7 transmembrane receptor (rhodopsin family); pfam00001
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Protein of unknown function (DUF2920); pfam11144
alpha/beta hydrolase fold; pfam07859
alpha/beta hydrolase fold; pfam07859
alpha/beta hydrolase fold; pfam07859
alpha/beta hydrolase fold; pfam07859
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
BRCA1 C Terminus (BRCT) domain; pfam00533
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Epithelial cell transforming 2 (ECT2) pleckstrin homology (PH) domain; cd01229
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
BRCA1 C Terminus (BRCT) domain; pfam00533
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Epithelial cell transforming 2 (ECT2) pleckstrin homology (PH) domain; cd01229
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
BRCA1 C Terminus (BRCT) domain; pfam00533
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Epithelial cell transforming 2 (ECT2) pleckstrin homology (PH) domain; cd01229
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
Carboxylesterase family; pfam00135
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
PA_hNAALADL2_like: Protease-associated domain containing proteins like human N-acetylated alpha-linked acidic dipeptidase-like 2 protein (hNAALADL2). This group contains various PA domain-containing proteins similar to hNAALADL2. The function of...; cd02131
Zinc peptidases M18, M20, M28, and M42; cl14876
LisH; pfam08513
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Eukaryotic translation initiation factor eIF2A; pfam08662
KCNMB2, ball and chain domain; pfam09303
Calcium-activated potassium channel, beta subunit; pfam03185
KCNMB2, ball and chain domain; pfam09303
Calcium-activated potassium channel, beta subunit; pfam03185
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
PI3-kinase family, p85-binding domain; smart00143
PI3-kinase family, ras-binding domain; pfam00794
C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks); cd08398
Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872
Phosphoinositide 3-kinase (PI3K), class IA, alpha isoform, catalytic domain; The PI3K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; cd05175
Phosphoinositide 3-kinase, catalytic domain; smart00146
Calcium-activated potassium channel, beta subunit; pfam03185
Calcium-activated potassium channel, beta subunit; pfam03185
Calcium-activated potassium channel, beta subunit; pfam03185
Calcium-activated potassium channel, beta subunit; pfam03185
Calcium-activated potassium channel, beta subunit; pfam03185
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; cd09912
Dynamin family; pfam00350
fzo-like conserved region; pfam04799
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Actin; pfam00022
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Actin; smart00268
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Actin; smart00268
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Mitochondrial 39-S ribosomal protein L47 (MRP-L47); pfam06984
Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; cl09943
NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit; pfam09781
NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit; pfam09781
NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit; pfam09781
Isopeptidase T [Posttranslational modification, protein turnover, chaperones]; COG5207
Zn-finger in ubiquitin-hydrolases and other protein; pfam02148
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02658
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Ribosomal protein S1-like RNA-binding domain; smart00316
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Ribosomal protein S1-like RNA-binding domain; smart00316
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Agenet domain; pfam05641
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Fragile X-related 1 protein C terminal; pfam12235
Agenet domain; pfam05641
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Fragile X-related 1 protein C terminal; pfam12235
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Fragile X-related 1 protein C terminal; pfam12235
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
SOX transcription factor; pfam12336
phospholipid-translocating P-type ATPase, flippase; TIGR01652
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
Haloacid Dehalogenase-like Hydrolases; cl11391
Cullin binding; pfam03556
Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]
Carbamoyl-phosphate synthase L chain, N-terminal domain; pfam00289
ATP-grasp domain; cl03087
Biotin carboxylase C-terminal domain; smart00878
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; cd06850
Lysosome-associated membrane glycoprotein (Lamp); pfam01299
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...; cd00170
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Dbs (DBL's big sister) pleckstrin homology (PH) domain; cd01227
Galactosyltransferase; cl09537
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
Kelch domain; smart00612
Transcription initiation factor IIF, auxiliary subunit [Transcription]; COG5033
YEATS family; pfam03366
STOP protein; pfam05217
Rhomboid family; pfam01694
Rhomboid family; pfam01694
ABC transporter transmembrane region; cl00549
ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; COG0410
Domain 1 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminas, but the function of these additional...; cd03250
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
ABC transporter transmembrane region; pfam00664
Domain 2 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional...; cd03244
ABC transporter C family member; Provisional
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; COG1208
The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2; cd04197
eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...; cd05787
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; cd11558
Domain present in Dishevelled and axin; smart00021
Dishevelled specific domain; pfam02377
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins.  Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway...; cd04438
Segment polarity protein dishevelled (Dsh) C terminal; pfam12316
Clathrin adaptor complex small chain; cl02092
Adaptor complexes medium subunit family; pfam00928
C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2; cd09251
Clathrin adaptor complex small chain; cl02092
Adaptor complexes medium subunit family; pfam00928
C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2; cd09251
ABC transporter F family; Provisional
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ABC transporter; pfam12848
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
Vault protein inter-alpha-trypsin domain; pfam13757
von Willebrand factor type A domain; pfam13768
ALG3 protein; pfam05208
ALG3 protein; pfam05208
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; COG3590
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; cd08662
Methyltransferase domain; pfam13847
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; COG3590
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; cd08662
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; COG3590
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; cd08662
Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; COG3590
Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; cd08662
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]; COG5110
Proteasome/cyclosome repeat; pfam01851
Proteasome/cyclosome repeat; pfam01851
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
MIF4G domain; pfam02854
MA3 domain; pfam02847
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; cd11559
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...; cd03683
Voltage gated chloride channel; pfam00654
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...; cd03683
Voltage gated chloride channel; pfam00654
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...; cd03683
Voltage gated chloride channel; pfam00654
ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is...; cd03683
Voltage gated chloride channel; pfam00654
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
RNA polymerase Rpb8; pfam03870
Erythropoietin/thrombopoietin; pfam00758
Erythropoietin/thrombopoietin; pfam00758
Erythropoietin/thrombopoietin; pfam00758
von Willebrand factor type C domain; cl02515
A domain in the BMP inhibitor chordin and in microbial proteins; smart00754
A domain in the BMP inhibitor chordin and in microbial proteins; smart00754
A domain in the BMP inhibitor chordin and in microbial proteins; smart00754
A domain in the BMP inhibitor chordin and in microbial proteins; smart00754
von Willebrand factor (vWF) type C domain; smart00214
von Willebrand factor type C domain; cl02515
Ligand Binding Domain of Ephrin type-B Receptor 3; cd10478
GCC2 and GCC3; pfam07699
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; cd05065
Protein tyrosine kinase; pfam07714
SAM domain of EPH-B3 subfamily of tyrosine kinase receptors; cd09553
SAM domain (Sterile alpha motif); pfam07647
MAGE family; pfam01454
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Golgi CORVET complex core vacuolar protein 8; pfam12816
Ring finger domain; pfam13639
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Golgi CORVET complex core vacuolar protein 8; pfam12816
Ring finger domain; pfam13639
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
multifunctional fatty acid oxidation complex subunit alpha; Reviewed; PRK11154
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; pfam02737
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; pfam00725
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; COG1250
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; pfam02737
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; pfam00725
Protein Kinases, catalytic domain; cl09925
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Tyrosine Kinases; cd00192
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Tyrosine Kinases; cd00192
SNARE associated Golgi protein; pfam09335
Pancreatic lipase-like enzymes.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the...; cd00707
Ulp1 protease family, C-terminal catalytic domain; pfam02902
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are...; cd02396
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
PEA3 subfamily ETS-domain transcription factor N terminal domain; pfam04621
erythroblast transformation specific domain; smart00413
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; COG1597
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain (presumed); smart00045
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); smart00109
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain (presumed); smart00045
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); smart00109
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; COG1597
