| UniProt/SwissProt ID: | APJ_HUMAN |
| Description: | apelin receptor [Source:HGNC Symbol;Acc:339] |
| Location: | chr11 q12.1 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y264 | LCWMPyHLVKT | 7tm_1; TM | PhosphoSitePlus |
| S248 | RRRLLsIIVVL | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| APJ_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000257254 | E367K | COSMIC | Lung Cancer | 20668451 | ENSP00000257254 | Y11N | COSMIC | Lung Cancer | 20668451 | ENSP00000257254 | T52N | COSMIC | Lung Cancer | 20668451 | ENSP00000257254 | R127H | COSMIC | Lung Cancer | 20668451 | ENSP00000257254 | R233L | COSMIC | Lung Cancer | 20668451 | ENSP00000257254 | C281Y | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| APJ_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| APJ_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| APEL_HUMAN | APJ_HUMAN | ligand -> receptor | HPMR |
| IP3KA_HUMAN | APJ_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0050909 | sensory perception of taste | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0050878 | regulation of body fluid levels | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |