| UniProt/SwissProt ID: | ANX11_HUMAN |
| Description: | annexin A11 [Source:HGNC Symbol;Acc:535] |
| Location: | chr10 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S486 | LYHDIsGDTSG | Annexin | PhosphoSitePlus |
| Y365 | DAQELyAAGEN | CHAD; Annexin | PhosphoSitePlus |
| T489 | DISGDtSGDYR | Annexin | PhosphoSitePlus |
| Y53 | QFNQDyLSGMA | PhosphoSitePlus | |
| Y482 | YGKSLyHDISG | Annexin | PhosphoSitePlus |
| T464 | VSRSEtDLLDI | HPRD | |
| Y365 | DAQELyAAGEN | HPRD; phosphoELM | |
| T272 | LALMKtPVLFD | CHAD | PhosphoSitePlus |
| T321 | AEFKKtLEEAI | CHAD; Annexin | PhosphoSitePlus |
| S462 | IMVSRsETDLL | HPRD | |
| Y279 | VLFDIyEIKEA | CHAD; Annexin | PhosphoSitePlus |
| S480 | RMYGKsLYHDI | Annexin | PhosphoSitePlus |
| Y482 | YGKSLyHDISG | HPRD; phosphoELM | |
| Y493 | DTSGDyRKILL | Annexin | PhosphoSitePlus |
| T321 | AEFKKtLEEAI | HPRD | |
| Dephosphorylation site |
| ANX11_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361308 | N41I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000265447 | Prostate Cancer | Metastasis | cell line | Up | 6.6 | 15102926 | ENSP00000265447 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000265447 | Melanoma | Treatment (none vs. kojic acid treatment) | cell line | Down | 0.65 | 18630942 | ENSP00000265447 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Down | 0.22 | 19422301 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y482 | Annexin | RMYGKSLyHDISGDT | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | ANX11_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ANX11_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007109 | cytokinesis, completion of separation | IMP | biological_process |
| GO:0045335 | phagocytic vesicle | IDA | cellular_component |
| GO:0030496 | midbody | IDA | cellular_component |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0005544 | calcium-dependent phospholipid binding | IEA | molecular_function |
| GO:0005819 | spindle | IDA | cellular_component |
| GO:0006909 | phagocytosis | IEP | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005654 | nucleoplasm | NAS | cellular_component |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0008429 | phosphatidylethanolamine binding | IEA | molecular_function |
| GO:0042582 | azurophil granule | IDA | cellular_component |
| GO:0005635 | nuclear envelope | NAS | cellular_component |
| GO:0051592 | response to calcium ion | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0048306 | calcium-dependent protein binding | IPI | molecular_function |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0042581 | specific granule | IDA | cellular_component |