Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AT2B4_HUMAN
Description:ATPase, Ca++ transporting, plasma membrane 4 [Source:HGNC Symbol;Acc:817]
Location:chr1 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1132IHSFMtHPEFAHPRD
T1102LNRIQtQIDVIPKC_group RegPhos
S1149KAFHSsLHESIPhosphoSitePlus
S1153SSLHEsIQKPYPhosphoSitePlus
T1181EELPRtPLLDEPhosphoSitePlus
S436ISLAYsVKKMME1-E2_ATPasePhosphoSitePlus
T415FIIGItVLVVAE1-E2_ATPase; TMPhosphoSitePlus
S1165QKSIHsFMTHPPhosphoSitePlus
Y905LKRRPyGRNKPCation_ATPase_CPhosphoSitePlus
T1203LQSLEtHPRD
Y435TISLAySVKKME1-E2_ATPasePhosphoSitePlus
S67PVEGLsGNPADCation_ATPase_NPhosphoSitePlus
S13VLPANsMAESRPhosphoSitePlus
Y1212GEVTPyANTNNPhosphoSitePlus
Y1212GEVTPyANTNNSRC_groupphosphoELM
Y1212GEVTPyANTNNSrc_groupRegPhos
T691KQAGItVRMVTHydrolasePhosphoSitePlus
S1115FQTGAsFKGVLPhosphoSitePlus
Y1158SIQKPyNQKSIPhosphoSitePlus
S328IQPLNsQEGIDE1-E2_ATPasePhosphoSitePlus; SysPTM
T783QVVAVtGDGTNHydrolasePhosphoSitePlus
T1168IHSFMtHPEFAPhosphoSitePlus; SysPTM
Y1176GEVTPyANTNNSRCHPRD
Y1212GEVTPyANTNNSRCRegPhos
T787VTGDGtNDGPAHydrolasePhosphoSitePlus
S464ATAICsDKTGTHydrolasePhosphoSitePlus
S328IQPLNsQEGIDHPRD; SysPTM

Dephosphorylation site
AT2B4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000375816P139ABIOMARTBreast Cancer21930507, 21930502
ENSP00000350310E174DBIOMARTBreast Cancer21930507, 21930502
ENSP00000356188P139ABIOMARTBreast Cancer21930507, 21930502
ENSP00000340930P139ABIOMARTBreast Cancer21930507, 21930502
ENSP00000350310P254SCOSMICMelanoma21499247
ENSP00000350310E1152VCOSMICOvarian Cancer21720365
ENSP00000350310P139ABIOMARTBreast Cancer21930507, 21930502
ENSP00000356187P139ABIOMARTBreast Cancer21930507, 21930502
ENSP00000356187E335DTCGAOvarian Cancer21720365, 18772890
ENSP00000350310E335DCOSMICOvarian Cancer21720365
ENSP00000340930E335DTCGAOvarian Cancer21720365, 18772890
ENSP00000356187E174DBIOMARTBreast Cancer21930507, 21930502
ENSP00000356188E174DBIOMARTBreast Cancer21930507, 21930502
ENSP00000375816E174DBIOMARTBreast Cancer21930507, 21930502
ENSP00000340930E174DBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356187Gastric CancerMetastasiscell lineDown17022644
ENSP00000356187Gastric CancerMetastasiscell lineDown17022644

Hyperphosphorylation site
AT2B4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANAT2B4_HUMANkinase -> substrateHPRD
SRC_HUMANAT2B4_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANAT2B4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0006812cation transportIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006810transportTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0019829cation-transporting ATPase activityIEAmolecular_function
GO:0005388calcium-transporting ATPase activityIEAmolecular_function
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0034220ion transmembrane transportTASbiological_process
GO:0005516calmodulin bindingIEAmolecular_function


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