onset or progression of DKD, i.e. (i) the decline of GFR below 60 ml/min per 1.73 m2 during the follow-up period for those with GFR>60 ml/min per 1.73 m2 at baseline or achieving ESRD or (ii) development of overt proteinuria in normo- and microalbuminuric subjects at baseline or (iii) progression of CKD by at least stage for those with CKD III and IV at baseline