7 transmembrane receptor (rhodopsin family)
SAM domain of Samd7,11 subfamily of Polycomb group
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors
ISG15 ubiquitin-like protein, first repeat of 2
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...
Laminin-type epidermal growth factor-like domain
Laminin-type epidermal growth factor-like domai
Domain found in sea urchin sperm protein, enterokinase, agrin
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...
Tumor necrosis factor receptor (TNFR) domain
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
Centaurin Pleckstrin homology (PH) domain
Putative GTPase activating protein for Arf
Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA
Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]
Ligand-binding domain of the T1R taste receptor
7 transmembrane sweet-taste receptor of 3 GCPR
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins.  Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway...
Segment polarity protein dishevelled (Dsh) C terminal
Mitochondrial domain of unknown function (DUF1713)
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...
von Willebrand factor (vWF) type A domain
ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC
ATPases associated with a variety of cellular activities
Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has...
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate...
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
Neurotransmitter-gated ion-channel ligand binding domain
PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3  proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific...
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...
Serine/Threonine protein kinases, catalytic domain
Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Phospholipase C (PLC) pleckstrin homology (PH) domain
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta
Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...
chromosome segregation protein SMC, common bacterial type
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...
CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are...
Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region
Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis
Death domain of Tumor Necrosis Factor Receptor superfamily 25
Molybdopterin guanine dinucleotide synthesis protein B
Pre-mRNA cleavage complex II protein Clp1
Type 1 periplasmic binding fold superfamily
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s
CG-1 domains are highly conserved domains of about 130 amino-acid residues
Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH...
Myb-Like Dna-Binding Domain of MTA3 and related proteins
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...
7 transmembrane receptor (Secretin family)
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]
Glucose-6-phosphate dehydrogenase, NAD binding domain
Domain in SPla and the RYanodine Receptor
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for...
ADP/ATP transporter on adenylate translocase
Protein of unknown function C-terminus (DUF2448)
C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase family, accessory domain (PIK domain)
Phosphoinositide 3-kinase (PI3K), class IA, delta isoform, catalytic domain
Lipocalin / cytosolic fatty-acid binding protein family
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...
CIDE_N domain of ICAD. The CIDE_N  (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are...
DNA Fragmentation factor 45kDa, C terminal domain
Peroxisomal membrane anchor protein (Pex14p) conserved region
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I
DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular...
TOR (Target of rapamycin), catalytic domain
Angiotensin II, type I receptor-associated protein
Angiotensin II, type I receptor-associated protein (AGTRAP)
Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...
ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes.  This family...
CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...
Domain in cystathionine beta-synthase and other proteins
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...
Prolyl 4-hydroxylase alpha subunit homologues
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
N-terminal region of Chorein, a TM vesicle-mediated sorter
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...
Short-chain dehydrogenases of various substrate specificities [General function prediction only]
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...
Caspase activation and recruitment domain of Caspase-9
Caspase, interleukin-1 beta converting enzyme (ICE) homologues
TRX domain, DnaJ domain containing protein family
Agmatinase-like family includes proclavaminic acid amidinohydrolase
DNA damage inducible protein 1 ubiquitin-like domain
LIM is a small protein-protein interaction domain, containing two zinc fingers
The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
The third LIM domain of Zyxin-like family
Ubiquinol-cytochrome C reductase hinge protein
Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect...
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...
Ligand Binding Domain of Ephrin type-A Receptor 2
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
SAM domain of EPH-A2 family of tyrosine kinase receptors
Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
chromosome segregation protein SMC, primarily archaeal type
P-type ATPase of unknown pump specificity (type V)
Putative hydrolase of sodium-potassium ATPase alpha subunit
2Fe-2S iron-sulfur cluster binding domain
Protein-arginine deiminase (PAD) N-terminal domain
Protein-arginine deiminase (PAD) middle domain
Regulator of chromosome condensation (RCC1) repeat
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
Ribosomal protein L10 family, P0-like protein subfamily
PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes
PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes
marine proteobacterial sortase target protein
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...
Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...
Oligosaccharyltransferase 48 kDa subunit beta
Kinesin motor domain, kinesins II or KIF3_like proteins. Subgroup of kinesins, which form heterotrimers composed of 2 kinesins and one non-motor accessory subunit. Kinesins II play important roles in ciliary transport, and have been implicated in...
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism
Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
Third immunoglobulin (Ig)-like domain found in Perlecan and similar proteins
cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
Ligand Binding Domain of Ephrin type-A Receptor 8
SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
Collagen triple helix repeat (20 copies)
Ligand Binding Domain of Ephrin type-B Receptor 2
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
heterogeneous nuclear ribonucleoprotein R, Q family
KRAB (Kruppel-associated box) domain -A box
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS)
Transcription factor S-II (TFIIS), central domain
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
E2F/DP family winged-helix DNA-binding domain
RNA polymerase II transcription factor SIII (Elongin) subunit A
UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]
3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
GST_N family, Chloride Intracellular Channel (CLIC) subfamily
C-terminal, alpha helical domain of Chloride Intracellular Channel 4
Platelet-activating factor acetylhydrolase, isoform II
cation diffusion facilitator family transporter
SAM domain of CNK1,2,3-suppressor subfamily
Connector enhancer of kinase suppressor of ras
PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated
Connector enhancer of KSR (Kinase suppressor of ras)  (CNK) pleckstrin homology (PH) domain
Protein-interacting V-domain of mammalian Alix and related domains
Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily
DNA polymerase III subunits gamma and tau
Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein
Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS)
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
14-3-3 sigma, an isoform of 14-3-3 protein
Conserved hypothetical ATP binding protein
P-loop containing Nucleoside Triphosphate Hydrolases
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I)...
Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]
C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
C2 domain second repeat present in Synaptotagmin-like proteins 1-4
Multi-glycosylated core protein 24 (MGC-24)
Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
Catalytic domain of Src kinase-like Protein Tyrosine Kinases
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain
Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears...
acid sphingomyelinase and related proteins, metallophosphatase domain
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]
TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...
Protein tyrosine phosphatase, catalytic domain
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments
putative band 4.1 homologues' binding motif
S1_pNO40: pNO40 , S1-like RNA-binding domain. pNO40 is a nucleolar protein of unknown function with an N-terminal S1 RNA binding domain, a CCHC type zinc finger, and clusters of basic amino acids representing a potential nucleolar targeting signal
G-protein-coupled receptor proteolytic site domain
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo
Src homology 3 domain of Lck Protein Tyrosine Kinase
Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]
Histone-binding protein RBBP4 or subunit C of CAF1 complex
catalytic core domain of tyrosinyl-tRNA synthetase
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae...
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
SAM domain of Ph (polyhomeotic) proteins of Polycomb group
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...
Gap junction channel protein cysteine-rich domain
MYM-type Zinc finger with FCS sequence motif
zinc finger in transposases and transcription factors
Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...
polycystic kidney disease I (PKD) domain
Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...
PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille
Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of...
Transport protein particle (TRAPP) component
Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...
Eukaryotic homologues of bacterial periplasmic substrate binding proteins
A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors
Cell division cycle-associated protein 8
Ligand Binding Domain of Ephrin Receptors
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10
SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase
Glycoside hydrolase families 71, 99, and related domains
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate...
GTPase-activator protein for Rho-like GTPases
Splicing factor 3a, subunit 3 [RNA processing and modification]
The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
The third LIM domain of Four and a half LIM domains protein (FHL)
The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
Found in Pit-Oct-Unc transcription factors
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
Spectrin repeats, found in several proteins involved in cytoskeletal structure
Transforming growth factor-beta (TGF-beta) family
polyadenylate binding protein, human types 1, 2, 3, 4 family
Poly-adenylate binding protein, unique domain
cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...
Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]
tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]
Adenylate cyclase associated (CAP) N terminal
Adenylate cyclase associated (CAP) C terminal
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
Defects in morphology protein 1, mitochondrial precursor
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
Histone-like transcription factor (CBF/NF-Y) and archaeal histone
CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...
Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
SAM domain of Scm proteins of Polycomb group
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...
DNA / pantothenate metabolism flavoprotein
peptidyl-prolyl cis-trans isomerase B (rotamase B)
Catalytic domain of the Protein Tyrosine Kinase, Tie1
Mediator of RNA polymerase II transcription complex subunit 8
Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
Small domain found in the jumonji family of transcription factors
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...
Transforming growth factor beta like domain
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
diphthamide biosynthesis enzyme Dph1/Dph2 domain
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Na(+)- and Cl(-)-dependent glycine transporter GlyT1
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
DNA methyltransferase 1-associated protein 1 (DMAP1)
DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
Eukaryotic protein of unknown function (DUF829)
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development
Eukaryotic/archaeal ribosomal protein S8e and similar proteins
Broad-Complex, Tramtrack and Bric a brac
The Eukaryotic (Putative) Sterol Transporter (EST) Family
Sterol-sensing domain of SREBP cleavage-activation
The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...
eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...
Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...
APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
Domain Homologous to E6-AP Carboxyl Terminus with
Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...
N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...
Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
N-terminal Src homology 2 (nSH2) domain found in p85
C-terminal Src homology 2 (cSH2) domain found in p85
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides
Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]
Na(+)/glucose cotransporter SGLT4 and related proteins
Peptidase M14-like domain of ATP/GTP binding protein AGBL-4 and related proteins
The BEN domain is found in diverse animal proteins
UAS family, FAS-associated factor 1 (FAF1) subfamily
TATA element modulatory factor 1 TATA binding
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
Endoplasmic reticulum protein 19 (ERp19) family
Smad anchor for receptor activation (SARA)
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241
C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1)
BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC...
Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
universal minicircle sequence binding protein (UMSBP)
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase
Na+/H+-dicarboxylate symporters [Energy production and conversion]
Eukaryotic protein of unknown function (DUF866)
Mago nashi proteins, integral members of the exon junction complex
Low-density lipoprotein receptor repeat class B
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Brain specific membrane anchored protein
Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...
Mitochondrial 28S ribosomal protein S30 (PDCD9)
Single-stranded DNA binding protein, SSDP
Lipid-binding START domain of mammalian STARDT14 and related proteins
Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...
ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding
FAD/FMN-containing dehydrogenases [Energy production and conversion]
Peptidase S8 family domain in ProteinaseK-like proteins
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the...
Catalytic domain of AGC family Protein Serine/Threonine Kinases
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...
Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup
CTF/NF-I family transcription modulation region
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 7
Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction
The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...
Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
C2 domain of PTEN tumour-suppressor protein
Metal dependent phosphohydrolases with conserved 'HD' motif
mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
Interleukin-6 receptor alpha chain, binding
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex
Wnt-binding factor required for Wnt secretion
Retinal pigment epithelial membrane protein
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain...
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...
Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying...
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable...
Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding
Zn-finger in ubiquitin-hydrolases and other protein
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...
KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
C-terminal substrate binding domain of DnaJ and HSP40
Catalytic domain of the Protein Serine/Threonine Kinase, cAMP-dependent protein kinase
SAM domain of Atherin/Atherin-like subfamily
Catalytic domain, repeat 1, of Deoxyribonuclease II beta and similar proteins
Catalytic domain, repeat 2, of Deoxyribonuclease II beta and similar proteins
The Brix domain is found in a number of eukaryotic proteins
Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying...
Caspase activation and recruitment domain of B-cell lymphoma 10
Insulin-like growth factor binding protein
Glycoprotein hormone beta chain homologues
Chromosome segregation ATPases [Cell division and chromosome partitioning]
calcium-activated chloride channel protein 1
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1
The first LIM domain of LMO4 (LIM domain only protein 4)
The second LIM domain of LMO4 (LIM domain only protein 4)
First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
C2 domain in Protein kinase C-like (PKN) proteins
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase N
Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...
Guanylate-binding protein (GBP) family (N-terminal domain)
Leucine-rich repeat containing protein 8
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine
Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...
Pancreatitis induced protein 49 C terminal
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
Src Homology 3 domain of Formin Binding Protein 1-Like
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking
Guanine nucleotide exchange factor for Ras-like small GTPases
The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts...
Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protei
Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...
Interferon-alpha/beta receptor, fibronectin type III
Oligosaccharide biosynthesis protein Alg14 like
Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]
Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...
The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7
The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
Eukaryotic cytochrome b(561), including the FRRS1 gene product
Alpha amylase catalytic domain found in glycogen debranching enzymes
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...
2-oxoacid dehydrogenases acyltransferase (catalytic domain)
RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...
Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
Glycosidases [Carbohydrate transport and metabolism]
First Src homology 3 domain of VAV3 protein
Src homology 2 (SH2) domain found in the Vav3 proteins
C-terminal (or second) Src homology 3 domain of VAV3 protein
N-terminal C2 in EEIG1 and EHBP1 proteins
LGN motif, putative GEFs specific for G-alpha GTPases
The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...
proteasome_alpha_type_5. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
Eukaryotic cytochrome b(561), including the CYB561D2 gene product
Leucine-rich repeats, typical (most populated) subfamily
Alpha subunit of G proteins (guanine nucleotide binding)
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway
Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
C-terminal, alpha helical domain of the Glutathione S-transferase family
C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
Epidermal growth factor receptor kinase substrate (EPS8) Phosphotyrosine-binding (PTB) domain
Macrophage colony stimulating factor-1 (CSF-1)
S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Domain always found upstream of DENN domain, found in a variety of signalling proteins
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active...
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...
Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
Rap1 family GTPase consists of Rap1a and Rap1b isoforms
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif
Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
Serine/threonine phosphatases, family 2C, catalytic domain
Subgroup of the immunoglobulin (Ig) superfamily
Male germ-cell putative homeodomain transcription factor
TRF2-binding region of apollo and similar proteins
C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
Breast carcinoma amplified sequence 2 (BCAS2)
Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain
PDIb family, Calsequestrin subfamily, Middle TRX-fold domain
Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins
Predicted coiled-coil domain-containing protein (DUF2360)
Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...
catalytic core domain of tryptophanyl-tRNA synthetase
Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...
human 3beta-HSD (hydroxysteroid dehydrogenase) and HSD3B1(delta 5-delta 4-isomerase)-like, extended (e) SDRs
Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...
C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
C-type lectin (CTL)/C-type lectin-like (CTLD) domain
Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
Repulsive guidance molecule (RGM) N-terminus
Repulsive guidance molecule (RGM) C-terminus
Arrestin (or S-antigen), N-terminal domain
Arrestin (or S-antigen), C-terminal domain
DNA-directed RNA polymerase III subunit Rpc31
Peroxisomal biogenesis factor 11 (PEX11)
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta...
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...
RNA polymerase III subunit RPC82 helix-turn-helix domain
Abscisic acid G-protein coupled receptor
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
5'-AMP-activated protein kinase beta subunit, interation domain
Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...
Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases
Histidine phosphatase domain found in histidine acid phosphatases and phytases
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core
Antagonist of mitotic exit network protein 1
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide
CID (CTD-Interacting Domain) domain family
TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...
Threonyl and Alanyl tRNA synthetase second additional domain
Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...
ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...
Cathepsin propeptide inhibitor domain (I29)
Peptidase C1A subfamily (MEROPS database nomenclature)
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins
Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion]
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
The Sema domain, a protein interacting module, of semaphorins and plexins
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y)
Lysine Motif is a small domain involved in binding peptidoglycan
Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment  includes type II...
26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of...
Phosphoinositide 4-kinase (PI4K), Type III, beta isoform, catalytic domain
proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
Ubiquitin domain of SNX27 (sorting nexin protein 27)
Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...
S-100A10: A subgroup of the S-100A10 domain found in proteins similar to S100A10. S100A10 is a member of the S100 family of EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this S-100A10 group belongs, contains...
S-100A11: S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100...
S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100...
Involucrin of squamous epithelia N-terminus
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...
Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs
S-100A6: S-100A6 domain found in proteins similar to S100A6. S100A6 is a member of the S100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A6 group belongs, contains only S-100 EF-hand...
S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy
C-terminal duplication domain of Friend of PRMT1
domain in DSRM or ZnF_C2H2 domain containing proteins
Ligand-binding domain of type A natriuretic peptide receptor
Adenylyl- / guanylyl cyclase, catalytic domain
Transducer of regulated CREB activity, N terminus
Transducer of regulated CREB activity middle domain
Transducer of regulated CREB activity, C terminus
Jumping translocation breakpoint protein (JTB)
Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...
Src homology 2 domain found in SH2 domain-containing adapter protein E (SHE)
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III
tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...
PEP-CTERM family integral membrane protein
Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...
This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...
Sugar efflux transporter for intercellular exchange
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
GST_N family, Metaxin subfamily, Metaxin 1-like proteins
C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
effector domain of the CAP family of transcription factors
Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...
Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]
Src homology 3 domain of RUN and SH3 domain-containing protein 1
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional...
Human Misato shows similarity with Tubulin/FtsZ family of GTPases and is localized to the the outer membrane of mitochondria. It has a role in mitochondrial fusion and in mitochondrial distribution and morphology. Mutations in its Drosophila homolog
Mitochondrial ribosomal death-associated protein 3
C2A domain first repeat present in Synaptotagmins 4 and 11
C2 domain second repeat present in Synaptotagmin 4
Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
Ubiquitin-like domain of hPLIC-1 and hPLIC2
Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A)
Immunoglobulin (Ig)-like domain of semaphorin
Domain containing Gla (gamma-carboxyglutamate) residues
PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
von Hippel-Landau (pVHL) tumor suppressor protein
TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...
Holliday junction regulator protein family C-terminal repeat
RasGAP: Ras-GTPase Activating Domain.  RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin.  Although the Rho (Ras...
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)
DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]
DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids.  The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation.  Most PWWP-domain proteins...
