Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BMI1_HUMAN
Description:BMI1 polycomb ring finger oncogene [Source:HGNC Symbol;Acc:1066]
Location:chr10 p12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S276CLPSPsTPVQSPhosphoSitePlus
Y203EPLKDyYTLMDPhosphoSitePlus
S269GIPSTsSCLPSPhosphoSitePlus
S274SSCLPsPSTPVPhosphoSitePlus
S281STPVQsPHPQFPhosphoSitePlus
S290QFPHIsSTMNGPhosphoSitePlus
S315NRPRKsSVNGSPhosphoSitePlus
S316RPRKSsVNGSSPhosphoSitePlus
S251AGELEsDSGSDPhosphoSitePlus; HPRD
S253ELESDsGSDKAPhosphoSitePlus; HPRD
Y204PLKDYyTLMDIPhosphoSitePlus
S255ESDSGsDKANSPhosphoSitePlus; HPRD
T277LPSPStPVQSPPhosphoSitePlus
T244QRDGLtNAGELPhosphoSitePlus

Dephosphorylation site
BMI1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365851T29KTCGAOvarian Cancer21720365, 18772890
ENSP00000365851P282SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000365851T29KCOSMICOvarian Cancer21720365
ENSP00000365851S315LCOSMICMelanoma21499247
ENSP00000365851P261LCOSMICSkin Cancer21984974

Differential expressed protein
BMI1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BMI1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANBMI1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
BMI1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006959humoral immune responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationIMPbiological_process
GO:0000151ubiquitin ligase complexIEAcellular_component
GO:0016573histone acetylationIEAbiological_process
GO:0007379segment specificationTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0048103somatic stem cell divisionIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0033092positive regulation of immature T cell proliferatiIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0031519PcG protein complexIEAcellular_component
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0051443positive regulation of ubiquitin-protein ligase acIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0035102PRC1 complexIDAcellular_component
GO:0071535RING-like zinc finger domain bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0021903rostrocaudal neural tube patterningIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0016574histone ubiquitinationIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0030097hemopoiesisIEPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016604nuclear bodyIEAcellular_component
GO:0010468regulation of gene expressionIMPbiological_process


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