| UniProt/SwissProt ID: | ADA15_HUMAN |
| Description: | ADAM metallopeptidase domain 15 [Source:HGNC Symbol;Acc:193] |
| Location: | chr1 q22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y735 | GPTCQyRAAQS | Src_group | RegPhos |
| Y715 | MLGASyWYRAR | RegPhos | |
| Y715 | MLGASyWYRAR | TM | PhosphoSitePlus |
| Y735 | GPTCQyRAAQS | RegPhos | |
| Y735 | GPTCQyRAAQS | Src | RegPhos |
| Y715 | MLGASyWYRAR | SRC | phosphoELM |
| Y735 | GPTCQyRAAQS | SRC | phosphoELM |
| Y715 | MLGASyWYRAR | SRC_group | phosphoELM |
| Y715 | MLGASyWYRAR | HCK | phosphoELM; RegPhos |
| Y735 | GPTCQyRAAQS | SRC_group | phosphoELM |
| Y715 | MLGASyWYRAR | Src_group | RegPhos |
| Y715 | MLGASyWYRAR | Src | RegPhos |
| Dephosphorylation site |
| ADA15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000271836 | G405E | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000271836 | G741D | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000349436 | G741D | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000349436 | L402F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000349436 | G405E | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000349436 | W478L | COSMIC | Skin Cancer | 21984974 | ENSP00000271836 | L402F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000271836 | G138E | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000349436 | G138E | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000349436 | G27S | COSMIC | Melanoma |
| Differential expressed protein |
| ADA15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ADA15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | ADA15_HUMAN | kinase -> substrate | RegPhos |
| HCK_HUMAN | ADA15_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ADA15_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0042995 | cell projection | IEA | cellular_component |
| GO:0060317 | cardiac epithelial to mesenchymal transition | IEA | biological_process |
| GO:0030574 | collagen catabolic process | IEA | biological_process |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0001669 | acrosomal vesicle | IEA | cellular_component |
| GO:0008237 | metallopeptidase activity | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042246 | tissue regeneration | IEA | biological_process |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0007160 | cell-matrix adhesion | TAS | biological_process |
| GO:0005912 | adherens junction | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0012505 | endomembrane system | IEA | cellular_component |