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1
Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
Class I Histocompatibility antigen, domains alpha 1 and 2
Pyrin: a protein-protein interaction domain
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...
Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
Death Effector Domain of Astrocyte phosphoprotein PEA-15
Coatomer (COPI) alpha subunit C-terminus
M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex
Signaling lymphocytic activation molecule (SLAM) protein
Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein 67B2 of Drosophila melanogaster and other similar proteins, many of which are uncharacterized
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins
Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes
Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...
Respiratory-chain NADH dehydrogenase, 49 Kd subunit
T-cell surface glycoprotein CD3 zeta chain
Translocase of outer mitochondrial membrane 40 (Tom40)
DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
Immunoglobulin (Ig)-like domain of Protein zero (P0)
Myelin-PO cytoplasmic C-term p65 binding region
Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit
Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
DYC-1 (DYB-1 binding and Capon related) Phosphotyrosine-binding (PTB) domain
Src homology 2 (SH2) domain found in SLAM-associated protein (SAP)1
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
Coagulation factor 5/8 C-terminal domain, discoidin domain
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
3-keto steroid reductase, classical (c) SDRs
Regulator of G protein signaling (RGS) domain found in the RGS4 protein
Regulator of G protein signaling (RGS) domain superfamily
Regulator of G protein signaling (RGS) domain found in the RGS5 protein
The second LIM domain of Lmx1a and Lmx1b
Nuclear/hormone receptor activator site AF-1
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
Uridine kinase [Nucleotide transport and metabolism]
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway
Transcriptional regulator of RNA polII, SAGA, subunit
Pou domain - N-terminal to homeobox domain
Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273)...
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also...
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also...
Cytochrome C oxidase subunit II, periplasmic domain
Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]
C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins:  P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
Centrosome microtubule-binding domain of Cep57
Dynamin_like protein family includes dynamins and Mx proteins
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
Peroxiredoxin (PRX) family, 1-cys PRX subfamily
NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]
EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...
Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...
Antithrombin is a serine proteinase inhibitor (serpin) which controls the process of coagulation. It is the most important anticoagulant molecule in mammalian circulation systems, controlled by its interaction with the co-factor, heparin, which...
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter...
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...
Vesicle coat trafficking protein Sec16 mid-region
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
RAS GTPase-activating protein (GAP) CG5898 Pleckstrin homology (PH) domain
C2 domain present in Ras GTPase activating protein (GAP) family
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP
The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...
C-terminal putative kinase domain of FAM20B xylose kinase
Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]
Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...
The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily
The second LIM domain of Lhx3-Lhx4 family
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2
RNase domain (also known as the kinase extension nuclease domain) of RNase L
Regulator of G protein signaling (RGS) domain found in the RGS16 protein
Regulator of G protein signaling (RGS) domain found in the RGS8 protein
Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...
N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL)
HrpA-like helicases [DNA replication, recombination, and repair]
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]
N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of  NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in...
C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
Guanine nucleotide exchange factor for Ras-like GTPases
Ubiquitin domain of  RalGDS-like factor (RLF) and related proteins
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...
PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar...
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Phosducin (Phd)-like family, Phd subfamily
Animal prostaglandin endoperoxide synthase and related bacterial proteins
C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
Cytoplasmic phospholipase A2, catalytic subunit
Regulator of G protein signaling (RGS) domain found in the RGS18 protein
Regulator of G protein signaling (RGS) domain found in the RGS21 protein
Regulator of G protein signaling (RGS) domain found in the RGS1 protein
Regulator of G protein signaling (RGS) domain found in the RGS13 protein
Regulator of G protein signaling (RGS) domain found in the RGS2 protein
Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily
RNA pol II accessory factor, Cdc73 family
Calcium-activated BK potassium channel alpha subunit
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
The second LIM domain of Lhx2 and Lhx9 family
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
The ligand binding domain of the liver receptor homolog-1, a member of  nuclear receptor superfamily
Kinesin motor domain, KIF4-like subfamily. Members of this group seem to perform a variety of functions, and have been implicated in neuronal organelle transport and chromosome segregation during mitosis. This catalytic (head) domain has ATPase activity...
The first LIM domain of Cysteine Rich Protein 1 (CRP1)
The second LIM domain of Cysteine Rich Protein (CRP)
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
Peptidase M1 family contains leukotriene A4 hydrolase
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
Arf-like 9 (Arl9) and 10 (Arl10) GTPases
C2 domain second repeat present in Synaptotagmin 1
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type
SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others
Plasma membrane calcium transporter ATPase C terminal
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...
Ethanolamine kinase (ETNK) in eukaryotes. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...
Renin stimulates production of angiotensin and thus affects blood pressure
eIF2-alpha phosphatase phosphorylation constitutive repressor
Phosphatase-1 catalytic subunit binding region
C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain)
Phosphoinositide 3-kinase (PI3K), class II, beta isoform, catalytic domain
The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
Zn-finger in Ran binding protein and others
Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
C-terminal domain of Fibronectin type III
Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
Fourth Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
Predicted transmembrane and coiled-coil 2 protein
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
Rab GTPase families 18 (Rab18) and 32 (Rab32)
Sulfate transporter N-terminal domain with GLY motif
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
Cellular and retroviral pepsin-like aspartate proteases
Cathepsin E, non-lysosomal aspartic protease
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs...
Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
N-terminal domain of eIF2D and related proteins
C-terminal domain of eIF2D and related proteins
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases
The Sema domain, a protein interacting module, of Plexin A2
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]
C2A domain first repeat present in Synaptotagmins 14 and 16
C2 domain second repeat present in Synaptotagmins 14 and 16
Biogenesis of lysosome-related organelles complex-1 subunit 2
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 2
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
Protein phosphatase 2A regulatory B subunit (B56 family)
Cytochrome b5-like Heme/Steroid binding domain
The phosphoinositide binding Phox Homology domain of RPK118-like proteins
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear
Microtubule Interacting and Trafficking molecule domain
Catalytic domain of the Protein Serine/Threonine Kinases, RPK118 and similar proteins
The Phox Homology domain, a phosphoinositide binding module
Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Rb-binding domain of kinetochore protein Cenp-F/LEK1
DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
The ligand binding domain of estrogen receptor-related nuclear receptors
Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
catalytic core domain of glutaminyl-tRNA synthetase
tRNA synthetases class I (E and Q), anti-codon binding domain
WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates...
ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...
catalytic core domain of isoleucyl-tRNA synthetases
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by...
Src Homology 3 domain of Melanoma Inhibitory Activity 3 protein
Protein-interacting Bro1-like domain of human Brox1 and related proteins
Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...
Src Homology 3 (SH3) domain of Apoptosis Stimulating of p53 protein 2
The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes, dihydroceramide Delta-4 desaturase, involved in the synthesis of sphingosine
Hydrolytic ATP binding site of dynein motor region D1
Microtubule-binding stalk of dynein motor
Dynein heavy chain and region D6 of dynein motor
Signal recognition particle 9 kDa protein (SRP9)
Late exocytosis, associated with Golgi transport
Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins,  which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a...
Predicted unusual protein kinase [General function prediction only]
Catalytic domain of Myotonic Dystrophy protein kinase-like Protein Serine/Threonine Kinases
ATPase involved in DNA repair [DNA replication, recombination, and repair]
MRCK (myotonic dystrophy-related Cdc42-binding kinase)  pleckstrin homology (PH) domain
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases
ADP-ribosylation factor-1 (Arf1) and ADP-ribosylation factor-5 (Arf5)
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...
Glycine cleavage T-protein C-terminal barrel domain
Src homology 3 domain of Obscurin and similar proteins
Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...
TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
COG (conserved oligomeric Golgi) complex component, COG2
Angiotensinogen is part of the renin-angiotensin system (RAS), which plays an important role in blood pressure regulation, renal haemodynamics, fluid and electrolyte homeostasis. It is also involved in normal and abnormal growth processes. The growth...
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
Exocyst complex 84-kDa subunit Pleckstrin Homology (PH) domain
Src Homology 3 domain of Mixed Lineage Kinase 4
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Interferon regulatory factor 2-binding protein zinc finger
mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit
RNA binding activity-knot of a chromodomain
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may...
U3 small nucleolar RNA-associated protein 10
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...
B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy)
Vitamin B12 dependent methionine synthase, activation domain
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]
PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
Ubiquitin domain of GABA-receptor-associated protein
Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
Catalytic domain of phospholipase D superfamily proteins
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase B
Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...
Kinesin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In...
Vomeronasal organ pheromone receptor family, V1R
Pyrin death domain found in NALP proteins
The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein
Low molecular weight phosphotyrosine protein phosphatase
Syntrophin pleckstrin homology (PH) domain
Animal heme peroxidases and related proteins
Third immunoglobulin (Ig)-like domain of peroxidasin
Fourth immunoglobulin (Ig)-like domain of peroxidasin
Animal heme peroxidase domain of peroxidasin and related proteins
von Willebrand factor (vWF) type C domain
TATA element modulatory factor 1 DNA binding
Eukaryotic RNase H is longer and more complex than their prokaryotic counterparts  and unlike prokaryote, RNase H are essential in higher eukaryote
C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
Thymidylate kinase [Nucleotide transport and metabolism]
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...
14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein
RNA polymerase I-specific transcription initiation factor Rrn7
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain
Diaminopimelate decarboxylase [Amino acid transport and metabolism]
P5 family, C-terminal redox inactive TRX-like domain
Catalytic domain of the Protein Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
PIN (PilT N terminus) domain: Superfamily
retinol dehydrogenases (retinol-DHs), classical (c) SDRs
Trimeric coiled-coil oligomerisation domain of matrilin
The phosphoinositide binding Phox Homology domain of HS1BP3
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the...
First Src homology 3 domain (or SH3A) of Intersectin-2
Second Src homology 3 domain (or SH3B) of Intersectin-2
Third Src homology 3 domain (or SH3C) of Intersectin-2
Fourth Src homology 3 domain (or SH3D) of Intersectin-2
Fifth Src homology 3 domain (or SH3E) of Intersectin-2
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported  to encode such activity, Pth present in...
The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis.  In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in...
ADDz domain of DNA (cytosine-5) methyltransferases (C5-MTases) 3 a (Dnmt3a)
Site-specific DNA methylase [DNA replication, recombination, and repair]
Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane...
PHD domain of transcriptional enhancer, Asx
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes
fatty acid oxidation complex, alpha subunit, mitochondrial
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins
Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
M14 family of metallocarboxypeptidases and related proteins
Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose.  KHK can also phosphorylate several other furanose sugars.  It is found in higher eukaryotes...
Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]
Na(+)/multivitamin cotransporter SMVT and related proteins
carbamoyl phosphate synthase small subunit
Carbamoyl-phosphate synthase small chain, CPSase domain
Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
Carbamoyl-phosphate synthase L chain, N-terminal domain
Carbamoyl-phosphate synthetase large chain, oligomerisation domain
Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain
Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]
The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the...
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
Bromodomain transcription factors and PHD domain containing proteins
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...
Brain and reproductive organ-expressed protein (BRE)
Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity.  It's members may be involved in the conversion of phosphatidylcholine to fatty acids and...
PP1, PPKL (PP1 and kelch-like) enzymes,  and related proteins, metallophosphatase domain
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
Eps15 homology domain (EHD), C-terminal domain
CO dehydrogenase flavoprotein C-terminal domain
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Molybdopterin-binding domain of aldehyde dehydrogenase
Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes
Caspase activation and recruitment domain found in Caspase-1 and related proteins
Baculoviral inhibition of apoptosis protein repeat domain
Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
Son of Sevenless (SOS) Pleckstrin homology (PH) domain
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase-like Protein Serine/Threonine Kinases
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
Domains in Na-Ca exchangers and integrin-beta4
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
G protein-coupled chemokine receptor-like protein
Putative death-receptor fusion protein (DUF2428)
The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors.  The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red...
The Eye Pigment Precursor Transporter (EPP) Family protein
Protein serine/threonine phosphatase 2C, C-terminal domain
Alpha amylase catalytic domain found in Solute Carrier family 3 member 1 proteins
Protease II [Amino acid transport and metabolism]
S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression
C2 domain in Protein Kinase C (PKC) epsilon
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C epsilon
HIF-1 alpha C terminal transactivation domain
SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting...
Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]
MutS2 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...
DNA-binding domain of DNA mismatch repair MUTS family
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...
Putative zinc finger in N-recognin (UBR box)
Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-1 (also called Stoned B-like factor)
Precursor of TFIIA alpha and beta subunits and similar proteins
Transcription factor IIA, alpha/beta subunit
Gonadotropin hormone receptor transmembrane region
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha...
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...
Glucosidase II beta subunit-like protein
Beta-spectrin pleckstrin homology (PH) domain
Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell
mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...
Component of IIS longevity pathway SMK-1
Polyribonucleotide nucleotidyltransferase, RNA binding domain
Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...
Ribosomal protein S1-like RNA-binding domain
Poly(A) polymerase predicted RNA binding domain
N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to...
Src Homology 3 domain of eumetazoan Peroxisomal biogenesis factor 13
TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a...
Cytoplasmic and cytosolic Malate dehydrogenases
Eukaryotic UGPase catalyses the synthesis of UDP-Glucose
Rab GTPase family 1 includes the yeast homolog Ypt1
EVH1 (Enabled, Vasp-Homology) or WASP Homology (WH1) domain
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins.  Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation
RhoGAP_ARHGAP22_24_25:  GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins
ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in...
Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...
SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...
Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...
Eukaryotic protein of unknown function (DUF842)
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)
C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
ATP synthase alpha/beta family, beta-barrel domain
V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...
ATP synthase alpha/beta chain, C terminal domain
U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
sepiapterin reductase (SPR)-like, classical (c) SDRs
C2 domain found in Rab11-family interacting proteins (FIP) class I
PA_hPAP21_like: Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex...
TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)
chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...
Acetyltransferases [General function prediction only]
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1
Oxygenase domain of the 2OGFeDO superfamily
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
Rho effector or protein kinase C-related kinase homology region 1 homologues
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...
PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...
Downstream of tyrosine kinase  (DOK) Phosphotyrosine-binding domain
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F)
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
GC-rich sequence DNA-binding factor-like protein
Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1  and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel...
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
Largest subunit of RNA polymerase (RNAP), C-terminal domain
Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
A domain family that is part of the cupin metalloenzyme superfamily
CTLH/CRA C-terminal to LisH motif domain
RING-type zinc-finger, LisH dimerisation motif
Immunoglobulin (Ig) like domain of CD8 alpha chain
Immunoglobulin (Ig) like domain of CD8 beta chain
Threonine synthase [Amino acid transport and metabolism]
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria
Tryptophan synthase beta superfamily (fold type II)
The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily
ribosomal protein S5, bacterial/organelle type
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]
Lipid-binding START domain of mammalian STARD7 and related proteins
Domain of unknown function in Sec63p, Brr2p and other proteins
BRIGHT, ARID (A/T-rich interaction domain) domain
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...
Hemolysins and related proteins containing CBS domains [General function prediction only]
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
Cytochrome c oxidase subunit Vb.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70)
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
Cytochrome c oxidase assembly protein PET191
Biotin/lipoate A/B protein ligase family
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear
Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...
Goose Egg White Lysozyme domain. Eukaryotic 'goose-type' lysozymes (GEWL). These enzymes catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc).  Members include tunicate, Japanese...
Phosducin (Phd)-like family, Thioredoxin (TRX) domain containing protein 9 (TxnDC9) subfamily
aeIF5B_II: This family represents the domain II of archeal and eukaryotic aeIF5B. aeIF5B is a homologue of prokaryotic Initiation Factor 2 (IF2).  Disruption of the eIF5B gene (FUN12) in yeast causes a severe slow-growth phenotype, associated with a...
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...
Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]
Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...
Catalytic domain of the Protein Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
First Src Homology 3 domain of Nck2 adaptor protein
Second Src Homology 3 domain of Nck2 adaptor protein
Third Src Homology 3 domain of Nck2 adaptor protein
Src homology 2 (SH2) domain found in Nck
Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins
First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
Src Homology 3 domain of Nephrocystin (or Nephrocystin-1)
Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
Catalytic Domain of Axl-like Protein Tyrosine Kinases
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...
Cobalamin synthesis protein cobW C-terminal domain
Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]
Dipeptidyl peptidase IV (DPP IV) N-terminal region
Engrailed homeobox C-terminal signature domain
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...
Ral (Ras-like) family containing highly homologous RalA and RalB
SAM domain of LBP9 transcriptional factors
The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3)...
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 2
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
Mitotic-spindle organizing gamma-tubulin ring associated
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of...
Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
Collybistin pleckstrin homology (PH) domain
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
Catalytic domain of the Protein Serine/Threonine Kinase, Yeast Sps1/Ste20-related kinase 4
Rab3 GTPase-activating protein catalytic subunit
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H...
Domain present in ubiquitin-regulatory proteins
AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop
Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...
Speckle-type POZ protein (SPOP) family, MATH domain
Low-density lipoprotein receptor domain class A
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins
Glycosyltransferase [Cell envelope biogenesis, outer membrane]
Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...
Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...
Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup. Members of this group have been associated with organelle transport. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...
Ly-6 antigen / uPA receptor -like domain
Interferon-induced 35 kDa protein (IFP 35) N-terminus
This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the...
The Nebulin repeat is present also in Las1
C-terminal Src Homology 3 domain of Nebulin
Voltage gated calcium channel subunit beta domain 4Aa N terminal
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
Src homology 3 domain of Signal Transducing Adaptor Molecule 2
DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
The ligand binding domain of  Nurr1, a member of conserved family of nuclear receptors
glycerol-3-phosphate dehydrogenase, anaerobic, B subunit
Transforming growth factor beta type I GS-motif
Uridine phosphorylase [Nucleotide transport and metabolism]
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A
domain in different transcription and chromosome remodeling factors
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting...
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and...
C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]
Caspase activation and recruitment domain found in MDA5, first repeat
The Death Domain Superfamily of protein-protein interaction domains
ERCC4-like helicases [DNA replication, recombination, and repair]
insert domain of MDA5 helicase and similar proteins
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
Transmembrane amino acid transporter protein
Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
putative PEP-CTERM system TPR-repeat lipoprotein
Anaphase-promoting complex, cyclosome, subunit 3
The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin) like proteins
Catalytic domain of the Protein Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
Oxidative-stress-responsive kinase 1 C terminal
Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an...
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...
human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc
This domain is found in various eukaryotic species, particularly in apicomplexans
La RNA-binding domain of La-related protein 3
Catalytic domain of the Protein Serine/Threonine Kinase, Class IIIB myosin
Myosin motor domain, type III myosins. Myosin III has been shown to play a role in  the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. This catalytic (head) domain has ATPase activity and...
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...
Vertebrate cytochrome b(561), CYBRD1 gene product
Cytoplasmic dynein 1 intermediate chain 2
Histone acetyl transferase HAT1 N-terminus
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides
Homeobox protein distal-less-like N terminal
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Signal transduction histidine kinase [Signal transduction mechanisms]
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by...
Zinc-finger domain of monoamine-oxidase A repressor R1
TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...
N-terminal domain of CBF1 interacting co-repressor CIR
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the...
Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two...
GCN4 central activation domain-like acidic activation domain
Predicted integral membrane metal-binding protein (DUF2296)
GST_N family, Metaxin subfamily, Metaxin 2
C-terminal, alpha helical domain of Metaxin 2
FOG: GAF domain [Signal transduction mechanisms]
Domain present in phytochromes and cGMP-specific phosphodiesterases
Immunoglobulin (Ig)-like domain of titin and similar proteins
M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins
Domain in DAP-5, eIF4G, MA-3 and other proteins
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
Protein Disulfide Isomerase (PDIa) family, redox active TRX domains
Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist
NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily
BPTI/Kunitz family of serine protease inhibitors
Gn_AT_II_novel.  This asparagine synthase-related domain is present in eukaryotes but its function has not yet been determined.  The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...
MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is...
HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone...
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]
STAT protein, protein interaction domain
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
Myosin motor domain, type I myosins. Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. This...
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In...
C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
Spt5 C-terminal nonapeptide repeat binding Spt4
U2 snRNP spliceosome subunit [RNA processing and modification]
Coenzyme Q-binding protein COQ10p and similar proteins
GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...
Chaperonin 10 Kd subunit (cpn10 or GroES)
catalytic core domain of methioninyl-tRNA synthetases
Anticodon-binding domain of methionyl tRNA synthetases
Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
N-terminal domain of SATB1 and similar proteins
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
Cyclophilin_PPIL3_like. Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a
cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...
NADH-ubiquinone oxidoreductase B12 subunit family
Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
Death effector domain, repeat 1, of Caspase-10
Death Effector Domain, repeat 2, of Caspase-10
Death effector domain, repeat 1, of Caspase-8
Pseudokinase domain of STE20-related kinase adapter protein beta
domain in receptor targeting proteins Lin-2 and Lin-7
Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
Vacuolar sorting protein 9 (VPS9) domain
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 7 (Fz7) receptor
Protein implicated in ribosomal biogenesis, Nop56p homolog [Translation, ribosomal structure and biogenesis]
The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
Islet cell autoantigen ICA69, C-terminal domain
Src homology 3 domain of Abl Interactor 2
Apbb1ip (Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein) pleckstrin homology (PH) domain
Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...
NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...
Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...
Peptidase M14 carboxypeptidase subfamily A/B-like
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol...
TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this...
Tau and MAP protein, tubulin-binding repeat
Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]
Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...
eukaryotic Lanthionine synthetase C-like protein. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 and LANCL2 (testes-specific adriamycin...
Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
Catalytic domain of the Protein Tyrosine Kinase, HER4
ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]
ABC-type multidrug transport system, ATPase component [Defense mechanisms]
Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces...
Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or...
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]
Insulin growth factor-binding protein homologues
Protein tyrosine phosphatase, catalytic domain motif
Src homology 2 domain found in Tensin-like proteins
Zn-dependent hydrolases, including glyoxylases [General function prediction only]
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
NRAMP (natural resistance-associated macrophage protein) metal ion transporters
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
Actin depolymerization factor/cofilin- and gelsolin-like domains
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...
Cyclin-dependent kinase 5 activator protein
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein
Xanthine/uracil permeases [Nucleotide transport and metabolism]
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
ATM1 is an ABC transporter that is expressed in the mitochondria.  Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...
Glycosyl hydrolases family 2, sugar binding domain
Aminopeptidase I zinc metalloprotease (M18)
Intermediate filament head (DNA binding) region
N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
Ligand Binding Domain of Ephrin type-A Receptor 4
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second...
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like
Protein present in Fab1, YOTB, Vac1, and EEA1
Plasminogen activator inhibitor-1_like. Plasminogen activator inhibitor-1 (PAI-1) is the primary, fast-acting inhibitor of plasminogen activators. It is often bound to vitronectin, an abundant component of the extracellular matrix in many tissues
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
Insulin receptor substrate (IRS) Phosphotyrosine-binding domain(PTB)
C-terminal tandem repeated domain in type 4 procollagen
Mitochondrial and peroxisomal fission factor Mff
Putative GTP-ase activating proteins for the small GTPase, ARF
Chemokine_CC_DCCL:  subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues
A-kinase anchor protein 110 kDa (AKAP 110)
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin...
This domain is the catalytic domain of ribonuclease II
GYF domain: contains conserved Gly-Tyr-Phe residues
Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...
Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
Diacylglycerol kinase catalytic domain (presumed)
Diacylglycerol kinase accessory domain (presumed)
SAM domain of diacylglycerol kinase delta
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...
Holliday junction recognition protein-associated repeat
Src Homology 3 domain of SH3 domain-binding protein 4
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...
VWA_collagen alpha 3(VI) like: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than...
Myelin-associated oligodendrocytic basic protein (MOBP)
Rab-related GTPase family includes Rab5 and Rab22
Double stranded RNA binding protein (DUF2051)
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The...
Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a...
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT)
occurring C-terminal to leucine-rich repeats
K homology RNA-binding domain_vigilin_like.  The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has...
Chondrocyte-derived ezrin-like domain containing protein (CDEP) Pleckstrin homology (PH) domain
Catalytic domain of the Protein Serine/Threonine Kinase, STK25 or Yeast Sps1/Ste20-related kinase 1
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...
Inhibitor of growth proteins N-terminal histone-binding
Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes
Probable RNA and SrmB- binding site of polymerase A
Ligand-binding domain of the group III metabotropic glutamate receptor
The first LIM domain of Testin-like family
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
Lipoma HMGIC fusion partner-like protein
VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae
The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2.   BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region.  In myeloid leukemias
8-oxoguanine DNA glycosylase, N-terminal domain
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...
Fanconi anemia ID complex proteins FANCI and FANCD2
Death domain of Interleukin 1 Receptor Associated Kinase-2
Na(+)- and Cl(-)-dependent GABA transporter 3
Na(+)- and Cl(-)-dependent GABA transporter 1
Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an...
Short repeats in human TONDU, fly vestigial and other proteins
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
The ligand binding domain of peroxisome proliferator-activated receptors
tRNA intron endonuclease, N-terminal domain
tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
tRNA intron endonuclease, catalytic C-terminal domain
Ubiquitin domain of  Raf serine/threonine kinases
Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...
Histone deacetylase class IV also known as histone deacetylase 11
Na(+)- and Cl(-)-dependent taurine transporter
DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
The ligand binding domain of the orphan nuclear receptors TR4 and TR2
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear
MIT (microtubule interacting and transport) domain
RNA polymerase II transcription elongation factor
Pyrimidine (PYR) binding domain of POX and related proteins
Thiamine pyrophosphate enzyme, central domain
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module
biotinidase and vanins (class 4 nitrilases)
Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...
PCAF (P300/CBP-associated factor) N-terminal domain
DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA.  S. cerevisiae Topo IIA is a homodimer encoded...
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of...
PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
domain present in PNGases and other hypothetical proteins
PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...
Cytochrome c oxidase biogenesis protein Cmc1 like
Transforming growth factor beta receptor 2 ectodomain
Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain
SAM domain of LBP1 (UBP1) transcription factors
Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
Protein-interacting Bro1-like domain of mammalian Alix and related domains
First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to...
TFIIF-interacting CTD phosphatases, including NLI-interacting factor [Transcription]
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
Death domain of Myeloid Differentation primary response protein MyD88
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...
C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...
Hypoxia induced protein conserved region
Kinesin motor domain, KLP2-like subgroup. Members of this subgroup seem to play a role in mitosis and meiosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent...
Transglutaminase family, C-terminal ig like domain
C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)
catalytic core domain of leucyl-tRNA synthetases
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases
The first LIM domain of Ajuba-like proteins
The second LIM domain of Ajuba-like proteins
The third LIM domain of Ajuba-like proteins
Na(+)- and Cl(-)-dependent imino acid transporter SIT1
Cysteine-rich motif following a subset of SET domains
Kinesin motor domain, KIF9-like subgroup
Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
Neural chondroitin sulphate proteoglycan cytoplasmic domain
Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to...
LPS binding domain of CAP18 (C terminal)
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6
Kazal-type serine protease inhibitor domain
The Sema domain, a protein interacting module, of Plexin B1
domain found in Plexins, Semaphorins and Integrins
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
Agonist of corticotropin releasing factor R2, Urocortin-2
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...
Predicted Zn-dependent peptidases [General function prediction only]
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the...
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...
Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has...
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90.  p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including...
Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain
Cadherin-like repeat domain of alpha dystroglycan
N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]
Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating
Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating
Repeat in ubiquitin-activating (UBA) protein
Ubiquitin-activating enzyme e1 C-terminal domain
Flagellar hook-length control protein FliK
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F)
Immunoglobulin (Ig)-like domain of class III semaphorin
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B)
Ubiquitin-like domain of RASSF1 tumour supproessor protein
Eukaryotic integral membrane protein (DUF1751)
Neuronal voltage-dependent calcium channel alpha 2acd
Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain
Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
Degradation arginine-rich protein for mis-folding
Ligand binding domain of the group II metabotropic glutamate receptor
WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
proline-specific peptidases, Bacillus coagulans-type subfamily
7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]
N-terminal ADF domain of twinfilin and related proteins
C-terminal ADF domain of twinfilin and related proteins
Putative glycerate kinase [Carbohydrate transport and metabolism]
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G)
The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...
A circularly permuted subfamily of the Ras GTPases
GT8_like_1 represents a subfamily of GT8 with unknown function
Microsomal signal peptidase 12 kDa subunit (SPC12)
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 4
Inter-alpha-trypsin inhibitor heavy chain C-terminus
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C delta
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module
Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at...
RIM-binding protein of the cytomatrix active zone
The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system
Docking domain of Afi1 for Arf3 in vesicle trafficking
Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...
The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon...
26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]
Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins
GT8_like_2 represents a subfamily of GT8 with unknown function
First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme)
Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes
Alpha amylase, C-terminal all-beta domain
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
Ligand Binding Domain of Ephrin type-A Receptor 3
SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5
tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]
Ligand Binding Domain of Ephrin type-A Receptor 6
The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in...
Ulp1 protease family, C-terminal catalytic domain
CBL proto-oncogene N-terminus, EF hand-like domain
Src homology 2 (SH2) domain found in the Cbl-b TKB domain
Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins...
Dppa2/4 conserved region in higher vertebrates
First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagocytosis associated protein, active-site domain
V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...
Pancreatic lipase-like enzymes.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the...
Cytochrome C oxidase copper chaperone (COX17)
DNA-binding domain of pregnane X receptor (PXRs) is composed of two C4-type zinc fingers
NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
C-terminal general transcription factor TFIIE alpha
DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]
Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
Src homology 3 domain of Hematopoietic lineage cell-specific protein 1
Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
Karyopherin (importin) alpha [Intracellular trafficking and secretion]
Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component...
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell
Domain found at the C-terminus of deltex-like
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B)
PDIb family, PDIR subfamily, N-terminal TRX-like b domain
Protein tyrosine phosphatase-like protein, PTPLA
Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]
First Src homology 3 domain of the RhoGEF kinase, Kalirin
Second Src homology 3 domain of the RhoGEF kinase, Kalirin
Phosphoribosyl transferase (PRT)-type I domain
Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...
Integrin beta subunits (N-terminal portion of extracellular region)
The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4
Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
thioredoxin and glutathione reductase selenoprotein
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
The Sema domain, a protein interacting module, of Plexin A1
SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding...
Amino terminal of the G-protein receptor rhodopsin
The Sema domain, a protein interacting module, of Plexin D1
golgi membrane calcium-translocating P-type ATPase
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 11
Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)
Acyl-CoA dehydrogenases similar to fadE2
ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...
thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily
Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP)
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
Ligand Binding Domain of Ephrin type-B receptors
SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
First Src Homology 3 domain of Nck1 adaptor protein
Second Src Homology 3 domain of Nck1 adaptor protein
Third Src Homology 3 domain of Nck1 adaptor protein
Glycosyltransferase sugar-binding region containing DXD motif
Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
Lariat debranching enzyme, C-terminal domain
NDP kinase domain of thioredoxin domain-containing proteins  (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which...
C2 domain first and third repeat in Synaptotagmin-like proteins
C2 domain second repeat present in Synaptotagmin-like proteins
C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
Fas apoptotic inhibitory molecule (FAIM1)
Phosphoinositide 3-kinase (PI3K) class I, accessory domain
Phosphoinositide 3-kinase (PI3K), class IA, beta isoform, catalytic domain
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for...
C2 domain first repeat present in RasA2 and RasA3
C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
RASA2 (or GAP1(m)) is a member of the GAP1 family of Ras GTPase-activating proteins that includes GAP1_IP4BP (or RASA3), CAPRI, and RASAL. In vitro, RASA2 has been shown to bind inositol 1,3,4,5-tetrakisphosphate (IP4), the water soluble inositol head...
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7
Glycerol kinase [Energy production and conversion]
metazoan glycerol kinase 5-like proteins
Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
ATR (Ataxia telangiectasia and Rad3-related), catalytic domain
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
domain present in proteins, which are involved in regulation of nuclear pre-mRNA
Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins
PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo...
Ribosome associated membrane protein RAMP4
Eukaryotic translation initiation factor eIF2A
Seven in absentia (Sina) protein family, C-terminal substrate binding domain
Transcription mediator complex subunit Med12
Eukaryotic Mediator 12 catenin-binding domain
Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c
Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
The C-terminal domain of GMP synthetase. It contains two subdomains
Translocon-associated protein, gamma subunit (TRAP-gamma)
Myelodysplasia-myeloid leukemia factor 1-interacting protein
Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...
EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...
Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)
This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two...
SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...
Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that...
eukaryotic translation initiation factor 5A
S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential...
Catalytic domain of the Protein Serine/Threonine Kinase, Traf2- and Nck-interacting kinase
The phosphoinositide binding Phox Homology domain of Phospholipase D1
Phospholipase D (PLD) pleckstrin homology (PH) domain
Catalytic domain, repeat 1, of vertebrate phospholipase D1
Catalytic domain, repeat 2, of vertebrate phospholipase D1
Epithelial cell transforming 2 (ECT2) pleckstrin homology (PH) domain
PA_hNAALADL2_like: Protease-associated domain containing proteins like human N-acetylated alpha-linked acidic dipeptidase-like 2 protein (hNAALADL2). This group contains various PA domain-containing proteins similar to hNAALADL2. The function of...
Calcium-activated potassium channel, beta subunit
C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K), class IA, alpha isoform, catalytic domain
Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...
Isopeptidase T [Posttranslational modification, protein turnover, chaperones]
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase
Dbs (DBL's big sister) pleckstrin homology (PH) domain
Transcription initiation factor IIF, auxiliary subunit [Transcription]
ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]
Domain 1 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminas, but the function of these additional...
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]
Domain 2 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional...
The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
A domain in the BMP inhibitor chordin and in microbial proteins
Ligand Binding Domain of Ephrin type-B Receptor 3
SAM domain of EPH-B3 subfamily of tyrosine kinase receptors
Golgi CORVET complex core vacuolar protein 8
multifunctional fatty acid oxidation complex subunit alpha
Catalytic domain of Protein Tyrosine Kinases
PEA3 subfamily ETS-domain transcription factor N terminal domain
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
Insulin-resistance promoting peptide in skeletal muscle
Acidic and basic fibroblast growth factor family
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
von Willebrand factor (vWF) type D domain
SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
Predicted aminopeptidases [General function prediction only]
PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28...
M28 Zn-peptidase Transferrin Receptor family
Phosphoenolpyruvate carboxylase [Energy production and conversion]
Catalytic domain of the Protein Serine/Threonine Kinase, Group I p21-activated kinase
Polyubiquitination (PEST) N-terminal domain of MAGUK
Src Homology 3 domain of Disks Large homolog 1
domain involved in Ras-like GTPase signaling
Type I phosphodiesterase / nucleotide pyrophosphatase
Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
Glycosyl hydrolases family 2, TIM barrel domain
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]
Transforming acidic coiled-coil-containing protein (TACC)
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...
Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
Regulator of G protein signaling (RGS) domain found in the RGS12 protein
D1 dopamine receptor-interacting protein (calcyon)
Catalytic domain of the Protein Serine/Threonine Kinase, Yank1
Ellis van Creveld protein 2 like protein
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins
Glycosyl hydrolases family 38 C-terminal domain
Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding
GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding
The first LIM domain of actin binding LIM (abLIM) proteins
The second LIM domain on actin binding LIM (abLIM) proteins
The third LIM domain of actin binding LIM (abLIM) proteins
The fourth LIM domain of actin binding LIM (abLIM) proteins
Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
Cysteine-rich domain of carboxypeptidase Z, a member of the carboxypeptidase E family
Peptidase M14 carboxypeptidase subfamily N/E-like
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
COMPASS (Complex proteins associated with Set1p) component shg1
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38
dihydropteridine reductase (DHPR), classical (c) SDRs
Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...
Nuclear condensing complex subunits, C-term domain
Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...
Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)
Anaphase-promoting complex subunit 4 WD40 domain
Anaphase-promoting complex, cyclosome, subunit 4
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known...
SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their...
Tumour necrosis factor receptor superfamily member 19
This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...
ATPase involved in DNA replication [DNA replication, recombination, and repair]
Replication factor RFC1 C terminal domain
UDP-glucose/GDP-mannose dehydrogenase family, central domain
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]
Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily
LepA also known as Elongation Factor 4 (EF4)
lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...
lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins
One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...
Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
Src homology 2 (SH2) domain found  in Tec protein, Txk
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
Ovarian carcinoma immunoreactive antigen (OCIA)
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)
Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
Frst immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR) alpha
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
Catalytic domain of the Protein Tyrosine Kinase, Kit
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
PQQ-dependent dehydrogenases and related proteins
Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
Ligand Binding Domain of Ephrin type-A Receptor 5
SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...
Albumin domain, contains five or six internal disulphide bonds
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues
epidermal growth factor-like protein (EGF-like protein)
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...
Uso1 / p115 like vesicle tethering protein, head region
Uso1 / p115 like vesicle tethering protein, C terminal region
Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...
Linear amide C-N hydrolases, choloylglycine hydrolase family
Genethonin-1, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Genethonin-1 is a human skeletal muscle protein with no known function. It contains a C-terminal CBM20 domain. The CBM20 domain is found in a large number of starch...
C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...
Metazoan glycerol kinase 1 and 3-like proteins
Catalytic domain of the Protein Serine/Threonine Kinase, cGMP-dependent protein kinase
Extension to Ser/Thr-type protein kinases
The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...
Glycosyl hydrolase family 79, N-terminal domain
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P.  Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also...
Secreted protein acidic and rich in cysteine Ca binding region
ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active...
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family
Bacterial extracellular solute-binding proteins, family 3
C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
The first LIM domain of the Enigma Homolog (ENH) family
The third LIM domain of the Enigma Homolog (ENH) family
pyruvate dehydrogenase E1 component, alpha subunit
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]
Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
Mitogen-activated protein kinase kinase 1 interacting
Protein phosphatase 2A homologues, catalytic domain
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
Death domain of the Nuclear Factor-KappaB1 precursor protein p105
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
Iron-containing outer mitochondrial membrane protein N-terminus
CDGSH-type zinc finger. Function unknown
Kinesin motor domain, CENP-E/KIP2-like subgroup, involved in chromosome movement and/or spindle elongation during mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers
The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site...
Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...
Gluconate kinase [Carbohydrate transport and metabolism]
4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
La RNA-binding domain of La-related protein 7
Domain present in ZO-1 and Unc5-like netrin receptors
Calcium/calmodulin dependent protein kinase II Association
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
polyubiquitin binding domain of NEMO and related proteins
Cell division protein 48 (CDC48) N-terminal domain
Catalytic domain of the Protein Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
La RNA-binding domain proteins similar to La-related proteins 1 and 2
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
C-terminal deadenylase domain of nocturnin and related domains
Rab GTPase family 33 includes Rab33A and Rab33B
Gab (Grb2-associated binder) pleckstrin homology (PH) domain
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination
APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
Possible Fer4-like domain in RNase L inhibitor, RLI
The ATPase domain 1 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids.  RLI s are not transport proteins and thus cluster...
The ATPase domain 2 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster...
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...
SBF-like CPA transporter family (DUF4137)
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase)
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
Second Src homology 3 domain of ADAM-binding protein Eve-1
Third Src homology 3 domain of ADAM-binding protein Eve-1
Fourth Src homology 3 domain of ADAM-binding protein Eve-1
Fifth Src homology 3 domain of ADAM-binding protein Eve-1
First Src homology 3 domain of ADAM-binding protein Eve-1
Centromere protein B dimerisation domain
The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity
NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
Dehydrogenases (flavoproteins) [Energy production and conversion]
Ferredoxin-like protein [Energy production and conversion]
Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
C-terminal immunoglobulin (Ig)-like domain of palladin
First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1
F0F1-type ATP synthase, subunit b [Energy production and conversion]
ClC-3-like chloride channel proteins.  This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...
Sin3 binding region of histone deacetylase complex subunit SAP30
insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
Myelin proteolipid protein (PLP or lipophilin)
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS...
N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)
Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...
Rhs family protein [Cell envelope biogenesis, outer membrane]
Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...
Gryzun, putative trafficking through Golgi
Eukaryotic and archaeal DNA primase small subunit
CENP-A nucleosome associated complex (NAC) subunit
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
This family represents the LIM domain of ALP, actinin-associated LIM protein
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
Succinate dehydrogenase [ubiquinone] flavoprotein subunit
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene...
Na(+)-dependent neutral amino acids transporter, B0AT1
Telomerase ribonucleoprotein complex - RNA binding domain
TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as...
Cleft lip and palate transmembrane protein 1 (CLPTM1)
Na(+)- and Cl(-)-dependent dopamine transporter 1
Motif in Iroquois-class homeodomain proteins (only). Unknown function
Transcription factor subunit Med10 of Mediator complex
Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred...
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
Mammalian taste receptor protein (TAS2R)
TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
Myosin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...
Uncharacterized protein conserved in bacteria (DUF2336)
Ligand-binding domain of type C natriuretic peptide receptor
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea.  These polymerase processivity factors play a role in DNA replication and repair.  PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the...
HEAT repeat associated with sister chromatid cohesion
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
Caspase activation and recruitment domain: a protein-protein interaction domain
C-terminal GTPase-like domain of F-Box Only Protein 4
Small cytokines (intecrine/chemokine), interleukin-8 like
NAD/NADP transhydrogenase beta subunit [Energy production and conversion]
The first LIM domain of Isl, a member of LHX protein family
The second LIM domain of Isl, a member of LHX protein family
Predicted RNA-binding proteins [General function prediction only]
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...
Alpha crystallin domain (ACD) found in mammalian HspB3, also known as heat-shock protein 27-like protein (HSPL27, 17-kDa) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are...
Src Homology 3 domain of Sorting nexin 18
The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 1
NADH ubiquinone oxidoreductase subunit NDUFA12
cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced...
cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
(ADP-ribosylation factor domain protein 1 (ARD1)
Zn-dependent oligopeptidases [Amino acid transport and metabolism]
Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region...
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins...
Cocaine and amphetamine regulated transcript protein (CART)
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins
Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the...
Glycosyl hydrolase family 20, catalytic domain
Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]
Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...
mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory...
EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...
mtEFG2_C: C-terminus of mitochondrial Elongation factor G2 (mtEFG2)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...
pre-ribosomal protein NSA2 (Nop seven-associated 2)
Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
Goodpasture antigen binding protein (GPBP) Pleckstrin homology (PH) domain
Ceramide-binding START domain of mammalian STARD11 and related domains
Death Domain: a protein-protein interaction domain
IQGAP2 is a member of the IQGAP family that contains a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeat, a single WW domain, four IQ motifs which mediate interactions with calmodulin, and a Ras-GTPase-activating protein (GAP)...
S-100Z: S-100Z domain found in proteins similar to S100Z. S100Z is a member of the S100 domain family within the EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100Z group belongs, contains only S-100 EF-hand...
Corticotropin-releasing factor binding protein (CRF-BP)
Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]
Fungal specific transcription factor domain
Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
Lipid-binding START domain of mammalian STARD15 and related proteins
S12-like family, 40S ribosomal protein S23 subfamily
DNA double-strand break repair and V(D)J recombination protein XRCC4
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
Src Homology 3 domain of Ras GTPase-Activating Protein 1
C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
C2 domain present in RAS p21 protein activator 1 (RasA1)
p120GAP is a negative regulator of Ras that stimulates hydrolysis of bound GTP to GDP. Once the Ras regulator p120GAP, a member of the GAP protein family, is recruited to the membrane, it is transiently immobilized to interact with Ras-GTP. The down...
DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
Peptidase S8 family domain in Protein convertases
Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]
Peptidase domain in the S8 and S53 families
Organic Anion Transporter Polypeptide (OATP) family
Copper type II ascorbate-dependent monooxygenase, N-terminal domain
Copper type II ascorbate-dependent monooxygenase, C-terminal domain
NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]
NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
Catalytic domain of the Protein Tyrosine Kinase, Fer
N-terminal catalytic domain of Golgi alpha-mannosidase II and similar proteins
Utp21 specific WD40 associated putative domain
Adenomatous polyposis coli tumour suppressor protein
mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical...
PDZ domain of MCC-2 bdg protein for Usher syndrome
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine...
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones]
Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes...
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A)
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...
HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit
The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
The phosphoinositide binding Phox Homology domain of Sorting Nexin 22
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B
NAD-dependent aldehyde dehydrogenases [Energy production and conversion]
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine...
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains.  The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and...
Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)
Voltage-dependent anion channel of the outer mitochondrial membrane
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
Sar1 is an essential component of COPII vesicle coats
PDIa family, endoplasmic reticulum protein 44 (ERp44)-like subfamily
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...
Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
C-terminal immunoglobulin (Ig)-like domain of myotilin
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be...
Kinesin motor domain, KIF23-like subgroup. Members of this group may play a role in mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play...
Anaphase promoting complex subunit 8 / Cdc23
Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins
Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
HisRS_RNA binding domain.  This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding...
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 1 (FCHSD1)
First Src Homology 3 domain of FCH and double SH3 domains proteins
Second Src Homology 3 domain of FCH and double SH3 domains protein 1
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
Oligophrenin Pleckstrin homology (PH) domain
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
First Src Homology 3 domain of SH3 domain containing ring finger 2
Second Src Homology 3 domain of SH3 domain containing ring finger 2
Third Src Homology 3 domain of SH3 domain containing ring finger 2
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical...
First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR) and similar proteins
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
Na(+)- and Cl(-)-dependent L-proline transporter PROT
Treacher Collins syndrome protein Treacle
Class II MHC-associated invariant chain trimerisation domain
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...
GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3
Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
La RNA-binding domain of La-related protein 1
Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...
Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved...
Cation transport ATPase [Inorganic ion transport and metabolism]
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins.  Little is known about the function of the proteins in this subgroup
dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
Arginyl tRNA synthetase N terminal domain
catalytic core domain of arginyl-tRNA synthetases
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
dendritic cell derived ubiquitin-like protein
The phosphoinositide binding Phox Homology domain of Five SH protein
First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
VIP36 and VIPL type 1 transmembrane proteins, lectin domain
Regulator of G protein signaling (RGS) domain found in the RGS14 protein
ADF homology domain of drebrin and actin-binding protein 1 (abp1)
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which...
Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears...
C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
GDP-mannose 4,6 dehydratase, extended (e) SDRs
Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell...
Death Domain of Receptor-Interacting Protein 1
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...
MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS)
Translocon-associated protein (TRAP), alpha subunit
Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily
Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9
Predicted dehydrogenases and related proteins [General function prediction only]
Oxidoreductase family, NAD-binding Rossmann fold
Oxidoreductase family, C-terminal alpha/beta domain
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+
Dysbindin (Dystrobrevin binding protein 1)
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
Phostensin PP1-binding and SH3-binding region
Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
catalytic core domain of valyl-tRNA synthetases
Anticodon-binding domain of valyl tRNA synthetases
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Alpha helical coiled-coil rod protein (HCR)
type VI secretion system FHA domain protein
C-terminal, alpha helical domain of Chloride Intracellular Channel 1
MutS5 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...
Glutathione S-transferase C-terminal-like, alpha helical domain of vertebrate Valyl-tRNA synthetase
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred...
Domain abundant in complement control proteins
Proteins similar to C3, C4 and C5 of vertebrate complement.  The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the...
NTR/C345C domain, complement C4 subfamily
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Class II histocompatibility antigen, alpha domain
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
Class II histocompatibility antigen, beta domain
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
TAP, the Transporter Associated with Antigen Processing
proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
Conjugate Transporter-2 (CT2) Family protein
proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]
Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins. Ncd is a spindle motor protein necessary for chromosome segregation in meiosis. KIFC2/KIFC3-like kinesins have been implicated in motility of the Golgi apparatus as well as dentritic...
fatty oxidation complex, alpha subunit FadB
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor
TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
SAM domain of AIDA1AB-like proteins, repeat 1
SAM domain of AIDA1AB-like proteins, repeat 2
Plasmodium ookinete surface protein Pvs28
Fanconi anemia complementation group E protein, C-terminal domain
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
Patatin-like phospholipase domain containing protein 1
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
Catalytic domain of the Protein Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
cyclophilin_SpCYP2_like: cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent...
SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins
FGD (faciogenital dysplasia protein) pleckstrin homology (PH) domain
Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione
molybdenum cofactor biosynthesis protein A
Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
Gastricsins, asparate proteases produced in gastric mucosa
Fibroblast growth factor receptor substrate 2 (FRS2/SNT1) Phosphotyrosine-binding domain
The PET domain of overexpressed breast tumor protein (OEBT)
The second LIM domain of Testin-like family
TATA-binding related factor (TRF) of subunit 20 of Mediator complex
TATA Binding Protein (TBP) Associated Factor 8
ATP-dependent Clp protease adaptor protein ClpS
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome.  The...
Mouse development and cellular proliferation protein Cullin-7
APC10-like DOC1 domain of CUL7, subunit of the SCF-ROC1-like E3 ubiquitin ligase complex that mediates substrate ubiquitination
Ribosomal Proteins L2, RNA binding domain
Ribosomal Proteins L2, C-terminal domain
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in...
The first LIM domain of thymus LIM protein (TLP)
The second LIM domain of thymus LIM protein (TLP)
putative bacteriocin export ABC transporter, lactococcin 972 group
AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
GTPase [General function prediction only]
GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
Domain II of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse...
Domain III of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse...
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
C-terminal, alpha helical domain of Chloride Intracellular Channel 5
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as...
Meprin family, Alpha subunit, MATH domain
Death domain of tumor necrosis factor receptor superfamily member 21
First Src Homology 3 domain (SH3A) of CD2-associated protein
Second Src Homology 3 domain (SH3B) of CD2-associated protein
Third Src Homology 3 domain (SH3C) of CD2-associated protein
Domain of unknown function, E. rectale Gene description (DUF3878)
Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily
methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...
CENP-A-nucleosome distal (CAD) centromere subunit
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B
BAG domains, present in regulator of Hsp70 proteins
Glutamine synthetase [Amino acid transport and metabolism]
Domain in the central regions of transcription elongation factor S-II (and elsewhere)
Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
Opioid growth factor receptor (OGFr) conserved region
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA
Elongation Factor 1-alpha (EF1-alpha) protein family
EF1_alpha_II: this family represents the domain II of elongation factor 1-alpha (EF-1a) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to...
Domain III of EF-1. Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to ribosomes. EF-1 is composed of four subunits: the alpha chain, which binds GTP and aminoacyl-tRNAs, the gamma chain that probably...
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester...
LEM3 (ligand-effect modulator 3) family / CDC50 family
Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head)...
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...
NAD(P) binding domain of malic enzyme (ME), subgroup 1
p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins.  NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining...
5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]
CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Origin recognition complex (ORC) subunit 3 N-terminus
Adenylation domain of GTP-dependent mRNA capping enzymes
M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily
VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The...
Caspase 8-associated protein 2 myb-like domain
Ligand Binding Domain of Ephrin type-A Receptor 7
SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
The first LIM domain of Four and a half LIM domains protein (FHL)
The second LIM domain of Four and a half LIM domains protein 5 (FHL5)
The fourth LIM domain of Four and a half LIM domains protein (FHL)
GST_N family, Metaxin subfamily, Metaxin-like proteins
C-terminal, alpha helical domain of Metaxin and related proteins
Prolyl oligopeptidase, N-terminal beta-propeller domain
Isoprenoid Biosynthesis enzymes, Class 1
Osteopetrosis-associated transmembrane protein 1 precursor
DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers
The ligand binding domain of Tailless-like proteins,  orphan nuclear receptors
The phosphoinositide binding Phox Homology domain of Sorting Nexin 3 and related proteins
The LIM domain of Mical (molecule interacting with CasL) like family
Adenylate kinase and related kinases [Nucleotide transport and metabolism]
Wiskott Aldrich syndrome homology region 2
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production...
C4-type zinc-finger of DNA polymerase delta
Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
Src homology 2 (SH2) domain found in Fyn
Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
Src homology 2 (SH2) domain found in Fyn isoform a like proteins
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not...
Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor
Catalytic domain of the Protein Tyrosine Kinase, C-ros
Undecaprenyl pyrophosphate synthase [Lipid metabolism]
Eukaryotic protein of unknown function (DUF914)
Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]
Vertebrate heat shock transcription factor
domain in TBC and LysM domain containing proteins
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
Mouse protein of unknown function (DUF781)
Bacterial protein of unknown function (DUF948)
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their...
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
PKA-RI-RII subunit binding domain of A-kinase anchor protein
Arginase types I and II and arginase-like family
DOMON-like domain of copper-dependent monooxygenases and related proteins
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
Human aldehyde dehydrogenase family 8 member A1-like
Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
eRF3_II_like: domain similar to domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1...
HBS1_C: this family represents the C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1) which is homologous to the domain III of EF-1alpha. This group contains proteins similar to yeast Hbs1, a G protein known to be important for efficient growth...
Src Homology 3 domain of Abelson helper integration site-1 (AHI-1)
Catalytic domain of the Protein Serine/Threonine Kinase, Apoptosis signal-regulating kinase
Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...
The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...
Ligand binding domain of the group I metabotropic glutamate receptor
Homer-binding domain of metabotropic glutamate receptor
Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain...
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 1
Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...
Uncharacterized ACR, YagE family COG1723
DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
Oestrogen-type nuclear receptor final C-terminal
Protein chain release factor B [Translation, ribosomal structure and biogenesis]
Regulator of G protein signaling (RGS) domain found in the RZ protein
PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...
Ferric reductase like transmembrane component
NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...
Src Homology 3 domain of Sorting nexin 9
The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 2
Transcription factor TFIIH complex subunit Tfb5
C2 domain first repeat present in Synaptotagmin-like protein 3
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by...
Superoxide dismutase [Inorganic ion transport and metabolism]
Iron/manganese superoxide dismutases, alpha-hairpin domain
Iron/manganese superoxide dismutases, C-terminal domain
TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 4
amino-terminal ubiquitin-like of parkin protein
Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...
proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation...
Programmed cell death protein 2, C-terminal putative domain
C-terminal putative kinase domain of FAM20C (also known as Dentin Matrix Protein 4, DMP4)
Platelet-derived growth factor, N terminal region
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
Centaurin alpha Pleckstrin homology (PH) domain
This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
23S rRNA methylase [Translation, ribosomal structure and biogenesis]
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...
The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels
Peptidase family M54, also called archaemetzincins or archaelysins
Caspase activation and recruitment domain of CARD11-like proteins
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the...
Fungal domain of unknown function (DUF1712)
MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...
Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
Cytohesin Pleckstrin homology (PH) domain
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3
Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...
First harmonin_N_like domain (repeat 1) of L-delphilin, and related domains
Second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains
RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest subunit of Replication protein A (RPA). RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including...
NADH-ubiquinone reductase complex 1 MLRQ subunit
CDP-ME synthetase is involved in mevalonate-independent isoprenoid production
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
N-terminal domain of ribose phosphate pyrophosphokinase
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an...
Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions
Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
Cytochrome c, mono- and diheme variants [Energy production and conversion]
Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...
Chromo Shadow Domain,  found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain
The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2
Calcium binding and coiled-coil domain (CALCOCO1) like
Caspase activation and recruitment domain similar to that found in NOD1
GlyRS_RNA binding domain.  This short RNA-binding domain is found at the  N-terminus of GlyRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix-turn-helix structure , which is similar to other RNA-binding...
Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...
GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...
Trypsin Inhibitor like cysteine rich domain
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides
TRX domain, TRX and NDP-kinase (NDPK) fusion protein family
Cysteine-rich domain of the secreted frizzled-related protein 4 (SFRP4), a Wnt antagonist
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
proteasome_alpha_type_2. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
Cytochrome oxidase complex assembly protein 1
Src homology 3 domain of eumetazoan Actin-binding protein 1
Nucleotidyltransferase (NT) domain of family X DNA Polymerases
PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins.   Little is known about the function of the proteins in this subgroup
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module
Transcription factor homologous to NACalpha-BTF3 [Transcription]
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological...
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
SecE/Sec61-gamma subunits of protein translocation complex
Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...
heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 9 (Fz9) receptor
ATP-utilising chromatin assembly and remodelling N-terminal
Modifier of rudimentary (Mod(r)) protein
Methyltransferase involved in Williams-Beuren syndrome
The first LIM domain of LIMK1 (LIM domain Kinase 1)
The second LIM domain of LIMK1 (LIM domain Kinase 1)
The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
NADPH oxidase subunit p47Phox, C terminal domain
Chemokine_CC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues
Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via...
Glyoxysomal and mitochondrial malate dehydrogenases
Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally...
14-3-3 gamma, an isoform of 14-3-3 protein
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E)
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A)
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D)
ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
Pericentrin-AKAP-450 domain of centrosomal targeting protein
Peroxisome biogenesis factor 1, N-terminal
ATPase family associated with various cellular activities (AAA)
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
Protein of unknown function N-terminal domain (DUF2450)
Protein of unknown function C-terminus (DUF2451)
Kunitz/Bovine pancreatic trypsin inhibitor domain
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p
10 TM Acyl Transferase domain found in Cas1p
SAM domain of SAM_Neurabin-like subfamily
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the...
Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1
Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)
TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain
C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
Casein kinase substrate phosphoprotein PP28
Mitochondrial F1F0-ATP synthase, subunit f
pentatricopeptide repeat domain (PPR motif)
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6
C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4
TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Rpp20 subunit of nuclear RNase MRP and P
This domain contains 8 conserved cysteine residues
Ligand Binding Domain of Ephrin type-B Receptor 4
SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
Mitochondria Fission Protein Fis1, cytosolic domain
Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
RPB11 subunit of Eukaryotic RNA polymerase II
C2 domain first repeat present in RasA1 and RasA4
C2 domain second repeat present in RasA1 and RasA4
Ras GTPase activating-like 4 protein (RASAL4), also known as Ca2+ -promoted Ras inactivator (CAPRI), is a member of the GAP1 family. Members of the GAP1 family are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a...
RAS_GTPase activating protein (GAP)_CG9209 pleckstrin homology (PH) domain
Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
Additional N-terminal subrepeat of reelin
Tandem repeat subunit of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general
C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K), class IB, gamma isoform, catalytic domain
Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
domain in Ataxins and HMG containing proteins
Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...
Plant protein of unknown function (DUF827)
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
Patatin-like phospholipase domain containing protein 8
Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
cystic fibrosis transmembrane conductor regulator (CFTR)
The CFTR subfamily domain 1.  The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical...
Cystic fibrosis TM conductance regulator (CFTR), regulator domain
The CFTR subfamily domain 2.  The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Protein kinase C conserved region 2 (CalB)
Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]
Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of...
hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal...
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats...
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
NLS-binding and DNA-binding and dimerisation domains of Nrf1
Nrf1 activator activation site binding domain
The Sema domain, a protein interacting module, of Plexin A4
Sec8 exocyst complex component specific domain
Guanylate kinase [Nucleotide transport and metabolism]
Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
Signal recognition particle, alpha subunit, N-terminal
Phorbol esters/diacylglycerol binding domain (C1 domain)
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Sugar phosphate permease [Carbohydrate transport and metabolism]
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...
Ligand Binding Domain of Ephrin type-B Receptor 6
SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily
Caspase activation and recruitment domain of Caspase-2
Ligand Binding Domain of Ephrin type-A Receptor 1
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
SAM domain of EPH-A1 subfamily of tyrosine kinase receptors
Herpesvirus transcription activation factor (transactivator)
PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b
PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'
PDIa family, C-terminal TRX domain (a') subfamily
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
Ras Homolog Enriched in Brain (RheB) is a small GTPase
RecA/RadA recombinase [DNA replication, recombination, and repair]
Condensin II non structural maintenance of chromosomes subunit
C-terminal immunoglobulin (Ig)-like domain of M-protein (also known as myomesin-2)
Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin...
Src homology 3 domain of Blk Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in B lymphoid kinase (Blk)
N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases
N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2)
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a...
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
PLAT/ LH2 domain present in lipoprotein lipase (LPL).  LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the...
Surfactant protein C, N terminal propeptide
PAZ domain,  Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...
Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of...
First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
RhoBTB protein is an atypical member of the Rho family of small GTPases
Tumor necrosis factor receptor / nerve growth factor receptor repeats
Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors
Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
epoxide hydrolase N-terminal domain-like phosphatase
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping...
TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
Nuclear protein with HMG-like acidic region [General function prediction only]
A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...
The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...
Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins
Cholesterol-binding START domain of mammalian STARD1 and related proteins
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...
Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
Alpha-helical domain of GINS complex protein Sld5
C-terminal domain of medium Mu3B subunit in neuron-specific adaptor protein (AP) complex AP-3
Protein prenyltransferase alpha subunit repeat
DNA-dependent protein kinase (DNA-PK), catalytic domain
Ubiquitin-conjugating enzyme E2, catalytic domain homologues
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p)
Src homology 3 domain of Lyn Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in Lyn
Catalytic domain of the Protein Tyrosine Kinase, Lyn
Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a...
ARC105 or Med15 subunit of Mediator complex non-fungal
domain in transcription and CHROMO domain helicases
Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
Ribosome biogenesis regulatory protein (RRS1)
Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
GST_N family, Ganglioside-induced differentiation-associated protein 1 (GDAP1) subfamily
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1
SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...
SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed...
DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...
The phosphoinositide binding Phox Homology domain of Sorting Nexin 16
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
C2 domain present in E3 ubiquitin ligase
Caspase activation and recruitment domain of Receptor Interacting Protein 2
putative bacillithiol system oxidoreductase, YpdA family
The Bin/Amphiphysin/Rvs (BAR) domain of Family with sequence similarity 92 (FAM92)
Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
Phafin2  Pleckstrin Homology (PH) domain
Ubiquinol-cytochrome C reductase complex 14kD subunit
PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions
M28 Zn-Peptidase Plasma glutamate carboxypeptidase
Ribonucleases P/MRP protein subunit POP1
Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Regulator of G protein signaling domain RGS_RGS22_2
Regulator of G protein signaling domain RGS_RGS22_3
Regulator of G protein signaling domain RGS_RGS22_4
14-3-3 beta and zeta isoforms of 14-3-3 protein
C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell...
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi
Conserved region of Rad21 / Rec8 like protein
C-terminal cystine knot-like domain (CTCK)
TATA binding protein (TBP) associated factor 2
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown
Hyaluronan synthases catalyze polymerization of hyaluronan
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83A
poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
Hereditary spastic paraplegia protein strumpellin
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The...
Src homology 3 domain of Src-Like Adaptor Protein
Src homology 2 domain found in Src-like adaptor proteins
Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I.  Topo I enzymes are divided into:  topo type IA (bacterial) and type IB (eukaryotic)
DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...
Eukaryotic DNA topoisomerase I, DNA binding fragment
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-1
Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...
Eukaryotic elongation factor 1 beta central acidic region
GDP-fucose synthetase, extended (e) SDRs
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83H
poly-U binding splicing factor, half-pint family
Superfamily II DNA helicase [DNA replication, recombination, and repair]
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
domain in helicases and associated with SANT domains
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone...
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a...
Membrane-associated phospholipid phosphatase [Lipid metabolism]
RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded in eukaryotic genomes. They lack a conserved catalytic histidine residue required for cyclase activity, so probably do not function as cyclases. They are...
Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1
amino-terminal ubiquitin-like domain of  Np95 and NIRF
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1
snRNA-activating protein of 50kDa MW C terminal
Lens epithelium-derived growth factor (LEDGF)
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus
Catalytic domain of the Protein Tyrosine Kinase, Tie2
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...
Caspase activation and recruitment domain found in RIG-I, second repeat
helical domain inserted in SF2-type helicase domain in Hef-, MDA5- and FancM-like proteins
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to...
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown...
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...
Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...
KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...
Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity
Cell division protein 48 (CDC48), N-terminal domain
Cell division protein 48 (CDC48) domain 2
C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
Munc13 (mammalian uncoordinated) homology domain
C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
Src homology 3 domain of RUN and SH3 domain-containing protein 2
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...
Ligand-binding domain of type B natriuretic peptide receptor
SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
A49-like RNA polymerase I associated factor
RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) [Translation, ribosomal structure and biogenesis]
S1_Rrp40: Rrp40 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation...
S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain
Src homology 2 domain found in SH2 domain-containing adapter protein B (SHB)
NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
cAMP-dependent protein kinase catalytic subunit
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR...
Src Homology 3 domain of metazoan osteoclast stimulating factor 1
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...
Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits
Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
Na+ dependent nucleoside transporter N-terminus
Na+ dependent nucleoside transporter C-terminus
Fifth domain (immunoglobulin-like) of Trk receptor TrkB
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
Death domain found in death-associated protein kinase 1
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
Vertebrate interleukin-3 regulated transcription factor
Cysteine-rich domain of tyrosine kinase-like orphan receptor 2
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1
Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase
7TM receptor with intracellular HD hydrolase
17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins
Middle domain of eukaryotic initiation factor 4G (eIF4G)
Escherichia coli YaeB and related proteins
C-terminal SAF domain of sialic acid synthetase
SAM domain of ANKS6 (or SamCystin) subfamily
This family is most closely related to the GT1 family of glycosyltransferases.  ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)...
PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily
PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b
PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'
Rix1 complex component involved in 60S ribosome maturation
Acyl-CoA thioester hydrolase/BAAT N-terminal region
BAAT / Acyl-CoA thioester hydrolase C terminal
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl
Predicted permease, member of the PurR regulon [General function prediction only]
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis
human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs
The phosphoinositide binding Phox Homology domain of Sorting Nexin 30
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 30
Anaphase-promoting complex APC subunit 1
Splicing Factor Motif, present in Prp18 and Pr04
Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...
C2 domain of the Regulator Of G-Protein Signaling (RGS) family
Regulator of G protein signaling (RGS) domain found in the RGS3 protein
First harmonin_N_like domain (repeat 1) of the long isoform of whirlin, and related domains
Second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain
NTR/C345C domain, complement C5 subfamily
proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers
The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
Protein of unknown function (DUF3550/UPF0682)
Nucleotide-binding domain of human HSPA5 and similar proteins
Rab5-activating protein 6 (RAP6) is an endosomal protein with a role in the regulation of receptor-mediated endocytosis. RAP6 contains a Vps9 domain, which is involved in the activation of Rab5, and a Ras GAP domain (RGD). Rab5 is a small GTPase required...
Stress-activated map kinase interacting protein 1 (SIN1)
Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...
Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...
ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9
Mur ligase family, glutamate ligase domain
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
Coenzyme Q (ubiquinone) biosynthesis protein Coq4
Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N3
Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
Nucleoporin subcomplex protein binding to Pom34
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is...
Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine...
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor...
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
Src Homology 3 domain of Formin Binding Protein 17
Argininosuccinate synthase [Amino acid transport and metabolism]
Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...
Exosome complex exonuclease RRP4 N-terminal region
S1_Rrp4: Rrp4 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in...
Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
Transcription factor IIIC subunit delta N-term
Putative zinc-finger of transcription factor IIIC complex
RNA polymerase III transcription factor (TF)IIIC subunit
Uracil-DNA glycosylases (UDG) and related enzymes
Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens
Surfeit locus protein 5 subunit 22 of Mediator complex
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...
DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
First Src homology 3 domain of VAV2 protein
Src homology 2 (SH2) domain found in the Vav2 proteins
C-terminal (or second) Src homology 3 domain of VAV2 protein
Caspase activation and recruitment domain of CARD9-like proteins
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain
C-terminal, alpha helical domain of Chloride Intracellular Channel 3
daunorubicin resistance ABC transporter ATP-binding subunit
Neural proliferation differentiation control-1 protein (NPDC1)
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
Anaphase promoting complex (APC) subunit 2
DEDDy 3'-5' exonuclease domain of Caenorhabditis elegans mut-7 and similar proteins
The PB1 domain is present in the p51 protein, a homolog of the p67 protein.  p51 plays an  important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical...
C-terminal Src Homology 3 domain of NADPH oxidase activator 1
Patatin-like phospholipase domain containing protein 6 and protein 7
Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]
The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions.  BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND...
La RNA-binding domain of La-related protein 5
Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...
Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent...
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system
Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C theta
Domain of Kin17 curved DNA-binding protein
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+
Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...
Nucleotide-binding domain of human HSPA14 and similar proteins
Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]
Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...
Src homology 3 domain of Signal Transducing Adaptor Molecules
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
The LIM domain of LIM and SH3 Protein (LASP)
C-terminal Src Homology 3 domain of Nebulette and LIM-nebulette (or Lasp2)
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the...
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...
Catalytic domain of the Protein Serine/Threonine Kinase, Class IIIA myosin
Src homology 3 domain of Abl Interactor 1
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase
Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
Src Homology 3 domain of Rho GTPase-activating protein 12
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and...
Tripartite ATP-independent periplasmic transporters, DctQ component
C2A domain first repeat present in Synaptotagmins 15 and 17
C2 domain second repeat present in Synaptotagmin 15
TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]
mitochondrial import inner membrane translocase subunit tim23
Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
Hinge domain of cleavage stimulation factor subunit 2
Transcription termination and cleavage factor C-terminal
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
SAM domain of BICC1 (bicaudal) subfamily
Uncharacterized conserved protein H4 (DUF2046)
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes-like
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4
Vacuolar protein sorting-associated protein 26
Mitochondrial degradasome RNA helicase subunit C terminal
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
Group XII secretory phospholipase A2 precursor (PLA2G12)
NADH pyrophosphatase-like rudimentary NUDIX domain
Zinc-finger of mitochondrial splicing suppressor 51
C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...
SAM domain of sphingomyelin synthase related subfamily
Src homology 3 domain of Disks Large homolog 5
Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
Lung surfactant protein D coiled-coil trimerisation
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
Wings apart-like protein regulation of heterochromatin
The first LIM domain of ZASP/Cypher family
The second LIM domain of Enigma-like family
The third LIM domain of ZASP/Cypher family
Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
Death domain of FAS or TNF receptor superfamily member 6
Kinesin motor domain, BimC/Eg5 spindle pole proteins, participate in spindle assembly and chromosome segregation during cell division. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...
Folate-sensitive fragile site protein Fra10Ac1
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]
This family represents the LIM domain of CLP36
First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme...
Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their...
S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation...
NER and RNAPII transcription protein n terminal
Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity
Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]
Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]
multi drug resistance-associated protein (MRP)
First N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Second N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Third N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Fourth N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
GP4d_helicase is a homohexameric 5'-3' helicases. Helicases couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands
Domains similar to the N-terminal protein-binding module of harmonin
Guanine nucleotide exchange factor in Golgi transport N-terminal
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
Death domain of the Nuclear Factor-KappaB2 precursor protein p100
Suppressor of Fused Gli/Ci N terminal binding domain
S1_Rrp5_repeat_hs1_sc1: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs2_sc2: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]
S1_Rrp5_repeat_hs3: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs4: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs5: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs6_sc5: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs7: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs8_sc7: Rrp5 Homo sapiens S1 repeat 8 (hs8) and Saccharomyces cerevisiae S1 repeat 7 (sc7)-like domains. Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits.  Rrp5 has two distinct...
S1_Rrp5_repeat_hs10: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs11_sc8: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs12_sc9: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats...
S1_Rrp5_repeat_hs13: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits.  Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
S1_Rrp5_repeat_hs14: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in...
First Src homology 3 domain of Tyrosine kinase substrate (Tks) proteins
Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which...
Catalytic domain of the Protein Serine/Threonine Kinase, Ste20-like kinase
C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline
Vesicle transport v-SNARE protein N-terminus
Snare region anchored in the vesicle membrane C-terminus
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal
C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of...
Nucleotide-binding domain of HSPA12A and similar proteins
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...
C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase
TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily
Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily
Domain with 2 conserved Trp (W) residues
Type I inositol polyphosphate 5-phosphatase I
Guanine nucleotide exchange factor synembryn
Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]
Glycosyl hydrolase family 65 central catalytic domain
Leucine rich repeat, ribonuclease inhibitor type
Transaldolases including both TalA and TalB
Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
Putative intracellular protease/amidase [General function prediction only]
Death Domain of p53-induced protein with a death domain
Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins...
Patatin-like phospholipase domain containing protein 2
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome.  SI-CLP has a glycosyl...
C2 domain present in Toll-interacting protein (Tollip)
Cathepsin_D2, pepsin family of proteinases
IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and...
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model...
catalytic core domain of cysteinyl tRNA synthetase
Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)
Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...
Plasmid replication region DNA-binding N-term
The TATA Binding Protein (TBP) Associated Factor 10
SAM domain of liprin-beta1,2 proteins repeat 1
SAM domain of liprin-beta1,2 proteins repeat 2
SAM domain of liprin-beta proteins repeat 3
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f
The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed...
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
Domain always found downstream of DENN domain, found in a variety of signalling proteins
Set binding factor Pleckstrin Homology (PH) domain
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding...
The LIM domain of Mical (molecule interacting with CasL)
fatty acyl CoA reductases (FARs), extended (e) SDRs
C-terminal domain of fatty acyl CoA reductases
proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
Phosphoinositide 3-kinase (PI3K), class II, alpha isoform, catalytic domain
The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]
N-terminal protein-binding module of harmonin
Basic domain in HLH proteins of MYOD family
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
lactate/malate dehydrogenase, alpha/beta C-terminal domain
The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
Na(+)- and Cl(-)-dependent glycine transporter GlyT2
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins
Kinesin motor domain, KIP3-like subgroup. The yeast kinesin KIP3 plays a role in positioning the mitotic spindle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent...
Potassium channel Kv1.4 tandem inactivation domain
Homo sapiens 239FB and related proteins, metallophosphatase domain
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function
Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
The first LIM domain of LMO2 (LIM domain only protein 2)
The second LIM domain of LMO2 (LIM domain only protein 2)
Cytoplasmic activation/proliferation-associated protein-1 C term
Catalase [Inorganic ion transport and metabolism]
Clade 3 of the heme-binding enzyme catalase
Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
branched-chain alpha-keto acid dehydrogenase subunit E2
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor...
C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain
Recombination-activating protein 1 zinc-finger domain
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
C2 domain second repeat present in Synaptotagmin 13
Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]
Src homology 3 domain of JNK-interacting protein 1
LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
PTN/MK heparin-binding protein family, N-terminal domain
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
Rapsyn N-terminal myristoylation and linker region
NADH (or F420H2) dehydrogenase, subunit C
PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...
M28 Zn-peptidase prostate-specific membrane antigen
Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
C1 inhibitor (C1-Inh) is a protease inhibitor of the serpin family. It plays a pivotal role in regulating the activation of the classical complement pathway and of the contact system, via regulating bradykinin formation, inhibiting factor XII and...
Predicted GTPase subunit of the pre-mRNA cleavage complex [Translation, ribosomal structure and biogenesis]
Mediator of RNA pol II transcription subunit 19
The fourth LIM domain of the Paxillin-like protein family
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...
Pepsin A, aspartic protease produced in gastric mucosa of mammals
Mono-functional DNA-alkylating methyl methanesulfonate N-term
Vertebrate cytochrome b(561), CYBASC3 gene product
C2A domain first repeat present in Synaptotagmin 7
C2 domain second repeat present in Synaptotagmin 7
Myelin gene regulatory factor -C-terminal domain 1
Myelin gene regulatory factor C-terminal domain 2
PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...
Chromosome passenger complex (CPC) protein INCENP N terminal
Inner centromere protein, ARK binding region
ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...
GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily
Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
Elongation factor 1 gamma, conserved domain
This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in...
DNA-directed RNA polymerase II subunit 7
RNAP_II_Rpb7_N: Rpb7, N-terminal ribonucleoprotein (RNP) domain. Rpb7 is a subunit of eukaryotic RNA polymerase (RNAP) II that is homologous to Rpc25 of RNAP III, RpoE of archaeal RNAP, and Rpa43 of eukaryotic RNAP I. Rpb7 heterodimerizes with Rpb4 and...
S1_RNAPII_Rpb7: Eukaryotic RNA polymerase II (RNAPII) Rpb7 subunit C-terminal S1 domain. RNAPII is composed of 12 subunits (Rpb1-12). Rpb4 and Rpb7 form a heterodimer that associate with the RNAPII core. Rpb7 is a homolog of the Rpc25 of RNA polymerase...
Alpha amylase catalytic domain found in solute carrier family 3 member 2 proteins
Cytochrome oxidase c subunit VIII.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...
RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]
RNA 2'-phosphotransferase, Tpt1 / KptA family
FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
Peroxiredoxin (PRX) family, PRX5-like subfamily
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...
Splicing factor (branch point binding protein) [RNA processing and modification]
The phosphoinositide binding Phox Homology domain of Sorting Nexin 15
Mitochondrial large subunit ribosomal protein (Img2)
DNA polymerase alpha subunit B N-terminal
Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
N-terminal sub-domain of the Rel homology domain (RHD) of RelA
Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
Ribonuclease H2-C is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
Cofilin, Destrin, and related actin depolymerizing factors
ERCC4-type nuclease [DNA replication, recombination, and repair]
Acidic fibroblast growth factor binding (FIBP)
S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found...
proline-rich domain in spliceosome associated proteins
C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins
Microtubule associated protein (MAP65/ASE1 family)
Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
C2 domain second repeat present in Synaptotagmin 12
Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and  G protein-coupled receptor kinase 3 (GRK3)
Catalytic domain of the Protein Serine/Threonine Kinase, beta-adrenergic receptor kinase
Beta adrenergic receptor kinase 1(beta ARK1)(GRK2) pleckstrin homology (PH) domain
N-terminal domain conserved in slingshot (SSH) phosphatases
Catalytic domain of the Protein Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
Eukaryotic protein of unknown function (DUF872)
Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...
Succinylglutamate desuccinylase / Aspartoacylase family
Peptidase M14 Aspartoacylase (ASPA) subfamily
Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Choline Kinase (ChoK) in eukaryotes. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK)
Galanin message associated peptide (GMAP)
R3H domain of Smubp-2_like proteins.  Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most...
Death Effector Domain found in Fas-Associated via Death Domain
Fas-associated Death Domain protein-protein interaction domain
Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
SAM domain of Shank1,2,3 family proteins
Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...
Orthopoxvirus interleukin 18 binding protein
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
SAM domain of Ship2 lipid phosphatase proteins
C-terminal, D2-small domain, of ClpB protein
Lipid-binding START domain of mammalian STARD10 and related proteins
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
Second Src Homology 3 domain of FCH and double SH3 domains protein 2
C2 domain found in C2 calcium-dependent domain containing 3 (C2cd3) proteins
Microsomal signal peptidase 25 kDa subunit (SPC25)
K homology RNA-binding (KH) domain of the eukaryotic 40S small ribosomal subunit protein S3. S3  is part of the head region of the 40S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE2 and similar proteins
Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]
Herpesvirus latent membrane protein 1 (LMP1)
UV radiation resistance protein and autophagy-related subunit 14
Myosin motor domain, type VII myosins. Myosins in this group have been associated with functions in sensory systems such as vision and hearing. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins...
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE6 and similar proteins
Nucleotide-sensitive chloride conductance regulator (ICln)
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the...
NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
Thyroid hormone-inducible hepatic protein Spot 14
EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...
RPA1_DBD_C: A subfamily of OB folds corresponding to the C-terminal OB fold, the ssDNA-binding domain (DBD)-C, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which...
Invertebrate innate immunity transcript family
Src Homology 3 domain of Disks Large homolog 2
Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta...
Amino acid permeases [Amino acid transport and metabolism]
Mre11 nuclease, N-terminal metallophosphatase domain
The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
Telomere-length maintenance and DNA damage repair
Ataxia telangiectasia mutated (ATM), catalytic domain
POU domain, class 2, associating factor 1
C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers...
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB2/heat shock 27kDa protein 2 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally...
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa
SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Eukaryotic SQRs reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric...
6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
C4-type Zn-finger protein [General function prediction only]
SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases
PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...
Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)
Immunoglobulin (Ig)-like domain of CD3 epsilon chain
Immunoglobulin (Ig)-like domain of CD3 gamma and delta chains
Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many...
Intraflagellar transport complex B protein 46 C terminal
Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit
Neutral trehalase [Carbohydrate transport and metabolism]
Vacuolar protein sorting protein 11 C terminal
Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...
UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is...
UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]
First immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or as CD111) and similar proteins
Second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or as CD111) and similar proteins
3-oxoacyl-(acyl carrier protein) synthase III
Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-3 (also known as cell adhesion molecules CADM3, CADM1, and CADM2 respectively)
Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]
Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like
16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]
Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]
SRP54-type protein, helical bundle domain
The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...
Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]
Scavenger mRNA decapping enzyme (DcpS) N-terminal
Scavenger mRNA decapping enzyme C-term binding
Sterile alpha motif (SAM)/Pointed domain of ETS-1
Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
The phosphoinositide binding Phox Homology domain of PX-RICS
Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
Copper-binding of amyloid precursor, CuBD
The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
non-SMC mitotic condensation complex subunit 1
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins
Na(+)- and Cl(-)-dependent GABA transporter 2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans...
Death domain of Tumor Necrosis Factor Receptor 1
non-SMC mitotic condensation complex subunit 1, N-term
Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Second immunoglobulin (Ig) domain of CD4
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for...
N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
N-methyl D-aspartate receptor 2B3 C-terminus
AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]
Ligand-binding domain of the membrane guanylyl cyclase C
Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b
Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'
Retinal cGMP phosphodiesterase, gamma subunit
2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family
Phosphoinositide 3-kinase (PI3K), class II, gamma isoform, catalytic domain
The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...
Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the...
The SUR domain 1.  The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains.  Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the...
The SUR domain 2.  The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family.  Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel...
CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety
C2 domain found in the Human KIAA0528 cDNA clone
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...
Catalytic domain of the Protein Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
FOG: TPR repeat [General function prediction only]
Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]
Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
Domain present in PSD-95, Dlg, and ZO-1/2
Death domain of Interleukin-1 Receptor-Associated Kinase 4
DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers
The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The...
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
N-terminal region of micro-spherule protein
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin...
The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)
La RNA-binding domain of La-related protein 4
SAM domain of TFCP2 transcription factors
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
Bacterial protein of unknown function (DUF883)
Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]
SMUG: single-strand-selective monofunctional uracil-DNA glycosylase
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans...
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of...
Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
Pseudokinase domain of the Protein Tyrosine Kinase, HER3
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
Signal transducer and activator of transcription 2 C terminal
F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...
p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis
AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its...
AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine
First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is...
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4
Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1
Eukaryotic protein of unknown function (DUF2003)
Death domain of Interleukin 1 Receptor Associated Kinase-M
ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]
TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Proteins similar to Escherichia coli YajQ
SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich...
The first LIM domain of Cysteine Rich Protein 2 (CRP2)
Plant protein of unknown function (DUF869)
Sodium-coupled branched-chain amino-acid transporter 1
Src homology 2 (SH2) domain found in  suppressor of cytokine signaling (SOCS) proteins
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate...
Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain
Death domain of RIP-associated ICH-1 homologous protein with a death domain
The Sema domain, a protein interacting module, of Plexin C1
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides
Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria
Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL)
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, phenylalanine hydroxylases (PAH)
G:T/U mismatch specific DNA glcosylase (MUG)
The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
present in yeast cell wall integrity and stress response component proteins
NifU homolog involved in Fe-S cluster formation [Energy production and conversion]
Family 1 of Uracil-DNA glycosylase (UDG) enzymes
Biotin carboxyl carrier protein [Lipid metabolism]
G protein-coupled receptor kinase-interacting protein 1 C term
sarco/endoplasmic reticulum calcium-translocating P-type ATPase
Homo sapiens Vps29 and related proteins, metallophosphatase domain
LNK-family Pleckstrin homology (PH) domain
PDIa family, endoplasmic reticulum protein 29 (ERp29) subfamily
N-acetyltransferase B complex (NatB) non catalytic subunit
C2 domain first repeat present in Rabphilin and Double C2 domain
C2 domain second repeat present in Rabphilin and Double C2 domain
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia
The first LIM domain of Lhx1 (also known as Lim1) and Lhx5
The second LIM domain of Lhx1 (also known as Lim1) and Lhx5
The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an
SAM like domain present in kinase suppressor RAS 1
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but...
Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and...
Catalytic domain of the Protein Serine/Threonine Kinase, Citron Rho-interacting kinase
Ribosomal protein L10 family, P0 and L10e subfamily
The first LIM domain of the paxillin like protein family
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs
Cytochrome c oxidase subunit VIa.   Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Di-glucose binding within endoplasmic reticulum
Hepatocyte nuclear factor 1 (HNF-1), N terminus
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
COMPASS (Complex proteins associated with Set1p) component N
Second Mitochondria-derived Activator of Caspases
C-terminal domain of DENR and related proteins
thiol reductant ABC exporter, CydD subunit
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 10 (Fz10) receptor
First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
DNA polymerase family B, exonuclease domain
DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed...
DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
Higher Eukarytoes and Prokaryotes Nucleotide-binding domain
Peptidase M3 mitochondrial intermediate peptidase (MIP)
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8
Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]
Translation initiation factor IF-3, N-terminal domain
Translation initiation factor IF-3, C-terminal domain
AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous...
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous...
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous...
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
DPG_synthase is involved in protein N-linked glycosylation
exosome complex RNA-binding protein Rrp42
Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
Transcription initiation factor IIF, beta subunit
Vitamin-D-receptor interacting Mediator subunit 4
Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...
Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs
ATPase, P-type (transporting), HAD superfamily, subfamily IC
This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown...
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 5
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 3
Vacuolar protein sorting protein 36 Vps36
p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the...
PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
Pollux (PLX) Phosphotyrosine-binding (PTB) domain
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in...
Uncharacterized protein involved in propionate catabolism [General function prediction only]
dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]
dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Protein Serine/Threonine Kinases
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
Citrate lyase beta subunit [Carbohydrate transport and metabolism]
Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
PIN domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
H3TH domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease
The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
C-terminal tandem repeated domain in type 4 procollagens
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily
Src Homology 3 domain of beta-Pak Interactive eXchange factor
Cool (cloned out of library)/Pix (PAK-interactive exchange factor) pleckstrin homology (PH) domain
Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 1 (GRK1)
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
RASA3 (or GAP1_IP4BP) is a member of the GAP1 family and has been shown to specifically bind 1,3,4,5-tetrakisphosphate (IP4). Thus, RASA3 may function as an IP4 receptor. The members of GAP1 family are characterized by a conserved domain structure...
WGR domain of poly(ADP-ribose) polymerases
Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
purine nucleoside phosphorylase I, inosine and guanosine-specific
RNase A family, or Pancreatic RNases family
Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity.  In the human genome 8 RNases , refered to as 'canonical' RNases, have been...
Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor
Preprotein translocase subunit YidC [Intracellular trafficking and secretion]
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Embryonal Fyn-associated Substrate
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins
CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases
Porcine peroxisomal carbonyl reductase like, classical (c) SDR
Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...
Inositol phospholipid synthesis and fat-storage-inducing TM
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)
PNGase/UBA or UBX (PUB) domain of the RNF31 (or HOIP) protein
Rab geranylgeranyl transferase alpha-subunit, insert domain
human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin...
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction
RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner
Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion]
MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and...
The phosphoinositide binding Phox Homology domain of Sorting Nexin 6
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 6
signal recognition particle protein SRP54
proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...
C-terminal Actin depolymerization factor-homology domain of Sec23
Survival motor neuron (SMN) interacting protein 1 (SIP1)
Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
insert domain of FANCM helicase and similar proteins
Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
Cyclin-dependent kinase inhibitor 3 (CDKN3)
ADF-homology domain of glia maturation factor beta and related proteins
GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...
Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the...
Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)
proteasome_alpha_type_3. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
CDK-activating kinase assembly factor MAT1
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C eta
Small nuclear RNA activating complex (SNAPc), subunit SNAP43
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the...
Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea
Molybdopterin biosynthesis enzyme [Coenzyme metabolism]
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...
Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)
Translation initiation factor 2, alpha subunit (eIF-2alpha) [Translation, ribosomal structure and biogenesis]
S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively)...
Eukaryotic translation initiation factor 2 alpha subunit
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins.  Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central...
GPI-GlcNAc transferase complex, PIG-H component
Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a...
DEDDy 3'-5' exonuclease domain of WRN and similar proteins
Cytochrome c oxidase assembly protein COX16
Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
Regulator of G protein signaling (RGS) domain found in the RGS6 protein
Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
Type II (General) Secretory Pathway (IISP) Family protein
Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived...
PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to...
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 9
C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
DNA alkylation damage repair protein AlkB
Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
Catalytic domain, repeat 1, of metazoan tyrosyl-DNA phosphodiesterase
Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase
26 proteosome regulatory subunit 4-like protein
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
Cleavage and polyadenylation factor 2 C-terminal
Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
Inositol 1, 3, 4-trisphosphate 5/6-kinase
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been...
Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa...
alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor
PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named...
RT_LTR: Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the...
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain
C-terminal W2 domain of eukaryotic translation initiation factor 5
tRNA methyltransferase complex GCD14 subunit
tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]
Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
Type I (cytosolic) bacterial L-asparaginase
Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD4
Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD4
The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...
Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]
Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or...
APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing...
This model contains proteins with the VRR-NUC domain
Neuroendocrine protein 7B2 precursor (Secretogranin V)
Nucleolar RNA-binding protein, Nop10p family
This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily
Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide
Signal recognition particle 14kD protein
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 6
Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
transcription termination factor NusA, C-terminal duplication
GTP cyclohydrolase I feedback regulatory protein (GFRP)
DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
Complex I intermediate-associated protein 30 (CIA30)
Short conserved domain in transcriptional regulators
Catalytic domain of the Protein Tyrosine Kinase, Tyro3
Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2
C-terminal START domain of mammalian STARD9, and related domains
Homo sapiens TMEM62, N-terminal metallophosphatase domain
Adenosine deaminase [Nucleotide transport and metabolism]
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...
PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b
Translation initiation factor eIF3 subunit
Class I major histocompatibility complex (MHC) beta2-microglobulin
Dual oxidase and related animal heme peroxidases
Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D)
PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the...
FOG: LysM repeat [Cell envelope biogenesis, outer membrane]
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 and 6
Myosin motor domain, type V myosins. Myosins V transport a variety of intracellular cargo processively along actin filaments, such as membraneous organelles and mRNA. This catalytic (head) domain has ATPase activity and belongs to the larger group of...
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD...
C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
Src homology 3 domain of Myosins Ie, If, and similar proteins
Gamma subunit of transcription initiation factor IIA, N-terminal helical domain
Transcription initiation factor IIA, gamma subunit [Transcription]
Gamma subunit of transcription initiation factor IIA, C-terminal domain
Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]
Carbonic anhydrase [Inorganic ion transport and metabolism]
The phosphoinositide binding Phox Homology domain of Sorting Nexin 1
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 1
ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...
Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
ATP-dependent protease ATP-binding subunit ClpX
Replication Fork Protection Component Swi3
Catalytic domain of the dual-specificity Protein Kinase, MAP/ERK Kinase 1
60S ribosomal protein L4 C-terminal domain
N-terminal Mad Homology 1 (MH1) domain in SMAD6
C-terminal Mad Homology 2 (MH2) domain in SMAD6
N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
Alpha and gamma adaptin binding protein p34
PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5...
Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 5
Gammaherpesvirus protein of unknown function (DUF848)
Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins...
La RNA-binding domain of La-related protein 6
DNA-binding domain of the photoreceptor cell-specific nuclear receptor (PNR) is composed of two C4-type zinc fingers
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a...
ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group.  They are found in certain hyperthermophilic archaea and in higher eukaryotes.  A functional...
First immunoglobulin (Ig)-like domain in neogenin and similar proteins
Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)
Src Homology 3 domain of C-terminal Src kinase
Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...
Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins
N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
Alpha-mannosidase [Carbohydrate transport and metabolism]
N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins
Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
C-terminal m3G cap-binding domain of nuclear import adaptor snurportin-1
Ribosomal protein S4 and related proteins [Translation, ribosomal structure and biogenesis]
S4/Hsp/ tRNA synthetase RNA-binding domain
Src Homology 3 domain of Sorting Nexin 33
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...
Electron transfer flavoprotein FAD-binding domain
electron transfer flavoprotein subunit alpha
Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Src homology 2 domain found in the SH2 domain containing protein 7 (SH2D7)
isocitrate dehydrogenase, NAD-dependent, mitochondrial type
Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]
proteasome_alpha_type_4. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
Chaperone for wingless signalling and trafficking of LDL receptor
Lipid-binding START domain of mammalian STARD5 and related proteins
EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast...
This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP
eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart...
Elongation Factor 2 (EF2) in archaea and eukarya
Uncharacterized ACR, YggU family COG1872
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A3
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the Nudix hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
IQGAP1 is a homodimeric protein that is widely expressed among vertebrate cell types from early embryogenesis. Mammalian IQGAP1 protein is the best characterized member of the IQGAP family, and contains several protein-interacting domains. Human IQGAP1...
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
N-terminal catalytic domain of Golgi alpha-mannosidase IIx, and similar proteins
Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]
Myosin-binding striated muscle assembly central
Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor
Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers.  Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/...
Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The...
type VII secretion-associated serine protease mycosin
Alkyladenine DNA glycosylase catalyzes the first step in base excision repair
Nitrogen Permease regulator of amino acid transport activity 3
Regulator of G protein signaling (RGS) domain found in the RGS11 protein
Tankyrase binding N-terminal segment of axin
Regulator of G protein signaling (RGS) domain found in the Axin protein
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...
Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as...
WAP-type (Whey Acidic Protein) 'four-disulfide core'
Mitochondrial Rho family 1 (Miro1), N-terminal
Mitochondrial Rho family 2 (Miro2), C-terminal
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]
Iron only hydrogenase large subunit, C-terminal domain
Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
Procyclic acidic repetitive protein (PARP)
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to...
Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]
RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which...
Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold
ribosomal protein S5(archaeal type)/S2(eukaryote cytosolic type)
First or N-terminal Src homology 3 domain of Nox Organizing protein 1
Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
The phosphoinositide binding Phox Homology domain of Nox Organizing protein 1
Repeats in polycystic kidney disease 1 (PKD1) and other proteins
Src Homology 3 domain of CASK interacting protein 1
The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
vacuolar ATP synthase 16 kDa proteolipid subunit
N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...
N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]
3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to...
Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that...
NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...
Septation ring formation regulator, EzrA
The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha.  In a variety of cell lines, NP60 has been shown to localize to the...
3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]
This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and...
Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain
Eukaryotic protein of unknown function (DUF846)
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the...
eRF3_II: domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1 functions as an omnipotent...
This family represents eEF1alpha-like C-terminal region of eRF3 homologous to the domain III of EF-Tu. eRF3 is a GTPase, which enhances the termination efficiency by stimulating the eRF1 activity in a GTP-dependent manner. The C-terminal region is...
The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
Homo sapiens CSTP1 and related proteins, metallophosphatase domain
R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H...
Nuclear pore complex interacting protein (NPIP)
RNA polymerase I specific transcription initiation factor RRN3
N-terminal LabA-like domain of limkain b1 and similar proteins
The first LOTUS domain on Limkain b1(LKAP)
The second LOTUS domain on Limkain b1(LKAP)
The third LOTUS domain on Limkain b1(LKAP)
The fourth LOTUS domain on Limkain b1(LKAP)
The fifth LOTUS domain on Limkain b1(LKAP)
The sixth LOTUS domain on Limkain b1(LKAP)
The seventh LOTUS domain on Limkain b1(LKAP)
The eighth LOTUS domain on Limkain b1(LKAP)
NUDE protein, C-terminal conserved region
Suppressor of morphogenetic effect on genitalia-1 (SMG-1), catalytic domain
Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain
C2 domain second repeat present in Synaptotagmin 17
C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins
catalytic core domain of discriminating glutamyl-tRNA synthetase
The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
RNase domain (also known as the kinase extension nuclease domain) of Ire1
C2 domain in Protein Kinase C (PKC) alpha and gamma
Catalytic domain of the Protein Serine/Threonine Kinase, Classical Protein Kinase C
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins
The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been...
Nse1 non-SMC component of SMC5-6 complex
Interleukin-4 receptor alpha chain, N-terminal
Eukaryotic translation initiation factor 3 subunit 8 N-terminus
Elongation Factor Tu (EF-Tu) GTP-binding proteins
EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...
Domain III of mitochondrial EF-TU (mtEF-TU). mtEF-TU is highly conserved and is 55-60% identical to bacterial EF-TU. The overall structure is similar to that observed in the Escherichia coli and Thermus aquaticus EF-TU. However, compared with that...
Src homology 2 (SH2) domain found in SH2B adapter protein family
Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its eukaryotic homologs
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...
Kinesin motor domain, KIF22/Kid-like subgroup. Members of this group might play a role in regulating chromosomal movement along microtubules in mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs
Family of likely enzymes that includes the catalytic subunit of vitamin K epoxide reductase
Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins
The second LIM domain of the paxillin like protein family
Na(+)/glucose cotransporter SGLT2 and related proteins
Vacuolar protein sorting-associated protein 35
Origin recognition complex subunit 6 (ORC6)
Middle domain of the origin recognition complex subunit 6
The phosphoinositide binding Phox Homology domain of Sorting Nexin 20
Caspase activation and recruitment domain of NOD2, repeat 1
Caspase activation and recruitment domain of NOD2, repeat 2
Na(+)- and Cl(-)-dependent norepinephrine transporter NET
Oxoglutarate and iron-dependent oxygenase degradation C-term
LBP / BPI / CETP family, C-terminal domain
N-terminal domain of NEFA-interacting nuclear protein NIP30
Chemokine_CX3C:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
RPB3 subunit of Eukaryotic RNA polymerase II
Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
Carbonic anhydrase alpha, CA isozyme VII_like subgroup.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
Death Domain of Tumor Necrosis Factor Receptor 1-Associated Death Domain protein
The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions...
Histones H3 and H4 [Chromatin structure and dynamics]
renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear
Protein involved in ribosomal biogenesis, contains PUA domain [Translation, ribosomal structure and biogenesis]
RAP1 binding motif of telomere repeat binding factor
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
Vacuolar protein 14 C-terminal Fig4p binding
Regulator of Vps4 activity in the MVB pathway
Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...
Dim1 family, Dim1-like protein (DLP) subfamily
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1
LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop
Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...
DNA-binding modules of yeast Rap1 and related proteins
C-terminal domain of RAP1 recruits proteins to telomeres
Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
Src homology 3 domain of Phospholipase C (PLC) gamma 2
3beta-hydroxysteroid dehydrogenase (3b-HSD)-like, subgroup1, extended (e) SDRs
NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]
Peptidase S8 family domain in SKI-1-like proteins
whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of...
Coactosin-like members of the ADF homology domain family
Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Carbonic anhydrase alpha, CA isozyme V_like subgroup.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases
This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
rRNA methylases [Translation, ribosomal structure and biogenesis]
RNA 2'-O ribose methyltransferase substrate binding
Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily
PDIb' family, NRX subgroup, redox inactive TRX-like domain b'
BCR (breakpoint cluster region)-related pleckstrin homology (PH) domain
C2 domain in the Active BCR (Breakpoint cluster region) Related protein
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain
14-3-3 epsilon, an isoform of 14-3-3 protein
Src homology 2 domain found in cancer-related signaling adaptor protein CRK
N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)
U5 snRNP spliceosome subunit [RNA processing and modification]
RNA recognition motif of the spliceosomal PrP8
Mpr1p, Pad1p N-terminal (MPN) domains without isopeptidase activity found in splicing factor Prp8
Alpha2-antiplasmin (alpha2AP) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-Antiplasmin forms an inactive 1 : 1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin...
Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This...
RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all...
RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which...
PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...
Translation initiation factor eIF3 subunit 135
APC10/DOC1-like domain of uncharacterized Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) and homologs
Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding
Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...
Gamma-glutamyltransferase [Amino acid transport and metabolism]
Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs
Vitelline membrane outer layer protein I (VOMI)
The phosphoinositide binding Phox Homology domain of Phospholipase D2
Catalytic domain, repeat 1, of vertebrate phospholipase D2
Catalytic domain, repeat 2, of vertebrate phospholipase D2
R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted...
Human TRX-related protein 14 (TRP14)-like family
Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...
Src Homology 3 domain of Disks Large homolog 4
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
phosphoribosylformylglycinamidine synthase, single chain form
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase
Phosphoinositide 3-kinase gamma adapter protein p101 subunit
Src homology 3 domain of Growth Arrest Specific protein 7
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
SCO (an acronym for Synthesis of Cytochrome c Oxidase) family
Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
P-loop containing dynein motor region D3
P-loop containing dynein motor region D4
Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 4
The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]
Outspread Pleckstrin homology (PH) domain
Catalytic domain of vertebrate phospholipase D6 and similar proteins
Vesicle coat protein involved in Golgi to plasma membrane transport
5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
RNA polymerase II transcription mediator complex subunit 9
Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
Developmentally Regulated GTP-binding protein (DRG)
TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...
Myosin motor domain, type XV myosins. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are...
Topoisomerase IA [DNA replication, recombination, and repair]
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...
Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]
Topoisomerase DNA binding C4 zinc finger
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]
Na(+)/glucose cotransporter SGLT5 and related proteins
N-terminal phospholipase D-like domain of the uncharacterized protein Family with sequence similarity 83G
N-terminal Src homology 3 domain of GRB2-related adaptor protein
Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
C-terminal Src homology 3 domain of GRB2-related adaptor protein
Ciliary basal body-associated, B9 protein
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
Na+-driven multidrug efflux pump [Defense mechanisms]
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
Catalytic domain of the dual-specificity Protein Kinases, MAP kinase kinases 3 and 6
Inward rectifier potassium channel N-terminal
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1...
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
Hemimethylated DNA-binding protein YccV like
Endoplasmic reticulum-based factor for assembly of V-ATPase
SAM domain ot SARM1-like proteins, repeat 1
Phosphatidylinositol-glycan biosynthesis class S protein
RNA pol II promoter Fmp27 protein domain
N-terminal Src homology 2 (SH2) domain found in Spt6
C-terminal Src homology 2 (SH2) domain found in Spt6
PLA2_group_III_like: A sub-family of  Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes
Rab GTPase families 34 (Rab34) and 36 (Rab36)
Ribosomal protein L23, N-terminal domain
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 8
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain
E. coli Ras-like protein (Era) is a multifunctional GTPase
retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and...
Coiled-coil domain-containing protein 55 (DUF2040)
Serotonin (5-HT) neurotransmitter transporter, N-terminus
Na(+)- and Cl(-)-dependent serotonin transporter SERT
Peptidase C1B subfamily (MEROPS database nomenclature)
Neurofibromin is the product of the neurofibromatosis type 1 gene (NF1) and shares a region of similarity with catalytic domain of the mammalian p120RasGAP protein and an extended similarity with the Saccharomyces cerevisiae RasGAP proteins Ira1 and Ira2
Ectropic viral integration site 2A protein (EVI2A)
U3 small nucleolar RNA-associated protein 6
The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase III is a DNA-binding module that is part of the catalytic core unit
DNA repair and recombination protein RadA
Ras-related protein on chromosome 22 (RRP22) family
Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal...
proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...
C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
Ribosomal protein L19e, eukaryotic.  L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an...
C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
Mediator of RNA polymerase II transcription subunit 1
Cholesterol-binding START domain of mammalian STARD3 and related proteins
Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
Catalytic domain of the Protein Tyrosine Kinase, HER2
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB9 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers...
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
human estrogenic 17beta-hydroxysteroid dehydrogenase type 1 (type 1 17beta-HSD)-like, classical (c) SDRs
phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis
Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily.  Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes.  Gamma-tubulin...
The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves...
S1_DHX8_helicase: The  N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide.  The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced...
Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
AAK_NAGS-Urea: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the urea cycle found in animals. Ureogenic NAGS is a mitochondrial enzyme catalyzing the formation of NAG from acetylcoenzyme A and L-glutamate
DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
Snu114p, a spliceosome protein, is a GTPase
Loc2 eEF2_C_snRNP, cd01514/C terminal domain:eEF2_C_snRNP: This family includes C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart Snu114p.  This domain is...
EF-2_domain IV_snRNP domain is a part of 116kD U5-specific protein of the U5 small nucleoprotein (snRNP) particle, essential component of the spliceosome. The protein is structurally closely related to the eukaryotic translational elongation factor EF2
eEF2_C_snRNP: This family includes a C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart Snu114p.  This domain is homologous to the C-terminal domain of the...
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
Src Homology 3 domain of Rho GTPase-activating protein 27
Presenilin, signal peptide peptidase, family
Cell division protein 48 (CDC48), domain 2
Karyopherin (importin) beta [Intracellular trafficking and secretion]
Ribosomal protein L10 family, L10 subfamily
Dipeptidase [Amino acid transport and metabolism]
Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
Src homology 3 domain of Abl Interactor proteins
Phosphoserine phosphatase [Amino acid transport and metabolism]
Death domain of p75 Neurotophin Receptor
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are...
Cytochrome c oxidase assembly protein CtaG/Cox11
cytochrome c oxidase assembly protein-like
Lipid-binding START domain of mammalian STARD2 and related proteins
Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
Tripartite motif containing protein 37 (TRIM37) family, MATH domain
Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in...
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...
Vertebrate cytochrome b(561), CYB561 gene product
Peptidase family M2 Angiotensin converting enzyme (ACE)
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 3
a LIM domain subfamily on a group of proteins with unknown function
Pseudokinase domain of STE20-related kinase adapter protein alpha
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
Intercellular adhesion molecule (ICAM), N-terminal domain
Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
Putative integral membrane protein conserved region (DUF2404)
C-terminal domain of mitochondrial DNA polymerase gamma B subunit, which is required for processivity. Polymerase gamma replicates and repairs mitochondrial DNA. The c-terminal domain of its B subunit is strikingly similar to the anticodon-binding domain...
Regulator of G protein signaling (RGS) domain found in the RGS9 protein
Lipid-binding SRPBCC domain of mammalian PITPNC1,and related proteins (Class IIB PITPs)
Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
C-terminal putative kinase domain of FAM20A
The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...
ATP synthase D chain, mitochondrial (ATP5H)
C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
Src Homology 3 domain of CASK interacting protein 2
tRNA-splicing endonuclease subunit sen54 N-term
SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the...
Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases
Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...
Calcitonin gene-related peptide regulator C terminal
Caspase activation and recruitment domain of CARD14-like proteins
Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases 1 and 3
recombination and DNA strand exchange inhibitor protein
NPL4 family, putative zinc binding region
Mov34/MPN/PAD-1 family: nuclear protein localization-4 (Npl4) domain
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases
VHS domain family, Hrs and Vps27p subfamily
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...
Anaphase-promoting complex subunit 11 RING-H2 finger
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs
xylulose reductase-like, classical (c) SDRs
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...
Dehydratase domain in polyketide synthase (PKS) enzymes
beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl...
THO complex subunit 1 transcription elongation factor
Death domain of Nuclear Matrix Protein P84
Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...
Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...
Src homology 3 domain of Yes Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in Yes
Protein involved in chromosome segregation, interacts with SMC proteins [Cell division and chromosome partitioning]
C-temrinal immunoglobulin (Ig)-like domain of myomesin and M-protein
Respiratory-chain NADH dehydrogenase 24 Kd subunit
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily
Twisted gastrulation (Tsg) protein conserved region
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1...
human MPPE1 and related proteins, metallophosphatase domain
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin...
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
Rok (Rho- associated kinase) pleckstrin homology (PH) domain
Tumour-suppressor protein CtIP N-terminal domain
DNA repair protein endonuclease SAE2/CtIP C-terminus
proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...
Transthyretin (TTR) is a 55 kDa protein responsible for the transport of thyroid hormones and retinol in vertebrates.  TTR distributes the two thyroid hormones T3 (3,5,3'-triiodo-L-thyronine) and T4 (Thyroxin, or 3,5,3',5'-tetraiodo-L-thyronine), as well...
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
Meprin family, Beta subunit, MATH domain
Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain)
Phosphoinositide 3-kinase (PI3K), class III, catalytic domain
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2
F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2)  domain.  It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins
N-terminal Mad Homology 1 (MH1) domain in SMAD7
C-terminal Mad Homology 2 (MH2) domain in SMAD7
CpG binding protein zinc finger C terminal domain
N-terminal Mad Homology 1 (MH1) domain in SMAD4
C-terminal Mad Homology 2 (MH2) domain in SMAD4
C-terminal domain of methyl-CpG binding protein 2 and 3
Lipid-binding START domain of mammalian STARD6 and related proteins
Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...
Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...
Aspartyl/asparaginyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]
AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...
Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
Signal peptidase I [Intracellular trafficking and secretion]
ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain
3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In...
The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory...
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the...
M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
Mgc45594 gene product and other MDR family members
N-terminal sub-domain of the Rel homology domain (RHD)
catalytic domain of ctd-like phosphatases
DNA-directed RNA polymerase II subunit family protein
F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]
ATP synthase, Delta/Epsilon chain, beta-sandwich domain
Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA).  MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase...
Ubiquinol-cytochrome C reductase complex, 6.4kD protein
Splicing factor 3a, subunit 2 [RNA processing and modification]
Cactus-binding C-terminus of cactin protein
Anti-Mullerian hormone, N terminal region
M28 Zn-Peptidase Nicalin, Nicastrin-like protein
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 3
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)
Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A2
Chromatin assembly factor 1 p150 subunit
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
Found in ATP-dependent protease La (LON)
Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease
Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA...
NTR/C345C domain, complement C3 subfamily
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
First Src homology 3 domain of VAV1 protein
Src homology 2 (SH2) domain found in the Vav1 proteins
C-terminal (or second) Src homology 3 domain of VAV1 protein
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
type IV pilus biogenesis/stability protein PilW
Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 7
Small nuclear RNA activating complex subunit 2-like
mitochondrial import inner membrane, translocase subunit
NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
S1_S28E: S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may...
Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
Eukaryotic translation initiation factor 3 subunit G
Cytosine specific DNA methyltransferase replication foci domain
BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG...
BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG...
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
C-terminal domain of medium Mu1B subunit in epithelial cell-specific clathrin-associated adaptor protein (AP) complex AP-1
Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]
Coactivator-associated arginine methyltransferase 1 N terminal
Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 6
Evolutionarily conserved signalling intermediate in Toll pathway
Transcription elongation factor Elf1 like
Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins
ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...
Mammalian RNase HII is functional when it forms a complex with two other accessory protein
Catalytic domain, repeat 1, of Deoxyribonuclease II alpha and similar proteins
Catalytic domain, repeat 2, of Deoxyribonuclease II alpha and similar proteins
Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]
Src homology 2 domain found in hematopoietic SH2 (HSH2) protein
C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a...
GIY-YIG domain of hypothetical proteins from Metazoa
Catalytic cysteine-containing C-terminus of GTPase, MnmE
Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
Src homology 2 (SH2) domain in the Janus kinase 3 (Jak3) proteins
Ribosomal protein L20A (L18A) [Translation, ribosomal structure and biogenesis]
Na(+)/iodide cotransporter NIS and related proteins
Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
Gamma interferon inducible lysosomal thiol reductase (GILT)
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras...
Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
Ubiquinol cytochrome reductase transmembrane region
ubiquinol-cytochrome c reductase, iron-sulfur subunit
Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain
A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2
Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-2
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...
Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
Presenilin enhancer-2 subunit of gamma secretase
Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress
The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
Eighth immunoglobulin-like domain of nephrin
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2) and similar proteins
Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
S12-like family, 30S ribosomal protein S12 subfamily
purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
Catalytic domain of the Protein Serine/Threonine Kinase, Group II p21-activated kinase
Clg (common-site lymphoma/leukemia guanine nucleotide exchange factor) pleckstrin homology (PH) domain
Spt5 transcription elongation factor, acidic N-terminal
Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
Fibrillarin-like rRNA methylase [Translation, ribosomal structure and biogenesis]
26S protease regulatory subunit 6B-like protein
Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins
Catalytic domain of the Protein Tyrosine Kinase, Axl
Coiled-coil domain containing protein (DUF2052)
archaeal exosome-like complex exonuclease 1
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
U2 snRNP auxilliary factor, large subunit, splicing factor
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
DNA-directed RNA polymerase I subunit RPA34.5
Symplekin tight junction protein C terminal
Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...
Adenylation domain of eukaryotic DNA Ligase I
The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
retinal dehydrogenase-like, classical (c) SDR
U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
Mediator complex subunit 25 von Willebrand factor type A
Mediator complex subunit 25 PTOV activation and synapsin 2
Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding...
Homoserine dehydrogenase, NAD binding domain
Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of the human endogenous retrovirus ENVV1, and related domains
Not1 N-terminal domain, CCR4-Not complex component
Ribosomal protein S4/S9 N-terminal domain
First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
Immunoglobulin (IG)-like domain of of FcalphaRI
Signal-regulatory protein (SIRP) immunoglobulin-like domain
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases
NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...
Nucleotide-binding domain of HSPA12B and similar proteins
Caspase activation and recruitment domain (CARD) found in IPS-1
proliferating cell nuclear antigen (pcna)
Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4...
Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
Ribosome receptor lysine/proline rich region
The phosphoinositide binding Phox Homology domain of Sorting Nexin 5
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
NAD(P)H-nitrite reductase [Energy production and conversion]
Thrombomodulin like fifth domain, EGF-like
Alpha-helical domain of GINS complex protein Psf1
Cell cycle regulated microtubule associated protein
Src homology 2 (SH2) domain found in HCK
GDP-fucose protein O-fucosyltransferase and related proteins
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins
ADDz domain of DNA (cytosine-5) methyltransferases (C5-MTases) 3 b (Dnmt3b)
LBP / BPI / CETP family, N-terminal domain
Ribosome anti-association factor IF6 binds the large ribosomal subunit and prevents the two subunits from associating during translation initiation. IF6 comprises a family of translation factors that includes both eukaryotic (eIF6) and archeal (aIF6)...
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83C
Reactive mitochondrial oxygen species modulator 1
Src homology 3 domain of Src-Like Adaptor Protein 2
Src homology 3 domain of Src Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
Eukaryotic domain of unknown function (DUF1716)
N-terminal phospholipase D-like domain of the protein, Family with sequence similarity 83D
Src homology 3 domain of Phospholipase C (PLC) gamma 1
Phosphatidylinositol-specific phospholipase C, Y domain
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1-like 1
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...
Trappin protein transglutaminase binding domain
Integral membrane protein S linking to the trans Golgi network
Gpi16 subunit, GPI transamidase component
The phosphoinositide binding Phox Homology domain of Sorting Nexin 21
Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...
Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) [Translation, ribosomal structure and biogenesis]
Phosphorylated CTD interacting factor 1 WW domain
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11
Kua-ubiquitin conjugating enzyme hybrid localisation domain
DPM1_like represents putative enzymes similar to eukaryotic DPM1
Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein...
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein family member 4
TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...
Neuroendocrine-specific golgi protein P55 (NESP55)
Mitochondrial ATP synthase epsilon chain
proteasome endopeptidase complex, archaeal, alpha subunit
Proteasome complex subunit Rpn13 ubiquitin receptor
Ubiquitin C-terminal hydrolase 37 receptor binding site
Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)
Catalytic domain of the Protein Tyrosine Kinases, Srm and Brk
Src homology 3 domain of Srms Protein Tyrosine Kinase
Src homology 2 (SH2) domain found in Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (srm)
Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]
Nucleotide-binding domain of human HSPA13 and similar proteins
Src homology 3 domain of SAM And SH3 Domain Containing Proteins
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
Mitochondrial ATP synthase coupling factor 6
Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
TCP-1 (CTT or eukaryotic type II) chaperonin family, theta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins
Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis
Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
First Src homology 3 domain (or SH3A) of Intersectin-1
Second Src homology 3 domain (or SH3B) of Intersectin-1
Third Src homology 3 domain (or SH3C) of Intersectin-1
Fourth Src homology 3 domain (or SH3D) of Intersectin-1
Fifth Src homology 3 domain (or SH3E) of Intersectin-1
Na(+)/myo-inositol cotransporter SMIT and related proteins
C-terminal, alpha helical domain of Chloride Intracellular Channel 6
Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs
Type 1 glutamine amidotransferase (GATase1)-like domain
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]
Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
Sterile alpha motif (SAM)/Pointed domain of ETS-2
Eight immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
Histidine phosphatase superfamily (branch 1)
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...
Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers...
Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...
Trafficking protein particle complex subunit 10, TRAPPC10
isoprenoid biosynthesis protein with amidotransferase-like domain
Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1
ADDz domain of DNA (cytosine-5) methyltransferases (C5-MTases) 3 like (Dnmt3l)
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than...
Squalene cyclase (SQCY) domain subgroup 1
Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning]
S-100B: S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which...
Src homology 3 domain of Protein arginine N-methyltransferase 2
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase
Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]
Apoptosis regulator proteins, Bcl-2 family
DiGeorge syndrome critical region 6 (DGCR6) protein
C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)
Ubiquitin fusion-degradation protein [Posttranslational modification, protein turnover, chaperones]
Ubiquitin fusion degradation protein UFD1
Carboxy-terminal domain of Formyltransferase and similar domains
SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]
Src homology 3 domains of Rab3-interacting molecules (RIMs) binding proteins
Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain)
Phosphoinositide 4-kinase (PI4K), Type III, alpha isoform, catalytic domain
Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic...
AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain
uncharacterized YdjC-like family proteins from eukaryotes
cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal...
Macrophage migration inhibitory factor (MIF)
C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
Adhesion-associated domain present in MUC4 and other proteins
mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases)
Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Ubiquitin-like domain of Mammalian splicing factor SF3a_120
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
PLA2_bee_venom_like: A sub-family of  Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes
The first LIM domain of LIMK2 (LIM domain Kinase 2)
The second LIM domain of LIMK2 (LIM domain Kinase 2)
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function
14-3-3 eta, an isoform of 14-3-3 protein
Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
Src Homology 3 domain of the p40phox subunit of NADPH oxidase
The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in...
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]
Thiosulfate sulfurtransferases (TST) contain 2 copies of the Rhodanese Homology Domain. Only the second repeat contains the catalytically active Cys residue. The role of the 1st repeat is uncertain, but believed to be involved in protein interaction
Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain
Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain
Caspase activation and recruitment domain of CARD10-like proteins
The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1
Bluetongue virus non-structural protein NS2
RNA polymerase I-associated factor PAF67
The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
Patatin-like phospholipase domain containing protein 9
N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83F
Src Homology 3 domain of Small G protein Signaling Modulator 3
Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...
DNA-directed RNA polymerase, subunit E' [Transcription]
RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains
ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase
Ribosomal RNA-processing protein 7 (RRP7)
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
Theoretical model of a pro-apoptotic protein
malonyl CoA-acyl carrier protein transacylase
Patatin-like phospholipase domain containing protein 5
Patatin-like phospholipase domain containing protein 3
Spinocerebellar ataxia type 10 protein domain
tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase
The Sema domain, a protein interacting module, of Plexin B2
Glycosyl transferase family, helical bundle domain
Pyrimidine nucleoside phosphorylase C-terminal domain
Src homology 3 domain of JNK-interacting protein 2
JNK-interacting protein (JIP) Phosphotyrosine-binding (PTB) domain
Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 3
GTPases [General function prediction only]
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases
Patatin-like phospholipase domain containing protein 4
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin...
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system
Src homology 2 (SH2) domain found  in Tec protein, Bmx
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5
First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A in archaea, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation...
Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid...
Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...
eukaryotic translation initiation factor 2 gamma subunit
Gamma subunit of initiation factor 2 (eIF2 gamma)
eIF2_gamma_II: this subfamily represents the domain II of the gamma subunit of eukaryotic translation initiation factor 2 (eIF2-gamma) found in Eukaryota and Archaea. eIF2 is a G protein that delivers the methionyl initiator tRNA to the small ribosomal...
Initiation factor eIF2 gamma, C terminal
Zfx / Zfy transcription activation region
DNA polymerase alpha subunit p180 N terminal
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively...
Melanoma associated antigen family N terminal
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...
Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...
ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]
mitochondrial import inner membrane translocase subunit tim17
Sperm protein associated with nucleus, mapped to X chromosome
17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
ribosome biogenesis GTP-binding protein YlqF
Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE3 and similar proteins
Src Homology 3 domain of Disks Large homolog 3
The phosphoinositide binding Phox Homology domain of Sorting Nexin 12
ADDz domain of ATRX (alpha-thalassemia/mental retardation, X-linked)
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...
Src Homology 3 domain of Bruton's tyrosine kinase
Src homology 2 (SH2) domain found  in Tec protein, Bruton's tyrosine kinase (Btk)
Catalytic domain of Class III myosin-like Protein Serine/Threonine Kinases
Glycosyltransferase family 28 C-terminal domain
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the...
N-terminal domain of multiple copies T cell malignancies 1 and related proteins
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
Transcription- and export-related complex subunit
Transcription factor/nuclear export subunit protein 2
Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a
Src homology 3 domain of Sam And SH3 Domain Containing Protein 3
Catalytic domain of the Protein Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4
The first LIM domain of Four and a half LIM domains protein 1
The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
Src Homology 3 domain of alpha-Pak Interactive eXchange factor
The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins
Na(+)- and Cl(-)-dependent creatine transporter 1
The Sema domain, a protein interacting module, of Plexin B3
Translocon-associated protein, delta subunit precursor (TRAP-delta)
Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
Src homology 3 domain of Slit-Robo GTPase Activating Protein 4
Death domain of Interleukin 1 Receptor Associated Kinase-1
Vacuolar ATP synthase subunit S1 (ATP6S1)
The Sema domain, a protein interacting module, of Plexin A3
type II restriction endonuclease, Alw26I/Eco31I/Esp3I family
Pseudouridine synthase, human dyskerin like
Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)
Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
C-terminal, alpha helical domain of Chloride Intracellular Channel 2
Eukaryotic core primase: Large subunit, PriL