Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:A2MG_HUMAN
Description:alpha-2-macroglobulin [Source:HGNC Symbol;Acc:7]
Location:chr12 p13.31
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y695PQLQQyEMHGPPhosphoSitePlus
T679GLKAFtNSKIRPhosphoSitePlus; HPRD
Y1021LNYKHyDGSYSA2M_compPhosphoSitePlus
S710VGFYEsDVMGRPhosphoSitePlus
Y1007SKAIGyLNTGYPhosphoSitePlus
Y1025HYDGSySTFGEA2M_compPhosphoSitePlus
T346SEITRtITKLSPhosphoSitePlus
S1387DVKMVsGFIPLA2M_recepPhosphoSitePlus
Y497KLSFYyLIMAKA2M_N_2PhosphoSitePlus
Y1012YLNTGyQRQLNA2M_compPhosphoSitePlus
Y708LRVGFyESDVMPhosphoSitePlus
T1395IPLKPtVKMLEA2M_recepPhosphoSitePlus
Y817ATVLNyLPKCIA2MPhosphoSitePlus

Dephosphorylation site
A2MG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000323929T306NBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000323929Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000323929Hepatocellular CarcinomaMetastasiscell lineDown0.1319016532
ENSP00000323929Brain CancerNormal vs. CancertissueUp4.218056677
ENSP00000323929Ovarian CancerNormal vs. CancertissueDown17137333

Hyperphosphorylation site
A2MG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
A2MG_HUMANLRP1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019899enzyme bindingIPImolecular_function
GO:0004867serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0043120tumor necrosis factor bindingIDAmolecular_function
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0001869negative regulation of complement activation, lectIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007597blood coagulation, intrinsic pathwayTASbiological_process
GO:0019959interleukin-8 bindingIPImolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0019966interleukin-1 bindingIDAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0002576platelet degranulationTASbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0019838growth factor bindingIDAmolecular_function
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0004866endopeptidase inhibitor activityIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0048863stem cell differentiationIEAbiological_process


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