Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AGGF1_HUMAN
Description:angiogenic factor with G patch and FHA domains 1 [Source:HGNC Symbol;Acc:24684]
Location:chr5 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S3APSPHPRD
S17PPPPTsPEPELPhosphoSitePlus; HPRD; phosphoELM
T16SPPPPtSPEPEHPRD; phosphoELM
S7ASEAPsPPRSPPhosphoSitePlus
T445KDMEHtLRIPEFHAPhosphoSitePlus
S11PSPPRsPPPPTPhosphoSitePlus; HPRD; phosphoELM
S7PRSPHPRD; phosphoELM
S615PASVHsEITDSPhosphoSitePlus
S171HFASNsQEPASPhosphoSitePlus
T341PTSGNtIESPLHPRD

Dephosphorylation site
AGGF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000316109G519VCOSMICOvarian Cancer21720365
ENSP00000316109D291NCOSMICSkin Cancer21984974
ENSP00000316109H166YCOSMICMelanoma21499247
ENSP00000316109R688QCOSMICCentral Nervous System Neoplasms21163964
ENSP00000316109G519VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
AGGF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AGGF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK4_HUMANAGGF1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
AGGF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001525angiogenesisIEAbiological_process
GO:0005576extracellular regionIDAcellular_component
GO:0001938positive regulation of endothelial cell proliferatIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001570vasculogenesisTASbiological_process
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0007155cell adhesionIDAbiological_process
GO:0006396RNA processingTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component


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