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain (presumed); smart00045
Beta/gamma crystallins; smart00247
Beta/Gamma crystallin; pfam00030
Tubulin binding cofactor C; pfam07986
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product; smart00673
Tubulin binding cofactor C; pfam07986
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product; smart00673
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
C-terminal substrate binding domain of DnaJ and HSP40; cd10747
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; cd00042
helicase 45; Provisional
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
replication factor C small subunit; Reviewed; PRK00440
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Replication factor C C-terminal domain; pfam08542
replication factor C small subunit; Reviewed; PRK00440
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Replication factor C C-terminal domain; pfam08542
Collagen triple helix repeat (20 copies); pfam01391
Complement component C1q domain; smart00110
Collagen triple helix repeat (20 copies); pfam01391
Complement component C1q domain; smart00110
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Ribosomal L39 protein; pfam00832
Zinc-binding domain; pfam13695
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Zinc-binding domain; pfam13695
Somatostatin/Cortistatin family; pfam03002
Zinc-binding domain; pfam13695
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09350
The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09356
The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09436
The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09350
The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09356
The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09436
The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09350
The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6); cd09356
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
Inositol phosphatase; pfam12456
P53 DNA-binding domain; cd08367
P53 tetramerisation motif; pfam07710
SAM domain (Sterile alpha motif); pfam07647
SAM domain of tumor-p63 proteins; cd09572
P53 DNA-binding domain; cd08367
P53 tetramerisation motif; pfam07710
P53 DNA-binding domain; cd08367
P53 tetramerisation motif; pfam07710
P53 DNA-binding domain; cd08367
P53 tetramerisation motif; pfam07710
SAM domain (Sterile alpha motif); pfam07647
SAM domain of tumor-p63 proteins; cd09572
P53 DNA-binding domain; cd08367
P53 tetramerisation motif; pfam07710
P53 DNA-binding domain; cd08367
P53 tetramerisation motif; pfam07710
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam13640
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam13640
PMP-22/EMP/MP20/Claudin family; cl15797
PMP-22/EMP/MP20/Claudin family; cl15797
IL-beta-binding protein; Provisional
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
Toll - interleukin 1 - resistance; smart00255
IL-beta-binding protein; Provisional
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
TIR domain; pfam01582
IL-beta-binding protein; Provisional
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
TIR domain; pfam01582
IL-beta-binding protein; Provisional
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
TIR domain; pfam01582
IL-1 receptor-like protein; Provisional
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
IL-1 receptor-like protein; Provisional
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
FIP domain; pfam09457
Insulin-resistance promoting peptide in skeletal muscle; pfam11037
Pyrin death domain found in NALP proteins; cd08320
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Mab-21 protein; pfam03281
Lecithin retinol acyltransferase; pfam04970
P5-type ATPase cation transporter; pfam12409
P-type ATPase of unknown pump specificity (type V); TIGR01657
Cation transporter/ATPase, N-terminus; pfam00690
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
Haloacid Dehalogenase-like Hydrolases; cl11391
P5-type ATPase cation transporter; pfam12409
P-type ATPase of unknown pump specificity (type V); TIGR01657
Cation transporter/ATPase, N-terminus; smart00831
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
Haloacid Dehalogenase-like Hydrolases; cl11391
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Dynamin_like protein family includes dynamins and Mx proteins; cd08771
Dynamin family; pfam00350
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Hairy Orange; pfam07527
Leucine rich repeat N-terminal domain; smart00013
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
P5-type ATPase cation transporter; pfam12409
P-type ATPase of unknown pump specificity (type V); TIGR01657
Cation transporter/ATPase, N-terminus; cl02930
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
Haloacid Dehalogenase-like Hydrolases; cl11391
A circularly permuted subfamily of the Ras GTPases; cd01857
Predicted GTPases [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
A circularly permuted subfamily of the Ras GTPases; cd01857
Pleckstrin homology-like domain; cl00273
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2; cd07638
Centaurin Pleckstrin homology (PH) domain; cd01250
Putative GTP-ase activating proteins for the small GTPase, ARF; smart00105
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Protein phosphatase inhibitor 2 (IPP-2); pfam04979
Lipocalin / cytosolic fatty-acid binding protein family; cl01150
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; smart00539
AMOP domain; pfam03782
von Willebrand factor (vWF) type D domain; smart00216
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; smart00539
AMOP domain; pfam03782
von Willebrand factor (vWF) type D domain; smart00216
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; smart00539
AMOP domain; pfam03782
von Willebrand factor (vWF) type D domain; smart00216
SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases; cd09539
Protein kinase; unclassified specificity; smart00221
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; cd05040
Src homology 3 domains; smart00326
GTPase binding; pfam09027
EGFR receptor inhibitor Mig-6; pfam11555
SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases; cd09539
Protein kinase; unclassified specificity; smart00221
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; cd05040
Src homology 3 domains; smart00326
GTPase binding; pfam09027
EGFR receptor inhibitor Mig-6; pfam11555
Zinc peptidases M18, M20, M28, and M42; cl14876
Predicted aminopeptidases [General function prediction only]; COG2234
PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28...; cd02128
M28 Zn-peptidase Transferrin Receptor family; cd09848
Transferrin receptor-like dimerisation domain; pfam04253
Zinc peptidases M18, M20, M28, and M42; cl14876
Predicted aminopeptidases [General function prediction only]; COG2234
PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28...; cd02128
M28 Zn-peptidase Transferrin Receptor family; cd09848
Transferrin receptor-like dimerisation domain; pfam04253
DHHC palmitoyltransferase; pfam01529
Organic solute transporter Ostalpha; pfam03619
CTP:phosphocholine cytidylyltransferase; cd02174
Cytidylyltransferase; pfam01467
Tctex-1 family; pfam03645
L6 membrane protein; pfam05805
L6 membrane protein; pfam05805
L6 membrane protein; pfam05805
UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain; cd02958
Faf1 ike-1 UBX domain; cd01773
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
F-box-like; pfam12937
Domain in SPla and the RYanodine Receptor; smart00449
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Phosphoenolpyruvate carboxylase [Energy production and conversion]; COG2352
PIG-X / PBN1; pfam08320
PIG-X / PBN1; pfam08320
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; cd01093
Catalytic domain of the Protein Serine/Threonine Kinase, Group I p21-activated kinase; cd06647
Serine/Threonine protein kinases, catalytic domain; smart00220
Ulp1 protease family, C-terminal catalytic domain; pfam02902
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Dolichyl-phosphate-mannose-protein mannosyltransferase; cl15769
Transferrin; pfam00405
Transferrin; smart00094
Transferrin; cl02460
L27_1; pfam09058
Polyubiquitination (PEST) N-terminal domain of MAGUK; pfam10608
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ-associated domain of NMDA receptors; pfam10600
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain of Disks Large homolog 1; cd12031
Guanylate kinase; pfam00625
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
L27_1; pfam09058
Polyubiquitination (PEST) N-terminal domain of MAGUK; pfam10608
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ-associated domain of NMDA receptors; pfam10600
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain of Disks Large homolog 1; cd12031
Guanylate kinase; pfam00625
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
L27_1; pfam09058
Polyubiquitination (PEST) N-terminal domain of MAGUK; pfam10608
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ-associated domain of NMDA receptors; pfam10600
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain of Disks Large homolog 1; cd12031
Guanylate kinase; pfam00625
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ-associated domain of NMDA receptors; pfam10600
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain of Disks Large homolog 1; cd12031
Guanylate kinase; pfam00625
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ-associated domain of NMDA receptors; pfam10600
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Src Homology 3 domain of Disks Large homolog 1; cd12031
Guanylate kinase; pfam00625
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; cd00071
human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs; cd09805
3-hydroxybutyrate dehydrogenase; TIGR01963
human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs; cd09805
3-hydroxybutyrate dehydrogenase; TIGR01963
human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs; cd09805
3-hydroxybutyrate dehydrogenase; TIGR01963
domain involved in Ras-like GTPase signaling; smart00593
Domain of unknown function (DUF4206); pfam13901
domain involved in Ras-like GTPase signaling; smart00593
Domain of unknown function (DUF4206); pfam13901
Forty-two-three protein; pfam07078
Forty-two-three protein; pfam07078
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Calponin homology domain; smart00033
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Ribosomal protein L35Ae; pfam01247
Leishmanolysin; cl03222
Leishmanolysin; cl03222
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
GAF domain; pfam13185
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
GAF domain; pfam13185
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
GAF domain; pfam13185
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
GAF domain; pfam13185
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
GAF domain; pfam13185
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
ATP synthase E chain; pfam05680
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Synaphin protein; pfam05835
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
C2 domain of PTEN tumour-suppressor protein; pfam10409
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Protein of unknown function (DUF1211); pfam06736
Protein of unknown function (DUF1211); pfam06736
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Ubiquitin-like domain of Diacylgylcerol kinase (DAGK); cd01783
Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; COG1597
Diacylglycerol kinase catalytic domain (presumed); smart00046
Diacylglycerol kinase accessory domain; cl02440
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Glycosyl hydrolases family 2, TIM barrel domain; cl15381
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); cd05856
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); cd05856
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); cd05856
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Spondin_N; pfam06468
Thrombospondin type 1 repeats; smart00209
Spondin_N; pfam06468
Thrombospondin type 1 repeats; smart00209
Spondin_N; pfam06468
Thrombospondin type 1 repeats; smart00209
Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; COG1052
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; pfam02826
Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; COG1052
D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; pfam02826
Lissencephaly type-1-like homology motif; smart00667
CTLH/CRA C-terminal to LisH motif domain; pfam10607
C-terminal to LisH motif; smart00668
CT11-RanBPM; smart00757
RING-type zinc-finger, LisH dimerisation motif; pfam13445
C-terminal to LisH motif; smart00668
CTLH/CRA C-terminal to LisH motif domain; pfam10607
CT11-RanBPM; smart00757
RING-type zinc-finger, LisH dimerisation motif; pfam13445
Uncharacterized conserved protein (DUF2043); pfam09740
Putative transmembrane protein precursor; pfam10272
Putative transmembrane protein precursor; pfam10272
Transforming acidic coiled-coil-containing protein (TACC); pfam05010
Immunoglobulin C-2 Type; smart00408
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04974
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; cd05100
Protein tyrosine kinase; pfam07714
Immunoglobulin C-2 Type; smart00408
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; cd05100
Protein tyrosine kinase; pfam07714
Immunoglobulin C-2 Type; smart00408
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; cd05857
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); cd04974
Protein Kinases, catalytic domain; cl09925
Protein tyrosine kinase; pfam07714
LETM1-like protein; pfam07766
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
PHD-finger; pfam00628
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
Proteins containing SET domain [General function prediction only]
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
PHD-finger; pfam00628
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
Proteins containing SET domain [General function prediction only]
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
PHD-finger; pfam00628
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
Proteins containing SET domain [General function prediction only]
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
PHD-finger; pfam00628
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
Proteins containing SET domain [General function prediction only]
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; cd04301
DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; cl10012
DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation; cd08638
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
TSG101 and ALIX binding domain of CEP55; pfam12180
TSG101 and ALIX binding domain of CEP55; pfam12180
Pleckstrin homology (PH) domain; cd00821
major capsid L1 protein; Provisional
Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2); cd10359
Pleckstrin homology (PH) domain; cd00821
major capsid L1 protein; Provisional
Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2); cd10359
Pleckstrin homology (PH) domain; cd00821
major capsid L1 protein; Provisional
Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2); cd10359
Pleckstrin homology (PH) domain; cd00821
major capsid L1 protein; Provisional
Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2); cd10359
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); cd00398
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
Nop14-like family; pfam04147
Cdc37 N terminal kinase binding; cl03951
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4); cd08750
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases; cd05605
Serine/Threonine protein kinases, catalytic domain; smart00220
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4); cd08750
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; cd05631
Serine/Threonine protein kinases, catalytic domain; smart00220
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4); cd08750
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases; cd05605
Serine/Threonine protein kinases, catalytic domain; smart00220
23Q repeat
Huntingtin protein region; pfam12372
Myb/SANT-like DNA-binding domain; pfam13837
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Phosphotyrosine-binding (PTB) domain; cd00934
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; cd08742
Ubiquitin domain of RGS12 and RGS14; cd01817
Raf-like Ras-binding domain; pfam02196
GoLoco motif; pfam02188
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Phosphotyrosine-binding (PTB) domain; cd00934
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; cd08742
Ubiquitin domain of RGS12 and RGS14; cd01817
Raf-like Ras-binding domain; pfam02196
GoLoco motif; pfam02188
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; cd08742
Ubiquitin domain of RGS12 and RGS14; cd01817
Ubiquitin-like proteins; cl00155
GoLoco motif; pfam02188
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and...; cd00062
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces...; cd00061
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology-like domain; cl00273
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology-like domain; cl00273
Alpha-2-macroglobulin RAP, N-terminal domain; pfam06400
Alpha-2-macroglobulin RAP, C-terminal domain; pfam06401
7 transmembrane receptor (rhodopsin family); pfam00001
Protein of unknown function, DUF270; pfam03189
Protein of unknown function, DUF270; pfam03189
consensus F-Y-R-[FM]-H-[SA]-X3[LF]-X-E-[VI]
LYAR-type C2HC zinc finger; pfam08790
LYAR-type C2HC zinc finger; pfam08790
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
D1 dopamine receptor-interacting protein (calcyon); pfam06387
D1 dopamine receptor-interacting protein (calcyon); pfam06387
SNARE-complex protein Syntaxin-18 N-terminus; pfam10496
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Catalytic domain of the Protein Serine/Threonine Kinase, Yank1; cd05578
Serine/Threonine protein kinases, catalytic domain; smart00220
Ellis van Creveld protein 2 like protein; pfam12297
Ellis van Creveld protein 2 like protein; pfam12297
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38); cd10811
Alpha mannosidase, middle domain; smart00872
Glycosyl hydrolases family 38 C-terminal domain; pfam07748
S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100...; cd00213
GTPase-activating protein [General function prediction only]
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
GTPase-activating protein [General function prediction only]
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
Domain of unknown function (DUF4201); pfam13870
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding; cd02335
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SWIRM domain; pfam04433
GrpE; pfam01025
GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; cd00446
VPS10 domain; smart00602
PKD domain; pfam00801
Saposin A-type domain; pfam02199
Saposin-like type B, region 1; pfam05184
Saposin (B) Domains; smart00741
Saposin (B) Domains; smart00741
Saposin-like type B, region 1; pfam05184
Saposin (B) Domains; smart00741
Saposin-like type B, region 2; pfam03489
Saposin (B) Domains; smart00741
Saposin-like type B, region 2; pfam03489
Saposin A-type domain; pfam02199
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains; cd11885
Tetratricopeptide repeat; pfam13424
Insulin growth factor-binding protein homologues; smart00121
Kazal-type serine protease inhibitor domain; pfam07648
Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; COG0265
Trypsin-like peptidase domain; pfam13365
PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; cd00987
Peroxisomal acyl-CoA oxidase; cd01150
acyl-CoA oxidase
Peroxisomal acyl-CoA oxidase; cd01150
Predicted AdoMet-dependent methyltransferase; pfam07757
7 transmembrane receptor (rhodopsin family); pfam00001
Cysteine-rich domain of carboxypeptidase Z, a member of the carboxypeptidase E family; cd07447
Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup; cd03867
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; cd11308
Cysteine-rich domain of carboxypeptidase Z, a member of the carboxypeptidase E family; cd07447
Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup; cd03867
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; cd11308
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain; cl02447
Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup; cd03867
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; cd11308
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Olfactory receptor; pfam13853
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02661
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Hyaluronan / mRNA binding family; pfam04774
Beta defensin; pfam13841
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
Sugar (and other) transporter; pfam00083
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Sugar (and other) transporter; pfam00083
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Zinc-finger double domain; pfam13465
Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76); cd09929
Sulfotransferase domain; pfam00685
Rab family protein; Provisional
Rab GTPase family 28 (Rab28); cd04109
Rab family protein; Provisional
Rab GTPase family 28 (Rab28); cd04109
Rab GTPase family 28 (Rab28); cd04109
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
COMPASS (Complex proteins associated with Set1p) component shg1; pfam05205
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
C1q domain; pfam00386
C1q domain; pfam00386
C1q domain; pfam00386
C2 domain; cl14603
Hemerythrin HHE cation binding domain; pfam01814
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Leucine Rich repeats (2 copies); pfam12799
Antagonist of mitotic exit network protein 1; cl15308
Hemerythrin HHE cation binding domain; pfam01814
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Leucine Rich repeats (2 copies); pfam12799
Antagonist of mitotic exit network protein 1; cl15308
Hemerythrin HHE cation binding domain; pfam01814
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Leucine Rich repeats (2 copies); pfam12799
Antagonist of mitotic exit network protein 1; cl15308
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; cd04759
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; cd04759
FGF binding protein 1 (FGF-BP1); pfam06473
FGF binding protein 1 (FGF-BP1); pfam06473
Prominin; pfam05478
Prominin; pfam05478
Prominin; pfam05478
Prominin; pfam05478
Prominin; pfam05478
Prominin; pfam05478
Prominin; pfam05478
Eukaryotic membrane protein family; pfam05346
LIM-domain binding protein; pfam01803
LIM-domain binding protein; pfam01803
short chain dehydrogenase; Provisional
dihydropteridine reductase (DHPR), classical (c) SDRs; cd05334
Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; cd00433
multifunctional aminopeptidase A; Provisional
Mediator complex subunit 28; pfam11594
MAEBL; Provisional
DNA topoisomerase 2-like protein; Provisional
HEAT repeats; pfam13646
Nuclear condensing complex subunits, C-term domain; pfam12719
helix-turn-helix, Psq domain; pfam05225
helix-turn-helix, Psq domain; pfam05225
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Parkin co-regulated protein; pfam10274
Parkin co-regulated protein; pfam10274
Parkin co-regulated protein; pfam10274
Parkin co-regulated protein; pfam10274
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Hormone receptor domain; cl02422
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
Glycosyl hydrolase family 1; cl01046
Glycosyl hydrolase family 1; cl01046
Glycosyl hydrolase family 1; cl01046
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
DEAD-like helicases superfamily; smart00487
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Helicase associated domain (HA2); pfam04408
Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717
Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; cd00305
Uncharacterized coiled-coil protein (DUF2353); pfam09789
Tho complex subunit THP2; pfam09432
Uncharacterized coiled-coil protein (DUF2353); pfam09789
Tho complex subunit THP2; pfam09432
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
EPTP domain; pfam03736
O-phosphoseryl-tRNA(Sec) selenium transferase; TIGR03531
Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen); pfam05889
Phosphatidylinositol 3- and 4-kinase; pfam00454
GRF zinc finger; pfam06839
Probable N6-adenine methyltransferase; pfam10237
DHHC palmitoyltransferase; pfam01529
Anaphase-promoting complex subunit 4 WD40 domain; pfam12894
Anaphase-promoting complex, cyclosome, subunit 4; pfam12896
Phosphate:Na+ Symporter (PNaS) Family; TIGR01013
Na+/Pi-cotransporter; pfam02690
Na+/Pi-cotransporter; pfam02690
Phosphate:Na+ Symporter (PNaS) Family; TIGR01013
Na+/Pi-cotransporter; pfam02690
Na+/Pi-cotransporter; pfam02690
Phosphate:Na+ Symporter (PNaS) Family; TIGR01013
Na+/Pi-cotransporter; pfam02690
Na+/Pi-cotransporter; pfam02690
FOG: TPR repeat, SEL1 subfamily [General function prediction only]
Sel1-like repeats; smart00671
Sel1-like repeats; smart00671
Sel1-like repeats; smart00671
LAG1, DNA binding; pfam09271
Beta-trefoil DNA-binding domain; pfam09270
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known...; cd01176
LAG1, DNA binding; pfam09271
Beta-trefoil DNA-binding domain; pfam09270
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known...; cd01176
LAG1, DNA binding; pfam09271
Beta-trefoil DNA-binding domain; pfam09270
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known...; cd01176
LAG1, DNA binding; pfam09271
Beta-trefoil DNA-binding domain; pfam09270
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known...; cd01176
Cholecystokinin A receptor, N-terminal; pfam09193
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
SAM domain of STIM2 subfamily proteins; cd09574
SAM domain (Sterile alpha motif); pfam07647
STIM1 Orai1-activating region; cd11722
SAM domain of STIM2 subfamily proteins; cd09574
SAM domain (Sterile alpha motif); pfam07647
STIM1 Orai1-activating region; cd11722
SAM domain of STIM2 subfamily proteins; cd09574
SAM domain (Sterile alpha motif); pfam07647
STIM1 Orai1-activating region; cd11722
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Protocadherin; pfam08374
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Protocadherin; pfam08374
Cadherin tandem repeat domain; cd11304
Cadherin repeat-like domain; cl15786
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Protocadherin; pfam08374
Cadherin tandem repeat domain; cd11304
Cadherin repeat-like domain; cl15786
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Protocadherin; pfam08374
SAM domain of Arap1,2,3 (angiotensin receptor-associated protein); cd09490
Sterile alpha motif; smart00454
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Putative GTPase activating protein for Arf; pfam01412
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology-like domain; cl00273
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their...; cd04385
GTPase-activator protein for Rho-like GTPases; smart00324
Ubiquitin-like proteins; cl00155
Pleckstrin homology (PH) domain; cd00821
The Death Domain Superfamily of protein-protein interaction domains; cl14633
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Tumour necrosis factor receptor superfamily member 19; pfam12606
Tumour necrosis factor receptor superfamily member 19; pfam12606
phosphoglucomutase-2-like protein; Provisional
This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; cd05799
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Domain of unknown function (DUF3350); pfam11830
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Domain of unknown function (DUF3350); pfam11830
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
Securin sister-chromatid separation inhibitor; pfam04856
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Protein of unknown function (DUF719); pfam05334
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
kelch-like protein; Provisional
Broad-Complex, Tramtrack and Bric a brac; smart00225
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
ATPase involved in DNA replication [DNA replication, recombination, and repair]; COG0470
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Replication factor RFC1 C terminal domain; pfam08519
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; cd00027
ATPase involved in DNA replication [DNA replication, recombination, and repair]; COG0470
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Replication factor RFC1 C terminal domain; pfam08519
Glycosyl hydrolase family 1; cl01046
Glycosyl hydrolase family 1; cl01046
60S ribosomal protein L6; Provisional
Ribosomal protein L6; pfam00347
Ribosomal protein L6; pfam00347
60S ribosomal protein L6; Provisional
Ribosomal protein L6; pfam00347
Ribosomal protein L6; pfam00347
lipoic acid synthase
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
Radical SAM superfamily; pfam04055
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
nucleotide sugar dehydrogenase; TIGR03026
UDP-glucose/GDP-mannose dehydrogenase family, central domain; pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; pfam03720
probable UDP-glucose 6-dehydrogenase
UDP-glucose/GDP-mannose dehydrogenase family, central domain; pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; pfam03720
UDP-glucose/GDP-mannose dehydrogenase family, central domain; pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; pfam03720
Protein of unknown function (DUF2615); pfam11027
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; cd00194
CUE domain; pfam02845
AAA domain; pfam13671
Domain of unknown function (DUF1771); pfam08590
Smr domain; pfam01713
GTPase SAR1 and related small G proteins [General function prediction only]
Ras homology family (Rho) of small guanosine triphosphatases (GTPases); cd00157
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
heterogeneous nuclear ribonucleoprotein R, Q family; TIGR01648
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
heterogeneous nuclear ribonucleoprotein R, Q family; TIGR01648
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; COG0144
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Fe65 Phosphotyrosine-binding (PTB) domain; cd01272
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Fe65 Phosphotyrosine-binding (PTB) domain; cd01272
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Fe65 Phosphotyrosine-binding (PTB) domain; cd01272
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Fe65 C-terminal Phosphotyrosine-binding (PTB) domain; cd01271
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3; cd09616
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368
LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368
LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Uncharacterized protein family (UPF0121); pfam03661
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
DNA repair protein; TIGR00598
Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; COG0053
Cation efflux family; pfam01545
basic region leucin zipper; smart00338
The BEN domain is found in diverse animal proteins; smart01025
Wnt and FGF inhibitory regulator; pfam13908
phospholipid-translocating P-type ATPase, flippase; TIGR01652
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
phospholipid-translocating P-type ATPase, flippase; TIGR01652
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This...; cd03031
BTB/POZ domain; cl02518
Yip1 domain; cl12048
GTP-binding protein LepA; Provisional
LepA also known as Elongation Factor 4 (EF4); cd01890
lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; cd03699
lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; cd03709
GTP-binding protein LepA C-terminus; pfam06421
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; cd01399
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cytochrome C oxidase chain VIIB; pfam05392
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several...; cd04756
E1-E2 ATPase; pfam00122
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
HAD-superfamily hydrolase, subfamily IIB; TIGR01484
Haloacid Dehalogenase-like Hydrolases; cl11391
One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease; cd07445
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease; cd07888
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Scavenger receptor Cys-rich; smart00202
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008
Ion transport protein; pfam00520
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Ion transport protein; pfam00520
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Magnesium transporter NIPA; pfam05653
Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk); cd11907
Src homology 2 (SH2) domain found  in Tec protein, Txk; cd10398
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; cd05114
Protein tyrosine kinase; pfam07714
Tec pleckstrin homology (PH) domain; cd01238
Bruton's tyrosine kinase Cys-rich motif; smart00107
Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma); cd11905
Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk); cd10396
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; cd05114
Protein tyrosine kinase; pfam07714
large tegument protein UL36; Provisional
Membrane transport protein; cl09117
bile acid transporter; TIGR00841
Zinc-binding domain; pfam13695
Cell morphogenesis N-terminal; pfam14222
Cell morphogenesis central region; pfam14228
Cell morphogenesis central region; pfam14228
Cell morphogenesis C-terminal; pfam14225
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Ovarian carcinoma immunoreactive antigen (OCIA); pfam07051
Cobalamin-5-phosphate synthase; cl00415
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; cl00490
Cullin binding; pfam03556
Cullin binding; pfam03556
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Sarcoglycan complex subunit protein; pfam04790
Ubiquitin carboxyl-terminal hydrolase; pfam00443
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02663
Ubiquitin carboxyl-terminal hydrolase; pfam00443
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02663
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); cl02885
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); cl02885
Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families; cd04146
Sec1 family; cl15415
Fip1 motif; pfam05182
Fip1 motif; pfam05182
Fip1 motif; pfam05182
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Golgin subfamily A member 7/ERF4 family; pfam10256
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Frst immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b); cd05861
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR) alpha; cd05859
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC; cd04972
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; cd05105
Protein tyrosine kinase; pfam07714
Immunoglobulin domain; pfam13895
Immunoglobulin domain; cd00096
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); cd05860
Immunoglobulin domain; cd00096
Catalytic domain of the Protein Tyrosine Kinase, Kit; cd05104
Protein tyrosine kinase; pfam07714
Immunoglobulin domain; pfam13895
Immunoglobulin domain; cd00096
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); cd05860
Immunoglobulin domain; cd00096
Catalytic domain of the Protein Tyrosine Kinase, Kit; cd05104
Protein tyrosine kinase; pfam07714
Immunoglobulin V-set domain; pfam07686
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); cd05862
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2); cd05864
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; cd05103
Protein tyrosine kinase; pfam07714
Phospholipid methyltransferase; cl00763
Predicted membrane protein [Function unknown]
Uncharacterized protein family UPF0016; pfam01169
Uncharacterized protein family UPF0016; pfam01169
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
PAS fold; pfam00989
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS fold; pfam08447
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
PAS fold; pfam00989
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS fold; pfam08447
Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human...; cd02988
Neuromedin U; smart00084
Exocyst complex component Sec3; pfam09763
Exocyst complex component Sec3; pfam09763
Exocyst complex component Sec3; pfam09763
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; COG0318
AMP-binding enzyme; cl15778
Phosphopantetheine attachment site; pfam00550
FOG: WD40-like repeat [Function unknown]
PQQ-dependent dehydrogenases and related proteins; cl11493
PQQ-dependent dehydrogenases and related proteins; cl11493
PQQ-like domain; pfam13360
amidophosphoribosyltransferase; TIGR01134
Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; cd00715
Phosphoribosyl transferase (PRT)-type I domain; cd06223
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; cd01416
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
phosphoribosylaminoimidazole carboxylase, PurE protein; TIGR01162
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; cd01416
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
phosphoribosylaminoimidazole carboxylase, PurE protein; TIGR01162
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; cd01416
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
phosphoribosylaminoimidazole carboxylase, PurE protein; TIGR01162
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Anaphase-promoting complex, cyclosome, subunit 3; pfam12895
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
SRP72 RNA-binding domain; pfam08492
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Anaphase-promoting complex, cyclosome, subunit 3; pfam12895
Tetratricopeptide repeat; pfam13424
SRP72 RNA-binding domain; pfam08492
Arf-like 9 (Arl9)/Arfrp2-like GTPase; cd04162
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cl00084
Kazal-type serine protease inhibitor domain; pfam00050
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Circularly permuted YqeH GTPase; cd01855
DNA-directed RNA polymerase subunit B; Provisional
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; cl04593
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; cl04593
RNA polymerase Rpb2, domain 4; pfam04566
RNA polymerase Rpb2, domain 5; pfam04567
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; cd00653
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Immunoglobulin domain; cd00096
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Immunoglobulin domain; cd00096
Galactose binding lectin domain; pfam02140
Olfactomedin-like domains; smart00284
Domain present in hormone receptors; smart00008
Domain of unknown function (DUF3497); pfam12003
G-protein-coupled receptor proteolytic site domain; smart00303
7 transmembrane receptor (Secretin family); pfam00002
Latrophilin Cytoplasmic C-terminal region; pfam02354
Ubiquitin-like proteins; cl00155
Phospholipid methyltransferase; cl00763
Ligand Binding Domain of Ephrin type-A Receptor 5; cd10483
GCC2 and GCC3; pfam07699
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; cd05066
Protein tyrosine kinase; pfam07714
SAM domain of EPH-A5 subfamily of tyrosine kinase receptors; cd09546
SAM domain (Sterile alpha motif); pfam07647
Ligand Binding Domain of Ephrin type-A Receptor 5; cd10483
GCC2 and GCC3; pfam07699
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; cd05066
Protein tyrosine kinase; pfam07714
SAM domain of EPH-A5 subfamily of tyrosine kinase receptors; cd09546
SAM domain (Sterile alpha motif); pfam07647
Mif2/CENP-C like; pfam11699
Pleckstrin homology-like domain; cl00273
Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1); cd10403
ubiquitin-activating enzyme E1; TIGR01408
Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating; cd01491
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating; cd01490
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
SEA domain; pfam01390
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
SEA domain; pfam01390
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
SEA domain; pfam01390
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
SEA domain; pfam01390
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
SEA domain; cl02507
SEA domain; pfam01390
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
YT521-B-like domain; pfam04146
YT521-B-like domain; pfam04146
SEA domain; pfam01390
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; cl10013
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
Putative binding domain; pfam13900
Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; cl10013
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
Sulfotransferase family; cl14559
Sulfotransferase domain; pfam00685
Sulfotransferase family; cl14559
Sulfotransferase domain; pfam00685
Statherin; pfam03875
Kappa casein; pfam00997
Ameloblastin precursor (Amelin); pfam05111
Sas10/Utp3/C1D family; pfam04000
Sas10 C-terminal domain; pfam09368
RUN domain; pfam02759
RUN domain; pfam02759
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
RUN domain; pfam02759
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Mob1/phocein family; pfam03637
Mob1/phocein family; pfam03637
Mob1/phocein family; pfam03637
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; cd01673
Deoxynucleoside kinases [Nucleotide transport and metabolism]
anion exchange protein; TIGR00834
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; cl00163
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; cl00163
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; cl00163
HCO3- transporter family; pfam00955
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
serum albumin; smart00103
Vitamin D binding protein, domain III; pfam09164
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
serum albumin; smart00103
Vitamin D binding protein, domain III; pfam09164
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
serum albumin; smart00103
Vitamin D binding protein, domain III; pfam09164
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
Thrombospondin type 1 repeats; smart00209
ADAM-TS Spacer 1; pfam05986
Thrombospondin type 1 domain; cl15278
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
PLAC (protease and lacunin) domain; pfam08686
60Kd inner membrane protein; pfam02096
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Serum albumin family; pfam00273
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; cd00015
Ubiquitin-like proteins; cl00155
Ubiquitin-like proteins; cl00155
Ubiquitin-like proteins; cl00155
Ubiquitin-like proteins; cl00155
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; pfam00763
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; cd01080
EGF-like protein; Provisional
EGF-like protein; Provisional
EGF-like protein; Provisional
EGF-like protein; Provisional
EGF-like protein; Provisional
epidermal growth factor-like protein (EGF-like protein); Provisional
EGF-like protein; Provisional
EGF-like protein; Provisional
CHY zinc finger; pfam05495
CHY zinc finger; pfam05495
Zinc finger, C3HC4 type (RING finger); pfam13923
Ring finger domain; pfam13639
CHY zinc finger; pfam05495
THAP domain; pfam05485
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; cd07846
Serine/Threonine protein kinases, catalytic domain; smart00220
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Uso1 / p115 like vesicle tethering protein, head region; pfam04869
Uso1 / p115 like vesicle tethering protein, C terminal region; pfam04871
Drosophila melanogaster RdgC and related proteins, metallophosphatase domain; cd07420
metallophosphatase superfamily, metallophosphatase domain; cl13995
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...; cd01903
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA).  AC catalyzes the hydrolysis of ceramide to sphingosine and...; cd01903
Linear amide C-N hydrolases, choloylglycine hydrolase family; pfam02275
NUC130/3NT domain; pfam08158
SDA1; pfam05285
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
NAD:arginine ADP-ribosyltransferase; pfam01129
NAD:arginine ADP-ribosyltransferase; pfam01129
NAD:arginine ADP-ribosyltransferase; pfam01129
Nucleoporin complex subunit 54; pfam13874
CD36 family; pfam01130
CD36 family; pfam01130
CD36 family; pfam01130
Genethonin-1, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Genethonin-1 is a human skeletal muscle protein with no known function. It contains a C-terminal CBM20 domain. The CBM20 domain is found in a large number of starch...; cd05813
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, common bacterial type; TIGR02168
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Apx/Shroom domain ASD1; pfam08688
Apx/Shroom domain ASD2; pfam08687
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
CDC/Septin GTPase family; cd01850
Septin; pfam00735
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Chemokine_CXC:  1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members...; cd00273
Leucine-rich repeat (LRR) protein [Function unknown]
C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like; cd10312
Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; cd00403
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like cysteine rich region; pfam00757
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like cysteine rich region; pfam00757
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Domains in Na-Ca exchangers and integrin-beta4; smart00237
Calx-beta domain; cl02522
Domains in Na-Ca exchangers and integrin-beta4; smart00237
Calx-beta domain; cl02522
Calx-beta domain; pfam03160
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; pfam00093
von Willebrand factor type C domain; cl02515
von Willebrand factor type C domain; cl02515
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors; cd00064
Furin-like repeats; smart00261
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Haemolysin-III related; pfam03006
Acetyltransferases [General function prediction only]; COG0456
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; cd04301
Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases; cd07792
glycerol kinase; TIGR01311
ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in...; cd01474
Anthrax receptor extracellular domain; pfam05587
Anthrax receptor C-terminus region; pfam05586
ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in...; cd01474
Anthrax receptor extracellular domain; pfam05587
Anthrax receptor C-terminus region; pfam05586
SET domain; cl02566
Zinc finger, C2H2 type; cl15478
SET domain; cl02566
Zinc finger, C2H2 type; cl15478
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cl00060
TGF-beta propeptide; pfam00688
Transforming growth factor-beta (TGF-beta) family; smart00204
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
protein kinase A catalytic subunit; Provisional
Catalytic domain of the Protein Serine/Threonine Kinase, cGMP-dependent protein kinase; cd05572
Extension to Ser/Thr-type protein kinases; smart00133
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Predicted enolase-phosphatase [Energy production and conversion]
Frag1/DRAM/Sfk1 family; pfam10277
The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; cd03505
Fatty acid desaturase; pfam00487
The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; cd03505
The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; cd03505
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; cl14807
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; cl14807
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; cl14807
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; cl14807
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; cl14807
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; cl14807
THAP domain; pfam05485
Tesmin/TSO1-like CXC domain; pfam03638
Tesmin/TSO1-like CXC domain; pfam03638
Tesmin/TSO1-like CXC domain; pfam03638
Tesmin/TSO1-like CXC domain; pfam03638
Tesmin/TSO1-like CXC domain; pfam03638
Tesmin/TSO1-like CXC domain; pfam03638
PCI domain; pfam01399
PCI domain; cl02111
PLAC8 family; cl04722
PLAC8 family; cl04722
PLAC8 family; cl04722
4-hydroxybenzoate nonaprenyltransferase
Glycosyl hydrolase family 79, N-terminal domain; pfam03662
Glycosyl hydrolase family 79, N-terminal domain; pfam03662
Glycosyl hydrolase family 79, N-terminal domain; pfam03662
Glycosyl hydrolase family 79, N-terminal domain; pfam03662
Superfamily II helicase [General function prediction only]
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Ribosomal protein S18; pfam01084
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Cytidylyltransferase family; cl00347
Concanavalin A-like lectin/glucanases superfamily; pfam13385
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor; cd06071
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Pleckstrin homology (PH) domain; cd00821
RhoGAP_ARHGAP22_24_25:  GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been...; cd04390
GTPase-activator protein for Rho-like GTPases; smart00324
Domain of unknown function (DUF4200); pfam13863
Pleckstrin homology-like domain; cl00273
RhoGAP_ARHGAP22_24_25:  GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been...; cd04390
GTPase-activator protein for Rho-like GTPases; smart00324
RhoGAP_ARHGAP22_24_25:  GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been...; cd04390
GTPase-activator protein for Rho-like GTPases; smart00324
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
kinase non-catalytic C-lobe domain; smart00750
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
kinase non-catalytic C-lobe domain; smart00750
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
kinase non-catalytic C-lobe domain; smart00750
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
kinase non-catalytic C-lobe domain; smart00750
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Protein tyrosine phosphatase, catalytic domain; smart00194
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cd00047
bile acid transporter; TIGR00841
Sodium Bile acid symporter family; pfam01758
AF-4 proto-oncoprotein; pfam05110
AF-4 proto-oncoprotein; pfam05110
AF-4 proto-oncoprotein; pfam05110
AF-4 proto-oncoprotein; pfam05110
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
Short-chain dehydrogenases of various substrate specificities [General function prediction only]; COG0300
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; cd05339
Short-chain dehydrogenases of various substrate specificities [General function prediction only]; COG0300
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; cd05339
Short-chain dehydrogenases of various substrate specificities [General function prediction only]; COG0300
human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; cd05339
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P.  Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also...; cd03670
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P.  Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also...; cd03670
ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P.  Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also...; cd03670
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cl00097
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cl00097
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Dentin matrix protein 1 (DMP1); pfam07263
Dentin matrix protein 1 (DMP1); pfam07263
Bone sialoprotein II (BSP-II); pfam05432
Osteoregulin; pfam07175
Osteoregulin; pfam07175
Osteoregulin; pfam07175
Osteoregulin; pfam07175
Osteoregulin; pfam07175
Osteopontin; smart00017
Osteopontin; smart00017
Osteopontin; pfam00865
Osteopontin; pfam00865
Osteopontin; pfam00865
Polycystin cation channel; pfam08016
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; cd03213
The Eye Pigment Precursor Transporter (EPP) Family protein; TIGR00955
ABC-2 type transporter; pfam01061
ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; cd03213
ABC-type multidrug transport system, ATPase component [Defense mechanisms]; COG1131
ABC-2 type transporter; pfam01061
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; cd00143
Protein phosphatase 2C; pfam00481
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam13540
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Uncharacterized conserved protein [Function unknown]
Regulator of chromosome condensation (RCC1) repeat; pfam13540
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
(NAP-L) nucleosome assembly protein -L; Provisional; cl08298
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active...; cd04393
GTPase-activator protein for Rho-like GTPases; smart00324
Helix-turn-helix domains; cl00088
Tc5 transposase DNA-binding domain; pfam03221
DDE superfamily endonuclease; pfam03184
Synuclein; pfam01387
Synuclein; pfam01387
Synuclein; pfam01387
Synuclein; pfam01387
EMI domain; pfam07546
ATPase involved in DNA repair [DNA replication, recombination, and repair]; COG0419
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Complement component C1q domain; smart00110
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family; cd06391
Receptor family ligand binding region; pfam01094
Bacterial extracellular solute-binding proteins, family 3; pfam00497
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
glutathione s-transferase; Provisional
GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; cd03039
C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases; cd10295
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The first LIM domain of the Enigma Homolog (ENH) family; cd09453
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The first LIM domain of the Enigma Homolog (ENH) family; cd09453
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of the Enigma Homolog (ENH) family; cd09459
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The first LIM domain of the Enigma Homolog (ENH) family; cd09453
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of the Enigma Homolog (ENH) family; cd09459
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The first LIM domain of the Enigma Homolog (ENH) family; cd09453
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of the Enigma Homolog (ENH) family; cd09459
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Putative binding domain; pfam13900
The first LIM domain of the Enigma Homolog (ENH) family; cd09453
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The third LIM domain of the Enigma Homolog (ENH) family; cd09459
The first LIM domain of the Enigma Homolog (ENH) family; cd09453
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
Activin types I and II receptor domain; pfam01064
Transforming growth factor beta type I GS-motif; cl02621
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Activin types I and II receptor domain; pfam01064
Transforming growth factor beta type I GS-motif; cl02621
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Activin types I and II receptor domain; pfam01064
Transforming growth factor beta type I GS-motif; cl02621
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Activin types I and II receptor domain; pfam01064
Transforming growth factor beta type I GS-motif; cl02621
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein Kinases, catalytic domain; cl09925
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
ZU5 domain; pfam00791
Death domain found in Uncoordinated-5C; cd08799
pyruvate dehydrogenase E1 component, alpha subunit; TIGR03182
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; cd02000
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03159
Eukaryotic initiation factor 4E; pfam01652
Eukaryotic initiation factor 4E; pfam01652
Eukaryotic initiation factor 4E; pfam01652
methionine aminopeptidase; Provisional
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; cd01086
class III alcohol dehydrogenases; cd08300
S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; TIGR02818
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
class I, II, IV alcohol dehydrogenases; cd08299
Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; COG1062
tRNA (Guanine-1)-methyltransferase; pfam01746
tRNA (Guanine-1)-methyltransferase; pfam01746
tRNA (Guanine-1)-methyltransferase; pfam01746
Lipoprotein amino terminal region; pfam01347
Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins; cd10355
Pleckstrin homology (PH) domain; cd00821
Mitogen-activated protein kinase kinase 1 interacting; pfam08923
Mitogen-activated protein kinase kinase 1 interacting; pfam08923
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Domain of unknown function (DUF1977); pfam09320
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
RTP801 C-terminal region; pfam07809
Endomucin; pfam07010
Endomucin; pfam07010
PP2B, metallophosphatase domain; cd07416
Protein phosphatase 2A homologues, catalytic domain; smart00156
PP2B, metallophosphatase domain; cd07416
Protein phosphatase 2A homologues, catalytic domain; smart00156
PP2B, metallophosphatase domain; cd07416
Protein phosphatase 2A homologues, catalytic domain; smart00156
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); cd07935
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to...; cd01177
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Death domain of the Nuclear Factor-KappaB1 precursor protein p105; cd08797
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); cd07935
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to...; cd01177
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Death domain of the Nuclear Factor-KappaB1 precursor protein p105; cd08797
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; COG3250
Glycosyl hydrolases family 2, sugar binding domain; cl08371
Glycosyl hydrolases family 2, TIM barrel domain; cl15381
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Iron-containing outer mitochondrial membrane protein N-terminus; pfam10660
CDGSH-type zinc finger. Function unknown; smart00704
Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; COG0475
Sodium/hydrogen exchanger family; pfam00999
Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; COG0475
Sodium/hydrogen exchanger family; pfam00999
Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; COG0475
Sodium/hydrogen exchanger family; pfam00999
short chain dehydrogenase; Provisional
human DHRS6-like, classical (c) SDRs; cd05368
Kinesin motor, catalytic domain. ATPase; smart00129
Kinesin motor domain, CENP-E/KIP2-like subgroup, involved in chromosome movement and/or spindle elongation during mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are...; cd01374
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
RecF/RecN/SMC N terminal domain; pfam02463
7 transmembrane receptor (rhodopsin family); pfam00001
CXXC zinc finger domain; pfam02008
Oxygenase domain of the 2OGFeDO superfamily; pfam12851
Oxygenase domain of the 2OGFeDO superfamily; pfam12851
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cl00217
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cl00217
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cl00217
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cd00412
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cd00412
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
BAR domain; smart00721
The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein; cd07589
Src Homology 3 domain superfamily; cl17036
Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains; cd12141
RhoGEF domain; pfam00621
PHD-finger; pfam00628
PHD-finger; pfam00628
Glutathione S-transferase, C-terminal domain; pfam00043
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
Methyltransferase domain; pfam13847
Glutathione S-transferase, C-terminal domain; pfam00043
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
Methyltransferase domain; pfam13847
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF domain; pfam07645
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF domain; pfam07645
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF domain; pfam07645
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF domain; pfam07645
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF domain; pfam07645
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Protein Kinases, catalytic domain; cl09925
Rab-GTPase-TBC domain; pfam00566
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site...; cd01525
Catalytic domain of Protein Kinases; cd00180
Rab-GTPase-TBC domain; pfam00566
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site...; cd01525
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Rab-GTPase-TBC domain; pfam00566
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site...; cd01525
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Rab-GTPase-TBC domain; pfam00566
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site...; cd01525
ATP synthase B/B' CF(0); cl07975
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae...; cd02799
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae...; cd02799
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae...; cd02799
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Dickkopf N-terminal cysteine-rich region; pfam04706
Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; cd02027
Gluconate kinase [Carbohydrate transport and metabolism]; COG3265
ATP sulphurylase; TIGR00339
ATP-sulfurylase; cd00517
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; cd01610
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; cl12078
3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; COG1250
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; pfam02737
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; pfam00725
3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; COG1250
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; pfam02737
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; pfam00725
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
60S ribosomal protein L34; Provisional
60S ribosomal protein L34; Provisional
OST3 / OST6 family; pfam04756
OST3 / OST6 family; pfam04756
OST3 / OST6 family; pfam04756
4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; COG0160
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; cd00610
4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; COG0160
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; cd00610
acetylornithine transaminase
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; cd00610
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
Sec23/Sec24 zinc finger; pfam04810
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...; cd01479
Sec23/Sec24 beta-sandwich domain; pfam08033
Sec23/Sec24 helical domain; pfam04815
Gelsolin repeat; pfam00626
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
Sec23/Sec24 zinc finger; pfam04810
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...; cd01479
Sec23/Sec24 beta-sandwich domain; pfam08033
Sec23/Sec24 helical domain; pfam04815
Gelsolin repeat; pfam00626
Protein of unknown function, DUF607; pfam04678
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cd00032
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cd00032
factor I membrane attack complex; smart00057
Scavenger receptor Cys-rich; smart00202
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Gar1/Naf1 RNA binding region; pfam04410
Gar1/Naf1 RNA binding region; pfam04410
7 transmembrane receptor (rhodopsin family); pfam00001
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Immunoglobulin domain; cl11960
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Low-density lipoprotein-receptor YWTD domain; smart00135
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain; smart00179
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; cl10508
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Low-density lipoprotein-receptor YWTD domain; smart00135
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain; smart00179
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; cl10508
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Low-density lipoprotein-receptor YWTD domain; smart00135
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein-receptor YWTD domain; smart00135
Low-density lipoprotein receptor repeat class B; cl10508
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
GNS1/SUR4 family; pfam01151
GNS1/SUR4 family; pfam01151
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Homeodomain-containing transcription factor [Transcription]
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Osmosensory transporter coiled coil; pfam08946
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cl00062
Alpha-kinase family; smart00811
Alpha-kinase family; smart00811
Alpha-kinase family; smart00811
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Protein of unknown function (DUF2439); pfam10382
GRF zinc finger; pfam06839
AAA domain; pfam13086
AAA domain; pfam13087
La RNA-binding domain of La-related protein 7; cd08032
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA binding motif; pfam08777
La RNA-binding domain of La-related protein 7; cd08032
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA binding motif; pfam08777
La RNA-binding domain of La-related protein 7; cd08032
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA binding motif; pfam08777
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-2; cd08804
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
C-terminal domain of homeodomain 1; pfam12737
Death domain of Ankyrin-2; cd08804
