| UniProt/SwissProt ID: | BIEA_HUMAN |
| Description: | biliverdin reductase A [Source:HGNC Symbol;Acc:1062] |
| Location: | chr7 p13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S237 | HFKSGsLENVP | HPRD | |
| Y83 | SSHEDyIRQFL | phosphoELM; RegPhos | |
| Y228 | LKRNRyLSFHF | INSR | phosphoELM |
| Y198 | RKEDQyMKMTV | INSR | phosphoELM |
| Y291 | EEIQKyCCSRK | InsR | RegPhos |
| S237 | HFKSGsLENVP | Biliv-reduc_cat | PhosphoSitePlus |
| S230 | RNRYLsFHFKS | HPRD; phosphoELM; SysPTM | |
| S149 | DLLKGsLLFTA | phosphoELM | |
| S33 | RNPHPsSAFLN | GFO_IDH_MocA; KSR1-SAM | PhosphoSitePlus |
| Y291 | EEIQKyCCS | INSR | phosphoELM |
| S178 | LTWLVsLFGEL | Biliv-reduc_cat | PhosphoSitePlus |
| T174 | GISRLtWLVSL | Biliv-reduc_cat | PhosphoSitePlus |
| S21 | VGRAGsVRMRD | GFO_IDH_MocA; KSR1-SAM | PhosphoSitePlus |
| S149 | DLLKGsLLFTA | Biliv-reduc_cat | PhosphoSitePlus |
| T207 | TVCLEtEKKSP | Biliv-reduc_cat | PhosphoSitePlus |
| Y83 | SSHEDyIRQFL | GFO_IDH_MocA; KSR1-SAM | PhosphoSitePlus |
| Y72 | EVEVAyICSES | phosphoELM; RegPhos | |
| T202 | QYMKMtVCLET | Biliv-reduc_cat | PhosphoSitePlus |
| Y72 | EVEVAyICSES | GFO_IDH_MocA; KSR1-SAM | PhosphoSitePlus |
| Y291 | EEIQKyCCSRK | PhosphoSitePlus | |
| Y228 | LKRNRyLSFHF | InsR | RegPhos |
| Y198 | RKEDQyMKMTV | Biliv-reduc_cat | PhosphoSitePlus |
| Y198 | RKEDQyMKMTV | InsR | RegPhos |
| S230 | RNRYLsFHFKS | Biliv-reduc_cat | PhosphoSitePlus; SysPTM |
| Y228 | LKRNRyLSFHF | Biliv-reduc_cat | PhosphoSitePlus |
| Dephosphorylation site |
| BIEA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265523 | R225* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385757 | R225* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265523 | R225* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000385757 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.9 | 14997500 | ENSP00000385757 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.78 | 20739354 | ENSP00000385757 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.78 | 20739354 |
| Hyperphosphorylation site |
| BIEA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | BIEA_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00860 | Porphyrin and chlorophyll metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IDA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004074 | biliverdin reductase activity | IDA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0006778 | porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0042167 | heme catabolic process | TAS | biological_process |