| UniProt/SwissProt ID: | BTC_HUMAN |
| Description: | betacellulin [Source:HGNC Symbol;Acc:1121] |
| Location: | chrHG706_PATCH q13.3 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| BTC_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| BTC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379092 | E159K | COSMIC | Melanoma | 21499247 | ENSP00000379092 | V127I | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| BTC_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BTC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BTC_HUMAN | ERBB4_HUMAN | ligand -> receptor | HPMR |
| BTC_HUMAN | EGFR_HUMAN | ligand -> receptor | HPMR |
| BTC_HUMAN | EGFR_HUMAN | other | KEGG |
| BTC_HUMAN | ERBB4_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04012 | ErbB signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
| GO:0005154 | epidermal growth factor receptor binding | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0051781 | positive regulation of cell division | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |