| UniProt/SwissProt ID: | AGGF1_HUMAN |
| Description: | angiogenic factor with G patch and FHA domains 1 [Source:HGNC Symbol;Acc:24684] |
| Location: | chr5 q13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S3 | APSP | HPRD | |
| S17 | PPPPTsPEPEL | PhosphoSitePlus; HPRD; phosphoELM | |
| T16 | SPPPPtSPEPE | HPRD; phosphoELM | |
| S7 | ASEAPsPPRSP | PhosphoSitePlus | |
| T445 | KDMEHtLRIPE | FHA | PhosphoSitePlus |
| S11 | PSPPRsPPPPT | PhosphoSitePlus; HPRD; phosphoELM | |
| S7 | PRSP | HPRD; phosphoELM | |
| S615 | PASVHsEITDS | PhosphoSitePlus | |
| S171 | HFASNsQEPAS | PhosphoSitePlus | |
| T341 | PTSGNtIESPL | HPRD | |
| Dephosphorylation site |
| AGGF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316109 | G519V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316109 | D291N | COSMIC | Skin Cancer | 21984974 | ENSP00000316109 | H166Y | COSMIC | Melanoma | 21499247 | ENSP00000316109 | R688Q | COSMIC | Central Nervous System Neoplasms | 21163964 | ENSP00000316109 | G519V | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| AGGF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AGGF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK4_HUMAN | AGGF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| AGGF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005576 | extracellular region | IDA | cellular_component |
| GO:0001938 | positive regulation of endothelial cell proliferat | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0001570 | vasculogenesis | TAS | biological_process |
| GO:0045766 | positive regulation of angiogenesis | IDA | biological_process |
| GO:0007155 | cell adhesion | IDA | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0043499 | eukaryotic cell surface binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |