMVPsQAGAPPhosphoSitePlus
S1670IRRAIsGDLTAPRKACAHPRD
S1998RGGDIsQKTVLPhosphoSitePlus
Y1142WPELLyRSIDSIon_transPhosphoSitePlus
S815TADGEsPPATKRegPhos
T6MVNENtRMYIPPhosphoSitePlus
Y1410FQALPyVALLIIon_transPhosphoSitePlus
S1760VSYYQsDGRSAPhosphoSitePlus
Y2217QDSRVyVSSL_PhosphoSitePlus
T1077KGKLYtCSDSSIon_transPhosphoSitePlus
S1718IRRAIsGDLTAPKACaRegPhos
S1901PSRCHsRESQAPhosphoSitePlus
S1645IWKRTsMKLLDPKACaRegPhos
S1981LGRRAsFHLECPKACaRegPhos
S2126EAVLIsEGLGQPhosphoSitePlus
Y988SFCRNyFNILDTM; Ion_transPhosphoSitePlus

Dephosphorylation site
CAC1C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385724L197VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382563G1047EBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000382563R462QTCGAOvarian Cancer21720365, 18772890
ENSP00000382506N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382563N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382547N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382557L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000341092N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382563A71ETCGAOvarian Cancer21720365, 18772890
ENSP00000382500L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382504N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382515L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382500N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382552N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382549N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341092L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000329877L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382563A1765DTCGAOvarian Cancer21720365, 18772890
ENSP00000382563A49DBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000329877N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382563L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382530N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382563V1969ATCGAOvarian Cancer21720365, 18772890
ENSP00000382537N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000266376L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382510N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382537L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382549L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382515N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382506L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382552L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382547L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382546N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382546L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382557N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000266376N348KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382510L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382530L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382563V1977ATCGAOvarian Cancer21720365, 18772890
ENSP00000382563R1329LTCGAOvarian Cancer21720365, 18772890
ENSP00000382504L167VBIOMARTBreast Cancer21930507, 21930502
ENSP00000382563A1699STCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CAC1C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CAC1C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCAC1C_HUMANkinase -> substrateRegPhos
KPCA_HUMANCAC1C_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa05031Amphetamine addiction
hsa05414Dilated cardiomyopathy
hsa04912GnRH signaling pathway
hsa05010Alzheimer's disease
hsa04725Cholinergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04270Vascular smooth muscle contraction
hsa04010MAPK signaling pathway
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04727GABAergic synapse
hsa04930Type II diabetes mellitus
hsa04720Long-term potentiation
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04726Serotonergic synapse
hsa04724Glutamatergic synapse
hsa04728Dopaminergic synapse
hsa04260Cardiac muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0030252growth hormone secretionIEAbiological_process
GO:0017156calcium ion-dependent exocytosisIEAbiological_process
GO:0043198dendritic shaftIEAcellular_component
GO:0030073insulin secretionIEAbiological_process
GO:0002095caveolar macromolecular signaling complexIEAcellular_component
GO:0055085transmembrane transportIEAbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0005516calmodulin bindingIPImolecular_function
GO:0005245voltage-gated calcium channel activityIDAmolecular_function
GO:0046620regulation of organ growthIEAbiological_process
GO:0050796regulation of insulin secretionTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0008217regulation of blood pressureIEAbiological_process
GO:0006811ion transportIEAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0006939smooth muscle contractionIEAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0007628adult walking behaviorIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0060083smooth muscle contraction involved in micturitionIEAbiological_process
GO:0030018Z discISScellular_component
GO:0016021integral to membraneIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0051393alpha-actinin bindingIPImolecular_function
GO:0005891voltage-gated calcium channel complexIDAcellular_component
GO:0008542visual learningIEAbiological_process
GO:0014069postsynaptic densityIDAcellular_component
GO:0019229regulation of vasoconstrictionIEAbiological_process
GO:0005216ion channel activityIEAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0060402calcium ion transport into cytosolTASbiological_process