Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BIEA_HUMAN
Description:biliverdin reductase A [Source:HGNC Symbol;Acc:1062]
Location:chr7 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S237HFKSGsLENVPHPRD
Y83SSHEDyIRQFLphosphoELM; RegPhos
Y228LKRNRyLSFHFINSRphosphoELM
Y198RKEDQyMKMTVINSRphosphoELM
Y291EEIQKyCCSRKInsRRegPhos
S237HFKSGsLENVPBiliv-reduc_catPhosphoSitePlus
S230RNRYLsFHFKSHPRD; phosphoELM; SysPTM
S149DLLKGsLLFTAphosphoELM
S33RNPHPsSAFLNGFO_IDH_MocA; KSR1-SAMPhosphoSitePlus
Y291EEIQKyCCSINSRphosphoELM
S178LTWLVsLFGELBiliv-reduc_catPhosphoSitePlus
T174GISRLtWLVSLBiliv-reduc_catPhosphoSitePlus
S21VGRAGsVRMRDGFO_IDH_MocA; KSR1-SAMPhosphoSitePlus
S149DLLKGsLLFTABiliv-reduc_catPhosphoSitePlus
T207TVCLEtEKKSPBiliv-reduc_catPhosphoSitePlus
Y83SSHEDyIRQFLGFO_IDH_MocA; KSR1-SAMPhosphoSitePlus
Y72EVEVAyICSESphosphoELM; RegPhos
T202QYMKMtVCLETBiliv-reduc_catPhosphoSitePlus
Y72EVEVAyICSESGFO_IDH_MocA; KSR1-SAMPhosphoSitePlus
Y291EEIQKyCCSRKPhosphoSitePlus
Y228LKRNRyLSFHFInsRRegPhos
Y198RKEDQyMKMTVBiliv-reduc_catPhosphoSitePlus
Y198RKEDQyMKMTVInsRRegPhos
S230RNRYLsFHFKSBiliv-reduc_catPhosphoSitePlus; SysPTM
Y228LKRNRyLSFHFBiliv-reduc_catPhosphoSitePlus

Dephosphorylation site
BIEA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265523R225*COSMICOvarian Cancer21720365
ENSP00000385757R225*TCGAOvarian Cancer21720365, 18772890
ENSP00000265523R225*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000385757colorectal cancerNormal vs. CancertissueUp1.914997500
ENSP00000385757Breast CancerNormal vs. CancertissueUp0.7820739354
ENSP00000385757Breast CancerNormal vs. CancertissueUp0.7820739354

Hyperphosphorylation site
BIEA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANBIEA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00860Porphyrin and chlorophyll metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0055114oxidation-reduction processIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0004074biliverdin reductase activityIDAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0006778porphyrin-containing compound metabolic processTASbiological_process
GO:0042167heme catabolic processTASbiological_process


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