| UniProt/SwissProt ID: | BC11A_HUMAN |
| Description: | B-cell CLL/lymphoma 11A (zinc finger protein) [Source:HGNC Symbol;Acc:13221] |
| Location: | chr2 p16.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S88 | KPPSPsPIEMK | PhosphoSitePlus | |
| S618 | ASGGLsKKLLL | PhosphoSitePlus | |
| T426 | KRHMKtHMHKS | zf-C2H2 | PhosphoSitePlus |
| S328 | AGNTSsPPLSP | PhosphoSitePlus | |
| S86 | VDKPPsPSPIE | PhosphoSitePlus | |
| S594 | SVAGEsDRIDD | PhosphoSitePlus | |
| T584 | EGHRDtCDEDS | PhosphoSitePlus | |
| S625 | KLLLGsPSSLS | PhosphoSitePlus | |
| T722 | GSGGStPHISG | PhosphoSitePlus | |
| T701 | SLRFStPPGEL | PhosphoSitePlus | |
| T765 | HRRSHtGERPY | PhosphoSitePlus | |
| S332 | SSPPLsPGRPS | PhosphoSitePlus | |
| S741 | KEGRRsDTCEY | PhosphoSitePlus | |
| S627 | LLGSPsSLSPF | PhosphoSitePlus | |
| T208 | HGSPLtPRVGI | PhosphoSitePlus | |
| S614 | PGESAsGGLSK | PhosphoSitePlus | |
| S608 | NGRGCsPGESA | PhosphoSitePlus; HPRD | |
| S718 | RSGTGsGGSTP | PhosphoSitePlus | |
| T743 | GRRSDtCEYCG | PhosphoSitePlus | |
| S589 | TCDEDsVAGES | PhosphoSitePlus | |
| S630 | SPSSLsPFSKR | PhosphoSitePlus | |
| T262 | GRFPPtPPLFS | PhosphoSitePlus | |
| S205 | ESEHGsPLTPR | PhosphoSitePlus; phosphoELM | |
| T435 | KSSPMtVKSDD | PhosphoSitePlus | |
| S432 | HMHKSsPMTVK | PhosphoSitePlus | |
| S267 | TPPLFsPPPRH | PhosphoSitePlus | |
| S201 | RIYLEsEHGSP | PhosphoSitePlus | |
| T357 | PPFLAtPPLPP | PhosphoSitePlus | |
| S721 | TGSGGsTPHIS | PhosphoSitePlus | |
| S447 | LSTASsPEPGT | PhosphoSitePlus | |
| S628 | LGSPSsLSPFS | PhosphoSitePlus | |
| Y198 | HGLRIyLESEH | PhosphoSitePlus | |
| Dephosphorylation site |
| BC11A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000338774 | G514S | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000351307 | V777M | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000338774 | R740C | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000338774 | H188Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000338774 | S431L | COSMIC | Melanoma | 21499247 | ENSP00000349300 | S142F | Sjoblom2006, BIOMART | Breast Cancer | 16959974, 18428421, 21930507, 21930502 | ENSP00000338774 | A189T | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000338774 | V811M | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000338774 | P305S | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000338774 | S142F | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000338774 | E200Q | COSMIC | Ovarian Cancer | 20826764 | ENSP00000338774 | S554F | COSMIC | Melanoma | ENSP00000338774 | S390N | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| BC11A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BC11A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | BC11A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BC11A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0042803 | protein homodimerization activity | TAS | molecular_function |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0010977 | negative regulation of neuron projection developme | IDA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0046982 | protein heterodimerization activity | IPI | molecular_function |
| GO:0048672 | positive regulation of collateral sprouting | IMP | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0050773 | regulation of dendrite development | IMP | biological_process |
| GO:0010976 | positive regulation of neuron projection developme | IDA | biological_process |
| GO:0003714 | transcription corepressor activity | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | ISS | biological_process |
| GO:2000171 | negative regulation of dendrite development | IMP | biological_process |
| GO:0005737 | cytoplasm | NAS | cellular_component |
| GO:0030097 | hemopoiesis | NAS | biological_process |
| GO:0010629 | negative regulation of gene expression | IEA | biological_process |
| GO:0016925 | protein sumoylation | ISS | biological_process |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0048671 | negative regulation of collateral sprouting | IMP | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0032463 | negative regulation of protein homooligomerization | IC | biological_process |
| GO:0030517 | negative regulation of axon extension | ISS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |