Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, C-ros; cd05044
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
LCCL domain; pfam03815
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Basic region leucine zipper; pfam07716
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Basic region leucine zipper; pfam07716
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; cl00230
Undecaprenyl pyrophosphate synthase [Lipid metabolism]; COG0020
Eukaryotic protein of unknown function (DUF914); pfam06027
EamA-like transporter family; pfam00892
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
phospholamban; TIGR01294
minichromosome maintenance proteins; smart00350
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ASF1 like histone chaperone; pfam04729
Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; COG1241
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Glycosyl hydrolase family 47; pfam01532
Rab-GTPase-TBC domain; cl02495
Connexin; pfam00029
Gap junction channel protein cysteine-rich domain; smart01089
Gap junction alpha-1 protein (Cx43); pfam03508
heat shock factor; smart00415
Vertebrate heat shock transcription factor; pfam06546
heat shock factor; smart00415
Vertebrate heat shock transcription factor; pfam06546
heat shock factor; smart00415
Serine incorporator (Serinc); pfam03348
cAMP-dependent protein kinase inhibitor; pfam02827
cAMP-dependent protein kinase inhibitor; pfam02827
cAMP-dependent protein kinase inhibitor; pfam02827
cAMP-dependent protein kinase inhibitor; pfam02827
cAMP-dependent protein kinase inhibitor; pfam02827
cAMP-dependent protein kinase inhibitor; pfam02827
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
acid sphingomyelinase and related proteins, metallophosphatase domain; cd00842
Calcineurin-like phosphoesterase; pfam00149
CRAL/TRIO, N-terminal domain; pfam03765
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...; cd00170
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Na,K-Atpase Interacting protein; pfam05640
Na,K-Atpase Interacting protein; pfam05640
Na,K-Atpase Interacting protein; pfam05640
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
HD domain; pfam13023
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Orange domain; smart00511
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
domain in TBC and LysM domain containing proteins; smart00584
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Predicted DNA modification methylase [DNA replication, recombination, and repair]
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cl00066
Thrombospondin type 1 domain; cl15278
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cl15762
Protein of unknown function (DUF3166); pfam11365
Protein of unknown function (DUF3166); pfam11365
Mouse protein of unknown function (DUF781); pfam05612
Cell-cycle sustaining, positive selection; pfam12736
Cell-cycle sustaining, positive selection; pfam12736
Cell-cycle sustaining, positive selection; pfam12736
Cell-cycle sustaining, positive selection; pfam12736
Putative binding domain; pfam13900
Cell-cycle sustaining, positive selection; pfam12736
Cell-cycle sustaining, positive selection; pfam12736
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Laminin N-terminal (Domain VI); pfam00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin B domain; smart00281
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin B domain; smart00281
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin Domain I; pfam06008
Bacterial protein of unknown function (DUF948); cl01972
Laminin Domain I; pfam06008
Laminin Domain II; pfam06009
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin N-terminal (Domain VI); pfam00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin B domain; smart00281
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin B domain; smart00281
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin Domain I; pfam06008
Bacterial protein of unknown function (DUF948); cl01972
Laminin Domain I; pfam06008
Laminin Domain II; pfam06009
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their...; cd04391
GTPase-activator protein for Rho-like GTPases; smart00324
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; smart00561
Zinc finger, C2HC type; pfam01530
Sterile alpha motif; smart00454
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; cd09582
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; smart00561
Zinc finger, C2HC type; pfam01530
Sterile alpha motif; smart00454
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; cd09582
SAM domain of Samd3 subfamily; cd09526
Sterile alpha motif; smart00454
SAM domain of Samd3 subfamily; cd09526
Sterile alpha motif; smart00454
Uncharacterized conserved protein (DUF2371); pfam10177
Uncharacterized conserved protein (DUF2371); pfam10177
Uncharacterized conserved protein (DUF2371); pfam10177
Uncharacterized conserved protein (DUF2371); pfam10177
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
4.1 protein C-terminal domain (CTD); pfam05902
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
4.1 protein C-terminal domain (CTD); pfam05902
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
4.1 protein C-terminal domain (CTD); pfam05902
4.1 protein C-terminal domain (CTD); pfam05902
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
4.1 protein C-terminal domain (CTD); pfam05902
4.1 protein C-terminal domain (CTD); pfam05902
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
4.1 protein C-terminal domain (CTD); pfam05902
4.1 protein C-terminal domain (CTD); pfam05902
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
4.1 protein C-terminal domain (CTD); pfam05902
SAB domain; pfam04382
4.1 protein C-terminal domain (CTD); pfam05902
AKAP7 2'5' RNA ligase-like domain; pfam10469
unknown protein; Provisional
PKA-RI-RII subunit binding domain of A-kinase anchor protein; pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; pfam10470
Arginase types I and II and arginase-like family; cd11587
Arginase types I and II and arginase-like family; cd11587
Mediator complex subunit 23; pfam11573
Mediator complex subunit 23; pfam11573
Mediator complex subunit 23; pfam11573
Mediator complex subunit 23; pfam11573
Somatomedin B -like domains; smart00201
Somatomedin B domain; pfam01033
Sulfatase; cl10460
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; cd00091
DNA/RNA non-specific endonuclease; smart00892
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Somatomedin B -like domains; smart00201
Sulfatase; cl10460
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; cd00091
DNA/RNA non-specific endonuclease; smart00892
Insulin-like growth factor binding protein; pfam00219
von Willebrand factor type C domain; pfam00093
Thrombospondin type 1 domain; pfam00090
Cystine-knot domain; pfam00007
DOMON-like domain of copper-dependent monooxygenases and related proteins; cd09631
DOMON domain; pfam03351
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; pfam01082
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; pfam03712
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; cd00179
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; cd00193
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
biotinidase and vanins (class 4 nitrilases); cd07567
Predicted amidohydrolase [General function prediction only]
Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; cl11424
Predicted amidohydrolase [General function prediction only]
biotinidase and vanins (class 4 nitrilases); cd07567
Predicted amidohydrolase [General function prediction only]
biotinidase and vanins (class 4 nitrilases); cd07567
Predicted amidohydrolase [General function prediction only]
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; pfam01248
eyes absent protein conserved domain; TIGR01658
eyes absent protein conserved domain; TIGR01658
eyes absent protein conserved domain; TIGR01658
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; cd04517
TATA-box-binding protein; Provisional
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; cd04517
TATA-box-binding protein; Provisional
Sugar (and other) transporter; pfam00083
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Phox Homology domain, a phosphoinositide binding module; cl02563
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; cd05602
The Phox Homology domain, a phosphoinositide binding module; cl02563
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; cd05575
The Phox Homology domain, a phosphoinositide binding module; cl02563
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; cd05602
The Phox Homology domain, a phosphoinositide binding module; cl02563
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; cd05602
Aldehyde dehydrogenase family; pfam00171
Human aldehyde dehydrogenase family 8 member A1-like; cd07093
Aldehyde dehydrogenase family; pfam00171
Human aldehyde dehydrogenase family 8 member A1-like; cd07093
Aldehyde dehydrogenase family; pfam00171
Human aldehyde dehydrogenase family 8 member A1-like; cd07093
Domain of unknown function (DUF1916); pfam08938
Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; COG5256
Elongation Factor 1-alpha (EF1-alpha) protein family; cd01883
eRF3_II_like: domain similar to domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1...; cd03698
HBS1_C: this family represents the C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1) which is homologous to the domain III of EF-1alpha. This group contains proteins similar to yeast Hbs1, a G protein known to be important for efficient growth...; cd04093
Domain of unknown function (DUF1916); pfam08938
Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; COG5256
Elongation Factor 1-alpha (EF1-alpha) protein family; cd01883
eRF3_II_like: domain similar to domain II of the eukaryotic class II release factor (eRF3). In eukaryotes, translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act as class I and II factors, respectively. eRF1...; cd03698
HBS1_C: this family represents the C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1) which is homologous to the domain III of EF-1alpha. This group contains proteins similar to yeast Hbs1, a G protein known to be important for efficient growth...; cd04093
Domain of unknown function (DUF1916); pfam08938
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
C-myb, C-terminal; pfam09316
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Src Homology 3 domain of Abelson helper integration site-1 (AHI-1); cd11812
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Src Homology 3 domain of Abelson helper integration site-1 (AHI-1); cd11812
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Src Homology 3 domain of Abelson helper integration site-1 (AHI-1); cd11812
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Mitochondrial fission regulator; pfam05308
Mitochondrial fission regulator; pfam05308
Domain of unknown function (DUF4071); pfam13281
Catalytic domain of the Protein Serine/Threonine Kinase, Apoptosis signal-regulating kinase; cd06624
Serine/Threonine protein kinases, catalytic domain; smart00220
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
EamA-like transporter family; cl01037
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interferon-alpha/beta receptor, fibronectin type III; pfam09294
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interferon-alpha/beta receptor, fibronectin type III; pfam09294
Tissue factor; pfam01108
Interferon-alpha/beta receptor, fibronectin type III; pfam09294
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Tissue factor; pfam01108
Interferon gamma receptor (IFNGR1); pfam07140
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
OTU-like cysteine protease; pfam02338
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc finger; cl11604
A20-like zinc fingers; smart00259
OTU-like cysteine protease; pfam02338
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc finger; cl11604
A20-like zinc fingers; smart00259
OTU-like cysteine protease; pfam02338
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc fingers; smart00259
A20-like zinc finger; cl11604
A20-like zinc fingers; smart00259
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Domain of unknown function (DUF1981); pfam09324
SOUL heme-binding protein; pfam04832
Putative binding domain; pfam13900
Domain of unknown function (DUF4061); pfam13270
F-box-like; pfam12937
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
F-box-like; pfam12937
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
Eps15 homology domain; smart00027
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A...; cd00052
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
Eps15 homology domain; smart00027
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A...; cd00052
Myosin-like coiled-coil protein; pfam09728
CITED; pfam04487
CITED; pfam04487
CITED; pfam04487
7 transmembrane receptor (rhodopsin family); pfam00001
Vta1 like; pfam04652
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FAR-17a/AIG1-like protein; pfam04750
Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; cd01285
Peroxin-3; pfam04882
Alpha-L-fucosidase; smart00812
Alpha-L-fucosidase [Carbohydrate transport and metabolism]
RPEL repeat; pfam02755
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
RPEL repeat; cl15286
RPEL repeat; pfam02755
RPEL repeat; cl15286
RPEL repeat; cl15286
RPEL repeat; pfam02755
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
RPEL repeat; cl15286
RPEL repeat; pfam02755
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
RPEL repeat; cl15286
Low temperature viability protein; pfam04180
zinc-finger of a C2HC-type; pfam13913
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc finger, C2H2 type; cl15478
Zinc finger, C2H2 type; cl15478
Splicing factor 3B subunit 10 (SF3b10); pfam07189
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; cd00179
SNARE domain; pfam05739
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
ATPase involved in DNA repair [DNA replication, recombination, and repair]; COG0419
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
EF hand; pfam09068
EF-hand; pfam09069
Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane...; cd02334
The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; cl15347
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; cl15347
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
TRAF-type zinc finger; pfam02176
F-box domain; pfam00646
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
PHD-finger; pfam00628
SNF2 family N-terminal domain; pfam00176
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; COG0553
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
PHD-finger; pfam00628
SNF2 family N-terminal domain; pfam00176
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; COG0553
Ligand binding domain of the group I metabotropic glutamate receptor; cd06374
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Homer-binding domain of metabotropic glutamate receptor; pfam10606
Ligand binding domain of the group I metabotropic glutamate receptor; cd06374
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Rab GTPase; Provisional
Rab GTPase families 18 (Rab18) and 32 (Rab32); cd04107
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; cl00051
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
LLGL2; pfam08366
Synaptobrevin; pfam00957
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
LLGL2; pfam08366
Synaptobrevin; pfam00957
SAM domain of Samd5 subfamily; cd09527
Sterile alpha motif; smart00454
Lymphocyte signaling adaptor protein; pfam12485
Src homology 3 domain of SAM And SH3 Domain Containing Protein 1; cd11967
SAM domain of SASH1 proteins, repeat 1; cd09559
Sterile alpha motif; smart00454
SAM domain of SASH1 proteins, repeat 2; cd09492
Sterile alpha motif; smart00454
Sulfotransferase family; pfam03567
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); smart00546
flagellar export protein FliJ; TIGR02473
Zinc finger domain; smart00547
Small ubiquitin-related modifier (SUMO); cd01763
Ubiquitin homologues; smart00213
Zc3h12a-like Ribonuclease NYN domain; pfam11977
peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional
cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain...; cd01921
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases associated with a variety of cellular activities; smart00382
Vps4 C terminal oligomerisation domain; pfam09336
ATPases associated with a variety of cellular activities; smart00382
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
UBA/TS-N domain; pfam00627
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 1; cd05625
Serine/Threonine protein kinases, catalytic domain; smart00220
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); pfam01135
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); pfam01135
Methyltransferase domain; pfam12847
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); pfam01135
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); pfam01135
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); pfam01135
Methyltransferase domain; pfam12847
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
MANEC domain; pfam07502
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
PKC-activated protein phosphatase-1 inhibitor; pfam05361
Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; cd02144
Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; cd02144
Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; cd02144
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; COG0190
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; pfam00763
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; cd05212
Formate--tetrahydrofolate ligase
Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; cd00477
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; COG0190
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; pfam00763
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; cd05212
Formate--tetrahydrofolate ligase
Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; cd00477
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; COG0190
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; pfam00763
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; COG0190
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; pfam00763
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; cd05212
Formate--tetrahydrofolate ligase
Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; cd00477
WSK motif; pfam03832
WSK motif; pfam03832
WSK motif; pfam03832
WSK motif; pfam03832
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Uncharacterized ACR, YagE family COG1723; pfam02582
Protein of unknown function DUF89; pfam01937
chromosome segregation protein SMC, common bacterial type; TIGR02168
Oestrogen receptor; pfam02159
DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers; cd07171
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen); cd06949
Oestrogen-type nuclear receptor final C-terminal; pfam12743
Oestrogen receptor; pfam02159
DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers; cd07171
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen); cd06949
Oestrogen-type nuclear receptor final C-terminal; pfam12743
Oestrogen receptor; pfam02159
DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers; cd07171
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen); cd06949
Oestrogen-type nuclear receptor final C-terminal; pfam12743
Oestrogen receptor; pfam02159
DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers; cd07171
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen); cd06949
Oestrogen-type nuclear receptor final C-terminal; pfam12743
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
chromosome segregation protein SMC, common bacterial type; TIGR02168
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Nuclear envelope localisation domain; pfam10541
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
ATPase involved in DNA repair [DNA replication, recombination, and repair]; COG0419
chromosome segregation protein SMC, common bacterial type; TIGR02168
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Nuclear envelope localisation domain; pfam10541
Peptide hormone; pfam00123
Glucagon like hormones; smart00070
Peptide hormone; pfam00123
Glucagon like hormones; smart00070
F-box domain; cl02535
IBR domain; pfam01485
F-box domain; cl02535
IBR domain; pfam01485
PCRF domain; pfam03462
Protein chain release factor B [Translation, ribosomal structure and biogenesis]; COG1186
RF-1 domain; pfam00472
PCRF domain; pfam03462
RF-1 domain; pfam00472
Regulator of G protein signaling (RGS) domain found in the RZ protein; cd08718
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
SAM domain of CNK1,2,3-suppressor subfamily; cd09511
Sterile alpha motif; smart00454
Connector enhancer of kinase suppressor of ras; pfam10534
PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; cd00988
Protein of unknown function (DUF1170); pfam06663
CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA...; cd03562
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Pleckstrin homology (PH) domain; cd00821
Ubiquitin-like proteins; cl00155
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
TIAM Pleckstrin homology (PH) domain; cd01255
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
PMP-22/EMP/MP20/Claudin family; cl15797
Predicted ferric reductase [Inorganic ion transport and metabolism]
Ferric reductase like transmembrane component; pfam01794
NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186
BRIGHT, ARID (A/T-rich interaction domain) domain; smart00501
Domain of unknown function (DUF3518); pfam12031
BRIGHT, ARID (A/T-rich interaction domain) domain; smart00501
Domain of unknown function (DUF3518); pfam12031
Protein of unknown function (DUF1358); pfam07096
DHHC palmitoyltransferase; pfam01529
Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
DHHC palmitoyltransferase; pfam01529
Src Homology 3 domain of Sorting nexin 9; cd11898
The phosphoinositide binding Phox Homology domain of Sorting Nexin 9; cd07285
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9; cd07668
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
SacI homology domain; pfam02383
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 2; cd09099
Domain of unknown function (DUF1866); pfam08952
SacI homology domain; pfam02383
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 2; cd09099
Domain of unknown function (DUF1866); pfam08952
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Transcription factor TFIIH complex subunit Tfb5; pfam06331
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
SOCS box; pfam07525
Tub family; pfam01167
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
SOCS box; pfam07525
Wnt-binding factor required for Wnt secretion; pfam06664
Tctex-1 family; pfam03645
Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064
C2 domain first repeat present in Synaptotagmin-like protein 3; cd08392
C2 domain second repeat present in Synaptotagmin-like proteins 1-4; cd04020
Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064
C2 domain first repeat present in Synaptotagmin-like protein 3; cd08392
C2 domain second repeat present in Synaptotagmin-like proteins 1-4; cd04020
Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064
C2 domain first repeat present in Synaptotagmin-like protein 3; cd08392
C2 domain second repeat present in Synaptotagmin-like proteins 1-4; cd04020
Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064
C2 domain first repeat present in Synaptotagmin-like protein 3; cd08392
C2 domain second repeat present in Synaptotagmin-like proteins 1-4; cd04020
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
Ezrin/radixin/moesin family; pfam00769
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
Ezrin/radixin/moesin family; pfam00769
Radial spoke protein 3; pfam06098
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by...; cd04402
GTPase-activator protein for Rho-like GTPases; smart00324
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; cl02570
GTPase-activator protein for Rho-like GTPases; smart00324
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Superoxide dismutase [Inorganic ion transport and metabolism]; COG0605
Iron/manganese superoxide dismutases, alpha-hairpin domain; pfam00081
Iron/manganese superoxide dismutases, C-terminal domain; pfam02777
superoxide dismutase [Mn]
Iron/manganese superoxide dismutases, alpha-hairpin domain; pfam00081
Iron/manganese superoxide dismutases, C-terminal domain; pfam02777
superoxide dismutase [Mn]
Iron/manganese superoxide dismutases, alpha-hairpin domain; pfam00081
Iron/manganese superoxide dismutases, C-terminal domain; pfam02777
hypothetical protein; Provisional
hypothetical protein; Provisional
putative acyltransferase; Provisional
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; cd00751
TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins; cd03335
TCP-1/cpn60 chaperonin family; pfam00118
chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; cl02777
TCP-1/cpn60 chaperonin family; pfam00118
Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; cd00432
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
7 transmembrane receptor (rhodopsin family); pfam00001
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and...; cd00062
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
Cation-independent mannose-6-phosphate receptor repeat; pfam00878
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; COG0477
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions...; cd01099
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions...; cd01099
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cl00100
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 4; cd06626
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 4; cd06626
Serine/Threonine protein kinases, catalytic domain; smart00220
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; cd07990
amino-terminal ubiquitin-like of parkin protein; cd01798
Ubiquitin family; pfam00240
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
Ubiquitin homologues; smart00213
amino-terminal ubiquitin-like of parkin protein; cd01798
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
Ubiquitin homologues; smart00213
amino-terminal ubiquitin-like of parkin protein; cd01798
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
Parkin co-regulated protein; pfam10274
Parkin co-regulated protein; pfam10274
Parkin co-regulated protein; pfam10274
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...; cd02395
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...; cd02395
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...; cd02395
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...; cd02395
FOG: GAF domain [Signal transduction mechanisms]; COG2203
GAF domain; pfam01590
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
GAF domain; pfam13185
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...; cd00182
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...; cd00182
Got1/Sft2-like family; pfam04178
Uncharacterized protein family (UPF0041); pfam03650
Uncharacterized protein family (UPF0041); pfam03650
Serine/Threonine protein kinases, catalytic domain; smart00220
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; cd05582
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
N-terminal catalytic domain of the Protein Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; cd05582
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; cd01061
FOP N terminal dimerisation domain; pfam09398
FOP N terminal dimerisation domain; pfam09398
G protein-coupled chemokine receptor-like protein; Provisional
Olfactory receptor; cl10458
G protein-coupled chemokine receptor-like protein; Provisional
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
Tubulin-tyrosine ligase family; pfam03133
Ubiquitin domain of AT-6, first repeat; cd01782
Ubiquitin domain of AT-6, second repeat; cd01781
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
DIL domain; pfam01843
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin domain of AT-6, first repeat; cd01782
Ubiquitin domain of AT-6, second repeat; cd01781
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
DIL domain; pfam01843
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Kinesin motor, catalytic domain. ATPase; smart00129
Kinesin motor domain; pfam00225
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; cl00286
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
Thrombospondin N-terminal -like domains; smart00210
von Willebrand factor type C domain; pfam00093
Thrombospondin type 1 domain; pfam00090
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
EGF domain; pfam12947
Thrombospondin type 3 repeat; pfam02412
Thrombospondin type 3 repeat; pfam02412
Thrombospondin C-terminal region; pfam05735
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Putative binding domain; pfam13900
PHD-finger; pfam00628
PHD-finger; pfam00628
PHD-finger; pfam00628
PHD-finger; pfam00628
Bacterial conjugation TrbI-like protein; cl04242
Tctex-1 family; pfam03645
Domain of unknown function (DUF4209); pfam13910
N terminus of Notch ligand; pfam07657
Delta serrate ligand; pfam01414
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
XPG domain containing; pfam12813
20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; COG0638
proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03757
38Q repeat
TATA-box-binding protein; Provisional
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation...; cd04516
38Q repeat
TATA-box-binding protein; Provisional
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation...; cd04516
MYND finger; pfam01753
Programmed cell death protein 2, C-terminal putative domain; pfam04194
MYND finger; pfam01753
Programmed cell death protein 2, C-terminal putative domain; pfam04194
MYND finger; pfam01753
MYND finger; pfam01753
MYND finger; pfam01753
MYND finger; pfam01753
C-terminal putative kinase domain of FAM20C (also known as Dentin Matrix Protein 4, DMP4); cd10471
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Platelet-derived growth factor, N terminal region; pfam04692
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived growth factor, N terminal region; pfam04692
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase; cd12102
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase; cd12102
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase; cd12102
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase; cd12102
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase; cd12102
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase; cd12102
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Mitochondrial RNA binding protein MRP; pfam09387
Mitochondrial RNA binding protein MRP; pfam09387
Sad1 / UNC-like C-terminal; pfam07738
Mitochondrial RNA binding protein MRP; pfam09387
Mitochondrial RNA binding protein MRP; pfam09387
Sad1 / UNC-like C-terminal; pfam07738
Mitochondrial RNA binding protein MRP; pfam09387
Mitochondrial RNA binding protein MRP; pfam09387
Sad1 / UNC-like C-terminal; pfam07738
Protein of unknown function (DUF410); pfam04190
Putative GTP-ase activating proteins for the small GTPase, ARF; smart00105
Pleckstrin homology (PH) domain; cd00821
Centaurin alpha Pleckstrin homology (PH) domain; cd01251
CHCH domain; pfam06747
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; cl12078
Uncharacterized conserved protein (DUF2373); pfam10180
Uncharacterized conserved protein (DUF2373); pfam10180
Uncharacterized conserved protein (DUF2373); pfam10180
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
AN1-like Zinc finger; pfam01428
AN1-like Zinc finger; pfam01428
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins; cd09444
Protein of unknown function (DUF3585); pfam12130
Protein of unknown function (DUF3677); pfam12432
bZIP Maf transcription factor; pfam03131
Organic solute transporter Ostalpha; pfam03619
Uncharacterized conserved protein (DUF2372); pfam10178
Uncharacterized conserved protein (DUF2372); pfam10178
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Mitotic checkpoint protein; pfam05557
Mitotic checkpoint protein; pfam05557
Mitotic checkpoint protein; pfam05557
23S rRNA methylase [Translation, ribosomal structure and biogenesis]; COG0293
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
encodes isoform p21
encodes isoform p18
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
encodes isoform p21
encodes isoform p18
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
encodes isoform p21
encodes isoform p18
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; cd03427
The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p; cd06866
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8; cd07597
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
Sulfotransferase family; pfam03567
Sulfotransferase family; pfam03567
Sulfotransferase family; pfam03567
Fringe-like; pfam02434
Fringe-like; pfam02434
Fringe-like; pfam02434
Fringe-like; pfam02434
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; cd07912
Peptidase family M54, also called archaemetzincins or archaelysins; cd11375
G protein alpha subunit; smart00275
Alpha subunit of G proteins (guanine nucleotide binding); cd00066
Caspase activation and recruitment domain of CARD11-like proteins; cd08808
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain superfamily; cl17036
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Immunoglobulin domain; cd00096
Immunoglobulin C-2 Type; smart00408
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cl00065
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
RA (Ras-associating) ubiquitin domain; cd01768
DIL domain; pfam01843
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Poly(A) polymerase central domain; pfam04928
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Poly(A) polymerase predicted RNA binding domain; pfam04926
channel protein, hemolysin III family; TIGR01065
channel protein, hemolysin III family; TIGR01065
Haemolysin-III related; cl03831
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
Nucleoside transporter; cl15430
Nucleoside transporter; cl15430
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the...; cd04714
F-box-like; pfam12937
Actin; pfam00022
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Fungal domain of unknown function (DUF1712); pfam08217
Uncharacterized protein conserved in bacteria [Function unknown]
MORN repeat; pfam02493
MORN repeat; pfam02493
Uncharacterized protein conserved in bacteria [Function unknown]
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; smart00698
MORN repeat; pfam02493
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; smart00698
DNA mismatch repair protein MutL; TIGR00585
Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; cd00075
MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; cd03484
MutL C terminal dimerisation domain; smart00853
Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2; cd03200
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Cytohesin Pleckstrin homology (PH) domain; cd01252
GTPase SAR1 and related small G proteins [General function prediction only]
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3; cd01871
GTPase SAR1 and related small G proteins [General function prediction only]
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3; cd01871
Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; cd00519
Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; cd00519
ER lumen protein retaining receptor; pfam00810
ER lumen protein retaining receptor; pfam00810
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
First harmonin_N_like domain (repeat 1) of L-delphilin, and related domains; cd07354
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains; cd07355
Formin Homology 2 Domain; pfam02181
Formin Homology 2 Domain; smart00498
DHHC palmitoyltransferase; pfam01529
DHHC palmitoyltransferase; pfam01529
DHHC palmitoyltransferase; pfam01529
DHHC palmitoyltransferase; pfam01529
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Uncharacterized protein conserved in bacteria [Function unknown]
MORN repeat; pfam02493
MORN repeat; pfam02493
Uncharacterized protein conserved in bacteria [Function unknown]
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; smart00698
MORN repeat; pfam02493
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; smart00698
Fungal domain of unknown function (DUF1712); pfam08217
Galactosyltransferase; cl09537
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cd01450
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cd01450
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest subunit of Replication protein A (RPA). RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including...; cd04479
Arfaptin-like domain; pfam06456
The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa; cd07661
Islet cell autoantigen ICA69, C-terminal domain; pfam04629
Arfaptin-like domain; pfam06456
The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa; cd07661
Islet cell autoantigen ICA69, C-terminal domain; pfam04629
Arfaptin-like domain; pfam06456
The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa; cd07661
Islet cell autoantigen ICA69, C-terminal domain; pfam04629
Neurexophilin; pfam06312
NADH-ubiquinone reductase complex 1 MLRQ subunit; pfam06522
PHD-finger; pfam00628
PHD-zinc-finger like domain; pfam13832
PHD-finger; pfam00628
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 domain; cl15278
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Protein of unknown function (DUF1356); pfam07092
Protein of unknown function (DUF1356); pfam07092
von Willebrand factor type D domain; cl02516
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Arf-like 4 (Arl4) and 7 (Arl7) GTPases; cd04152
GTPase SAR1 and related small G proteins [General function prediction only]
Arf-like 4 (Arl4) and 7 (Arl7) GTPases; cd04152
GTPase SAR1 and related small G proteins [General function prediction only]
Arf-like 4 (Arl4) and 7 (Arl7) GTPases; cd04152
GTPase SAR1 and related small G proteins [General function prediction only]
Arf-like 4 (Arl4) and 7 (Arl7) GTPases; cd04152
GTPase SAR1 and related small G proteins [General function prediction only]
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
Ets-domain; pfam00178
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; COG1597
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain (presumed); smart00045
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; COG1597
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain (presumed); smart00045
Sterol desaturase [Lipid metabolism]; COG3000
Fatty acid hydroxylase superfamily; pfam04116
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; cd02516
CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; cd02516
Sclerostin (SOST); pfam05463
Leucine Rich repeats (2 copies); pfam12799
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Ankyrin repeats (many copies); pfam13857
MYND finger; pfam01753
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; cd11560
Tetraspanin family; pfam00335
Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of...; cd02960
Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of...; cd02960
PAS fold; pfam00989
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS fold; pfam08447
PXA domain; cl02564
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; cd08719
The phosphoinositide binding Phox Homology domain of Sorting Nexin 13; cd06873
Sorting nexin C terminal; pfam08628
ribose-phosphate pyrophosphokinase; Provisional
N-terminal domain of ribose phosphate pyrophosphokinase; pfam13793
Phosphoribosyl transferase (PRT)-type I domain; cd06223
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Histone deacetylase 9; cd10009
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; COG0123
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Histone deacetylase 9; cd10009
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; COG0123
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Histone deacetylase 9; cd10009
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; COG0123
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase; cd10163
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an...; cd04328
Death Domain: a protein-protein interaction domain; cd01670
Integrin beta subunits (N-terminal portion of extracellular region); smart00187
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Dynein heavy chain, N-terminal region 1; pfam08385
Dynein heavy chain, N-terminal region 2; pfam08393
Hydrolytic ATP binding site of dynein motor region D1; pfam12774
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Microtubule-binding stalk of dynein motor; pfam12777
ATP-binding dynein motor region D5; pfam12781
Dynein heavy chain and region D6 of dynein motor; pfam03028
Zinc-finger domain of monoamine-oxidase A repressor R1; pfam10497
Zinc-finger domain of monoamine-oxidase A repressor R1; pfam10497
Zinc-finger domain of monoamine-oxidase A repressor R1; pfam10497
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; cl02442
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Interleukin-6 homologues; smart00126
TOM7 family; pfam08038
Hyccin; pfam09790
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
BTB/POZ domain; pfam00651
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
zinc finger; smart00356
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
Oligomerisation domain; pfam02410
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein Kinases, catalytic domain; cl09925
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein Kinases, catalytic domain; cl09925
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein Kinases, catalytic domain; cl09925
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein Kinases, catalytic domain; cl09925
Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with...; cd00126
domain in receptor targeting proteins Lin-2 and Lin-7; smart00569
L27 domain; pfam02828
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6); cd12038
Guanylate kinase; pfam00625
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
Gasdermin family; pfam04598
Gasdermin family; pfam04598
Gasdermin family; pfam04598
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Oxysterol-binding protein; pfam01237
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Oxysterol-binding protein; pfam01237
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Oxysterol-binding protein; pfam01237
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Oxysterol-binding protein; pfam01237
Cytochrome c; cl11414
Cytochrome c, mono- and diheme variants [Energy production and conversion]; COG2010
Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; cl00333
basic region leucin zipper; smart00338
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
Chromo Shadow Domain,  found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g; cd00034
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
Chromo Shadow Domain,  found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g; cd00034
The phosphoinositide binding Phox Homology domain of Sorting Nexin 10; cd06898
The phosphoinositide binding Phox Homology domain of Sorting Nexin 10; cd06898
The phosphoinositide binding Phox Homology domain of Sorting Nexin 10; cd06898
The Phox Homology domain, a phosphoinositide binding module; cl02563
Pleckstrin homology (PH) domain; cd00821
Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2; cd12045
Homeodomain-containing transcription factor [Transcription]
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Domain of unknown function (DUF4074); pfam13293
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Domain of unknown function (DUF4074); pfam13293
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Hox9 activation region; pfam04617
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Protein of unknown function (DUF3528); pfam12045
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Hox protein A13 N terminal; pfam12284
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
3-hydroxyisobutyrate dehydrogenase; TIGR01692
Calcium binding and coiled-coil domain (CALCOCO1) like; pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; pfam07888
chromosome segregation protein SMC, common bacterial type; TIGR02168
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]; COG5189
basic region leucin zipper; smart00338
basic region leucin zipper; smart00338
basic region leucin zipper; smart00338
basic region leucin zipper; smart00338
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Serine carboxypeptidase; pfam00450
Serine carboxypeptidase; pfam00450
Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins; cd10352
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two...; cd04372
GTPase-activator protein for Rho-like GTPases; smart00324
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two...; cd04372
GTPase-activator protein for Rho-like GTPases; smart00324
WH2 motif; pfam02205
Peptidase family C69; pfam03577
Peptidase family C69; pfam03577
Peptidase family C69; pfam03577
Peptidase family C69; pfam03577
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Glycolipid transfer protein (GLTP); pfam08718
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Glycolipid transfer protein (GLTP); pfam08718
Oxysterol binding protein (OSBP) Pleckstrin homology (PH) domain; cd01246
Glycolipid transfer protein (GLTP); pfam08718
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Caspase activation and recruitment domain similar to that found in NOD1; cd08324
ATPases associated with a variety of cellular activities; smart00382
NACHT domain; pfam05729
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; cl15777
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; cl15777
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; cd06661
glycyl-tRNA synthetase
GlyRS_RNA binding domain.  This short RNA-binding domain is found at the  N-terminus of GlyRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix-turn-helix structure , which is similar to other RNA-binding...; cd00935
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; cl00268
Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; cd00774
GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00858
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
NNMT/PNMT/TEMT family; pfam01234
NNMT/PNMT/TEMT family; pfam01234
Domain of unknown function (DUF4205); pfam13898
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cd00333
Domain present in hormone receptors; smart00008
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Domain present in hormone receptors; smart00008
7 transmembrane receptor (Secretin family); pfam00002
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Neuronal helix-loop-helix transcription factor; pfam12533
3'5'-cyclic nucleotide phosphodiesterase N-terminal; pfam08499
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
YbgS-like protein; pfam13985
3'5'-cyclic nucleotide phosphodiesterase N-terminal; pfam08499
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
YbgS-like protein; pfam13985
3'5'-cyclic nucleotide phosphodiesterase N-terminal; pfam08499
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
YbgS-like protein; pfam13985
3'5'-cyclic nucleotide phosphodiesterase N-terminal; pfam08499
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
3'5'-cyclic nucleotide phosphodiesterase N-terminal; pfam08499
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Like-Sm protein 5; cd01732
Like-Sm protein 5; cd01732
Like-Sm protein 5; cd01732
Transport protein Avl9; pfam09794
Docking domain of Afi1 for Arf3 in vesicle trafficking; pfam07792
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch motif; pfam01344
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
haloacid dehalogenase superfamily, subfamily IE hydrolase, TIGR01544
Haloacid Dehalogenase-like Hydrolases; cl11391
haloacid dehalogenase superfamily, subfamily IE hydrolase, TIGR01544
Haloacid Dehalogenase-like Hydrolases; cl11391
haloacid dehalogenase superfamily, subfamily IE hydrolase, TIGR01544
Haloacid Dehalogenase-like Hydrolases; cl11391
haloacid dehalogenase superfamily, subfamily IE hydrolase, TIGR01544
Haloacid Dehalogenase-like Hydrolases; cl11391
S-layer domain [Cell envelope biogenesis, outer membrane]
S-layer domain [Cell envelope biogenesis, outer membrane]
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; cl02515
von Willebrand factor type D domain; pfam00094
C8 domain; pfam08742
Trypsin Inhibitor like cysteine rich domain; pfam01826
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Q-cell neuroblast polarisation; pfam10034
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...; cd00182
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...; cd00182
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein; cd01790
Ubiquitin homologues; smart00213
CDC/Septin GTPase family; cd01850
Septin; pfam00735
CDC/Septin GTPase family; cd01850
Septin; pfam00735
CDC/Septin GTPase family; cd01850
Septin; pfam00735
Helix-hairpin-helix motif; pfam12836
Helix-hairpin-helix motif; pfam00633
Helix-hairpin-helix motif; pfam12836
Mycoplasma pulmonis MnuA nuclease-like; cd10283
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Domain of unknown function (DUF1704); cl06858
Cell division protein anillin; pfam08174
Anillin Pleckstrin homology (PH) domain; cd01263
Saposin (B) Domains; smart00741
Saposin-like type B, region 2; pfam03489
Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides; cd01826
Saposin (B) Domains; smart00741
Saposin-like type B, region 2; pfam03489
Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides; cd01826
Saposin (B) Domains; smart00741
Saposin-like type B, region 2; pfam03489
Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides; cd01826
Domain of unknown function (DUF3361); pfam11841
ELMO/CED-12 family; pfam04727
Pleckstrin homology-like domain; cl00273
Domain of unknown function (DUF3361); pfam11841
ELMO/CED-12 family; pfam04727
Pleckstrin homology-like domain; cl00273
Domain of unknown function (DUF3361); pfam11841
ELMO/CED-12 family; pfam04727
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
G protein-coupled chemokine receptor-like protein; Provisional
TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of...; cd02948
NDP kinase domain of thioredoxin domain-containing proteins  (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which...; cd04416
NDP kinase domain of thioredoxin domain-containing proteins  (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which...; cd04416
NDP kinase domain of thioredoxin domain-containing proteins  (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which...; cd04416
Cysteine-rich domain of the secreted frizzled-related protein 4 (SFRP4), a Wnt antagonist; cd07442
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; cl02512
Ependymin; pfam00811
Ependymin; pfam00811
Cholesterol-capturing domain; pfam10457
Immunoglobulin domain; cl11960
BAR domain; smart00721
The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II; cd07611
Src Homology 3 domain of Amphiphysin I; cd12140
BAR domain; smart00721
The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II; cd07611
Src Homology 3 domain of Amphiphysin I; cd12140
Clathrin heavy chain repeat homology; smart00299
Clathrin heavy chain repeat homology; smart00299
Pou domain - N-terminal to homeobox domain; cl02582
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Pou domain - N-terminal to homeobox domain; cl02582
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Essential protein Yae1, N terminal; pfam09811
Ral (Ras-like) family containing highly homologous RalA and RalB; cd04139
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; cd07864
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; cd07864
Serine/Threonine protein kinases, catalytic domain; smart00220
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
TGF-beta propeptide; pfam00688
Transforming growth factor-beta (TGF-beta) family; smart00204
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Protein of unknown function (DUF1308); pfam07000
Protein of unknown function (DUF1308); pfam07000
proteasome subunit alpha; Provisional
proteasome_alpha_type_2. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...; cd03750
Ribosomal L32p protein family; pfam01783
C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1); cd08691
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Cytochrome oxidase complex assembly protein 1; pfam08695
Oxidoreductase family, NAD-binding Rossmann fold; pfam01408
Biliverdin reductase, catalytic; pfam09166
Oxidoreductase family, NAD-binding Rossmann fold; pfam01408
Biliverdin reductase, catalytic; pfam09166
Protein of unknown function (DUF460); pfam04312
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Protein of unknown function (DUF460); pfam04312
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Protein of unknown function (DUF460); pfam04312
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Cell cycle regulatory protein; pfam11357
ADF homology domain of drebrin and actin-binding protein 1 (abp1); cd11281
Src homology 3 domain of eumetazoan Actin-binding protein 1; cd11960
ADF homology domain of drebrin and actin-binding protein 1 (abp1); cd11281
Src homology 3 domain of eumetazoan Actin-binding protein 1; cd11960
ADF homology domain of drebrin and actin-binding protein 1 (abp1); cd11281
Src homology 3 domain of eumetazoan Actin-binding protein 1; cd11960
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07067
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07067
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
DNA polymerase X family; smart00483
Nucleotidyltransferase (NT) domain of family X DNA Polymerases; cd00141
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup; cd03869
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; cd11308
PolD2 (DNA polymerase delta, subunit 2), C-terminal domain; cd07387
PolD2 (DNA polymerase delta, subunit 2), C-terminal domain; cd07387
PolD2 (DNA polymerase delta, subunit 2), C-terminal domain; cd07387
calmodulin; Provisional
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Hexokinase [Carbohydrate transport and metabolism]
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Hexokinase; pfam03727
hexokinase
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Hexokinase; pfam03727
hexokinase
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Hexokinase; pfam03727
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]; COG5143
Regulated-SNARE-like domain; pfam13774
Synaptobrevin; pfam00957
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; cl09109
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins.   Little is known about the function of the proteins in this subgroup; cd06495
Niemann-Pick C type protein family; TIGR00917
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
Niemann-Pick C type protein family; TIGR00917
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
emp24/gp25L/p24 family/GOLD; pfam01105
2-oxoglutarate dehydrogenase E1 component; Reviewed; PRK09404
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; cd02016
Transketolase, pyrimidine binding domain; pfam02779
2-oxoglutarate dehydrogenase E1 component; Reviewed; PRK09404
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; cd02016
Transketolase, pyrimidine binding domain; pfam02779
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; cl01629
MIZ/SP-RING zinc finger; pfam02891
MIZ/SP-RING zinc finger; pfam02891
cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; cd01926
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cl00074
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cl00074
PurA ssDNA and RNA-binding protein; pfam04845
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
Myosin. Large ATPases; smart00242
Myosin motor domain, type I myosins. Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. This...; cd01378
Myosin tail; pfam06017
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Transcription factor homologous to NACalpha-BTF3 [Transcription]; COG1308
NAC domain; pfam01849
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
Receptor activity modifying family; pfam04901
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Insulin growth factor-binding protein homologues; smart00121
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Insulin growth factor-binding protein homologues; smart00121
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Insulin growth factor-binding protein homologues; smart00121
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Protein tyrosine phosphatase, catalytic domain motif; smart00404
C2 domain of PTEN tumour-suppressor protein; pfam10409
Src homology 2 domain found in Tensin-like proteins; cd09927
Tensin Phosphotyrosine-binding (PTB) domain; cd01213
PKD domain; pfam00801
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological...; cd01752
Polycystin cation channel; pfam08016
Hus1-like protein; pfam04005
Sad1 / UNC-like C-terminal; pfam07738
Sad1 / UNC-like C-terminal; pfam07738
uridine phosphorylase; TIGR01719
uridine phosphorylase; TIGR01719
retinal-specific rim ABC transporter; TIGR01257
The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; cd03263
The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; cd03263
von Willebrand factor type C domain; cl02515
Zona-pellucida-binding protein (Sp38); pfam07354
Immunoglobulin like; smart00410
Zona-pellucida-binding protein (Sp38); pfam07354
Immunoglobulin domain; cl11960
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases associated with a variety of cellular activities; smart00382
Vps4 C terminal oligomerisation domain; pfam09336
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases associated with a variety of cellular activities; smart00382
Vps4 C terminal oligomerisation domain; pfam09336
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl00321
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; COG0076
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; COG0076
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl00321
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl00321
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; COG0076
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; COG0076
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; COG0076
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450
Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; COG0076
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450
RA (RAS-associated like) domain of Grb7; cd01787
Pleckstrin homology-like domain; cl00273
BPS (Between PH and SH2); pfam08947
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins; cd10415
RA (RAS-associated like) domain of Grb7; cd01787
Pleckstrin homology-like domain; cl00273
BPS (Between PH and SH2); pfam08947
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins; cd10415
RA (RAS-associated like) domain of Grb7; cd01787
Pleckstrin homology-like domain; cl00273
BPS (Between PH and SH2); pfam08947
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins; cd10415
RA (RAS-associated like) domain of Grb7; cd01787
Pleckstrin homology-like domain; cl00273
BPS (Between PH and SH2); pfam08947
Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins; cd10415
Cordon-bleu domain; pfam09469
Immunoglobulin V-set domain; pfam07686
Immunoglobulin like; smart00410
SecE/Sec61-gamma subunits of protein translocation complex; cl00481
SecE/Sec61-gamma subunits of protein translocation complex; cl00481
Receptor L domain; pfam01030
Furin-like cysteine rich region; pfam00757
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Receptor L domain; pfam01030
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase; cd12093
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; cd05108
Tyrosine kinase, catalytic domain; smart00219
Receptor L domain; pfam01030
Furin-like cysteine rich region; pfam00757
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cl00066
Receptor L domain; pfam01030
Furin-like cysteine rich region; pfam00757
Furin-like repeats; smart00261
Receptor L domain; pfam01030
Furin-like cysteine rich region; pfam00757
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cl00066
Receptor L domain; pfam01030
Furin-like cysteine rich region; pfam00757
Furin-like repeats; smart00261
Receptor L domain; pfam01030
Furin-like cysteine rich region; pfam00757
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cl00066
Receptor L domain; pfam01030
Lanthionine synthetase C-like protein; pfam05147
eukaryotic Lanthionine synthetase C-like protein. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 and LANCL2 (testes-specific adriamycin...; cd04794
CDC/Septin GTPase family; cd01850
Septin; pfam00735
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Ribosomal protein S17; cl00351
NIPSNAP; pfam07978
NIPSNAP; pfam07978
phosphoserine phosphatase SerB; TIGR00338
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...; cd03342
TCP-1/cpn60 chaperonin family; pfam00118
TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...; cd03342
TCP-1/cpn60 chaperonin family; pfam00118
Uncharacterized conserved protein [Function unknown]
Formylglycine-generating sulfatase enzyme; pfam03781
Uncharacterized conserved protein [Function unknown]
Formylglycine-generating sulfatase enzyme; pfam03781
Uncharacterized conserved protein [Function unknown]
Formylglycine-generating sulfatase enzyme; pfam03781
Uncharacterized conserved protein [Function unknown]
Formylglycine-generating sulfatase enzyme; cl15394
Uncharacterized conserved protein [Function unknown]
Formylglycine-generating sulfatase enzyme; pfam03781
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
CHCH domain; pfam06747
DNA-binding nuclear phosphoprotein p8; pfam10195
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Vitamin K epoxide reductase family; pfam07884
beta-D-glucuronidase; Provisional
Glycosyl hydrolases family 2, sugar binding domain; pfam02837
Glycosyl hydrolases family 2, TIM barrel domain; pfam02836
argininosuccinate lyase
Argininosuccinate lyase (argininosuccinase, ASAL); cd01359
argininosuccinate lyase
Argininosuccinate lyase (argininosuccinase, ASAL); cd01359
argininosuccinate lyase
Argininosuccinate lyase (argininosuccinase, ASAL); cd01359
argininosuccinate lyase
Argininosuccinate lyase (argininosuccinase, ASAL); cd01359
DNA-directed RNA-polymerase II subunit; smart00657
DNA-directed RNA-polymerase II subunit; smart00657
RNA polymerase Rpb4; cl00638
RNA polymerase Rpb4; cl00638
Sulfotransferase family; pfam13469
BTB/POZ domain; cl02518
BTB/POZ domain; cl02518
A20-like zinc finger; pfam01754
Vacuolar sorting protein 9 (VPS9) domain; pfam02204
Predicted exosome subunit [Translation, ribosomal structure and biogenesis]
Shwachman-Bodian-Diamond syndrome (SBDS) protein; pfam01172
SBDS protein C-terminal domain; pfam09377
Flavodoxin; pfam00258
tRNA-modifying enzyme; Provisional
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
Predicted glycosyltransferases [General function prediction only]
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
Ricin-type beta-trefoil lectin domain; pfam00652
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Fe-S oxidoreductases [Energy production and conversion]
Wyosine base formation; pfam08608
Flavodoxin; pfam00258
Radical SAM superfamily; pfam04055
Wyosine base formation; pfam08608
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
NOL1/NOP2/sun family; pfam01189
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
NOL1/NOP2/sun family; pfam01189
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; COG0144
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
NOL1/NOP2/sun family; pfam01189
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 9 (Fz9) receptor; cd07463
Frizzled/Smoothened family membrane region; pfam01534
ATP-utilising chromatin assembly and remodelling N-terminal; pfam10537
domain in different transcription and chromosome remodeling factors; smart00571
TolA protein; TIGR02794
PHD-finger; pfam00628
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two...; cd05505
BCL7, N-terminal conserver region; pfam04714
BCL7, N-terminal conserver region; pfam04714
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Modifier of rudimentary (Mod(r)) protein; pfam07200
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Methyltransferase involved in Williams-Beuren syndrome; pfam12589
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Methyltransferase involved in Williams-Beuren syndrome; pfam12589
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; cd00179
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; cd00193
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; cd00179
Helical region found in SNAREs; smart00397
acyl-CoA esterase; Provisional
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
acyl-CoA esterase; Provisional
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
acyl-CoA esterase; Provisional
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
PMP-22/EMP/MP20/Claudin family; cl15797
PMP-22/EMP/MP20/Claudin family; cl15797
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
The first LIM domain of LIMK1 (LIM domain Kinase 1); cd09462
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Kinases; cd00180
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The second LIM domain of LIMK1 (LIM domain Kinase 1); cd09464
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Kinases; cd00180
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
replication factor C subunit; Provisional
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Replication factor C C-terminal domain; pfam08542
replication factor C subunit; Provisional
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Replication factor C C-terminal domain; pfam08542
CAP-Gly domain; pfam01302
CAP-Gly domain; pfam01302
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
CAP-Gly domain; pfam01302
CAP-Gly domain; pfam01302
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase; cd06887
First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1; cd12021
Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1; cd12022
NADPH oxidase subunit p47Phox, C terminal domain; pfam08944
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
Family description; pfam13840
Family description; pfam13840
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
GTF2I-like repeat; pfam02946
GTF2I-like repeat; pfam02946
Family description; pfam13840
Family description; pfam13840
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
Cell cycle regulatory protein; pfam11357
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
Uncharacterized archaeal coiled-coil protein [Function unknown]
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
I/LWEQ domain; smart00307
I/LWEQ domain; pfam01608
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
Uncharacterized archaeal coiled-coil protein [Function unknown]
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
I/LWEQ domain; smart00307
I/LWEQ domain; pfam01608
Chemokine_CC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g; cd00272
Chemokine_CC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g; cd00272
Rhomboid family; pfam01694
Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; COG0369
Flavodoxin; pfam00258
NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via...; cd06204
TMPIT-like protein; pfam07851
Rhodanese Homology Domain; smart00450
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
malate dehydrogenase, NAD-dependent; TIGR01772
Glyoxysomal and mitochondrial malate dehydrogenases; cd01337
cwf21 domain; pfam08312
Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally...; cd06475
Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; COG0071
14-3-3 gamma, an isoform of 14-3-3 protein; cd10024
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Zona pellucida (ZP) domain; smart00241
Zona pellucida (ZP) domain; smart00241
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Domain found at the C-terminus of deltex-like; cd09633
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Domain found at the C-terminus of deltex-like; cd09633
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Domain found at the C-terminus of deltex-like; cd09633
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Domain found at the C-terminus of deltex-like; cd09633
Uroplakin IIIb, IIIa and II; cl06408
Uroplakin IIIb; cd09969
Zona pellucida-like domain; cl02523
chromosome segregation protein SMC, common bacterial type; TIGR02168
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Male germ-cell putative homeodomain transcription factor; pfam12129
Male germ-cell putative homeodomain transcription factor; pfam12129
Male germ-cell putative homeodomain transcription factor; pfam12129
Male germ-cell putative homeodomain transcription factor; pfam12129
Male germ-cell putative homeodomain transcription factor; pfam12129
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Guanylate kinase homologues; smart00072
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
G protein alpha subunit; smart00275
Alpha subunit of G proteins (guanine nucleotide binding); cd00066
G protein alpha subunit; smart00275
Alpha subunit of G proteins (guanine nucleotide binding); cd00066
G protein alpha subunit; smart00275
Alpha subunit of G proteins (guanine nucleotide binding); cd00066
CD36 family; pfam01130
CD36 family; pfam01130
CD36 family; pfam01130
CD36 family; pfam01130
CD36 family; pfam01130
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); cd11251
semaphorin domain; smart00630
domain found in Plexins, Semaphorins and Integrins; smart00423
Immunoglobulin (Ig)-like domain of class III semaphorin; cd05871
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; cd00129
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; cd00129
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; cd00129
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; cd00129
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; cd00129
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
VWA N-terminal; pfam08399
VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at...; cd01463
Cache domain; pfam02743
Neuronal voltage-dependent calcium channel alpha 2acd; pfam08473
Piccolo Zn-finger; pfam05715
Piccolo Zn-finger; pfam05715
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain; cl14603
Piccolo Zn-finger; pfam05715
Piccolo Zn-finger; pfam05715
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); cd11253
semaphorin domain; smart00630
domain found in Plexins, Semaphorins and Integrins; smart00423
Immunoglobulin (Ig)-like domain of class III semaphorin; cd05871
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); cd11253
semaphorin domain; smart00630
domain found in Plexins, Semaphorins and Integrins; smart00423
Immunoglobulin (Ig)-like domain of class III semaphorin; cd05871
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); cd11249
semaphorin domain; smart00630
domain found in Plexins, Semaphorins and Integrins; smart00423
Immunoglobulin (Ig)-like domain of class III semaphorin; cd05871
Immunoglobulin V-set domain; pfam07686
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); cd11252
semaphorin domain; smart00630
domain found in Plexins, Semaphorins and Integrins; smart00423
Immunoglobulin (Ig)-like domain of class III semaphorin; cd05871
Ligand binding domain of the group II metabotropic glutamate receptor; cd06375
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Nine Cysteines Domain of family 3 GPCR; pfam07562
GCC2 and GCC3; pfam07699
Nine Cysteines Domain of family 3 GPCR; pfam07562
GCC2 and GCC3; pfam07699
GCC2 and GCC3; pfam07699
Myb-like DNA-binding domain; pfam13921
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Myb-like DNA-binding domain; pfam13921
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Myb-like DNA-binding domain; pfam13921
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Protein of unknown function (DUF2678); pfam10856
Choline/Carnitine o-acyltransferase; pfam00755
Choline/Carnitine o-acyltransferase; pfam00755
Choline/Carnitine o-acyltransferase; pfam00755
ABC transporter transmembrane region; pfam00664
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; COG1122
ABC transporter transmembrane region; pfam00664
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; COG5265
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
multidrug resistance protein (mdr1); Provisional
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
multidrug resistance protein (mdr1); Provisional
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
RUN domain; pfam02759
RUN domain; pfam02759
RUN domain; pfam02759
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
DBF zinc finger; cl02684
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand domain pair; pfam13833
EF-hand domain; pfam13405
EF-hand domain pair; pfam13499
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Predicted dinucleotide-binding enzymes [General function prediction only]
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Ferric reductase like transmembrane component; pfam01794
Predicted dinucleotide-binding enzymes [General function prediction only]
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Ferric reductase like transmembrane component; pfam01794
Zinc-finger double-stranded RNA-binding; pfam12171
Predicted dinucleotide-binding enzymes [General function prediction only]
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Ferric reductase like transmembrane component; pfam01794
Predicted dinucleotide-binding enzymes [General function prediction only]
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Ferric reductase like transmembrane component; pfam01794
Predicted dinucleotide-binding enzymes [General function prediction only]
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Ferric reductase like transmembrane component; pfam01794
Predicted dinucleotide-binding enzymes [General function prediction only]
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Ferric reductase like transmembrane component; pfam01794
Predicted dinucleotide-binding enzymes [General function prediction only]
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Ferric reductase like transmembrane component; pfam01794
Predicted dinucleotide-binding enzymes [General function prediction only]
NADP oxidoreductase coenzyme F420-dependent; pfam03807
Ferric reductase like transmembrane component; pfam01794
GTPase CgtA; Reviewed; PRK12299
GTP1/OBG; pfam01018
Obg GTPase; cd01898
Obg GTPase; cd01898
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; cd07869
cyclin-dependent kinase A; Provisional
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor; cd07465
Frizzled/Smoothened family membrane region; pfam01534
mTERF; pfam02536
Pericentrin-AKAP-450 domain of centrosomal targeting protein; pfam10495
Pericentrin-AKAP-450 domain of centrosomal targeting protein; pfam10495
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Zinc finger, C3HC4 type (RING finger); pfam13923
Ring finger domain; pfam13639
IBR domain; pfam01485
In Between Ring fingers; smart00647
In Between Ring fingers; smart00647
IBR domain; pfam01485
Peroxisome biogenesis factor 1, N-terminal; pfam09263
Peroxisome biogenesis factor 1, N-terminal; pfam09262
ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; COG0464
ATPase family associated with various cellular activities (AAA); pfam00004
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases associated with a variety of cellular activities; smart00382
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); pfam13893
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; cd07862
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; cd07862
Sterile alpha motif; smart00454
SAM domain of Samd9/Samd9L subfamily; cd09528
Sterile alpha motif; smart00454
SAM domain of Samd9/Samd9L subfamily; cd09528
SAM domain of Samd9/Samd9L subfamily; cd09528
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cd00096
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cd00096
Protein of unknown function N-terminal domain (DUF2450); pfam10475
Protein of unknown function C-terminus (DUF2451); pfam10474
Protein of unknown function N-terminal domain (DUF2450); pfam10475
Protein of unknown function N-terminal domain (DUF2450); pfam10475
Protein of unknown function C-terminus (DUF2451); pfam10474
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
Kunitz/Bovine pancreatic trypsin inhibitor domain; pfam00014
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
Kunitz/Bovine pancreatic trypsin inhibitor domain; pfam00014
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors; cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors; cd00068
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; cd00193
Collagen triple helix repeat (20 copies); pfam01391
Fibrillar collagens C-terminal domain; smart00038
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; pfam13839
10 TM Acyl Transferase domain found in Cas1p; pfam07779
Sarcoglycan alpha/epsilon; pfam05510
Sarcoglycan alpha/epsilon; pfam05510
Sarcoglycan alpha/epsilon; pfam05510
Putative binding domain; pfam13900
basic region leucin zipper; smart00338
Retrotransposon gag protein; pfam03732
Retropepsins; pepsin-like aspartate proteases; cd00303
Retrotransposon gag protein; pfam03732
basic region leucin zipper; smart00338
Retrotransposon gag protein; pfam03732
Retropepsins; pepsin-like aspartate proteases; cd00303
Retrotransposon gag protein; pfam03732
basic region leucin zipper; smart00338
Retrotransposon gag protein; pfam03732
Retropepsins; pepsin-like aspartate proteases; cd00303
Retrotransposon gag protein; pfam03732
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
SAM domain of SAM_Neurabin-like subfamily; cd09512
Sterile alpha motif; smart00454
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
SAM domain of SAM_Neurabin-like subfamily; cd09512
Sterile alpha motif; smart00454
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
SAM domain of SAM_Neurabin-like subfamily; cd09512
Sterile alpha motif; smart00454
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
SAM domain of SAM_Neurabin-like subfamily; cd09512
Sterile alpha motif; smart00454
Arylesterase; pfam01731
Strictosidine synthase; pfam03088
Arylesterase; pfam01731
Strictosidine synthase; pfam03088
Arylesterase; pfam01731
Arylesterase; pfam01731
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the...; cd03723
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; pfam10436
Signal transduction histidine kinase [Signal transduction mechanisms]; COG0642
Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; cd00075
Cytoplasmic dynein 1 intermediate chain 2; pfam11540
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Cytoplasmic dynein 1 intermediate chain 2; pfam11540
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Cytoplasmic dynein 1 intermediate chain 2; pfam11540
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand domain pair; pfam13499
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand domain pair; pfam13499
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Homeodomain-containing transcription factor [Transcription]
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeobox protein distal-less-like N terminal; pfam12413
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Complex1_LYR-like; pfam13233
asparagine synthetase B; Provisional; PRK09431
Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; cd00712
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; cd01991
asparagine synthetase B; Provisional; PRK09431
Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; cd00712
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; cd01991
asparagine synthetase B; Provisional; PRK09431
Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; cd00712
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; cd01991
Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; cd00712
asparagine synthetase B; Provisional; PRK09431
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; cd01991
Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; cl00319
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; cd01991
Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; cl00319
The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; cd01991
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; cd05086
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Dysferlin domain, N-terminal region; smart00693
Propeller; pfam06462
Propeller; pfam06462
Propeller; pfam06462
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; smart00706
Pleckstrin homology (PH) domain; cd00821
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; smart00706
Dysferlin domain, N-terminal region; smart00693
Dysferlin domain, C-terminal region; smart00694
Propeller; pfam06462
Propeller; pfam06462
Propeller; pfam06462
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; smart00706
Uncharacterized conserved protein (DUF2367); pfam10164
Uncharacterized conserved protein (DUF2367); pfam10164
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1; cd07645
IRSp53/MIM homology domain; pfam08397
Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS); cd11913
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; cd00152
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
FAT domain; pfam02259
TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain; The TRRAP catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; cd05163
FAT domain; pfam02259
TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain; The TRRAP catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; cd05163
C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins; cd08382
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins; cd08382
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins; cd08382
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; COG5064
Importin beta binding domain; pfam01749
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Casein kinase substrate phosphoprotein PP28; pfam10252
G10 protein; pfam01125
Mitochondrial F1F0-ATP synthase, subunit f; pfam10206
PPR repeat family; pfam13041
pentatricopeptide repeat domain (PPR motif); TIGR00756
PPR repeat family; pfam13041
PPR repeat family; pfam13041
pentatricopeptide repeat domain (PPR motif); TIGR00756
PPR repeat family; pfam13041
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]; COG5084
zinc finger; smart00356
Zinc finger C-x8-C-x5-C-x3-H type (and similar); cl11592
zinc finger; smart00356
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]; COG5084
zinc finger; smart00356
Zinc finger C-x8-C-x5-C-x3-H type (and similar); cl11592
Zinc finger C-x8-C-x5-C-x3-H type (and similar); cl11592
Mitochondrial F1F0-ATP synthase, subunit f; pfam10206
Mitochondrial F1F0-ATP synthase, subunit f; pfam10206
Mitochondrial F1F0-ATP synthase, subunit f; pfam10206
Mitochondrial F1F0-ATP synthase, subunit f; pfam10206
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
SCAN oligomerization domain; cd07936
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; cl02686
Domain in SPla and the RYanodine Receptor; smart00449
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; cl02686
Domain in SPla and the RYanodine Receptor; smart00449
Connexin; cl02435
Gap junction channel protein cysteine-rich domain; pfam10582
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6; cd08063
minichromosome maintenance proteins; smart00350
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
minichromosome maintenance proteins; smart00350
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Adaptor complexes medium subunit family; pfam00928
C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4; cd09253
TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd08050
TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd08050
TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd08050
TLR4 regulator and MIR-interacting MSAP; pfam11938
Metallo-beta-lactamase superfamily; smart00849
Galactose-3-O-sulfotransferase; pfam06990
Glypican; pfam01153
STAG domain; pfam08514
Immunoglobulin domain; cl11960
Family description; pfam13840
Cell cycle regulatory protein; pfam11357
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
CW-type Zinc Finger; pfam07496
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
CW-type Zinc Finger; pfam07496
The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids.  The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation.  Most PWWP-domain proteins...; cl02554
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
TSC-22/dip/bun family; pfam01166
Putative GTPase activating protein for Arf; cl02464
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
F-box-like; pfam12937
Regulator of chromosome condensation (RCC1) repeat; pfam00415
F-box-like; pfam12937
Regulator of chromosome condensation (RCC1) repeat; pfam00415
F-box-like; pfam12937
Regulator of chromosome condensation (RCC1) repeat; pfam00415
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which...; cd03576
MSP (Major sperm protein) domain; pfam00635
MSP (Major sperm protein) domain; pfam00635
MSP (Major sperm protein) domain; pfam00635
MSP (Major sperm protein) domain; pfam00635
Zinc peptidases M18, M20, M28, and M42; cl14876
PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28...; cd02128
Predicted aminopeptidases [General function prediction only]; COG2234
M28 Zn-peptidase Transferrin Receptor family; cd09848
Transferrin receptor-like dimerisation domain; pfam04253
PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28...; cd02128
Predicted aminopeptidases [General function prediction only]; COG2234
M28 Zn-peptidase Transferrin Receptor family; cd09848
Transferrin receptor-like dimerisation domain; pfam04253
Actin; pfam00022
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species; cd00072
Rpp20 subunit of nuclear RNase MRP and P; pfam12328
Erythropoietin/thrombopoietin; pfam00758
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Trypsin Inhibitor like cysteine rich domain; pfam01826
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
This domain contains 8 conserved cysteine residues; smart00832
Trypsin Inhibitor like cysteine rich domain; pfam01826
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
This domain contains 8 conserved cysteine residues; smart00832
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
C8 domain; pfam08742
Trypsin Inhibitor like cysteine rich domain; pfam01826
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
This domain contains 8 conserved cysteine residues; smart00832
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Trypsin Inhibitor like cysteine rich domain; pfam01826
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
This domain contains 8 conserved cysteine residues; smart00832
Trypsin Inhibitor like cysteine rich domain; pfam01826
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
This domain contains 8 conserved cysteine residues; smart00832
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
C8 domain; pfam08742
Trypsin Inhibitor like cysteine rich domain; pfam01826
TILa domain; pfam12714
von Willebrand factor type D domain; pfam00094
This domain contains 8 conserved cysteine residues; smart00832
TILa domain; pfam12714
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Ligand Binding Domain of Ephrin type-B Receptor 4; cd10474
GCC2 and GCC3; pfam07699
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; cd05065
Protein tyrosine kinase; pfam07714
SAM domain (Sterile alpha motif); pfam07647
SAM domain of EPH-B4 subfamily of tyrosine kinase receptors; cd09554
Amino acid permease; pfam00324
K-Cl cotransporter; TIGR00930
Amino acid permease; pfam00324
The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09350
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of Zyxin-like family; cd09357
Domain of unknown function (DUF3546); pfam12066
Arsenite-resistance protein 2; pfam04959
Domain of unknown function (DUF3546); pfam12066
Arsenite-resistance protein 2; pfam04959
Domain of unknown function (DUF3546); pfam12066
Arsenite-resistance protein 2; pfam04959
Domain of unknown function (DUF3546); pfam12066
Arsenite-resistance protein 2; pfam04959
Peptidase family C78; pfam07910
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cd00312
Carboxylesterase family; pfam00135
Acetylcholinesterase tetramerisation domain; pfam08674
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cd00312
Carboxylesterase family; pfam00135
peptide released upon proteolytic cleavage
SEA domain; pfam01390
SEA domain; pfam01390
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
Plasminogen activator inhibitor-1_like. Plasminogen activator inhibitor-1 (PAI-1) is the primary, fast-acting inhibitor of plasminogen activators. It is often bound to vitronectin, an abundant component of the extracellular matrix in many tissues; cd02051
SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; cl00137
Clathrin adaptor complex small chain; pfam01217
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; cd07987
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam03171
HIT zinc finger; pfam04438
PMP-22/EMP/MP20/Claudin family; cl15797
PMP-22/EMP/MP20/Claudin family; cl15797
Mitochondria Fission Protein Fis1, cytosolic domain; cd12212
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
GTPase SAR1 and related small G proteins [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
EMI domain; pfam07546
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
CASP C terminal; pfam08172
CASP C terminal; pfam08172
CASP C terminal; pfam08172
CASP C terminal; pfam08172
CASP C terminal; pfam08172
Tropomyosin; pfam00261
SH3 domain protein; TIGR04211
CUT domain; pfam02376
CUT domain; pfam02376
CUT domain; pfam02376
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Tropomyosin; pfam00261
SH3 domain protein; TIGR04211
CUT domain; pfam02376
CUT domain; pfam02376
CUT domain; pfam02376
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Phenylalanine zipper; pfam08916
Pleckstrin homology-like domain; cl00273
Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3); cd10411
Cell cycle regulatory protein; pfam11357
Cell cycle regulatory protein; pfam11357
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Protein of unknown function (DUF1168); pfam06658
Mediator of CRAC channel activity; pfam07856
Mediator of CRAC channel activity; pfam07856
Leucine-rich repeats, outliers; smart00370
Leucine rich repeat; pfam13855
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
RPB11 subunit of Eukaryotic RNA polymerase II; cd06926
Cell cycle regulatory protein; pfam11357
Cell cycle regulatory protein; pfam11357
RPB11 subunit of Eukaryotic RNA polymerase II; cd06926
C2 domain first repeat present in RasA1 and RasA4; cd04054
C2 domain second repeat present in RasA1 and RasA4; cd04025
Ras GTPase activating-like 4 protein (RASAL4), also known as Ca2+ -promoted Ras inactivator (CAPRI), is a member of the GAP1 family. Members of the GAP1 family are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a...; cd05395
BTK motif; pfam00779
C2 domain first repeat present in RasA1 and RasA4; cd04054
C2 domain second repeat present in RasA1 and RasA4; cd04025
Ras GTPase activating-like 4 protein (RASAL4), also known as Ca2+ -promoted Ras inactivator (CAPRI), is a member of the GAP1 family. Members of the GAP1 family are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a...; cd05395
RAS_GTPase activating protein (GAP)_CG9209 pleckstrin homology (PH) domain; cd01244
BTK motif; pfam00779
Uroplakin IIIb, IIIa and II; cl06408
Cell cycle regulatory protein; pfam11357
Cell cycle regulatory protein; pfam11357
RPB11 subunit of Eukaryotic RNA polymerase II; cd06926
Domain of unknown function (DUF4098); pfam13345
Domain of unknown function (DUF4098); pfam13345
Domain of unknown function (DUF4098); pfam13345
Domain of unknown function (DUF4098); pfam13345
Domain of unknown function (DUF4098); pfam13345
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Antagonist of mitotic exit network protein 1; cl15308
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Antagonist of mitotic exit network protein 1; cl15308
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat; pfam13855
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Armadillo-like; pfam04826
Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]
Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]
Predicted Zn-dependent peptidases [General function prediction only]; COG0612
Insulinase (Peptidase family M16); pfam00675
Peptidase M16 inactive domain; pfam05193
Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]; COG5269
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]; COG5269
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; COG1222
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; COG1222
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; cl15842
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; pfam00916
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; cd08544
Additional N-terminal subrepeat of reelin; cd10036
Tandem repeat subunit of reelin and related proteins; cl15240
Tandem repeat subunit of reelin and related proteins; cl15240
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; cd10037
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; cd10045
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; cd10038
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; cd10046
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; cd10039
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; cd10047
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; cd10040
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; cd10048
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; cd10041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; cd10049
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; cd10042
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; cd10050
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; cd10043
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; cd10051
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; cd10044
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; cd10052
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; cd08544
Additional N-terminal subrepeat of reelin; cd10036
Tandem repeat subunit of reelin and related proteins; cl15240
Tandem repeat subunit of reelin and related proteins; cl15240
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; cd10037
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; cd10045
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; cd10038
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; cd10046
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; cd10039
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; cd10047
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; cd10040
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; cd10048
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; cd10041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; cd10049
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; cd10042
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; cd10050
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; cd10043
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; cd10051
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; cd10044
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; cd10052
AAA ATPase domain; pfam13191
Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; COG1474
AAA ATPase domain; pfam13191
Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; COG1474
Lipoma HMGIC fusion partner-like protein; pfam10242
PHD-finger; pfam00628
Proteins containing SET domain [General function prediction only]
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
PHD-finger; pfam00628
Proteins containing SET domain [General function prediction only]
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); cl00130
Uncharacterized conserved protein [Function unknown]
Pseudouridine synthase, TruD family; cd02576
RINT-1 / TIP-1 family; pfam04437
SCA7, zinc-binding domain; pfam08313
SCA7, zinc-binding domain; pfam08313
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Membrane-associating domain; pfam01284
Membrane-associating domain; pfam01284
putative nicotinate phosphoribosyltransferase; Provisional
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; cd01569
PI3-kinase family, Ras-binding domain; smart00144
C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks); cd08399
Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872
Phosphoinositide 3-kinase (PI3K), class IB, gamma isoform, catalytic domain; The PI3K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; cd00894
Phosphoinositide 3-kinase, catalytic domain; smart00146
Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase; cd12104
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
domain in Ataxins and HMG containing proteins; smart00536
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
domain in Ataxins and HMG containing proteins; smart00536
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
Golgi transport complex subunit 5; pfam10392
Golgi transport complex subunit 5; pfam10392
Golgi transport complex subunit 5; pfam10392
Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; cd02801
tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; cd02801
tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
B-cell receptor-associated protein 31-like; pfam05529
B-cell receptor-associated protein 31-like; pfam05529
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
dihydrolipoamide dehydrogenase; Validated
NAD(P)-binding Rossmann-like domain; pfam13450
Pyridine nucleotide-disulphide oxidoreductase; pfam00070
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852
N-terminal domain
Laminin N-terminal (Domain VI); pfam00055
contains 5 EGF-like repeats
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
contains 8 EGF-like repeats
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cd07307
Plant protein of unknown function (DUF827); pfam05701
C-terminal domain
ATP synthase B/B' CF(0); cl07975
Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; cl09111
Laminin N-terminal (Domain VI); cl02806
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domai; smart00180
ATPase involved in DNA repair [DNA replication, recombination, and repair]; COG0419
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); cd05874
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); cd05731
Immunoglobulin I-set domain; pfam07679
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule); cd05868
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
C-terminal domain of Fibronectin type III; pfam13882
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); cd05874
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); cd05731
Immunoglobulin I-set domain; pfam07679
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule); cd05868
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
C-terminal domain of Fibronectin type III; pfam13882
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); cd05874
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); cd05731
Immunoglobulin I-set domain; pfam07679
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule); cd05868
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
C-terminal domain of Fibronectin type III; pfam13882
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); cd05874
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); cd05731
Immunoglobulin I-set domain; pfam07679
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule); cd05868
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
C-terminal domain of Fibronectin type III; pfam13882
Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); cd05874
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); cd05731
Immunoglobulin I-set domain; pfam07679
Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule); cd05868
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin; smart00409
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
C-terminal domain of Fibronectin type III; pfam13882
Patatin-like phospholipase domain containing protein 8; cd07211
Patatins and Phospholipases; cl11396
Patatin-like phospholipase domain containing protein 8; cd07211
Patatin-like phospholipase domain containing protein 8; cd07211
Patatin-like phospholipase domain containing protein 8; cd07211
Patatin-like phospholipase domain containing protein 8; cd07211
Patatin-like phospholipase domain containing protein 8; cd07211
THAP domain; pfam05485
THAP domain; pfam05485
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
signal peptidase I, bacterial type; TIGR02227
The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; cd06530
signal peptidase I, bacterial type; TIGR02227
The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; cd06530
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Src Homology 3 domain of Class B Dedicator of Cytokinesis 4; cd12049
C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins; cd08695
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4; cd11705
C2H2 type zinc-finger (2 copies); pfam12756
Zinc-finger double-stranded RNA-binding; pfam12171
C2H2 type zinc-finger (2 copies); pfam12756
Interferon-related developmental regulator (IFRD); pfam05004
Interferon-related protein conserved region; pfam04836
Interferon-related developmental regulator (IFRD); pfam05004
Interferon-related protein conserved region; pfam04836
Interferon-related developmental regulator (IFRD); pfam05004
Interferon-related protein conserved region; pfam04836
Interferon-related developmental regulator (IFRD); pfam05004
Interferon-related protein conserved region; pfam04836
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Putative phosphatase regulatory subunit; pfam03370
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Domain of unknown function (DUF3371); pfam11851
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Domain of unknown function (DUF3371); pfam11851
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Domain of unknown function (DUF3371); pfam11851
The PET domain of Testin; cd09829
The first LIM domain of Testin; cd09413
The second LIM domain of Testin; cd09416
The third LIM domain of Testin; cd09419
The PET domain of Testin; cd09829
The first LIM domain of Testin; cd09413
The second LIM domain of Testin; cd09416
The third LIM domain of Testin; cd09419
Caveolin; pfam01146
Caveolin; pfam01146
Caveolin; pfam01146
Caveolin; pfam01146
Caveolin; pfam01146
Caveolin; pfam01146
Caveolin; pfam01146
Caveolin; pfam01146
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); cd11278
semaphorin domain; smart00630
Plexin repeat; pfam01437
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01180
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01179
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; cl15674
ig-like, plexins, transcription factors; smart00429
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; cd05058
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); cd11278
semaphorin domain; smart00630
Plexin repeat; pfam01437
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01180
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01179
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01181
ig-like, plexins, transcription factors; smart00429
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; cd05058
F-actin capping protein alpha subunit; pfam01267
ST7 protein; pfam04184
Suppression of tumorigenicity 7; cd11557
ST7 protein; pfam04184
Suppression of tumorigenicity 7; cd11557
wnt family; pfam00110
found in Wnt-1; smart00097
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
SAM domain of ASZ1 subfamily; cd09521
SAM domain (Sterile alpha motif); pfam07647
cystic fibrosis transmembrane conductor regulator (CFTR); TIGR01271
ABC transporter transmembrane region; pfam00664
The CFTR subfamily domain 1.  The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical...; cd03291
Cystic fibrosis TM conductance regulator (CFTR), regulator domain; pfam14396
ABC transporter transmembrane region; pfam00664
The CFTR subfamily domain 2.  The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical...; cd03289
Cortactin-binding protein-2; pfam09727
Tropomyosin like; pfam12718
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Like-Sm protein 8; cd01727
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Shal-type voltage-gated potassium channels; pfam11601
K+ channel tetramerisation domain; pfam02214
Ion transport protein; pfam00520
Ion channel; pfam07885
Domain of unknown function (DUF3399); pfam11879
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03157
Inhibitor of growth proteins N-terminal histone-binding; pfam12998
PHD-finger; pfam00628
Inhibitor of growth proteins N-terminal histone-binding; pfam12998
Cadherin-like beta sandwich domain; pfam12733
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; pfam13839
Cadherin-like beta sandwich domain; pfam12733
wnt family; pfam00110
found in Wnt-1; smart00097
wnt family; pfam00110
found in Wnt-1; smart00097
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon...; cd03122
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon...; cd03122
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon...; cd03122
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Alanine dehydrogenase/PNT, N-terminal domain; pfam05222
Alanine dehydrogenase/PNT, C-terminal domain; pfam01262
Alanine dehydrogenase/PNT, C-terminal domain; smart01002
Saccharopine dehydrogenase; pfam03435
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Protein kinase C conserved region 2 (CalB); smart00239
Pleckstrin homology-like domain; cl00273
Domain of Unknown Function (DUF1041); pfam06292
Protein kinase C conserved region 2 (CalB); smart00239
Pleckstrin homology-like domain; cl00273
Domain of Unknown Function (DUF1041); pfam06292
Protein kinase C conserved region 2 (CalB); smart00239
Pleckstrin homology-like domain; cl00273
Domain of Unknown Function (DUF1041); pfam06292
PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...; cd02122
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...; cd02122
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Mammalian taste receptor protein (TAS2R); pfam05296
Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; COG0471
Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; cl15356
Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; cl15356
Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; COG0471
Ubiquitin-like domain of UBL; cd01769
ETC complex I subunit conserved region; pfam04716
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of...; cd03731
Tropomodulin; pfam03250
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
WASP-type EVH1 domain; cd01205
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; cd00132
Wiskott Aldrich syndrome homology region 2; smart00246
Hyaluronidase; pfam01630
Hyaluronidase; pfam01630
Hyaluronidase; pfam01630
Hyaluronidase; pfam01630
Hyaluronidase; pfam01630
Hyaluronidase; pfam01630
7 transmembrane receptor (rhodopsin family); pfam00001
hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal...; cd04497
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats...; cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats...; cd04498
Ligand-binding domain of the group III metabotropic glutamate receptor; cd06376
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Ligand-binding domain of the group III metabotropic glutamate receptor; cd06376
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
C2H2-type zinc finger; pfam13912
GRIP domain; pfam01465
GTPase SAR1 and related small G proteins [General function prediction only]
ADP-ribosylation factor-1 (Arf1) and ADP-ribosylation factor-5 (Arf5); cd04150
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; cd00257
Helix-turn-helix domains; cl00088
Paired Box domain; smart00351
Homeodomain-containing transcription factor [Transcription]
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Staphylococcal nuclease homologues; smart00318
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; cd00175
Staphylococcal nuclease homologues; smart00318
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; cd00175
Staphylococcal nuclease homologues; smart00318
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; cd00175
Staphylococcal nuclease homologues; smart00318
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; cd00175
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; cl00140
Leucine rich repeat N-terminal domain; smart00013
Leucine-rich repeat (LRR) protein [Function unknown]
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin like; smart00410
Leptin; pfam02024
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
inosine-5'-monophosphate dehydrogenase; Provisional
TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; cl09108
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; cd04602
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
Methyltransferase domain; pfam13847
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Protein of unknown function (DUF3699); pfam12480
Protein of unknown function (DUF3699); pfam12480
Protein of unknown function (DUF3699); pfam12480
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
7 transmembrane receptor (rhodopsin family); pfam00001
chromosome segregation protein SMC, common bacterial type; TIGR02168
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
Filamin-type immunoglobulin domains; smart00557
vacuolar ATP synthase F subunit; TIGR01101
vacuolar ATP synthase F subunit; TIGR01101
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor (vWF) type D domain; smart00216
This domain contains 8 conserved cysteine residues; smart00832
Trypsin Inhibitor like cysteine rich domain; pfam01826
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
Importin-beta N-terminal domain; smart00913
Exportin 1-like protein; pfam08389
Importin-beta N-terminal domain; smart00913
Exportin 1-like protein; pfam08389
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03158
Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein; cd07451
Frizzled/Smoothened family membrane region; pfam01534
7 transmembrane receptor (Secretin family); cl12142
S-adenosyl-L-homocysteine hydrolase; Provisional
S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; cd00401
S-adenosyl-L-homocysteine hydrolase; Provisional
S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; cd00401
S-adenosyl-L-homocysteine hydrolase; Provisional
S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; cd00401
S-adenosyl-L-homocysteine hydrolase; Provisional
S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; cd00401
N1221-like protein; pfam07923
Domain of unknown function (DUF3402); pfam11882
N1221-like protein; pfam07923
Domain of unknown function (DUF3402); pfam11882
NLS-binding and DNA-binding and dimerisation domains of Nrf1; pfam10491
Nrf1 activator activation site binding domain; pfam10492
NLS-binding and DNA-binding and dimerisation domains of Nrf1; pfam10491
Nrf1 activator activation site binding domain; pfam10492
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cl00154
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cl00154
C3HC zinc finger-like; pfam07967
Rsm1-like; pfam08600
Galactose oxidase, central domain; pfam13418
Galactose oxidase, central domain; pfam13418
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam01344
Cytochrome B561, N terminal; pfam09786
Carboxypeptidase activation peptide; pfam02244
Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup; cd03870
Carboxypeptidase activation peptide; pfam02244
Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup; cd03870
Predicted carboxypeptidase [Amino acid transport and metabolism]
Carboxypeptidase activation peptide; pfam02244
M14 family of metallocarboxypeptidases and related proteins; cl11393
Carboxypeptidase activation peptide; pfam02244
M14 family of metallocarboxypeptidases and related proteins; cl11393
Carboxypeptidase activation peptide; pfam02244
M14 family of metallocarboxypeptidases and related proteins; cl11393
Carboxypeptidase activation peptide; pfam02244
M14 family of metallocarboxypeptidases and related proteins; cl11393
Carboxypeptidase activation peptide; pfam02244
Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup; cd03870
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; cd00158
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12697
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12697
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12697
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12697
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12697
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12697
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]; COG5240
Coatomer gamma subunit appendage domain; pfam08752
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Muskelin N-terminus; pfam06588
F5/8 type C domain; pfam00754
Galactose oxidase, central domain; pfam13415
Muskelin N-terminus; pfam06588
F5/8 type C domain; pfam00754
Galactose oxidase, central domain; pfam13415
CD34/Podocalyxin family; pfam06365
CD34/Podocalyxin family; pfam06365
The Sema domain, a protein interacting module, of Plexin A4; cd11274
semaphorin domain; smart00630
Plexin repeat; pfam01437
Plexin repeat; pfam01437
Plexin repeat; pfam01437
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01180
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01179
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present...; cd01181
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
Plexin cytoplasmic RasGAP domain; pfam08337
The Sema domain, a protein interacting module, of semaphorins and plexins; cl15693
semaphorin domain; smart00630
The Sema domain, a protein interacting module, of semaphorins and plexins; cl15693
semaphorin domain; smart00630
Protein of unknown function (DUF737); pfam05300
CHCH domain; pfam06747
Sec8 exocyst complex component specific domain; pfam04048
Sec8 exocyst complex component specific domain; pfam04048
Leucine Rich repeats (2 copies); pfam12799
Leucine Rich repeats (2 copies); pfam12799
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine Rich repeats (2 copies); pfam12799
Leucine Rich repeats (2 copies); pfam12799
Guanylate kinase [Nucleotide transport and metabolism]; COG0194
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
UAA transporter family; pfam08449
EamA-like transporter family; cl01037
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; cd06660
Aldo/keto reductase family; pfam00248
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; cd06660
Aldo/keto reductase family; pfam00248
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; cd06660
Aldo/keto reductase family; pfam00248
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07067
Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07040
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07067
Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07040
Caldesmon; pfam02029
Caldesmon; pfam02029
Caldesmon; pfam02029
Caldesmon; pfam02029
Caldesmon; pfam02029
Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins; cd06907
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Protein of unknown function (DUF3414); pfam11894
Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; COG0471
Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; cl15356
Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; cl15356
Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; COG0471
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
7 transmembrane receptor (rhodopsin family); pfam00001
Signal recognition particle, alpha subunit, N-terminal; pfam04086
Pleiotrophin / midkine family; smart00193
Phorbol esters/diacylglycerol binding domain (C1 domain); pfam00130
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; COG1597
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain (presumed); smart00045
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
basic region leucin zipper; smart00338
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; cd06660
Aldo/keto reductase family; pfam00248
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; cd06660
Aldo/keto reductase family; pfam00248
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; cd06660
Aldo/keto reductase family; pfam00248
Ring finger; smart00184
B-Box-type zinc finger; smart00336
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
PHD-finger; pfam00628
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or...; cd05502
Ring finger; smart00184
B-Box-type zinc finger; smart00336
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
PHD-finger; pfam00628
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or...; cd05502
benzoate transport; TIGR00895
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
V-type ATPase 116kDa subunit family; pfam01496
V-type ATPase 116kDa subunit family; pfam01496
V-type ATPase 116kDa subunit family; pfam01496
Domain of unknown function (DUF3827); pfam12877
Domain of unknown function (DUF3827); pfam12877
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component...; cd01439
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
Hpc2-related domain; pfam08729
Ubinuclein conserved middle domain; pfam14075
Complex1_LYR-like; pfam13233
LUC7 N_terminus; pfam03194
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]; COG5200
Complex1_LYR-like; pfam13233
LUC7 N_terminus; pfam03194
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]; COG5200
LUC7 N_terminus; pfam03194
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]; COG5200
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]; COG5200
LUC7 N_terminus; pfam03194
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; cl02432
C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs); cd03593
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; cl12078
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
zinc finger; smart00356
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component...; cd01439
PHD zinc finger; smart00249
A domain family that is part of the cupin metalloenzyme superfamily; smart00558
JmjC domain, hydroxylase; cl15814
Sugar phosphate permease [Carbohydrate transport and metabolism]; COG2271
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Sugar phosphate permease [Carbohydrate transport and metabolism]; COG2271
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Rab GTPase; Provisional
Rab GTPase family 19 (Rab19); cd01864
zinc finger; smart00356
zinc finger; smart00356
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
zinc finger; smart00356
zinc finger; smart00356
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
Domain always found upstream of DENN domain, found in a variety of signalling proteins; smart00800
DENN (AEX-3) domain; pfam02141
dDENN domain; pfam03455
Predicted unusual protein kinase [General function prediction only]; COG0661
Protein Kinases, catalytic domain; cl09925
Predicted unusual protein kinase [General function prediction only]; COG0661
Protein Kinases, catalytic domain; cl09925
Ubiquitin domain of  Raf serine/threonine kinases; cd01816
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase domain; pfam00069
Protein Kinases, catalytic domain; cl09925
Mitochondrial ribosomal subunit S27; pfam08293
Mitochondrial ribosomal subunit S27; pfam08293
PMP-22/EMP/MP20/Claudin tight junction; pfam13903
Diacylglycerol kinase catalytic domain; pfam00781
Uncharacterized conserved protein (DUF2347); pfam09804
Docking domain of Afi1 for Arf3 in vesicle trafficking; pfam07792
Stabilisation of polarity axis; pfam08616
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; COG0629
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; cd04496
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; COG0629
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; cd04496
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; COG0629
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; cd04496
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; COG0629
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; cd04496
Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; COG0629
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; cd04496
Mammalian taste receptor protein (TAS2R); pfam05296
Mammalian taste receptor protein (TAS2R); pfam05296
Mammalian taste receptor protein (TAS2R); pfam05296
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs); cd03593
Vomeronasal organ pheromone receptor family, V1R; cl12106
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a...; cd00111
Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]
This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two...; cd06602
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a...; cd00111
Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]
This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two...; cd06602
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Ligand Binding Domain of Ephrin type-B Receptor 6; cd10475
GCC2 and GCC3; pfam07699
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cl00065
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein Kinases, catalytic domain; cl09925
Protein tyrosine kinase; pfam07714
SAM domain of EPH-B6 subfamily of tyrosine kinase receptors; cd09555
SAM domain (Sterile alpha motif); pfam07647
transient-receptor-potential calcium channel protein; TIGR00870
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
transient-receptor-potential calcium channel protein; TIGR00870
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; COG3590
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; cd08662
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Seminal vesicle autoantigen (SVA); pfam05326
Vomeronasal organ pheromone receptor family, V1R; cl12106
Vomeronasal organ pheromone receptor family, V1R; cl12106
DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and...; cd03021
DSBA-like thioredoxin domain; pfam01323
DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and...; cd03021
DSBA-like thioredoxin domain; pfam01323
DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and...; cd03021
DSBA-like thioredoxin domain; pfam01323
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; cl00388
DSBA-like thioredoxin domain; pfam01323
Caspase activation and recruitment domain of Caspase-2; cd08332
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cd00032
The Death Domain Superfamily of protein-protein interaction domains; cl14633
Caspase activation and recruitment domain of Caspase-2; cd08332
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cl00042
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...; cd03683
Voltage gated chloride channel; pfam00654
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cl15354
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
The first LIM domain of Zyxin; cd09349
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of Zyxin; cd09435
The first LIM domain of Zyxin; cd09349
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of Zyxin; cd09435
Ligand Binding Domain of Ephrin type-A Receptor 1; cd10479
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; cd05033
Protein tyrosine kinase; pfam07714
Sterile alpha motif; smart00454
SAM domain of EPH-A1 subfamily of tyrosine kinase receptors; cd09542
Vomeronasal organ pheromone receptor family, V1R; cl12106
Mammalian taste receptor protein (TAS2R); pfam05296
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Peptidase M60-like family; pfam13402
Peptidase M60-like family; pfam13402
Putative binding domain; pfam13900
Peptidase M60-like family; pfam13402
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Peptidase M60-like family; pfam13402
Peptidase M60-like family; pfam13402
Peptidase M60-like family; pfam13402
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Ephexin Pleckstrin homology (PH) domain; cd01221
Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19; cd11940
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Herpesvirus transcription activation factor (transactivator); pfam03326
Thiamine pyrophosphokinase; cd07995
thiamin pyrophosphokinase
Thiamine pyrophosphokinase; cd07995
thiamin pyrophosphokinase
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Fibrillar collagen C-terminal domain; cl02436
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
putative band 4.1 homologues' binding motif; smart00294
Cullin family; pfam00888
Cullin; smart00182
Cullin protein neddylation domain; pfam10557
WD repeat binding protein EZH2; pfam11616
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
WD repeat binding protein EZH2; pfam11616
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
WD repeat binding protein EZH2; pfam11616
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
WD repeat binding protein EZH2; pfam11616
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
WD repeat binding protein EZH2; pfam11616
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; cd02961
protein disulfide isomerases, eukaryotic; TIGR01130
Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; cd02961
PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b; ERp72 exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting as...; cd03068
PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of...; cd03073
PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein...; cd02995
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc finger, C2H2 type; cl15478
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger protein; pfam12417
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
von Willebrand factor (vWF) type D domain; smart00216
C8 domain; pfam08742
Trypsin Inhibitor like cysteine rich domain; pfam01826
von Willebrand factor (vWF) type D domain; smart00216
This domain contains 8 conserved cysteine residues; smart00832
Trypsin Inhibitor like cysteine rich domain; pfam01826
von Willebrand factor (vWF) type D domain; smart00216
C8 domain; pfam08742
Trypsin Inhibitor like cysteine rich domain; pfam01826
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cl00104
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
von Willebrand factor type C domain; cl02515
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
Trypsin Inhibitor like cysteine rich domain; pfam01826
Thrombospondin type 1 repeats; smart00209
von Willebrand factor type C domain; cl02515
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
zinc finger in transposases and transcription factors; smart00597
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
zinc finger in transposases and transcription factors; smart00597
hAT family dimerisation domain; pfam05699
ATP synthase subunit H; pfam05493
ATP synthase subunit H; pfam05493
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AIG1 family; pfam04548
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
AvrRpt2-Induced Gene 1 (AIG1); cd01852
CD20-like family; pfam04103
CD20-like family; pfam04103
CD20-like family; pfam04103
CD20-like family; pfam04103
CD20-like family; pfam04103
Copper amine oxidase, N2 domain; pfam02727
Copper amine oxidase, N3 domain; pfam02728
Copper amine oxidase, enzyme domain; pfam01179
PAS domain; pfam13426
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
Ion transport protein; pfam00520
Ion channel; pfam07885
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Ion transport protein; pfam00520
Ion channel; pfam07885
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
PAS domain; pfam13426
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
Ion transport protein; pfam00520
Ion channel; pfam07885
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Ion transport protein; pfam00520
Ion channel; pfam07885
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; cd00795
Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; COG0369
Flavodoxin; pfam00258
Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; cl06868
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; cd00795
Flavodoxin; pfam00258
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; cd00795
Flavodoxin; pfam00258
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; cd00795
Flavodoxin; pfam00258
Autophagy protein Apg9; pfam04109
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
ABC transporter transmembrane region; pfam00664
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; cd03249
Amiloride-sensitive sodium channel; pfam00858
Amiloride-sensitive sodium channel; pfam00858
Amiloride-sensitive sodium channel; pfam00858
cyclin-dependent kinase A; Provisional
Protein Kinases, catalytic domain; cl09925
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; cd07839
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
Ubiquitin homologues; smart00213
Ubiquitin-like domain of UBL; cd01769
Ubiquitin homologues; smart00213
Ubiquitin-like domain of UBL; cd01769
GTPase SAR1 and related small G proteins [General function prediction only]
Centaurin gamma (CENTG) GTPase; cd04103
Centaurin Pleckstrin homology (PH) domain; cd01250
Putative GTPase activating protein for Arf; pfam01412
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
GTPase SAR1 and related small G proteins [General function prediction only]
Centaurin gamma (CENTG) GTPase; cd04103
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ABC transporter; pfam12848
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ABC transporter; pfam12848
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
Galactosyltransferase; cl09537
Chondroitin N-acetylgalactosaminyltransferase; pfam05679
SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]
SWI complex, BAF60b domains; smart00151
SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]
SWI complex, BAF60b domains; smart00151
SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]
SWI complex, BAF60b domains; smart00151
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cl00153
Ubiquitin associated domain; smart00165
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin associated domain; smart00165
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
WD40 repeats; smart00320
Beta/Gamma crystallin; pfam00030
Beta/Gamma crystallin; cl02528
Ras Homolog Enriched in Brain (RheB) is a small GTPase; cd04137
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cd04618
FOG: CBS domain [General function prediction only]
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cd04641
FOG: CBS domain [General function prediction only]
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cd04618
FOG: CBS domain [General function prediction only]
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cd04641
FOG: CBS domain [General function prediction only]
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cd04618
FOG: CBS domain [General function prediction only]
The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; cd04641
FOG: CBS domain [General function prediction only]
Predicted glycosyltransferases [General function prediction only]
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
Predicted glycosyltransferases [General function prediction only]
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
Ricin-type beta-trefoil lectin domain; pfam00652
PHD-like zinc-binding domain; pfam13771
PHD-finger; pfam00628
PHD-finger; pfam00628
PHD-finger; pfam00628
PHD-finger; pfam00628
PHD-finger; pfam00628
PHD-finger; pfam00628
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
PHD-like zinc-binding domain; pfam13771
PHD zinc finger; smart00249
F/Y-rich N-terminus; pfam05964
F/Y rich C-terminus; pfam05965
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
Cysteine-rich motif following a subset of SET domains; smart00508
RecA/RadA recombinase [DNA replication, recombination, and repair]; COG0468
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Actin-related protein 3; Provisional
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Dipeptidyl peptidase IV (DPP IV) N-terminal region; pfam00930
Prolyl oligopeptidase family; pfam00326
Dipeptidyl peptidase IV (DPP IV) N-terminal region; pfam00930
Prolyl oligopeptidase family; pfam00326
Dipeptidyl peptidase IV (DPP IV) N-terminal region; pfam00930
Prolyl oligopeptidase family; pfam00326
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
7 transmembrane receptor (rhodopsin family); pfam00001
Insulin-induced protein (INSIG); pfam07281
Insulin-induced protein (INSIG); pfam07281
Insulin-induced protein (INSIG); pfam07281
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Engrailed homeobox C-terminal signature domain; pfam10525
TLR4 regulator and MIR-interacting MSAP; pfam11938
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Hedgehog amino-terminal signalling domain; pfam01085
Hint module; pfam01079
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; cd00081
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
IQ calmodulin-binding motif; cl15479
Ring finger domain; pfam13639
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
IQ calmodulin-binding motif; cl15479
Ring finger domain; pfam13639
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
IQ calmodulin-binding motif; cl15479
Ring finger domain; pfam13639
LMBR1-like membrane protein; pfam04791
MIF4G domain; pfam02854
Domain in DAP-5, eIF4G, MA-3 and other proteins; smart00544
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Protein-tyrosine phosphatase receptor IA-2; pfam11548
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein-tyrosine phosphatase receptor IA-2; pfam11548
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein-tyrosine phosphatase receptor IA-2; pfam11548
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Condensin II non structural maintenance of chromosomes subunit; pfam12422
Condensin II non structural maintenance of chromosomes subunit; pfam12422
C2 domain first and third repeat in Synaptotagmin-like proteins; cd08391
C2 domain second repeat present in Synaptotagmin-like proteins; cd04050
C2 domain third repeat present in uncharacterized human KIAA1228-like proteins; cd04030
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Domain present in hormone receptors; smart00008
7 transmembrane receptor (Secretin family); pfam00002
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
DNA polymerase phi; pfam04931
Guanylate-kinase-associated protein (GKAP) protein; pfam03359
TRAM, LAG1 and CLN8 homology domains; smart00724
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
BTB/POZ domain; pfam00651
Kelch domain; smart00612
Kelch motif; pfam01344
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin; smart00409
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
C-terminal immunoglobulin (Ig)-like domain of M-protein (also known as myomesin-2); cd05891
Immunoglobulin I-set domain; pfam07679
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Microcephalin protein; pfam12258
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Microcephalin protein; pfam12258
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
Microcephalin protein; pfam12258
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; cd07990
XK-related protein; pfam09815
Beta defensin; pfam00711
Defensin propeptide; pfam00879
Mammalian defensin; pfam00323
Defensin propeptide; pfam00879
Mammalian defensin; pfam00323
Defensin propeptide; pfam00879
Mammalian defensin; pfam00323
Defensin propeptide; pfam00879
Mammalian defensin; pfam00323
Defensin propeptide; pfam00879
Mammalian defensin; pfam00323
Defensin propeptide; pfam00879
Mammalian defensin; pfam00323
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Beta defensin; pfam00711
Beta defensin; pfam00711
Sperm antigen HE2; pfam05324
Sperm antigen HE2; pfam05324
Sperm antigen HE2; pfam05324
Beta defensin; pfam00711
Beta defensin; pfam00711
Sperm antigen HE2; pfam05324
Sperm antigen HE2; pfam05324
Beta defensin; pfam00711
Beta defensin; pfam13841
Beta defensin; pfam13841
Beta defensin; pfam13841
Beta defensin; pfam13841
Beta defensin; pfam13841
Beta defensin; pfam13841
Sperm antigen HE2; pfam05324
Beta defensin; pfam00711
Beta defensin; pfam00711
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
Protein Kinases, catalytic domain; cl09925
Protein Kinases, catalytic domain; cl09925
PMP-22/EMP/MP20/Claudin family; cl15797
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; cd06133
Putative phosphatase regulatory subunit; pfam03370
Putative phosphatase regulatory subunit; pfam03370
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
SAM domain of tankyrase1,2 subfamily; cd09524
SAM domain (Sterile alpha motif); pfam07647
Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin...; cd01438
methionine sulfoxide reductase A; Provisional
Peptide methionine sulfoxide reductase; cl00366
methionine sulfoxide reductase A; Provisional
methionine sulfoxide reductase A; Provisional
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
Sox C-terminal transactivation domain; pfam12067
glycine rich nucleic binding domain; smart00443
Myotubularin-related; pfam06602
Myotubularin Y_phosphatase-like; pfam13849
Protein of unknown function (DUF3259); pfam11652
Src homology 3 domain of Blk Protein Tyrosine Kinase; cd12009
Src homology 2 (SH2) domain found in B lymphoid kinase (Blk); cd10371
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; cd05067
Protein tyrosine kinase; pfam07714
GATA-type transcription activator, N-terminal; pfam05349
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C; cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C; cd00202
N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; cl03119
Formamidopyrimidine-DNA glycosylase H2TH domain; pfam06831
N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2); cd08968
Formamidopyrimidine-DNA glycosylase H2TH domain; pfam06831
N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2); cd08968
Formamidopyrimidine-DNA glycosylase H2TH domain; pfam06831
N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2); cd08968
Formamidopyrimidine-DNA glycosylase H2TH domain; pfam06831
Trans-Isoprenyl Diphosphate Synthases, head-to-head; cd00683
Peptidase family C1 propeptide; pfam08127
Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620
Peptidase family C1 propeptide; pfam08127
Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620
Peptidase family C1 propeptide; pfam08127
Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620
Peptidase family C1 propeptide; pfam08127
Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620
Peptidase family C1 propeptide; pfam08127
Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620
Beta defensin; pfam13841
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
ATP-dependent protease La (LON) domain; pfam02190
Methyltransferase domain; pfam13489
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
SAM domain (Sterile alpha motif); pfam07647
SAM domain of DLC1 subfamily; cd09591
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a...; cd04375
GTPase-activator protein for Rho-like GTPases; smart00324
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; cd08908
SAM domain (Sterile alpha motif); pfam07647
SAM domain of DLC1 subfamily; cd09591
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a...; cd04375
GTPase-activator protein for Rho-like GTPases; smart00324
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; cd08908
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a...; cd04375
GTPase-activator protein for Rho-like GTPases; smart00324
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; cd08908
Sarcoglycan complex subunit protein; pfam04790
TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; cd02947
OST3 / OST6 family; pfam04756
Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; cd02961
OST3 / OST6 family; pfam04756
Macrophage scavenger receptor; pfam03523
Collagen triple helix repeat (20 copies); pfam01391
Scavenger receptor cysteine-rich domain; pfam00530
Macrophage scavenger receptor; pfam03523
Tho complex subunit 7; pfam05615
Collagen triple helix repeat (20 copies); pfam01391
Scavenger receptor Cys-rich; smart00202
Macrophage scavenger receptor; pfam03523
Collagen triple helix repeat (20 copies); pfam01391
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
EF-hand domain pair; pfam13833
centrin; Provisional
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13833
Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
DHHC palmitoyltransferase; pfam01529
CAF1 family ribonuclease; pfam04857
CAF1 family ribonuclease; pfam04857
Modifier of rudimentary (Mod(r)) protein; pfam07200
Modifier of rudimentary (Mod(r)) protein; pfam07200
Myotubularin-related; pfam06602
Myotubularin Y_phosphatase-like; pfam13849
cationic amino acid transport permease; TIGR00906
Spore germination protein; cl15802
Spore germination protein; cl15802
C-terminus of AA_permease; pfam13906
cationic amino acid transport permease; TIGR00906
Spore germination protein; cl15802
Spore germination protein; cl15802
C-terminus of AA_permease; pfam13906
cationic amino acid transport permease; TIGR00906
Spore germination protein; cl15802
Spore germination protein; cl15802
C-terminus of AA_permease; pfam13906
Immunoglobulin like; smart00410
Immunoglobulin domain; cl11960
Myosin-like coiled-coil protein; pfam09728
Snf7; cl02305
Myosin-like coiled-coil protein; pfam09728
Snf7; cl02305
Snf7; cl02305
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...; cd01903
Linear amide C-N hydrolases, choloylglycine hydrolase family; pfam02275
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...; cd01903
Linear amide C-N hydrolases, choloylglycine hydrolase family; pfam02275
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...; cd01903
Linear amide C-N hydrolases, choloylglycine hydrolase family; pfam02275
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
N-acetyltransferase; pfam00797
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Pleckstrin homology-like domain; cl00273
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Pleckstrin homology-like domain; cl00273
Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A); cd10350
Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A); cd10350
Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A); cd10350
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394
lipoprotein lipase; TIGR03230
Pancreatic lipase-like enzymes.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the...; cd00707
PLAT/ LH2 domain present in lipoprotein lipase (LPL).  LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the...; cd01758
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
V-type (H+)-ATPase V1, B subunit; TIGR01040
ATP synthase alpha/beta family, beta-barrel domain; pfam02874
V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; cd01135
ATP synthase alpha/beta chain, C terminal domain; pfam00306
Fez1; pfam06818
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
Pleckstrin homology domain; smart00233
Downstream of tyrosine kinase  (DOK) Phosphotyrosine-binding domain; cd01203
Importin-beta N-terminal domain; smart00913
Nucleoplasmin; pfam03066
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Villin headpiece domain; pfam02209
Villin headpiece domain; pfam02209
Villin headpiece domain; pfam02209
Villin headpiece domain; pfam02209
Villin headpiece domain; pfam02209
Villin headpiece domain; pfam02209
Retinoic acid induced 16-like protein; pfam10257
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; cd04671
JmjC domain, hydroxylase; cl15814
TB2/DP1, HVA22 family; pfam03134
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat C-terminal domain; smart00082
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
Pulmonary surfactant proteins; smart00019
Surfactant protein C, N terminal propeptide; pfam08999
BRICHOS domain; pfam04089
Pulmonary surfactant proteins; smart00019
Surfactant protein C, N terminal propeptide; pfam08999
BRICHOS domain; pfam04089
Pulmonary surfactant proteins; smart00019
Surfactant protein C, N terminal propeptide; pfam08999
BRICHOS domain; pfam04089
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins; cd04281
Astacin (Peptidase family M12A); pfam01400
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain; smart00179
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins; cd04281
Astacin (Peptidase family M12A); pfam01400
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
RNA polymerase III RPC4; pfam05132
PAZ domain,  Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; cd02845
Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of...; cd04658
PAZ domain,  Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; cd02845
Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of...; cd04658
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
Putative binding domain; pfam13900
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
PP2B, metallophosphatase domain; cd07416
Protein phosphatase 2A homologues, catalytic domain; smart00156
PP2B, metallophosphatase domain; cd07416
Protein phosphatase 2A homologues, catalytic domain; smart00156
PP2B, metallophosphatase domain; cd07416
Protein phosphatase 2A homologues, catalytic domain; smart00156
Sorbin homologous domain; smart00459
First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3); cd11921
Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3); cd11924
Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3); cd11918
First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3); cd11921
Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3); cd11924
Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3); cd11918
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The LIM domain of Mystique, a subfamily of ALP LIM domain proteins; cd09449
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The LIM domain of Mystique, a subfamily of ALP LIM domain proteins; cd09449
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
S1-like; pfam14444
DBC1; pfam14443
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3; cd07590
BAR domain; smart00721
Domain of unknown function (DUF3446); pfam11928
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Domain of unknown function (DUF3446); pfam11928
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Domain of unknown function (DUF3446); pfam11928
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; cd00866
GTPase SAR1 and related small G proteins [General function prediction only]
RhoBTB protein is an atypical member of the Rho family of small GTPases; cd01873
BTB/POZ domain; cl02518
Broad-Complex, Tramtrack and Bric a brac; smart00225
Broad-Complex, Tramtrack and Bric a brac; smart00225
GTPase SAR1 and related small G proteins [General function prediction only]
RhoBTB protein is an atypical member of the Rho family of small GTPases; cd01873
BTB/POZ domain; cl02518
Broad-Complex, Tramtrack and Bric a brac; smart00225
Broad-Complex, Tramtrack and Bric a brac; smart00225
GTPase SAR1 and related small G proteins [General function prediction only]
RhoBTB protein is an atypical member of the Rho family of small GTPases; cd01873
BTB/POZ domain; cl02518
Broad-Complex, Tramtrack and Bric a brac; smart00225
Broad-Complex, Tramtrack and Bric a brac; smart00225
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor / nerve growth factor receptor repeats; smart00208
Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors; cd08315
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor / nerve growth factor receptor repeats; smart00208
Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors; cd08315
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor / nerve growth factor receptor repeats; smart00208
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor / nerve growth factor receptor repeats; smart00208
The Death Domain Superfamily of protein-protein interaction domains; cl14633
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor / nerve growth factor receptor repeats; smart00208
Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors; cd08315
Snf7; cl02305
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Lysyl oxidase; pfam01186
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Stanniocalcin family; pfam03298
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM cysteine-rich; cl15456
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Intermediate filament protein; pfam00038
Intermediate filament protein; pfam00038
MAEBL; Provisional
Intermediate filament protein; pfam00038
Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5; cd12051
C2 domain; cl14603
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5; cd11708
Domain of unknown function (DUF3354); pfam11834
K+ channel tetramerisation domain; pfam02214
Pentapeptide repeats (8 copies); pfam00805
Pentapeptide repeats (9 copies); pfam13599
Pentapeptide repeats (8 copies); pfam00805
Pentapeptide repeats (9 copies); pfam13599
Pentapeptide repeats (8 copies); pfam00805
Pentapeptide repeats (8 copies); pfam00805
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; cd11606
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved...; cd01175
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
BNIP3; pfam06553
Zinc peptidases M18, M20, M28, and M42; cl14876
Retrotransposon gag protein; pfam03732
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
Stathmin family; pfam00836
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
B-Box C-terminal domain; smart00502
associated with SPRY domains; smart00589
SPRY domain; pfam00622
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Tyrosine kinase, catalytic domain; smart00219
Focal adhesion targeting region; pfam03623
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Tyrosine kinase, catalytic domain; smart00219
Focal adhesion targeting region; pfam03623
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Tyrosine kinase, catalytic domain; smart00219
Focal adhesion targeting region; pfam03623
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Tyrosine kinase, catalytic domain; smart00219
Focal adhesion targeting region; pfam03623
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
epoxide hydrolase N-terminal domain-like phosphatase; TIGR02247
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
alpha/beta hydrolase fold; pfam00561
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
alpha/beta hydrolase fold; pfam00561
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
alpha/beta hydrolase fold; pfam00561
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
alpha/beta hydrolase fold; pfam00561
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
CLUSTERIN Beta chain; smart00030
Clusterin; pfam01093
CLUSTERIN alpha chain; smart00035
Domain of unknown function (DUF814); pfam05670
zinc-finger of acetyl-transferase ESCO; pfam13878
ESCO1/2 acetyl-transferase; pfam13880
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Scavenger receptor Cys-rich; smart00202
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); cd00882
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
histone acetyltransferase, ELP3 family; TIGR01211
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
Vertebrate endogenous opioids neuropeptide; pfam01160
F-box-like; pfam12937
F-box-like; pfam12937
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor; cd07449
Frizzled/Smoothened family membrane region; pfam01534
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor; cd07449
Frizzled/Smoothened family membrane region; pfam01534
Exostosin family; pfam03016
Glycosyl transferase family 64 domain; pfam09258
Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; COG1236
Beta-Casp domain; smart01027
Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; COG1236
Beta-Casp domain; smart01027
Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; COG1236
Beta-Casp domain; smart01027
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...; cd01365
Kinesin motor, catalytic domain. ATPase; smart00129
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Kinesin protein 1B; pfam12423
Kinesin protein; pfam12473
Kinesin protein; pfam12473
CAP-Gly domain; pfam01302
N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by...; cd01446
Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; cd00127
Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; cd00127
Protein of unknown function (DUF1183); pfam06682
Vacuolar protein sorting 55; pfam04133
Vacuolar protein sorting 55; pfam04133
MBOAT, membrane-bound O-acyltransferase family; cl00738
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping...; cd04646
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity; cd07977
glutathione reductase; Validated
Pyridine nucleotide-disulphide oxidoreductase; pfam00070
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852
glutathione-disulfide reductase, animal/bacterial; TIGR01421
Pyridine nucleotide-disulphide oxidoreductase; pfam00070
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852
glutathione-disulfide reductase, animal/bacterial; TIGR01421
Pyridine nucleotide-disulphide oxidoreductase; pfam00070
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852
glutathione-disulfide reductase, animal/bacterial; TIGR01421
Pyridine nucleotide-disulphide oxidoreductase; pfam00070
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852
UBX domain; pfam00789
serine/threonine protein phosphatase 2A; Provisional
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
Protein of unknown function (DUF3276); cl15305
PurA ssDNA and RNA-binding protein; pfam04845
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins; cd06129
ATP-dependent DNA helicase, RecQ family; TIGR00614
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; smart00956
Helicase and RNase D C-terminal; smart00341
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; cd05895
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; cd05895
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; cd05895
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; cd05895
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
epidermal growth factor-like protein (EGF-like protein); Provisional
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
epidermal growth factor-like protein (EGF-like protein); Provisional
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
epidermal growth factor-like protein (EGF-like protein); Provisional
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
epidermal growth factor-like protein (EGF-like protein); Provisional
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
epidermal growth factor-like protein (EGF-like protein); Provisional
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
EGF-like protein; Provisional
epidermal growth factor-like protein (EGF-like protein); Provisional
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Glycosyltransferase family 10 (fucosyltransferase); pfam00852
Nuclear protein with HMG-like acidic region [General function prediction only]; COG5129
Ribosomal L28e protein family; pfam01778
Mak16 protein C-terminal region; pfam04874
Protein of unknown function (DUF2454); pfam10521
Protein of unknown function (DUF2454); pfam10521
Protein of unknown function (DUF2454); pfam10521
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; cd00127
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Thrombospondin type 1 repeats; smart00209
ZU5 domain; pfam00791
Death domain found in Uncoordinated-5D; cd08801
Ion transport protein; pfam00520
Ion channel; pfam07885
Calcium-activated BK potassium channel alpha subunit; pfam03493
NocA-like zinc-finger protein 1; pfam12402
A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; cd03406
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; COG0330
The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; cl02525
The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; cl02525
Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins; cd06822
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Hormone receptor domain; pfam02793
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; COG1405
TFIIB zinc-binding; pfam08271
C2 domain found in Rab11-family interacting proteins (FIP) class I; cd08682
FIP domain; pfam09457
C2 domain found in Rab11-family interacting proteins (FIP) class I; cd08682
FIP domain; pfam09457
aromatic amino acid aminotransferase; Provisional
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; cd00609
7 transmembrane receptor (rhodopsin family); pfam00001
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); pfam05456
Domain in SPla and the RYanodine Receptor; smart00449
Domain in SPla and the RYanodine Receptor; smart00449
SPRY domain; pfam00622
Cholesterol-binding START domain of mammalian STARD1 and related proteins; cd08905
Like-Sm protein 1; cd01728
BAG domains, present in regulator of Hsp70 proteins; smart00264
BAG domains, present in regulator of Hsp70 proteins; smart00264
WWE domain; cl02729
SAM domain of DDHD2; cd09585
Sterile alpha motif; smart00454
DDHD domain; pfam02862
WWE domain; cl02729
SAM domain of DDHD2; cd09585
Sterile alpha motif; smart00454
DDHD domain; pfam02862
WWE domain; cl02729
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...; cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...; cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...; cd03390
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]; COG5034
PHD-finger; pfam00628
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
PHD-finger; pfam00628
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
LETM1-like protein; pfam07766
LETM1-like protein; pfam07766
LETM1-like protein; pfam07766
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04973
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04973
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04973
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04973
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04973
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04973
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; cd05098
Protein tyrosine kinase; pfam07714
Transforming acidic coiled-coil-containing protein (TACC); pfam05010
Transforming acidic coiled-coil-containing protein (TACC); pfam05010
Transforming acidic coiled-coil-containing protein (TACC); pfam05010
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Insulin growth factor-binding protein homologues; smart00121
Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; COG0265
Trypsin-like peptidase domain; pfam13365
PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; cd00987
TM2 domain; pfam05154
TM2 domain; pfam05154
TM2 domain; pfam05154
TM2 domain; pfam05154
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM cysteine-rich; pfam08516
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Homologues of snake disintegrins; smart00050
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Homologues of snake disintegrins; smart00050
ADAM Cysteine-Rich Domain; smart00608
Indoleamine 2,3-dioxygenase; pfam01231
Indoleamine 2,3-dioxygenase; pfam01231
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger of C2H2 type; pfam12874
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger of C2H2 type; pfam12874
U1-like zinc finger; smart00451
Zinc-finger of C2H2 type; pfam12874
Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity; cd07443
NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse...; cd03580
Golgin subfamily A member 7/ERF4 family; pfam10256
Golgin subfamily A member 7/ERF4 family; pfam10256
Golgin subfamily A member 7/ERF4 family; pfam10256
Alpha-helical domain of GINS complex protein Sld5; cd11711
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cl00084
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13857
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-1; cd08805
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13857
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-1; cd08805
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13857
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-1; cd08805
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13857
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-1; cd08805
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13857
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-1; cd08805
Domain in histone families 1 and 5; smart00526
PHD-finger; pfam00628
PHD-finger; pfam00628
probable histone acetyltransferase MYST; Provisional
MOZ/SAS family; pfam01853
Domain in histone families 1 and 5; smart00526
PHD-finger; pfam00628
PHD-finger; pfam00628
probable histone acetyltransferase MYST; Provisional
MOZ/SAS family; pfam01853
Domain in histone families 1 and 5; smart00526
PHD-finger; pfam00628
PHD-finger; pfam00628
probable histone acetyltransferase MYST; Provisional
MOZ/SAS family; pfam01853
C-terminal domain of medium Mu3B subunit in neuron-specific adaptor protein (AP) complex AP-3; cd09261
Adaptor complexes medium subunit family; pfam00928
C-terminal domain of medium Mu3B subunit in neuron-specific adaptor protein (AP) complex AP-3; cd09261
Adaptor complexes medium subunit family; pfam00928
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces...; cd00061
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Ubiquitin family; pfam00240
Ubiquitin-like domain of UBL; cd01769
I-kappa-kinase-beta NEMO binding domain; pfam12179
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Ubiquitin family; pfam00240
Ubiquitin-like domain of UBL; cd01769
I-kappa-kinase-beta NEMO binding domain; pfam12179
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Ubiquitin family; pfam00240
Ubiquitin-like domain of UBL; cd01769
I-kappa-kinase-beta NEMO binding domain; pfam12179
DNA polymerase X family; smart00483
Nucleotidyltransferase (NT) domain of family X DNA Polymerases; cd00141
Dickkopf N-terminal cysteine-rich region; pfam04706
Prokineticin; pfam06607
Voltage-dependent anion channel of the outer mitochondrial membrane; cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; cd07306
Phosphate transporter family; pfam01384
Phosphate transporter family; pfam01384
Phosphate transporter family; pfam01384
Phosphate transporter family; pfam01384
Phosphate transporter family; pfam01384
Phosphate transporter family; pfam01384
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; smart00980
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
HOOK protein; pfam05622
farnesyltranstransferase
Protein prenyltransferase alpha subunit repeat; pfam01239
Protein prenyltransferase alpha subunit repeat; pfam01239
Protein prenyltransferase alpha subunit repeat; pfam01239
Protein prenyltransferase alpha subunit repeat; pfam01239
Protein prenyltransferase alpha subunit repeat; pfam01239
Protein kinase domain; pfam00069
Protein Kinases, catalytic domain; cl09925
Protein of unknown function (DUF1624); cl01394
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Basic region leucine zipper; pfam07716
NUC194 domain; pfam08163
FAT domain; pfam02259
DNA-dependent protein kinase (DNA-PK), catalytic domain; The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); cd05172
Phosphoinositide 3-kinase, catalytic domain; smart00146
FATC domain; pfam02260
NUC194 domain; pfam08163
FAT domain; pfam02259
DNA-dependent protein kinase (DNA-PK), catalytic domain; The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); cd05172
Phosphoinositide 3-kinase, catalytic domain; smart00146
FATC domain; pfam02260
minichromosome maintenance proteins; smart00350
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
minichromosome maintenance proteins; smart00350
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; smart00212
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Animal heme peroxidase domain of peroxidasin and related proteins; cd09826
von Willebrand factor type C domain; pfam00093
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); pfam01135
Methyltransferase domain; pfam12847
Zinc finger, C2HC type; pfam01530
Zinc finger, C2HC type; pfam01530
Myelin transcription factor 1; pfam08474
Zinc finger, C2HC type; pfam01530
Zinc finger, C2HC type; pfam01530
Zinc finger, C2HC type; pfam01530
Zinc finger, C2HC type; pfam01530
Protein of unknown function (DUF964); cl01483
Autophagy-related protein 11; pfam10377
Autophagy-related protein 11; pfam10377
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The...; cd00256
V-ATPase subunit H; pfam03224
V-ATPase subunit H; pfam11698
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The...; cd00256
V-ATPase subunit H; pfam03224
V-ATPase subunit H; pfam11698
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The...; cd00256
V-ATPase subunit H; pfam03224
V-ATPase subunit H; pfam11698
Regulator of G protein signaling (RGS) domain superfamily; cl02565
Regulator of G protein signaling (RGS) domain superfamily; cl02565
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme; cd00183
transcription elongation factor S-II; TIGR01385
Transcription factor S-II (TFIIS), central domain; pfam07500
Transcription factor S-II (TFIIS); pfam01096
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme; cd00183
transcription elongation factor S-II; TIGR01385
Transcription factor S-II (TFIIS), central domain; pfam07500
Transcription factor S-II (TFIIS); pfam01096
Phospholipase/Carboxylesterase; pfam02230
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
50S ribosomal protein L15; Reviewed; PRK05592
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
Sox C-terminal transactivation domain; pfam12067
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
XK-related protein; pfam09815
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; cd07987
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Src homology 3 domain of Lyn Protein Tyrosine Kinase; cd12004
Src homology 2 (SH2) domain found in Lyn; cd10364
Catalytic domain of the Protein Tyrosine Kinase, Lyn; cd05072
Protein tyrosine kinase; pfam07714
Src homology 3 domain of Lyn Protein Tyrosine Kinase; cd12004
Src homology 2 (SH2) domain found in Lyn; cd10364
Catalytic domain of the Protein Tyrosine Kinase, Lyn; cd05072
Protein tyrosine kinase; pfam07714
Ribosomal protein S10p/S20e; cl00314
Ribosomal protein S10p/S20e; cl00314
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cl02794
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cl02794
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cl02794
Short-chain dehydrogenases of various substrate specificities [General function prediction only]; COG0300
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; cd05339
Vertebrate endogenous opioids neuropeptide; pfam01160
Vertebrate endogenous opioids neuropeptide; pfam01160
IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may...; cd01640
Centrosome-associated N terminus; pfam14161
Centrosome-associated C terminus; pfam14160
Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47; smart00553
p47-like ubiquitin domain; cd01770
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; cl12078
Cytochrome P450; pfam00067
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
GRAM domain; pfam02893
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor; cd06071
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
GRAM domain; pfam02893
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor; cd06071
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a...; cd03120
Rab GTPase family 2 (Rab2); cd01866
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ARC105 or Med15 subunit of Mediator complex non-fungal; pfam09606
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
BRK domain; pfam07533
domain in transcription and CHROMO domain helicases; smart00592
CRAL/TRIO, N-terminal domain; pfam03765
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...; cd00170
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Tetratricopeptide repeat; pfam13432
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Aspartyl/Asparaginyl beta-hydroxylase; pfam05118
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Tetratricopeptide repeat; pfam13432
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Aspartyl/Asparaginyl beta-hydroxylase; pfam05118
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Aspartyl beta-hydroxylase N-terminal region; pfam05279
Na,K-Atpase Interacting protein; pfam05640
Peptidase C26; pfam07722
Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase; cd01747
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...; cd00170
YT521-B-like domain; pfam04146
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Mitochondrial fission regulator; pfam05308
Mitochondrial fission regulator; pfam05308
Mitochondrial fission regulator; pfam05308
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-box zinc finger; pfam00643
B-Box C-terminal domain; smart00502
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-box zinc finger; pfam00643
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
Corticotropin-releasing factor family; pfam00473
Ribosome biogenesis regulatory protein (RRS1); pfam04939
Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; cd08190
Iron-containing alcohol dehydrogenase; pfam00465
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
LMSTEN motif; pfam07988
C-myb, C-terminal; pfam09316
OTU-like cysteine protease; pfam02338
The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase; cd06870
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; cd05604
The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase; cd06870
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; cd05604
The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase; cd06870
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; cd05604
The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase; cd06870
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; COG1241
Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; COG1241
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Leucine Rich repeats (2 copies); pfam12799
Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5; cd08069
SEC7 domain proteins [General function prediction only]
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Domain of unknown function (DUF1981); pfam09324
Carboxypeptidase activation peptide; pfam02244
Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A6 subgroup; cd03872
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...; cd04439
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...; cd04440
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...; cd04439
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF...; cd04440
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
Sulfatase protein; pfam12548
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
Sulfatase protein; pfam12548
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
Sulfatase protein; pfam12548
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
Sulfatase protein; pfam12548
Organic Anion Transporter Polypeptide (OATP) family; pfam03137
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...; cd01330
Organic Anion Transporter Polypeptide (OATP) family; pfam03137
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...; cd01330
Organic Anion Transporter Polypeptide (OATP) family; pfam03137
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...; cd01330
Protein of unknown function (DUF3169); pfam11368
SET domain; pfam00856
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
helix loop helix domain; smart00353
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; pfam13426
Steroid receptor coactivator; pfam08832
Nuclear receptor coactivator; pfam08815
Domain of unknown function (DUF1518); pfam07469
TRAM1-like protein; pfam08390
TRAM, LAG1 and CLN8 homology domains; smart00724
Zn-dependent hydrolases, including glyoxylases [General function prediction only]; COG0491
Metallo-beta-lactamase superfamily; smart00849
eyes absent protein conserved domain; TIGR01658
eyes absent protein conserved domain; TIGR01658
eyes absent protein conserved domain; TIGR01658
eyes absent protein conserved domain; TIGR01658
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Polycystin cation channel; pfam08016
Ion transport protein; pfam00520
K+ channel tetramerisation domain; pfam02214
Ion transport protein; pfam00520
Polycystin cation channel; pfam08016
Ion channel; pfam07885
Kv2 voltage-gated K+ channel; pfam03521
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability; cd00280
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; cd11660
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability; cd00280
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; cd11660
Thrombospondin type 1 domain; cl15278
Ribosomal L30 N-terminal domain; pfam08079
60S ribosomal protein L7, eukaryotic; TIGR01310
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome.  The...; cd01657
Short-chain dehydrogenases of various substrate specificities [General function prediction only]; COG0300
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; cd05339
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Found in Skp1 protein family; smart00512
Protein of unknown function (DUF1301); pfam06979
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...; cl00274
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...; cl00274
MORN repeat; pfam02493
MORN repeat; pfam02493
Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; COG0625
GST_N family, Ganglioside-induced differentiation-associated protein 1 (GDAP1) subfamily; GDAP1 was originally identified as a highly expressed gene at the differentiated stage of GD3 synthase-transfected cells. More recently, mutations in GDAP1 have...; cd03052
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1; cd10303
Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; COG0625
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; cl00388
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1; cd10303
SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; cl00133
SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed...; cd05380
LCCL domain; smart00603
LCCL domain; smart00603
DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers; cd06960
The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes; cd06931
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain-containing transcription factor [Transcription]
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Pex2 / Pex12 amino terminal region; pfam04757
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Pex2 / Pex12 amino terminal region; pfam04757
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Pex2 / Pex12 amino terminal region; pfam04757
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Pex2 / Pex12 amino terminal region; pfam04757
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
cAMP-dependent protein kinase inhibitor; pfam02827
cAMP-dependent protein kinase inhibitor; pfam02827
zinc-finger of a C2HC-type; pfam13913
Interleukin 7/9 family; cl11602
Interleukin 7/9 family; cl11602
Interleukin-7 and interleukin-9 family; smart00127
Interleukin-7 and interleukin-9 family; smart00127
Stathmin family; pfam00836
Stathmin family; pfam00836
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Hairy Orange; pfam07527
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Hairy Orange; pfam07527
Mitochondrial ribosomal protein MRP-S35; pfam10246
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
zinc finger in transposases and transcription factors; smart00597
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
zinc finger in transposases and transcription factors; smart00597
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; cd01639
IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; cd01639
IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; cd01639
bile acid transporter; TIGR00841
Sodium Bile acid symporter family; pfam01758
AN1-like Zinc finger; pfam01428
AN1-like Zinc finger; pfam01428
AN1-like Zinc finger; pfam01428
AN1-like Zinc finger; pfam01428
AN1-like Zinc finger; pfam01428
AN1-like Zinc finger; pfam01428
Snf7; pfam03357
The Phox Homology domain, a phosphoinositide binding module; cl02563
The phosphoinositide binding Phox Homology domain of Sorting Nexin 16; cd07276
The phosphoinositide binding Phox Homology domain of Sorting Nexin 16; cd07276
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Leucine Rich repeats (2 copies); pfam12799
Leucine Rich repeats (2 copies); pfam12799
Leucine Rich repeats (2 copies); pfam12799
E2F/DP family winged-helix DNA-binding domain; pfam02319
E2F/DP family winged-helix DNA-binding domain; pfam02319
N-6 DNA Methylase; pfam02384
N-6 DNA Methylase; pfam02384
N-6 DNA Methylase; pfam02384
N-6 DNA Methylase; pfam02384
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII.  Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on...; cd03119
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; cd06145
DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; COG0847
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
ATP synthase (C/AC39) subunit; pfam01992
V-type ATP synthase subunit C; Provisional; cl00660
Amino acid permease; pfam13520
C2 domain present in E3 ubiquitin ligase; cd04021
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
C2 domain first repeat in Copine; cd04048
C2 domain second repeat in Copine; cd04047
VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae; cd01459
Ion transport protein; pfam00520
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Putative peptidoglycan binding domain; pfam01471
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate...; cd04278
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...; cd00094
Domain of unknown function (DUF3377); pfam11857
Protein kinase domain; pfam00069
Protein Kinases, catalytic domain; cl09925
Caspase activation and recruitment domain of Receptor Interacting Protein 2; cd08786
putative bacillithiol system oxidoreductase, YpdA family; TIGR04018
putative bacillithiol system oxidoreductase, YpdA family; TIGR04018
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
DNA damage repair protein Nbs1; pfam08599
Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; cd05369
short chain dehydrogenase; Provisional
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
SNARE associated Golgi protein; cl00429
SNARE associated Golgi protein; pfam09335
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Antibiotic biosynthesis monooxygenase; pfam03992
Transmembrane protein 55A; pfam09788
OTU-like cysteine protease; pfam02338
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
NHR1 homology to TAF; pfam07531
NHR2 domain like; pfam08788
ATP synthase B/B' CF(0); cl07975
MYND finger; pfam01753
The Bin/Amphiphysin/Rvs (BAR) domain of Family with sequence similarity 92 (FAM92); cd07598
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Meckelin (Transmembrane protein 67); pfam09773
Meckelin (Transmembrane protein 67); pfam09773
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; cd00143
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin repeat-like domain; cl15786
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin repeat-like domain; cl15786
Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases; cd04148
GTPase SAR1 and related small G proteins [General function prediction only]
Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases; cd04148
GTPase SAR1 and related small G proteins [General function prediction only]
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; COG0513
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; COG0513
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Myb/SANT-like DNA-binding domain; pfam13873
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain); pfam14259
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
DAZ associated protein 2 (DAZAP2); pfam11029
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain); pfam14259
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain); pfam14259
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain); pfam14259
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
DAZ associated protein 2 (DAZAP2); pfam11029
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain); pfam14259
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
DAZ associated protein 2 (DAZAP2); pfam11029
Q-cell neuroblast polarisation; pfam10034
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin, C-terminal domain; pfam02984
Squalene/phytoene synthase; pfam00494
Phafin2  Pleckstrin Homology (PH) domain; cd01218
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
TGF-beta propeptide; pfam00688
Transforming growth factor-beta (TGF-beta) family; smart00204
Ubiquinol-cytochrome C reductase complex 14kD subunit; pfam02271
Ubiquinol-cytochrome C reductase complex 14kD subunit; pfam02271
Ubiquinol-cytochrome C reductase complex 14kD subunit; pfam02271
mTERF; pfam02536
Phosphatidyl serine synthase; pfam03034
Syndecan domain; pfam01034
Zinc peptidases M18, M20, M28, and M42; cl14876
Predicted aminopeptidases [General function prediction only]; COG2234
PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; cd04815
M28 Zn-Peptidase Plasma glutamate carboxypeptidase; cd03883
Nucleosome assembly protein (NAP); pfam00956
(NAP-L) nucleosome assembly protein -L; Provisional; cl08298
Golgi 4-transmembrane spanning transporter; cl04276
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments; cd01475
Complement Clr-like EGF-like; pfam12662
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Complement Clr-like EGF-like; pfam12662
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments; cd01475
Trimeric coiled-coil oligomerisation domain of matrilin; pfam10393
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments; cd01475
Complement Clr-like EGF-like; pfam12662
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Complement Clr-like EGF-like; pfam12662
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments; cd01475
Trimeric coiled-coil oligomerisation domain of matrilin; pfam10393
60S ribosomal protein L30; Provisional
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; cd00448
Ribonucleases P/MRP protein subunit POP1; pfam06978
POPLD (NUC188) domain; pfam08170
Ribonucleases P/MRP protein subunit POP1; pfam06978
POPLD (NUC188) domain; pfam08170
Ribonucleases P/MRP protein subunit POP1; pfam06978
POPLD (NUC188) domain; pfam08170
Magnesium transporter NIPA; pfam05653
K+ channel tetramerisation domain; pfam02214
Ion transport protein; pfam00520
Ion channel; pfam07885
Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2; cd06612
Serine/Threonine protein kinases, catalytic domain; smart00220
C terminal SARAH domain of Mst1; pfam11629
Protein Kinases, catalytic domain; cl09925
Protein Kinases, catalytic domain; cl09925
C terminal SARAH domain of Mst1; pfam11629
Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2; cd06612
Serine/Threonine protein kinases, catalytic domain; smart00220
C terminal SARAH domain of Mst1; pfam11629
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Protein of unknown function (DUF1162); pfam06650
ATG C terminal domain; pfam09333
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Protein of unknown function (DUF1162); pfam06650
ATG C terminal domain; pfam09333
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd00927
Regulator of G protein signaling domain RGS_RGS22_2; cd08727
Regulator of G protein signaling domain RGS_RGS22_3; cd08726
Regulator of G protein signaling domain RGS_RGS22_4; cd08725
F-box domain; cl02535
IBR domain; pfam01485
RNA polymerase subunit CX; smart00659
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Potential Monad-binding region of RPAP3; pfam13877
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Potential Monad-binding region of RPAP3; pfam13877
Ring finger; smart00184
IBR domain; pfam01485
In Between Ring fingers; smart00647
IBR domain; pfam01485
In Between Ring fingers; smart00647
Ring finger; smart00184
IBR domain; pfam01485
In Between Ring fingers; smart00647
IBR domain; pfam01485
In Between Ring fingers; smart00647
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31; cd06885
Ubiquitin-like proteins; cl00155
polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Poly-adenylate binding protein, unique domain; pfam00658
14-3-3 beta and zeta isoforms of 14-3-3 protein; cd10022
14-3-3 beta and zeta isoforms of 14-3-3 protein; cd10022
14-3-3 beta and zeta isoforms of 14-3-3 protein; cd10022
14-3-3 beta and zeta isoforms of 14-3-3 protein; cd10022
14-3-3 beta and zeta isoforms of 14-3-3 protein; cd10022
14-3-3 beta and zeta isoforms of 14-3-3 protein; cd10022
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; cl09952
CP2 transcription factor; pfam04516
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; cd01049
E3 ubiquitin ligase EDD; pfam11547
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; smart00396
C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein; smart00517
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
HECT-domain (ubiquitin-transferase); pfam00632
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell...; cd06482
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor; cd06831
Diaminopimelate decarboxylase [Amino acid transport and metabolism]; COG0019
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor; cd06831
Diaminopimelate decarboxylase [Amino acid transport and metabolism]; COG0019
V-ATPase subunit C; pfam03223
BAALC N-terminus; pfam06989
BAALC N-terminus; pfam06989
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor; cd07450
Frizzled/Smoothened family membrane region; pfam01534
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor; cd07450
Frizzled/Smoothened family membrane region; pfam01534
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor; cd07450
Frizzled/Smoothened family membrane region; pfam01534
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Mitochondrial carrier protein; pfam00153
ADP/ATP transporter on adenylate translocase; Provisional
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Sof1-like domain; pfam04158
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
DC-STAMP-like protein; pfam07782
DC-STAMP-like protein; pfam07782
phenylhydantoinase; Validated
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
C2H2-type zinc finger; pfam13912
C2H2-type zinc finger; pfam13912
C2H2-type zinc finger; pfam13912
C2H2-type zinc finger; pfam13912
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
domain in TBC and LysM domain containing proteins; smart00584
domain in TBC and LysM domain containing proteins; smart00584
domain in TBC and LysM domain containing proteins; smart00584
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cl00066
eIF3 subunit 6 N terminal domain; pfam09440
PCI domain; pfam01399
Tetratricopeptide repeat; pfam13432
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
TPR repeat; pfam13414
7 transmembrane receptor (rhodopsin family); pfam00001
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen; cd06493
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen; cd06493
Transcription factor e(y)2; pfam10163
Transcription factor e(y)2; pfam10163
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
PA14 domain; cl08459
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
Cytochrome C oxidase subunit II, periplasmic domain; cl11412
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
IPT/TIG domain; pfam01833
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; cl15674
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
G8 domain; pfam10162
G8 domain; pfam10162
Right handed beta helix region; pfam13229
Protein of unknown function (DUF1682); pfam07946
Protein of unknown function (DUF1682); pfam07946
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
flagellar biosynthesis regulator FlhF; Validated; PRK05703
K+ channel tetramerisation domain; pfam02214
Ion transport protein; pfam00520
Ion channel; pfam07885
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C; cd00202
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h; cd08065
PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi; cd09866
N terminus of Rad21 / Rec8 like protein; pfam04825
Conserved region of Rad21 / Rec8 like protein; pfam04824
cation diffusion facilitator family transporter; TIGR01297
Cation efflux family; pfam01545
cation diffusion facilitator family transporter; TIGR01297
Cation efflux family; pfam01545
cation diffusion facilitator family transporter; TIGR01297
Cation efflux family; pfam01545
cation diffusion facilitator family transporter; TIGR01297
Cation efflux family; pfam01545
cation diffusion facilitator family transporter; TIGR01297
Cation efflux family; pfam01545
Mediator complex subunit 30; pfam11315
Exostosin family; pfam03016
Glycosyl transferase family 64 domain; pfam09258
SAM domain of aveugle-like subfamily; cd09510
SAM domain (Sterile alpha motif); pfam07647
SAM domain of aveugle-like subfamily; cd09510
SAM domain (Sterile alpha motif); pfam07647
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cl12111
Death domain; pfam00531
C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1); cd03591
Membrane-associating domain; pfam01284
Insulin-like growth factor binding protein; pfam00219
von Willebrand factor type C domain; cl02515
Thrombospondin type 1 domain; cl15278
C-terminal cystine knot-like domain (CTCK); smart00041
Somatomedin B -like domains; smart00201
Somatomedin B -like domains; smart00201
Sulfatase; cl10460
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; cd00091
DNA/RNA non-specific endonuclease; smart00892
Somatomedin B -like domains; smart00201
Somatomedin B -like domains; smart00201
Sulfatase; cl10460
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; cd00091
DNA/RNA non-specific endonuclease; smart00892
Somatomedin B -like domains; smart00201
Somatomedin B -like domains; smart00201
Sulfatase; cl10460
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; cd00091
DNA/RNA non-specific endonuclease; smart00892
TATA binding protein (TBP) associated factor 2; cd09839
Uncharacterized conserved protein (DUF2036); pfam09724
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown; cd04442
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown; cd04441
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type III domain; pfam00041
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Thrombospondin N-terminal -like domains; smart00210
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; cd00392
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Pleckstrin homology-like domain; cl00273
Hyaluronan synthases catalyze polymerization of hyaluronan; cd06434
Glycosyltransferase like family 2; pfam13641
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Der1-like family; pfam04511
Der1-like family; pfam04511
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Rab-GTPase-TBC domain; cl02495
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Rab-GTPase-TBC domain; cl02495
Tumour suppressor, Mitostatin; pfam13868
Protein of unknown function (DUF1669); pfam07894
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83A; cd09181
Protein of unknown function (DUF1669); pfam07894
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83A; cd09181
poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; TIGR03939
poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; TIGR03939
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases associated with a variety of cellular activities; smart00382
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this...; cd05528
N-terminal glutamine amidase; pfam09764
Broad-Complex, Tramtrack and Bric a brac; smart00225
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
C2 domain second repeat in Ferlin; cd04011
FerI (NUC094) domain; pfam08151
C2 domain third repeat in Ferlin; cd04018
FerB (NUC096) domain; pfam08150
C2 domain fourth repeat in Ferlin; cd04017
C2 domain fifth repeat in Ferlin; cd04037
C2 domain sixth repeat in Ferlin; cd08374
Protein of unknown function (DUF2453); pfam10507
Predicted methyltransferase [General function prediction only]
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
TRC8 N-terminal domain; pfam13705
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; cd01310
TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; cd01310
Complex 1 protein (LYR family); pfam05347
Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis; cd07643
IRSp53/MIM homology domain; pfam08397
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Squalene epoxidase; pfam08491
Hereditary spastic paraplegia protein strumpellin; pfam10266
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Lecithin retinol acyltransferase; pfam04970
Found in Pit-Oct-Unc transcription factors; smart00352
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Myc amino-terminal region; pfam01056
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Myc leucine zipper domain; pfam02344
Gasdermin family; pfam04598
Protein of unknown function (DUF1394); pfam07159
Protein of unknown function (DUF1394); pfam07159
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1; cd07641
Centaurin Pleckstrin homology (PH) domain; cd01250
Putative GTPase activating protein for Arf; pfam01412
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1; cd11965
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1; cd07641
Centaurin Pleckstrin homology (PH) domain; cd01250
Putative GTPase activating protein for Arf; pfam01412
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1; cd11965
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Domain of Unknown Function (DUF1053); pfam06327
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The...; cd04707
otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The...; cd04707
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
Ankyrin-G binding motif of KCNQ2-3; pfam11956
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
Ankyrin-G binding motif of KCNQ2-3; pfam11956
occurring C-terminal to leucine-rich repeats; smart00446
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cl15261
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein of unknown function (DUF3776); pfam12618
Protein of unknown function (DUF3776); pfam12618
PHD-finger; pfam00628
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cl15261
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein of unknown function (DUF3776); pfam12618
Protein of unknown function (DUF3776); pfam12618
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cl15261
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Protein of unknown function (DUF3776); pfam12618
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats; smart00211
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
GCC2 and GCC3; pfam07699
Thyroglobulin type I repeats; smart00211
Carboxylesterase family; pfam00135
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Src homology 3 domain of Src-Like Adaptor Protein; cd12010
Src homology 2 domain found in Src-like adaptor proteins; cd10344
Src homology 3 domain of Src-Like Adaptor Protein; cd12010
Src homology 2 domain found in Src-like adaptor proteins; cd10344
Src homology 3 domain of Src-Like Adaptor Protein; cd12010
Src homology 2 domain found in Src-like adaptor proteins; cd10344
Insulin-like growth factor binding protein; pfam00219
von Willebrand factor type C domain; cl02515
Thrombospondin type 1 domain; cl15278
Insulin-like growth factor binding protein; pfam00219
Thrombospondin type 1 domain; cl15278
Glycoprotein hormone beta chain homologues; cl00070
Glycoprotein hormone beta chain homologues; cl00070
Insulin-like growth factor binding protein; pfam00219
Ndr family; pfam03096
Ndr family; pfam03096
Alpha/beta hydrolase family; pfam12697
Alpha/beta hydrolase family; pfam12697
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...; cd02395
Protein of unknown function (DUF3657); pfam12394
Protein of unknown function (DUF3657); pfam12394
Putative serine esterase (DUF676); pfam05057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Ion channel; pfam07885
Ion channel; pfam07885
Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit; pfam08626
Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit; pfam08626
Histone-like transcription factor (CBF/NF-Y) and archaeal histone; pfam00808
protein argonaute; Provisional
Domain of unknown function (DUF1785); pfam08699
PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; cd02846
Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of...; cd04657
protein argonaute; Provisional
Domain of unknown function (DUF1785); pfam08699
PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; cd02846
Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of...; cd04657
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Protein tyrosine kinase; pfam07714
Focal adhesion targeting region; pfam03623
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Protein tyrosine kinase; pfam07714
Focal adhesion targeting region; pfam03623
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; cd05056
Protein tyrosine kinase; pfam07714
Focal adhesion targeting region; pfam03623
DENN (AEX-3) domain; cl11519
dDENN domain; pfam03455
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
GPH family sucrose/H+ symporter; TIGR01301
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
7 transmembrane receptor (rhodopsin family); pfam00001
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
Myb/SANT-like DNA-binding domain; pfam13873
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; cl00143
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; cd00193
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Domain present in hormone receptors; smart00008
Domain of unknown function (DUF3497); pfam12003
G-protein-coupled receptor proteolytic site domain; smart00303
7 transmembrane receptor (Secretin family); pfam00002
CENP-B N-terminal DNA-binding domain; pfam04218
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; smart00674
DDE superfamily endonuclease; pfam03184
CENP-B N-terminal DNA-binding domain; pfam04218
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; smart00674
DDE superfamily endonuclease; pfam03184
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cl10471
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; cd00586
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cl10471
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cl10471
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cl10471
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cl10471
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cl10471
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these...; cd00117
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I.  Topo I enzymes are divided into:  topo type IA (bacterial) and type IB (eukaryotic); cd03488
DNA Topoisomerase I (eukaryota); smart00435
DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; cd00659
C-terminal topoisomerase domain; pfam14370
Eukaryotic DNA topoisomerase I, DNA binding fragment; pfam02919
DNA Topoisomerase I (eukaryota); smart00435
DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; cd00659
C-terminal topoisomerase domain; pfam14370
Eukaryotic DNA topoisomerase I, DNA binding fragment; pfam02919
DNA Topoisomerase I (eukaryota); smart00435
DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; cd00659
C-terminal topoisomerase domain; pfam14370
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-1; cd11633
BRO1-like domain; smart01041
Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1; cd09248
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Maf N-terminal region; pfam08383
bZIP Maf transcription factor; pfam03131
Zinc finger C-x8-C-x5-C-x3-H type (and similar); pfam00642
zinc finger; smart00356
zinc finger; smart00356
Zinc finger C-x8-C-x5-C-x3-H type (and similar); pfam00642
Gasdermin family; pfam04598
Gasdermin family; pfam04598
nicotinate phosphoribosyltransferase
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; cd01570
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Eukaryotic elongation factor 1 beta central acidic region; pfam10587
Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl...; cd00292
Helix-turn-helix domains; cl00088
Tc5 transposase DNA-binding domain; pfam03221
Integrase core domain; cl01316
pyrroline-5-carboxylate reductase; Reviewed
pyrroline-5-carboxylate reductase
GDP-fucose synthetase, extended (e) SDRs; cd05239
GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15; cd07852
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein of unknown function (DUF1669); pfam07894
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83H; cd09188
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine-rich repeat (LRR) protein [Function unknown]
Leucine-rich repeat (LRR) protein [Function unknown]
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine-rich repeat (LRR) protein [Function unknown]
Leucine-rich repeat (LRR) protein [Function unknown]
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
poly-U binding splicing factor, half-pint family; TIGR01645
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Catalytic domain of Protein Kinases; cd00180
Serine/Threonine protein kinases, catalytic domain; smart00220
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin/S10 domain; pfam03501
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; cl02531
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component...; cd01439
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; cd10428
5-oxoprolinase
Hydantoinase/oxoprolinase N-terminal region; pfam05378
Hydantoinase/oxoprolinase; pfam01968
exosome complex exonuclease Rrp41; Provisional
RRP41 subunit of eukaryotic exosome; cd11370
Gaa1-like, GPI transamidase component; pfam04114
Cytochrome C1 family; pfam02167
Ubiquitin-like proteins; cl00155
Maf1 regulator; pfam09174
Domain of unknown function (DUF383); pfam04063
Domain of unknown function (DUF384); pfam04064
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
BOP1NT (NUC169) domain; smart01035
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
heat shock factor; smart00415
Vertebrate heat shock transcription factor; pfam06546
MBOAT, membrane-bound O-acyltransferase family; cl00738
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Protein of unknown function (DUF1011); pfam06237
Protein of unknown function (DUF1011); pfam06237
Protein of unknown function (DUF1011); pfam06237
Predicted unusual protein kinase [General function prediction only]; COG0661
Protein Kinases, catalytic domain; cl09925
CPSF A subunit region; pfam03178
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
VPS28 protein; pfam03997
VPS28 protein; pfam03997
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
TPR repeat; pfam13414
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; cl00286
Kinesin motor, catalytic domain. ATPase; smart00129
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
alanine aminotransferase; Provisional
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; cd00609
DNA replication and checkpoint protein; pfam11719
Superfamily II DNA helicase [DNA replication, recombination, and repair]; COG0514
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
WW domain; pfam00397
MyTH4 domain; cl02480
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into...; cd04389
GTPase-activator protein for Rho-like GTPases; smart00324
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
60S ribosomal protein L8; Provisional
Ribosomal Proteins L2, RNA binding domain; pfam00181
Ribosomal Proteins L2, C-terminal domain; pfam03947
60S ribosomal protein L8; Provisional
Ribosomal Proteins L2, RNA binding domain; pfam00181
Ribosomal Proteins L2, C-terminal domain; pfam03947
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
hypothetical protein; Provisional
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal...; cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal...; cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal...; cd04753
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
WAHD domain of WASH complex; pfam11945
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Putative GTPases (G3E family) [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Cobalamin synthesis protein cobW C-terminal domain; pfam07683
Putative GTPases (G3E family) [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Cobalamin synthesis protein cobW C-terminal domain; pfam07683
Putative GTPases (G3E family) [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Cobalamin synthesis protein cobW C-terminal domain; pfam07683
Domain of unknown function (DUF3398); pfam11878
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; cd08696
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; cl06123
Domain of unknown function (DUF3398); pfam11878
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; cd08696
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; cl06123
Domain of unknown function (DUF3398); pfam11878
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; cd08696
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; cl06123
KN motif; pfam12075
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
KN motif; pfam12075
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
KN motif; pfam12075
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
DM DNA binding domain; pfam00751
DM DNA binding domain; pfam00751
DMRTA motif; pfam03474
DM DNA binding domain; pfam00751
DM DNA binding domain; pfam00751
DM DNA binding domain; pfam00751
QLQ; pfam08880
domain in helicases and associated with SANT domains; smart00573
BRK domain; pfam07533
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone...; cd05516
QLQ; pfam08880
domain in helicases and associated with SANT domains; smart00573
BRK domain; pfam07533
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone...; cd05516
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Low-density lipoprotein receptor repeat class B; pfam00058
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; pfam00058
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; pfam00058
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Low-density lipoprotein receptor repeat class B; pfam00058
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; pfam00058
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; pfam00058
Complement Clr-like EGF-like; pfam12662
BTB/POZ domain; cl02518
Ion transport protein; pfam00520
Ion channel; pfam07885
Pumilio-family RNA binding domain; cl02427
CPL (NUC119) domain; pfam08144
RFX1 transcription activation region; pfam04589
RFX DNA-binding domain; pfam02257
RFX1 transcription activation region; pfam04589
RFX DNA-binding domain; pfam02257
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Na+/H+-dicarboxylate symporters [Energy production and conversion]; COG1301
Sodium:dicarboxylate symporter family; pfam00375
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a...; cd03391
Membrane-associated phospholipid phosphatase [Lipid metabolism]; COG0671
Cdc37 Hsp90 binding domain; smart01070
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
Adenylate kinase; pfam00406
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
Adenylate kinase; pfam00406
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded in eukaryotic genomes. They lack a conserved catalytic histidine residue required for cyclase activity, so probably do not function as cyclases. They are...; cd00875
18S rRNA biogenesis protein RCL1; TIGR03400
Band 4.1 homologues; smart00295
Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins; cd10379
Protein tyrosine kinase; pfam07714
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3; cd05078
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3; cd05081
Protein tyrosine kinase; pfam07714
Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig...; cl02453
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4); cd04365
Uncharacterized conserved protein (DUF2368); pfam10166
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin Constant domain; cd00098
Immunoglobulin Constant domain; cd00098
Immunoglobulin like; smart00410
Immunoglobulin domain; cl11960
RIC1; pfam07064
RIC1; pfam07064
RIC1; pfam07064
M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; cd03875
Predicted aminopeptidases [General function prediction only]; COG2234
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; cd04369
HEAT-like repeat; pfam13513
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
HEAT repeats; pfam13646
HEAT-like repeat; pfam13513
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
Tumour protein D52 family; pfam04201
amino-terminal ubiquitin-like domain of  Np95 and NIRF; cd01797
Ubiquitin family; pfam00240
Protein of unknown function (DUF3590); pfam12148
PHD-finger; pfam00628
YDG/SRA domain; pfam02182
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
glycine dehydrogenase; Provisional
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; cd00613
jmjN domain; pfam02375
JmjC domain, hydroxylase; pfam02373
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
jmjN domain; pfam02375
JmjC domain, hydroxylase; pfam02373
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
Tudor domain; smart00333
Tudor domain; smart00333
jmjN domain; pfam02375
JmjC domain, hydroxylase; pfam02373
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
Tudor domain; smart00333
Tudor domain; smart00333
jmjN domain; pfam02375
JmjC domain, hydroxylase; pfam02373
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05738
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05739
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05738
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05739
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05738
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05739
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05738
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05739
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05738
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05739
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Second immunoglobulin (Ig)-like domain of  the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05738
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR; cd05739
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Common central domain of tyrosinase; pfam00264
L27_2; pfam09045
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
L27_2; pfam09045
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
L27_2; pfam09045
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Nuclear factor I protein pre-N-terminus; pfam10524
N-terminal Mad Homology 1 (MH1) domain; cl00055
CTF/NF-I family transcription modulation region; pfam00859
Nuclear factor I protein pre-N-terminus; pfam10524
N-terminal Mad Homology 1 (MH1) domain; cl00055
CTF/NF-I family transcription modulation region; pfam00859
Nuclear factor I protein pre-N-terminus; pfam10524
N-terminal Mad Homology 1 (MH1) domain; cl00055
CTF/NF-I family transcription modulation region; pfam00859
DHHC palmitoyltransferase; pfam01529
DAN domain; pfam03045
Calx-beta domain; cl02522
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; cd00037
Calx-beta domain; cl02522
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; cd00037
Protein of unknown function (DUF3808); pfam10300
Tetratricopeptide repeat; pfam13424
Protein of unknown function (DUF3808); pfam10300
Tetratricopeptide repeat; pfam13424
Protein of unknown function (DUF3808); pfam10300
Tetratricopeptide repeat; pfam13424
Protein of unknown function (DUF3808); pfam10300
Tetratricopeptide repeat; pfam13424
Protein of unknown function (DUF3808); pfam10300
Tetratricopeptide repeat; pfam13424
snRNA-activating protein of 50kDa MW C terminal; pfam12251
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1; cd05834
Lens epithelium-derived growth factor (LEDGF); pfam11467
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1; cd05834
Lens epithelium-derived growth factor (LEDGF); pfam11467
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1; cd05834
chromosome segregation protein SMC, common bacterial type; TIGR02168
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, common bacterial type; TIGR02168
BAR domain; smart00721
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1; cd07613
Src homology 3 domain of Endophilin-A; cd11803
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 domain; cl15278
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Immunoglobulin domain; cd00096
Immunoglobulin domain; cl11960
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin C-2 Type; smart00408
Thrombospondin type 1 repeats; smart00209
PLAC (protease and lacunin) domain; pfam08686
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
STOP protein; pfam05217
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B; cd11384
Gtr1/RagA G protein conserved region; pfam04670
Perilipin family; pfam03036
Domain always found upstream of DENN domain, found in a variety of signalling proteins; smart00800
DENN (AEX-3) domain; pfam02141
dDENN domain; pfam03455
Ribosomal protein S6e; cl00931
Ceramidase; pfam05875
Sodium/calcium exchanger protein; pfam01699
Sodium/calcium exchanger protein; pfam01699
Sodium/calcium exchanger protein; pfam01699
Sodium/calcium exchanger protein; pfam01699
YEATS family; pfam03366
Protein of unknown function (DUF3730); pfam12530
Protein of unknown function (DUF3730); pfam12530
Protein of unknown function (DUF3028); pfam11229
Protein tyrosine phosphatase-like protein, PTPLA; pfam04387
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Galactose oxidase, central domain; cl02701
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cl00092
Phosphorylase superfamily; cl00303
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; pfam07392
encodes the smARF isoform; PMID:16713577
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
DM DNA binding domain; pfam00751
DMRTA motif; pfam03474
ELAV/HuD family splicing factor; TIGR01661
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
ELAV/HuD family splicing factor; TIGR01661
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
ELAV/HuD family splicing factor; TIGR01661
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Trimeric dUTP diphosphatases; cl00493
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
PFU (PLAA family ubiquitin binding); pfam09070
PUL domain; pfam08324
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, common bacterial type; TIGR02168
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Tie-2 Ig-like domain 1; pfam10430
Laminin-type epidermal growth factor-like domai; smart00180
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Immunoglobulin like; smart00410
Fibronectin type III domain; pfam00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of the Protein Tyrosine Kinase, Tie2; cd05088
Protein kinase; unclassified specificity; smart00221
Mob1/phocein family; pfam03637
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; cl00092
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
aconitate hydratase-like protein; Provisional
Aconitase A catalytic domain; cd01586
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; cd01580
The Death Domain Superfamily of protein-protein interaction domains; cl14633
Caspase activation and recruitment domain found in RIG-I, second repeat; cd08817
ERCC4-like helicases [DNA replication, recombination, and repair]; COG1111
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
helical domain inserted in SF2-type helicase domain in Hef-, MDA5- and FancM-like proteins; cd12088
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
C-terminal domain of RIG-I; pfam11648
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit; pfam09782
NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit; pfam09782
NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit; pfam09782
TATA box-binding protein binding; pfam09247
Protein of unknown function (DUF3591); pfam12157
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to...; cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to...; cd05511
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cl00062
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are...; cd01278
DnaJ_C chaperone protein; Provisional
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
C-terminal substrate binding domain of DnaJ and HSP40; cl03262
Zinc finger domain of DnaJ and HSP40; cd10719
C-terminal substrate binding domain of DnaJ and HSP40; cd10747
Lissencephaly type-1-like homology motif; smart00667
C-terminal to LisH motif; smart00668
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; cd00899
Kazal type serine protease inhibitors; smart00280
Ubiquitin-like domain of BAG1; cd01812
Ubiquitin homologues; smart00213
BAG domains, present in regulator of Hsp70 proteins; smart00264
Ubiquitin-like domain of BAG1; cd01812
Ubiquitin homologues; smart00213
BAG domain; pfam02179
Snf7; cl02305
Snf7; cl02305
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown...; cd02643
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; cl00297
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cd00333
Nrap protein; pfam03813
Nrap protein; pfam03813
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Domain of unknown function (DUF3496); pfam12001
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin-associated protein 2; pfam12478
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
SAM domain of KIF24-like subfamily; cd09541
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain...; cd01367
Kinesin motor, catalytic domain. ATPase; smart00129
Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; cd03428
Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; cd03428
Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; cd03428
Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; cd03428
Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]
KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; cd06592
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Immunoglobulin C-2 Type; smart00408
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Immunoglobulin C-2 Type; smart00408
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Immunoglobulin C-2 Type; smart00408
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Alba; pfam01918
Alba; pfam01918
Dynactin subunit p22; pfam07426
Dynactin subunit p22; pfam07426
BRIGHT, ARID (A/T-rich interaction domain) domain; smart00501
ERG2 and Sigma1 receptor like protein; pfam04622
ERG2 and Sigma1 receptor like protein; pfam04622
galactose-1-phosphate uridylyltransferase; Provisional
Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; cd00608
Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; cd00608
Immunoglobulin like; smart00410
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided...; cl00134
Chemokine_CC_DCCL:  subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic...; cd01119
Chemokine_CC_DCCL:  subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic...; cd01119
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
C-terminal substrate binding domain of DnaJ and HSP40; cd10747
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
C-terminal substrate binding domain of DnaJ and HSP40; cd10747
chaperone protein DnaJ; Provisional
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
C-terminal substrate binding domain of DnaJ and HSP40; cd10747
AAA family ATPase, CDC48 subfamily; TIGR01243
Cell division protein 48 (CDC48), N-terminal domain; pfam02359
Cell division protein 48 (CDC48) domain 2; smart01072
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Vps4 C terminal oligomerisation domain; pfam09336
Uncharacterized proteins of the AP superfamily [General function prediction only]
Uncharacterized proteins of the AP superfamily [General function prediction only]
Uncharacterized proteins of the AP superfamily [General function prediction only]
Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; cd03403
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; COG0330
Domain of unknown function (DUF4210); pfam13915
Chromosome segregation during meiosis; pfam13889
C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins; cd08394
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins; cd04027
Domain of Unknown Function (DUF1041); pfam06292
Munc13 (mammalian uncoordinated) homology domain; pfam10540
C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins; cd08395
RUN domain; pfam02759
Src homology 3 domain of RUN and SH3 domain-containing protein 2; cd11957
RUN domain; pfam02759
Src homology 3 domain of RUN and SH3 domain-containing protein 2; cd11957
Protein of unknown function (DUF2475); pfam10629
Protein of unknown function (DUF2475); pfam10629
Protein of unknown function (DUF2475); pfam10629
Protein of unknown function (DUF2475); pfam10629
Protein kinase; unclassified specificity; smart00221
Catalytic domain of Protein Kinases; cd00180
DMPK coiled coil domain like; pfam08826
C-type lectin (CTL) or carbohydrate-recognition domain (CRD); smart00034
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology (PH) domain; cd00821
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; cd03150
Tropomyosin; pfam00261
Tropomyosin; pfam00261
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
Talin, middle domain; pfam09141
I/LWEQ domain; smart00307
Vinculin Binding Site; pfam08913
I/LWEQ domain; smart00307
I/LWEQ domain; pfam01608
basic region leucin zipper; smart00338
beta-Glucocerebrosidase 2 N terminal; pfam12215
Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]
Protein of unknown function, DUF608; pfam04685
Rgp1; pfam08737
Beta-microseminoprotein (PSP-94); pfam05825
Ligand-binding domain of type B natriuretic peptide receptor; cd06384
Receptor family ligand binding region; pfam01094
Protein Kinases, catalytic domain; cl09925
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; cd01276
Protein of unknown function (DUF3522); pfam12036
Protein of unknown function (DUF3522); pfam12036
Protein of unknown function (DUF3522); pfam12036
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Kazal-type serine protease inhibitor domain; pfam07648
SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; cd05382
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; smart00875
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam13964
Clathrin light chain; pfam01086
Clathrin light chain; pfam01086
Clathrin light chain; pfam01086
Clathrin light chain; pfam01086
Clathrin light chain; pfam01086
Clathrin light chain; pfam01086
UDP-N-acetylglucosamine 2-epimerase; pfam02350
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; cd03786
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; COG1940
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; cd03786
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; TIGR03568
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; COG1940
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; cd03786
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; TIGR03568
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cl17037
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; COG1940
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cl17037
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; cd03786
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; TIGR03568
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; COG1940
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; cd03786
UDP-N-acetylglucosamine 2-epimerase; pfam02350
Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; COG1940
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Kinase associated domain 1; pfam02149
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Kinase associated domain 1; pfam02149
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
Protein Kinases, catalytic domain; cl09925
Kinase associated domain 1; pfam02149
paired box DNA-binding motif
Paired Box domain; cd00131
Paired Box domain; smart00351
Paired-box protein 2 C terminal; pfam12403
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5082
Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; COG1052
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; pfam02826
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
A49-like RNA polymerase I associated factor; pfam06870
F-box-like; pfam12937
Right handed beta helix region; pfam13229
Right handed beta helix region; pfam13229
Right handed beta helix region; pfam13229
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
tRNA (Guanine-1)-methyltransferase; pfam01746
RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) [Translation, ribosomal structure and biogenesis]; COG1097
S1_Rrp40: Rrp40 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation...; cd05790
S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; cl09927
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Src homology 2 domain found in SH2 domain-containing adapter protein B (SHB); cd10389
aldehyde dehydrogenase family 2 member
NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like; cd07141
Kazal type serine protease inhibitors; smart00280
Immunoglobulin like; smart00410
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Domain of unknown function (DUF3496); pfam12001
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cl00085
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cl00085
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Putative GTPases (G3E family) [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Cobalamin synthesis protein cobW C-terminal domain; pfam07683
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Putative GTPases (G3E family) [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Cobalamin synthesis protein cobW C-terminal domain; pfam07683
Putative GTPases (G3E family) [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Cobalamin synthesis protein cobW C-terminal domain; pfam07683
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
phosphoglucomutase
The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; cl03757
Protein of unknown function (DUF3955); pfam13127
Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment  includes type II...; cd00139
Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment  includes type II...; cl02572
cAMP-dependent protein kinase catalytic subunit; Provisional
Catalytic domain of the Protein Serine/Threonine Kinase, cAMP-dependent protein kinase; cd05580
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; cl00238
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; cl00238
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2; cd12027
Guanylate kinase homologues; smart00072
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2; cd12027
Guanylate kinase homologues; smart00072
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2; cd12027
Guanylate kinase homologues; smart00072
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2; cd12027
Guanylate kinase homologues; smart00072
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2; cd12027
Guanylate kinase homologues; smart00072
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2; cd12027
Guanylate kinase homologues; smart00072
X11 Phosphotyrosine-binding (PTB) domain; cd01208
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein prenyltransferase alpha subunit repeat; pfam01239
Protein prenyltransferase alpha subunit repeat; pfam01239
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Eukaryotic SMC5 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains.  Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...; cd03277
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Eukaryotic SMC5 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains.  Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...; cd03277
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Ion transport protein; pfam00520
Ion transport protein; pfam00520
Ion transport protein; pfam00520
Ion transport protein; pfam00520
Ion transport protein; pfam00520
Ion transport protein; pfam00520
Ion transport protein; pfam00520
G8 domain; pfam10162
G8 domain; pfam10162
Alpha/beta hydrolase family; pfam12695
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Alpha/beta hydrolase family; pfam12695
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
Uncharacterized conserved protein (DUF2039); pfam10217
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; cd01303
guanine deaminase; TIGR02967
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; cd01303
guanine deaminase; TIGR02967
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; cd01303
Amidohydrolase; pfam13147
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; cd01303
Amidohydrolase; pfam13147
A20-like zinc finger; pfam01754
AN1-like Zinc finger; smart00154
A20-like zinc finger; pfam01754
AN1-like Zinc finger; smart00154
A20-like zinc finger; pfam01754
AN1-like Zinc finger; smart00154
TMC domain; pfam07810
NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like; cd07141
Aldehyde dehydrogenase family; pfam00171
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers; cd06968
The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily; cd06939
Ion transport protein; pfam00520
Alpha-kinase family; smart00811
Ion transport protein; pfam00520
Alpha-kinase family; smart00811
Ion transport protein; pfam00520
Alpha-kinase family; smart00811
N2227-like protein; pfam07942
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR...; cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR...; cd02024
AAA domain; pfam13238
Src Homology 3 domain of metazoan osteoclast stimulating factor 1; cd11772
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Peptidase S8 family domain in Protein convertases; cd04059
Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; COG1404
Proprotein convertase P-domain; pfam01483
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cl00066
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats; smart00261
Peptidase S8 family domain in Protein convertases; cd04059
Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; COG1404
Proprotein convertase P-domain; pfam01483
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
PLAC (protease and lacunin) domain; pfam08686
Riboflavin kinase; smart00904
Core-2/I-Branching enzyme; pfam02485
Core-2/I-Branching enzyme; pfam02485
Core-2/I-Branching enzyme; pfam02485
Core-2/I-Branching enzyme; pfam02485
Core-2/I-Branching enzyme; pfam02485
Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion]; COG1227
DHHA2 domain; pfam02833
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; pfam12496
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...; cd00170
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; COG5043
Protein of unknown function (DUF1162); pfam06650
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; COG5043
Protein of unknown function (DUF1162); pfam06650
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; COG5043
Protein of unknown function (DUF1162); pfam06650
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; COG5043
Protein of unknown function (DUF1162); pfam06650
G protein alpha subunit; smart00275
Alpha subunit of G proteins (guanine nucleotide binding); cd00066
G protein alpha subunit; smart00275
Alpha subunit of G proteins (guanine nucleotide binding); cd00066
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; cd00611
Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; COG0520
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl00321
Groucho/TLE N-terminal Q-rich domain; pfam03920
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Groucho/TLE N-terminal Q-rich domain; pfam03920
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); cd00154
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
Fushi tarazu (FTZ), N-terminal region; pfam03867
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
FERM N-terminal domain; pfam09379
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; cd02021
Gluconate kinase [Carbohydrate transport and metabolism]; COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; COG3265
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; cd02021
Ubiquitin family; pfam00240
Ubiquitin-like domain of hPLIC-1 and hPLIC2; cd01808
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin family; pfam00240
Ubiquitin-like domain of hPLIC-1 and hPLIC2; cd01808
XPC-binding domain; cl15287
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; cl17044
chromosome segregation protein SMC, common bacterial type; TIGR02168
Kinesin motor domain, KIF4-like subfamily. Members of this group seem to perform a variety of functions, and have been implicated in neuronal organelle transport and chromosome segregation during mitosis. This catalytic (head) domain has ATPase activity...; cd01372
Kinesin motor, catalytic domain. ATPase; smart00129
Protein of unknown function (DUF2419); pfam10343
ROKNT (NUC014) domain; pfam08067
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
ROKNT (NUC014) domain; pfam08067
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
ROKNT (NUC014) domain; pfam08067
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
Domain of unknown function (DUF1767); pfam08585
nucleoside transporter; TIGR00804
Na+ dependent nucleoside transporter N-terminus; pfam01773
Nucleoside recognition; pfam07670
Na+ dependent nucleoside transporter C-terminus; pfam07662
nucleoside transporter; TIGR00804
Na+ dependent nucleoside transporter N-terminus; pfam01773
Nucleoside recognition; pfam07670
Na+ dependent nucleoside transporter C-terminus; pfam07662
Leucine rich repeat N-terminal domain; pfam01462
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin; smart00409
Fifth domain (immunoglobulin-like) of Trk receptor TrkB; cd05855
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; cd05093
Protein tyrosine kinase; pfam07714
Leucine rich repeat N-terminal domain; pfam01462
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin; smart00409
Fifth domain (immunoglobulin-like) of Trk receptor TrkB; cd05855
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; cd05093
Protein tyrosine kinase; pfam07714
Leucine rich repeat N-terminal domain; pfam01462
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin like; smart00410
Fifth domain (immunoglobulin-like) of Trk receptor TrkB; cd05855
Leucine rich repeat N-terminal domain; pfam01462
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin like; smart00410
Fifth domain (immunoglobulin-like) of Trk receptor TrkB; cd05855
Leucine rich repeat N-terminal domain; pfam01462
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Immunoglobulin like; smart00410
Fifth domain (immunoglobulin-like) of Trk receptor TrkB; cd05855
Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; cd06906
Mak10 subunit, NatC N(alpha)-terminal acetyltransferase; pfam04112
GC-rich sequence DNA-binding factor-like protein; pfam07842
Iron-sulfur cluster assembly accessory protein
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Zinc knuckle; pfam00098
Zinc knuckle; pfam00098
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Zinc knuckle; pfam00098
Zinc knuckle; pfam00098
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Zinc knuckle; pfam00098
Zinc knuckle; pfam00098
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Death domain found in death-associated protein kinase 1; cd08782
cathepsin L protease; Provisional
Cathepsin propeptide inhibitor domain (I29); smart00848
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
cathepsin L protease; Provisional
Cathepsin propeptide inhibitor domain (I29); smart00848
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
cathepsin L protease; Provisional
Cathepsin propeptide inhibitor domain (I29); smart00848
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
cathepsin L protease; Provisional
Cathepsin propeptide inhibitor domain (I29); smart00848
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; cd07832
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; cd07832
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; cd07832
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
cyclin-dependent kinase A; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; cd07832
Spin/Ssty Family; pfam02513
Spin/Ssty Family; pfam02513
Spin/Ssty Family; pfam02513
Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are...; cd02964
Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are...; cd02964
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
SHC phosphotyrosine-binding (PTB) domain; cd01209
Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC); cd09925
Cyclin-dependent kinase regulatory subunit; pfam01111
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; pfam01248
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); cd11259
semaphorin domain; smart00630
domain found in Plexins, Semaphorins and Integrins; smart00423
Immunoglobulin domain; pfam13895
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); cd11259
semaphorin domain; smart00630
Plexin repeat; pfam01437
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D; cd05873
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; pfam01248
GTPase SAR1 and related small G proteins [General function prediction only]
A Ras homolog member I (ARHI); cd04140
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins; cd09938
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins; cd10401
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; cd05116
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins; cd09938
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins; cd10401
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; cd05116
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins; cd09938
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins; cd10401
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; cd05116
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins; cd09938
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins; cd10401
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; cd05116
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
enoyl-CoA hydratase
Basic region leucine zipper; pfam07716
Vertebrate interleukin-3 regulated transcription factor; pfam06529
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Cysteine-rich domain of tyrosine kinase-like orphan receptor 2; cd07468
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Protein Kinases, catalytic domain; cl09925
Protein tyrosine kinase; pfam07714
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl00321
7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; COG0156
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl00321
7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; COG0156
aminoacyl-tRNA ligase
catalytic core domain of isoleucyl-tRNA synthetases; cd00818
catalytic core domain of isoleucyl-tRNA synthetases; cd00818
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; cd07961
aminoacyl-tRNA ligase
catalytic core domain of isoleucyl-tRNA synthetases; cd00818
catalytic core domain of isoleucyl-tRNA synthetases; cd00818
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; cd07961
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Family description; pfam13096
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
von Willebrand factor type C domain; pfam00093
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
von Willebrand factor type C domain; pfam00093
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
von Willebrand factor type C domain; pfam00093
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Inositol-pentakisphosphate 2-kinase; pfam06090
Inositol-pentakisphosphate 2-kinase; pfam06090
Microtubule-associated protein Bicaudal-D; pfam09730
Microtubule-associated protein Bicaudal-D; pfam09730
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Pleckstrin homology domain; smart00233
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Pleckstrin homology domain; smart00233
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Ninjurin; pfam04923
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Oxidative-stress-responsive kinase 1 C terminal; pfam12202
PHD zinc finger; smart00249
A domain family that is part of the cupin metalloenzyme superfamily; smart00558
JmjC domain, hydroxylase; pfam02373
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; COG2453
Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; COG2453
Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; COG2453
Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; COG2453
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
NUT protein N terminus; pfam12881
NUT protein C terminal; pfam12882
NUT protein C terminal; pfam12882
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; cd00354
fructose-1,6-bisphosphatase family protein
Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; cd00354
fructose-1,6-bisphosphatase family protein
Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; cd00354
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase; cd09595
Leukotriene A4 hydrolase, C-terminal; pfam09127
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Leukotriene A4 hydrolase, C-terminal; pfam09127
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Fanconi anaemia group C protein; pfam02106
Fanconi anaemia group C protein; pfam02106
Fanconi anaemia group C protein; pfam02106
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
The Eukaryotic (Putative) Sterol Transporter (EST) Family; TIGR00918
Sterol-sensing domain of SREBP cleavage-activation; pfam12349
7TM receptor with intracellular HD hydrolase; pfam07698
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Short-chain dehydrogenases of various substrate specificities [General function prediction only]; COG0300
17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs; cd05356
Tpt phosphate/phosphoenolpyruvate translocator; TIGR00817
EamA-like transporter family; cl01037
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Hyaluronan / mRNA binding family; pfam04774
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; cd02970
AhpC/TSA antioxidant enzyme; pfam13911
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
NUT protein N terminus; pfam12881
NUT protein C terminal; pfam12882
NUT protein N terminus; pfam12881
NUT protein C terminal; pfam12882
NUT protein C terminal; pfam12882
Cathepsin propeptide inhibitor domain (I29); smart00848
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
Cathepsin propeptide inhibitor domain (I29); smart00848
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
The first LOTUS domain on Tudor-containing protein 7 (TDRD7); cd09986
The second LOTUS domain on Tudor-containing protein 7 (TDRD7); cd09973
The third LOTUS domain on Tudor-containing protein 7 (TDRD7); cd09974
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tropomodulin; pfam03250
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Tropomodulin; pfam03250
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
putative rhodanese-related sulfurtransferase; Provisional
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; cd01518
Middle domain of eukaryotic initiation factor 4G (eIF4G); smart00543
MIF4G like; pfam09088
MIF4G like; pfam09090
XPA protein N-terminal; pfam01286
DNA repair protein; TIGR00598
XPA protein C-terminus; pfam05181
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Escherichia coli YaeB and related proteins; cd09281
Leucine Rich repeats (2 copies); pfam12799
N-acetylneuraminate synthase; TIGR03569
NeuB family; pfam03102
C-terminal SAF domain of sialic acid synthetase; cd11615
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Domain of unknown function (DUF1899); pfam08953
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Domain of unknown function (DUF1900); pfam08954
Domain of unknown function (DUF1899); pfam08953
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Domain of unknown function (DUF1900); pfam08954
PARIS-1 pleckstrin homology (PH) domain; cd01265
Rab-GTPase-TBC domain; pfam00566
PARIS-1 pleckstrin homology (PH) domain; cd01265
Rab-GTPase-TBC domain; pfam00566
Rab-GTPase-TBC domain; pfam00566
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); cd06366
Receptor family ligand binding region; pfam01094
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
SAM domain of ANKS6 (or SamCystin) subfamily; cd09518
Sterile alpha motif; smart00454
Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; COG0463
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
Ricin-type beta-trefoil lectin domain; pfam00652
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
Thrombospondin N-terminal -like domains; smart00210
Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; cd00247
Activin types I and II receptor domain; pfam01064
Transforming growth factor beta type I GS-motif; pfam08515
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Activin types I and II receptor domain; pfam01064
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
This family is most closely related to the GT1 family of glycosyltransferases.  ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)...; cd03805
Glycosyltransferase [Cell envelope biogenesis, outer membrane]; COG0438
Sec61beta family; pfam03911
DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B; cd06969
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; cl11397
DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B; cd06969
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; cl11397
DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B; cd06969
Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; cd00193
PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by...; cd02996
PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed...; cd03070
Thioredoxin-like domain; pfam13848
PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif...; cd03072
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
Rix1 complex component involved in 60S ribosome maturation; pfam12333
Rix1 complex component involved in 60S ribosome maturation; pfam12333
Myb/SANT-like DNA-binding domain; pfam13873
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Myb/SANT-like DNA-binding domain; pfam13873
Myb/SANT-like DNA-binding domain; pfam13873
Myb/SANT-like DNA-binding domain; pfam13873
Myb/SANT-like DNA-binding domain; pfam13873
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the...; cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the...; cd03384
Acyl-CoA thioester hydrolase/BAAT N-terminal region; pfam04775
BAAT / Acyl-CoA thioester hydrolase C terminal; pfam08840
Acyl-CoA thioester hydrolase/BAAT N-terminal region; pfam04775
BAAT / Acyl-CoA thioester hydrolase C terminal; pfam08840
Ribosomal subunit 39S; pfam10501
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Fructose-1,6-bisphosphate aldolase; cd00948
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family; cd06377
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Eukaryotic SMC2 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains.  Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...; cd03273
RecF/RecN/SMC N terminal domain; pfam02463
SMC proteins Flexible Hinge Domain; smart00968
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Eukaryotic SMC2 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains.  Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...; cd03273
RecF/RecN/SMC N terminal domain; pfam02463
SMC proteins Flexible Hinge Domain; smart00968
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Eukaryotic SMC2 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains.  Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...; cd03273
RecF/RecN/SMC N terminal domain; pfam02463
SMC proteins Flexible Hinge Domain; smart00968
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Eukaryotic SMC2 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains.  Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...; cd03273
RecF/RecN/SMC N terminal domain; pfam02463
SMC proteins Flexible Hinge Domain; smart00968
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
NIPSNAP; pfam07978
NIPSNAP; pfam07978
NIPSNAP; pfam07978
NIPSNAP; pfam07978
retinal-specific rim ABC transporter; TIGR01257
The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; cd03263
The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; cd03263
Plasma-membrane choline transporter; pfam04515
B-Box C-terminal domain; smart00502
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Domain in SPla and the RYanodine Receptor; smart00449
B-Box C-terminal domain; smart00502
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Domain in SPla and the RYanodine Receptor; smart00449
B-Box C-terminal domain; smart00502
LicD family; pfam04991
LicD family; pfam04991
LicD family; pfam04991
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
TRIC channel; pfam05197
Ubiquitin-like domain of RAD23; cd01805
Ubiquitin homologues; smart00213
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
XPC-binding domain; pfam09280
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin-like proteins; cl00155
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
XPC-binding domain; pfam09280
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
UV excision repair protein Rad23; TIGR00601
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
XPC-binding domain; pfam09280
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Actin; pfam00022
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cl17037
Actin; pfam00022
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
IKI3 family; pfam04762
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; cl11404
Vinculin family; pfam01044
Predicted permease, member of the PurR regulon [General function prediction only]; COG0628
DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins; cd09628
DOMON domain; pfam03351
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
FERM C-terminal PH-like domain; pfam09380
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
FERM C-terminal PH-like domain; pfam09380
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
Paralemmin; pfam03285
Paralemmin; pfam03285
TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; cd02947
TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; cd02947
TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; cd02947
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cd01450
GCC2 and GCC3; pfam07699
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
HYR domain; pfam02494
HYR domain; pfam02494
GCC2 and GCC3; pfam07699
GCC2 and GCC3; pfam07699
GCC2 and GCC3; pfam07699
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
secreted complement-binding protein; Provisional
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin domain; cd00096
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain; cl02447
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; cd05050
Protein tyrosine kinase; pfam07714
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin domain; cd00096
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain; cl02447
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; cd05050
Protein tyrosine kinase; pfam07714
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin domain; cd00096
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain; cl02447
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; cd05050
Protein tyrosine kinase; pfam07714
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Proteasome stabiliser; pfam13001
SCAN oligomerization domain; cd07936
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
SCAN oligomerization domain; cd07936
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity; cd08294
leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase; TIGR02825
13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity; cd08294
leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase; TIGR02825
13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity; cd08294
leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase; TIGR02825
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors; cd00068
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors; cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors; cd00068
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; cd02520
Glycosyl transferase family 21; pfam13506
EGF domain; pfam12947
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
hnRNP-L/PTB/hephaestus splicing factor family; TIGR01649
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
hnRNP-L/PTB/hephaestus splicing factor family; TIGR01649
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
hnRNP-L/PTB/hephaestus splicing factor family; TIGR01649
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
hnRNP-L/PTB/hephaestus splicing factor family; TIGR01649
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
hnRNP-L/PTB/hephaestus splicing factor family; TIGR01649
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
hnRNP-L/PTB/hephaestus splicing factor family; TIGR01649
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
short chain dehydrogenase; Provisional
human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; cd09762
SCP-2 sterol transfer family; pfam02036
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
SCP-2 sterol transfer family; pfam02036
Domain of unknown function (DUF3504); pfam12012
The phosphoinositide binding Phox Homology domain of Sorting Nexin 30; cd07283
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 30; cd07667
Major Facilitator Superfamily; pfam07690
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Ctr copper transporter family; pfam04145
Pleckstrin homology-like domain; cl00273
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
Tropomyosin like; pfam12718
Growth-arrest specific micro-tubule binding; pfam13851
Ctr copper transporter family; pfam04145
Anaphase-promoting complex APC subunit 1; pfam10471
Splicing Factor Motif, present in Prp18 and Pr04; smart00500
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Splicing Factor Motif, present in Prp18 and Pr04; smart00500
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Ring finger domain; pfam13639
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Predicted hydrolase (HAD superfamily) [General function prediction only]
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; cd04824
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cl00074
C2 domain of the Regulator Of G-Protein Signaling (RGS) family; cd08685
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; cd08713
C2 domain of the Regulator Of G-Protein Signaling (RGS) family; cd08685
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; cd08713
C2H2-type zinc finger; pfam13912
Lipocalin / cytosolic fatty-acid binding protein family; cl01150
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; cd00109
Kinesin motor, catalytic domain. ATPase; smart00129
Kinesin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In...; cd00106
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Fibrillar collagen C-terminal domain; cl02436
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
AT-hook-containing transcription factor; pfam12443
First harmonin_N_like domain (repeat 1) of the long isoform of whirlin, and related domains; cd07356
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains; cd07357
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
First harmonin_N_like domain (repeat 1) of the long isoform of whirlin, and related domains; cd07356
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains; cd07357
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains; cd07357
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
vacuolar ATP synthase, subunit G; TIGR01147
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type III domain; pfam00041
Fibronectin type III domain; pfam00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
LamG-like jellyroll fold domain; smart00560
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; cd04275
Myxococcus cysteine-rich repeat; TIGR02232
Domain of unknown function (DUF4215); pfam13948
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Domain found in Notch and Lin-12; smart00004
MAC/Perforin domain; cl02616
MAC/Perforin domain; cl02616
MAC/Perforin domain; cl02616
membrane-attack complex / perforin; smart00457
MAC/Perforin domain; cl02616
MAC/Perforin domain; cl02616
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
TIR domain; pfam01582
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
TIR domain; pfam01582
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
TIR domain; pfam01582
membrane-attack complex / perforin; smart00457
Microtubule associated; pfam07989
Protein-interacting V-domain of mammalian Alix and related domains; cl14654
Microtubule associated; pfam07989
Protein-interacting V-domain of mammalian Alix and related domains; cl14654
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
F-box domain; cl02535
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
Proteasome non-ATPase 26S subunit; pfam10508
Proteasome non-ATPase 26S subunit; pfam10508
Tudor domain; smart00333
PHD-finger; pfam00628
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
Polycomb-like MTF2 factor 2; pfam14061
Tudor domain; smart00333
PHD-finger; pfam00628
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of...; cd03779
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of...; cd03779
Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of...; cd03779
Alpha-2-macroglobulin MG1 domain; pfam11974
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to...; cd00017
Alpha-2-macroglobulin family; pfam00207
Proteins similar to C3, C4 and C5 of vertebrate complement.  The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the...; cd02896
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
NTR/C345C domain, complement C5 subfamily; The NTR domain found in complement C5 is also known as C345C because it occurs at the C-terminus of complement C3, C4 and C5. Complement C5 is activated by C5 convertase, which itself is a complex between C3b...; cd03582
Leucine Rich repeats (2 copies); pfam12799
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Rab family protein; Provisional
Rab GTPase family 14 (Rab14); cd04122
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; cd11290
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; cd11289
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; cd11292
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; cd11293
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; cd11288
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; cd11291
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; COG0330
Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; cd03403
The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; cl02525
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; COG0330
Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; cd03403
Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; COG0330
Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; cd03403
RAS GTPase-activating protein (GAP) CG5898 Pleckstrin homology (PH) domain; cd01245
C2 domain present in Ras GTPase activating protein (GAP) family; cd04013
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP; also known as ASK-interacting protein 1 (AIP1)), is a member of the GTPase-activating proteins, down-regulates Ras-mediated...; cd05136
Domain of unknown function (DUF3498); pfam12004
Pleckstrin homology-like domain; cl00273
C2 domain present in Ras GTPase activating protein (GAP) family; cd04013
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP; also known as ASK-interacting protein 1 (AIP1)), is a member of the GTPase-activating proteins, down-regulates Ras-mediated...; cd05136
Domain of unknown function (DUF3498); pfam12004
ATP-grasp domain; cl03087
ATP-grasp domain; cl03087
CHCH domain; pfam06747
MORN repeat; cl14787
The first LIM domain of Lhx6; cd09380
The second LIM domain of Lhx6; cd09382
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
The first LIM domain of Lhx6; cd09380
The second LIM domain of Lhx6; cd09382
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
The first LIM domain of Lhx6; cd09380
The second LIM domain of Lhx6; cd09382
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
The first LIM domain of Lhx6; cd09380
The second LIM domain of Lhx6; cd09382
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
ribosome recycling factor; Reviewed; PRK00083
Ribosome recycling factor; pfam01765
Ribosome recycling factor; pfam01765
Ribosome recycling factor; pfam01765
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes...; cd02987
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger C-x8-C-x5-C-x3-H type (and similar); pfam00642
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger C-x8-C-x5-C-x3-H type (and similar); pfam00642
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Pleckstrin homology-like domain; cl00273
Kinesin protein; pfam12473
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
7 transmembrane receptor (rhodopsin family); pfam00001
domain in DSRM or ZnF_C2H2 domain containing proteins; smart00572
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
domain in DSRM or ZnF_C2H2 domain containing proteins; smart00572
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Domain always found upstream of DENN domain, found in a variety of signalling proteins; smart00800
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; smart00799
dDENN domain; pfam03455
Domain always found upstream of DENN domain, found in a variety of signalling proteins; smart00800
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; smart00799
dDENN domain; pfam03455
The first LIM domain of Lhx2; cd09469
The second LIM domain of Lhx2 and Lhx9 family; cd09377
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; cd08224
Serine/Threonine protein kinases, catalytic domain; smart00220
20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; COG0638
proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03763
Proteasome beta subunits C terminal; pfam12465
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; cd00037
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers; cd07167
The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily; cd07070
DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers; cd07169
The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; cd06953
DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers; cd07169
The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; cd06953
Olfactomedin-like domain; pfam02191
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; cl09943
ARP2/3 complex 16 kDa subunit (p16-Arc); pfam04699
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
golgin-97, RanBP2alpha,Imh1p and p230/golgin-245; smart00755
Protein of unknown function (DUF3550/UPF0682); pfam12070
Protein of unknown function (DUF3550/UPF0682); pfam12070
serine/threonine protein phosphatase 2A; Provisional
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415
serine/threonine protein phosphatase 2A; Provisional
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415
serine/threonine protein phosphatase 2A; Provisional
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam01344
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam01344
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam01344
Galactose oxidase, central domain; cl02701
Nucleotide-binding domain of human HSPA5 and similar proteins; cd10241
Hsp70 protein; pfam00012
Rab5-activating protein 6 (RAP6) is an endosomal protein with a role in the regulation of receptor-mediated endocytosis. RAP6 contains a Vps9 domain, which is involved in the activation of Rab5, and a Ras GAP domain (RGD). Rab5 is a small GTPase required...; cd05129
Vacuolar sorting protein 9 (VPS9) domain; pfam02204
Stress-activated map kinase interacting protein 1 (SIN1); pfam05422
Stress-activated map kinase interacting protein 1 (SIN1); pfam05422
Stress-activated map kinase interacting protein 1 (SIN1); pfam05422
Stress-activated map kinase interacting protein 1 (SIN1); pfam05422
Stress-activated map kinase interacting protein 1 (SIN1); pfam05422
Stress-activated map kinase interacting protein 1 (SIN1); pfam05422
PBC domain; pfam03792
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
PBC domain; pfam03792
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Protein of unknown function (DUF2464); pfam10240
Protein of unknown function (DUF2464); pfam10240
The first LIM domain of Lmx1b; cd09371
The second LIM domain of Lmx1a and Lmx1b; cd09378
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
The first LIM domain of Lmx1b; cd09371
The second LIM domain of Lmx1a and Lmx1b; cd09378
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
The first LIM domain of Lmx1b; cd09371
The second LIM domain of Lmx1a and Lmx1b; cd09378
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Pleckstrin homology (PH) domain; cd00821
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Pleckstrin homology (PH) domain; cd00821
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Pleckstrin homology (PH) domain; cd00821
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Rap/ran-GAP; pfam02145
CNH domain; pfam00780
Sugar (and other) transporter; pfam00083
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
60S ribosomal protein L12; Provisional
Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; cd00349
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
SAM domain of TAL subfamily; cd09523
Zinc finger, C3HC4 type (RING finger); pfam13920
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
SAM domain of TAL subfamily; cd09523
Zinc finger, C3HC4 type (RING finger); pfam13920
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
SAM domain of TAL subfamily; cd09523
Zinc finger, C3HC4 type (RING finger); pfam13920
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
SAM domain of TAL subfamily; cd09523
Zinc finger, C3HC4 type (RING finger); pfam13920
Sec1 family; pfam00995
Sec1 family; pfam00995
chromosome segregation protein SMC, common bacterial type; TIGR02168
Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; cd00462
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13432
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ATPases associated with a variety of cellular activities; smart00382
ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; COG0542
ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; COG0542
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3; cd10337
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3; cd10337
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3; cd10337
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3; cd10337
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3; cd10337
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cl02485
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; cd07865
Serine/Threonine protein kinases, catalytic domain; smart00220
tetrahydrofolylpolyglutamate synthase
Mur ligase family, glutamate ligase domain; pfam02875
tetrahydrofolylpolyglutamate synthase
Mur ligase family, glutamate ligase domain; pfam02875
Zona pellucida-like domain; pfam00100
Zona pellucida-like domain; pfam00100
adenylate kinase, isozyme 1 subfamily; TIGR01360
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Phosphatidylinositol-4-phosphate 5-Kinase; pfam01504
Phosphatidylinositol-4-phosphate 5-Kinase; pfam01504
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2); pfam07297
N-terminal C2 in EEIG1 and EHBP1 proteins; pfam10358
Myb/SANT-like DNA-binding domain; pfam13873
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
calmodulin; Provisional
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; COG0625
GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal...; cd03040
C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2; cd03197
C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2; cd03197
C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2; cd03197
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Uncharacterized protein family (UPF0184); pfam03670
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Zinc-finger double-stranded RNA-binding; cl09952
Zinc-finger double-stranded RNA-binding; pfam12171
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin central region; pfam01031
Dynamin pleckstrin homology (PH) domain; cd01256
Dynamin GTPase effector domain; pfam02212
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin central region; pfam01031
Dynamin pleckstrin homology (PH) domain; cd01256
Dynamin GTPase effector domain; pfam02212
chromosome segregation protein SMC, common bacterial type; TIGR02168
Swi5; pfam07061
Pseudouridine synthase, humanTRUB2_like; cd02868
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; pfam05019
long-chain-acyl-CoA synthetase; Validated
AMP-binding enzyme; pfam00501
Urm1-like ubuitin domain; cd01764
Urm1 (Ubiquitin related modifier); pfam09138
Ubiquitin-like proteins; cl00155
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; cd06532
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Intermediate filament protein; pfam00038
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Intermediate filament protein; pfam00038
Intermediate filament protein; pfam00038
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Intermediate filament protein; pfam00038
chromosome segregation protein SMC, common bacterial type; TIGR02168
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
GLE1-like protein; pfam07817
GLE1-like protein; pfam07817
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeat; pfam00435
Src homology 3 domain of Alpha Spectrin; cd11808
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeat; pfam00435
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Ca2+ insensitive EF hand; pfam08726
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeat; pfam00435
Src homology 3 domain of Alpha Spectrin; cd11808
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeat; pfam00435
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Ca2+ insensitive EF hand; pfam08726
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176