Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARI2_HUMAN
Description:ariadne homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:690]
Location:chr3 p21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S466VERADsYDRGDPhosphoSitePlus
Y337THGSEyYECSRIBRPhosphoSitePlus
Y338HGSEYyECSRYIBRPhosphoSitePlus
S353DIVNQsQQAQAPhosphoSitePlus; HPRD; phosphoELM
Y422LAKCRyTLQYTPhosphoSitePlus
Y430QYTYPyAYYMEPhosphoSitePlus
Y432TYPYAyYMESGPhosphoSitePlus
Y433YPYAYyMESGPPhosphoSitePlus
Y428TLQYTyPYAYYPhosphoSitePlus

Dephosphorylation site
ARI2_HUMAN do not have dephosphorylation site.

Mutation site
ARI2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000403222Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
ARI2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANARI2_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANARI2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ARI2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042787protein ubiquitination involved in ubiquitin-depenIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007275multicellular organismal developmentTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071425hematopoietic stem cell proliferationIDAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0070936protein K48-linked ubiquitinationIDAbiological_process
GO:0048588developmental cell growthIDAbiological_process
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component


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