| UniProt/SwissProt ID: | ARI2_HUMAN |
| Description: | ariadne homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:690] |
| Location: | chr3 p21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S466 | VERADsYDRGD | PhosphoSitePlus | |
| Y337 | THGSEyYECSR | IBR | PhosphoSitePlus |
| Y338 | HGSEYyECSRY | IBR | PhosphoSitePlus |
| S353 | DIVNQsQQAQA | PhosphoSitePlus; HPRD; phosphoELM | |
| Y422 | LAKCRyTLQYT | PhosphoSitePlus | |
| Y430 | QYTYPyAYYME | PhosphoSitePlus | |
| Y432 | TYPYAyYMESG | PhosphoSitePlus | |
| Y433 | YPYAYyMESGP | PhosphoSitePlus | |
| Y428 | TLQYTyPYAYY | PhosphoSitePlus | |
| Dephosphorylation site |
| ARI2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ARI2_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000403222 | Lung Cancer | Normal vs. Cancer | tissue | Up | 15626334 | |
| Hyperphosphorylation site |
| ARI2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | ARI2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ARI2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ARI2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042787 | protein ubiquitination involved in ubiquitin-depen | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0071425 | hematopoietic stem cell proliferation | IDA | biological_process |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0070936 | protein K48-linked ubiquitination | IDA | biological_process |
| GO:0048588 | developmental cell growth | IDA | biological_process |
| GO:0070534 | protein K63-linked ubiquitination | IDA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0000209 | protein polyubiquitination | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |