| UniProt/SwissProt ID: | AT2B4_HUMAN |
| Description: | ATPase, Ca++ transporting, plasma membrane 4 [Source:HGNC Symbol;Acc:817] |
| Location: | chr1 q32.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1132 | IHSFMtHPEFA | HPRD | |
| T1102 | LNRIQtQIDVI | PKC_group | RegPhos |
| S1149 | KAFHSsLHESI | PhosphoSitePlus | |
| S1153 | SSLHEsIQKPY | PhosphoSitePlus | |
| T1181 | EELPRtPLLDE | PhosphoSitePlus | |
| S436 | ISLAYsVKKMM | E1-E2_ATPase | PhosphoSitePlus |
| T415 | FIIGItVLVVA | E1-E2_ATPase; TM | PhosphoSitePlus |
| S1165 | QKSIHsFMTHP | PhosphoSitePlus | |
| Y905 | LKRRPyGRNKP | Cation_ATPase_C | PhosphoSitePlus |
| T1203 | LQSLEt | HPRD | |
| Y435 | TISLAySVKKM | E1-E2_ATPase | PhosphoSitePlus |
| S67 | PVEGLsGNPAD | Cation_ATPase_N | PhosphoSitePlus |
| S13 | VLPANsMAESR | PhosphoSitePlus | |
| Y1212 | GEVTPyANTNN | PhosphoSitePlus | |
| Y1212 | GEVTPyANTNN | SRC_group | phosphoELM |
| Y1212 | GEVTPyANTNN | Src_group | RegPhos |
| T691 | KQAGItVRMVT | Hydrolase | PhosphoSitePlus |
| S1115 | FQTGAsFKGVL | PhosphoSitePlus | |
| Y1158 | SIQKPyNQKSI | PhosphoSitePlus | |
| S328 | IQPLNsQEGID | E1-E2_ATPase | PhosphoSitePlus; SysPTM |
| T783 | QVVAVtGDGTN | Hydrolase | PhosphoSitePlus |
| T1168 | IHSFMtHPEFA | PhosphoSitePlus; SysPTM | |
| Y1176 | GEVTPyANTNN | SRC | HPRD |
| Y1212 | GEVTPyANTNN | SRC | RegPhos |
| T787 | VTGDGtNDGPA | Hydrolase | PhosphoSitePlus |
| S464 | ATAICsDKTGT | Hydrolase | PhosphoSitePlus |
| S328 | IQPLNsQEGID | HPRD; SysPTM | |
| Dephosphorylation site |
| AT2B4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000375816 | P139A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350310 | E174D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356188 | P139A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000340930 | P139A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350310 | P254S | COSMIC | Melanoma | 21499247 | ENSP00000350310 | E1152V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350310 | P139A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356187 | P139A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356187 | E335D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000350310 | E335D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000340930 | E335D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356187 | E174D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356188 | E174D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000375816 | E174D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000340930 | E174D | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356187 | Gastric Cancer | Metastasis | cell line | Down | 17022644 | ENSP00000356187 | Gastric Cancer | Metastasis | cell line | Down | 17022644 |
| Hyperphosphorylation site |
| AT2B4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | AT2B4_HUMAN | kinase -> substrate | HPRD |
| SRC_HUMAN | AT2B4_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | AT2B4_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04970 | Salivary secretion |
| hsa04972 | Pancreatic secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006812 | cation transport | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006810 | transport | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006754 | ATP biosynthetic process | IEA | biological_process |
| GO:0019829 | cation-transporting ATPase activity | IEA | molecular_function |
| GO:0005388 | calcium-transporting ATPase activity | IEA | molecular_function |
| GO:0070588 | calcium ion transmembrane transport | IEA | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0034220 | ion transmembrane transport | TAS | biological_process |
| GO:0005516 | calmodulin binding | IEA | molecular_function |