Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AFAP1_HUMAN
Description:actin filament associated protein 1 [Source:HGNC Symbol;Acc:24017]
Location:chr4 p16.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S687SSCDTsDTEGPHPRD
S631EAERVsLELELERMPhosphoSitePlus
Y94LPEGYyEEAVPPhosphoSitePlus
S664PKSGTsSPQSPERMPhosphoSitePlus
Y93SLPEGyYEEAVSRCHPRD
T675VFRHRtLENSPERMPhosphoSitePlus
S336GKKKPsTDEQTPhosphoSitePlus; HPRD
S282SSERPsSDGEGPhosphoSitePlus; HPRD; SysPTM
T663EPKSGtSSPQSHPRD
S682ENSPIsSCDTSHPRD
T637LELELtEVKESERMPhosphoSitePlus
Y93SLPEGyYEEAVPhosphoSitePlus
S283SERPSsDGEGVPhosphoSitePlus; HPRD; SysPTM
S665KSGTSsPQSPVERMPhosphoSitePlus
S668TSSPQsPVFRHHPRD; SysPTM
S265PPPPSsPVHKAPhosphoSitePlus; HPRD; SysPTM
Y353VPTCGyLNVLSPHPhosphoSitePlus
Y483ISANPyLGGTSPhosphoSitePlus
S520KPPVAsNGVTGPhosphoSitePlus
T337KKKPStDEQTSPhosphoSitePlus; HPRD
S495GYAHPsGTALHPhosphoSitePlus
T546AVVKRtGSNAAERMPhosphoSitePlus
Y453ALHYDyIDVEMSRCHPRD
T686ISSCDtSDTEGHPRD
S679RTLENsPISSCERMPhosphoSitePlus
S277LEKKLsSERPSPhosphoSitePlus; HPRD; SysPTM
S683NSPISsCDTSDHPRD
Y501GTALHyDDVPCPhosphoSitePlus
Y553SNAAQyKYGKNERMPhosphoSitePlus
Y453ALHYDyIDVEMPhosphoSitePlus
S687SSCDTsDTEGPERMPhosphoSitePlus
S664PKSGTsSPQSPHPRD
S548VKRTGsNAAQYERMPhosphoSitePlus; SysPTM
T497AHPSGtALHYDPhosphoSitePlus
S343DEQTSsAEEDVPhosphoSitePlus; HPRD; SysPTM
S342TDEQTsSAEEDPhosphoSitePlus; HPRD
S668TSSPQsPVFRHERMPhosphoSitePlus; SysPTM
Y451PEALHyDYIDVPhosphoSitePlus
Y125SSYESyDEEEEPhosphoSitePlus
S510PCINGsLKGKKPhosphoSitePlus
Y248VIKEAySGCSGPHPhosphoSitePlus
Y451PEALHyDYIDVSRCHPRD
S278EKKLSsERPSSHPRD; SysPTM
T315SEAKGtVSKVTPhosphoSitePlus; HPRD
S665KSGTSsPQSPVHPRD
T341STDEQtSSAEEPhosphoSitePlus; HPRD
T220HELKItQQGTDHPRD
S360NVLSNsRWRERHPRD
T350EEDVPtCGYLNPHPhosphoSitePlus
S710QAAPGsSPCRGPhosphoSitePlus; HPRD
S548VKRTGsNAAQYHPRD; SysPTM
S488YLGGTsNGYAHPhosphoSitePlus
T487PYLGGtSNGYAPhosphoSitePlus
S264CPPPPsSPVHKPhosphoSitePlus; HPRD
Y491GTSNGyAHPSGPhosphoSitePlus
T546AVVKRtGSNAAHPRD
T686ISSCDtSDTEGERMPhosphoSitePlus
Y94LPEGYyEEAVPSRCHPRD
S679RTLENsPISSCHPRD

Dephosphorylation site
AFAP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353402E427*COSMICSkin Cancer21984974
ENSP00000351245T137PBIOMARTBreast Cancer21930507, 21930502
ENSP00000353402V542LCOSMICSkin Cancer21984974
ENSP00000353402T137PBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
AFAP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AFAP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANAFAP1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
AFAP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003779actin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005925focal adhesionIDAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component


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