| UniProt/SwissProt ID: | ATX1_HUMAN |
| Description: | ataxin 1 [Source:HGNC Symbol;Acc:10548] |
| Location: | chr6 p22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S238 | LITPGsPPPAQ | DUF4192; Suf | PhosphoSitePlus |
| S253 | VHISSsPQNTG | HPRD | |
| S776 | RKRRWsAPESR | AKT1 | RegPhos |
| S312 | KKAESsRLQQA | PhosphoSitePlus | |
| S254 | VHISSsPQNTG | phosphoELM | |
| T236 | APGLItPGSPP | phosphoELM; RegPhos | |
| S776 | RKRRWsAPESR | AKT_group | RegPhos |
| S711 | VLLKHsKADGL | PhosphoSitePlus | |
| S776 | RKRRWsAPESR | PKB_group | phosphoELM |
| S251 | QYVHIsSSPQN | HPRD | |
| S88 | TGLDYsPPSAP | PhosphoSitePlus; SysPTM | |
| T595 | VEDLKtEDFIQ | HPRD | |
| S775 | RKRRWsAPESR | AKT1 | HPRD |
| S775 | RKRRWsAPESR | PhosphoSitePlus | |
| S238 | LITPGsPPPAQ | HPRD | |
| T235 | APGLItPGSPP | DUF4192; Suf | PhosphoSitePlus |
| S776 | RKRRWsAPESR | phosphoELM | |
| S239 | LITPGsPPPAQ | phosphoELM; RegPhos | |
| Dephosphorylation site |
| ATX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000244769 | S95F | COSMIC | Melanoma | 21499247 | ENSP00000244769 | A105P | COSMIC | Skin Cancer | 21984974 | ENSP00000244769 | H354R | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| ATX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ATX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | ATX1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | ATX1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| ATX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042405 | nuclear inclusion body | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016363 | nuclear matrix | IDA | cellular_component |
| GO:0008266 | poly(U) RNA binding | IDA | molecular_function |
| GO:0008219 | cell death | IEA | biological_process |
| GO:0043569 | negative regulation of insulin-like growth factor | IEA | biological_process |
| GO:0060079 | regulation of excitatory postsynaptic membrane pot | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0042405 | nuclear inclusion body | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0051168 | nuclear export | IDA | biological_process |
| GO:0043621 | protein self-association | IDA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0042272 | nuclear RNA export factor complex | IDA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0006396 | RNA processing | NAS | biological_process |
| GO:0008344 | adult locomotory behavior | IEA | biological_process |
| GO:0008542 | visual learning | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0042326 | negative regulation of phosphorylation | IEA | biological_process |
| GO:0034046 | poly(G) RNA binding | IDA | molecular_function |