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain of Ankyrin-2; cd08804
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
heparan sulfate-N-deacetylase; pfam12062
Sulfotransferase domain; pfam00685
TRAM1-like protein; pfam08390
TRAM, LAG1 and CLN8 homology domains; smart00724
heparan sulfate-N-deacetylase; pfam12062
Sulfotransferase domain; pfam00685
Kringle domain; smart00130
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Scavenger receptor Cys-rich; smart00202
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
MT-A70; pfam05063
Sec23/Sec24 zinc finger; pfam04810
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...; cd01479
Sec23/Sec24 beta-sandwich domain; pfam08033
Sec23/Sec24 helical domain; pfam04815
Gelsolin repeat; pfam00626
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Calcineurin-binding protein (Calsarcin); pfam05556
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cd02257
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Metal dependent phosphohydrolases with conserved 'HD' motif; cl00076
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Metal dependent phosphohydrolases with conserved 'HD' motif; cl00076
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Metal dependent phosphohydrolases with conserved 'HD' motif; cl00076
HORMA domain; pfam02301
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
FOG: Zn-finger [General function prediction only]
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Uncharacterized conserved protein (DUF2369); pfam10179
Uncharacterized conserved protein (DUF2369); pfam10179
polyubiquitin binding domain of NEMO and related proteins; cd09803
polyubiquitin binding domain of NEMO and related proteins; cd09803
polyubiquitin binding domain of NEMO and related proteins; cd09803
7 transmembrane receptor (rhodopsin family); pfam00001
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
RNase PH-related exoribonuclease [Translation, ribosomal structure and biogenesis]
RRP45 subunit of eukaryotic exosome; cd11368
RNase PH-related exoribonuclease [Translation, ribosomal structure and biogenesis]
RRP45 subunit of eukaryotic exosome; cd11368
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; COG5333
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
transient-receptor-potential calcium channel protein; TIGR00870
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Transient receptor ion channel II; pfam08344
Polycystin cation channel; pfam08016
transient-receptor-potential calcium channel protein; TIGR00870
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Transient receptor ion channel II; pfam08344
Polycystin cation channel; pfam08016
Fragile site-associated protein C-terminus; pfam10479
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase); smart00552
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase); smart00552
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase); smart00552
Interleukin 2; pfam00715
Interleukin 15; pfam02372
Interleukin 15; pfam02372
chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; cl02777
chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; cl02777
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; cd04670
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; cd04670
Cell division protein 48 (CDC48) N-terminal domain; smart01073
ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; COG0464
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Sprouty protein (Spry); pfam05210
Sprouty protein (Spry); pfam05210
Sprouty protein (Spry); pfam05210
Sprouty protein (Spry); pfam05210
AAA ATPase domain; pfam13191
Ankyrin repeats (many copies); pfam13637
Ankyrin repeat; pfam00023
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
Ankyrin repeat; pfam00023
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; cd00136
Mitochondrial carrier protein; pfam00153
ADP/ATP transporter on adenylate translocase; Provisional
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Nucleotide-binding domain of HSPA4L; cd11738
Hsp70 protein; pfam00012
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
POLO box duplicated region; pfam00659
Catalytic domain of the Protein Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; cd05581
Serine/Threonine protein kinases, catalytic domain; smart00220
POLO box duplicated region; pfam00659
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Serine/Threonine protein kinases, catalytic domain; smart00220
POLO box duplicated region; pfam00659
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
Uncharacterized conserved protein (DUF2048); pfam09752
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
La RNA-binding domain proteins similar to La-related proteins 1 and 2; cd08034
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function; smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function; smart00684
La RNA-binding domain proteins similar to La-related proteins 1 and 2; cd08034
La RNA-binding domain proteins similar to La-related proteins 1 and 2; cd08034
Cytochrome b5-like Heme/Steroid binding domain; pfam00173
Enhancer of polycomb-like; pfam10513
PHD-finger; pfam00628
PHD-zinc-finger like domain; pfam13832
PHD zinc finger; smart00249
Enhancer of polycomb-like; pfam10513
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Domon-like ligand-binding domains; cl14783
Domon-like ligand-binding domains; cl14783
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
L-type amino acid transporter; TIGR00911
Spore germination protein; cl15802
C-terminal deadenylase domain of nocturnin and related domains; cd09096
Transcription factor protein N terminal; pfam12310
erythroblast transformation specific domain; smart00413
Transcription factor protein N terminal; pfam12310
erythroblast transformation specific domain; smart00413
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
NMDA receptor-regulated protein 1; pfam12569
Rab GTPase family 33 includes Rab33A and Rab33B; cd04115
Rab family protein; Provisional
SET domain; pfam00856
MAPEG family; pfam01124
MAPEG family; pfam01124
MAPEG family; cl09190
MAPEG family; cl09190
MamL-1 domain; pfam09596
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Predicted coiled-coil protein (DUF2205); pfam10224
Calreticulin family; pfam00262
Calreticulin family; pfam00262
ELMO/CED-12 family; pfam04727
Mitochondrial carrier protein; pfam00153
ADP/ATP transporter on adenylate translocase; Provisional
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
GRAM domain; pfam02893
GRAM domain; pfam02893
GTPase-activating protein [General function prediction only]
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...; cd02122
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
NOA36 protein; pfam06524
Interleukin 15; pfam02372
Interleukin 15; pfam02372
C2 domain first repeat in Copine; cd04048
C2 domain first repeat in Copine; cd04048
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02664
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Gab (Grb2-associated binder) pleckstrin homology (PH) domain; cd01266
Gab (Grb2-associated binder) pleckstrin homology (PH) domain; cd01266
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
HAND; pfam09110
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SLIDE; pfam09111
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; pfam03160
Glycophorin A; pfam01102
Glycophorin A; pfam01102
Folate receptor family; pfam03024
dehydrogenase, PQQ-dependent, s-GDH family; TIGR03606
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; cl02148
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
APC10 subunit of the anaphase-promoting complex (APC) that mediates substrate ubiquitination; cd08366
Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]
Possible Fer4-like domain in RNase L inhibitor, RLI; pfam04068
The ATPase domain 1 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids.  RLI s are not transport proteins and thus cluster...; cd03236
The ATPase domain 2 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster...; cd03237
Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]
Possible Fer4-like domain in RNase L inhibitor, RLI; pfam04068
The ATPase domain 1 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids.  RLI s are not transport proteins and thus cluster...; cd03236
The ATPase domain 2 of RNase L inhibitor.  The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster...; cd03237
OTU-like cysteine protease; pfam02338
OTU-like cysteine protease; pfam02338
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8); cd10490
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9; cd10497
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8); cd10490
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9; cd10497
membrane ATPase/protein kinase; Provisional
The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; cd03114
Zinc-finger double domain; pfam13465
Like-Sm protein 6; cd01726
Predicted Na+-dependent transporter [General function prediction only]
SBF-like CPA transporter family (DUF4137); pfam13593
Membrane transport protein; cl09117
Found in Pit-Oct-Unc transcription factors; smart00352
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cl02429
7 transmembrane receptor (rhodopsin family); pfam00001
CC chemokine receptor-like protein; Provisional
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Organic solute transporter Ostalpha; pfam03619
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2; cd07635
Pleckstrin homology-like domain; cl00273
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences...; cd04374
GTPase-activator protein for Rho-like GTPases; smart00324
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2; cd12065
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; cl11397
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily; cd07075
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Concanavalin A-like lectin/glucanases superfamily; pfam13385
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Domain of Unknown Function (DUF1088); pfam06469
Neurobeachin Pleckstrin homology-like domain; cd01201
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor; cd06071
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Concanavalin A-like lectin/glucanases superfamily; pfam13385
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Domain of Unknown Function (DUF1088); pfam06469
Neurobeachin Pleckstrin homology-like domain; cd01201
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking,  are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor; cd06071
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Mab-21 protein; pfam03281
Ribosomal S3Ae family; pfam01015
Ribosomal S3Ae family; cl00821
Src Homology 3 domain superfamily; cl17036
Second Src homology 3 domain of ADAM-binding protein Eve-1; cd11815
Third Src homology 3 domain of ADAM-binding protein Eve-1; cd11816
Fourth Src homology 3 domain of ADAM-binding protein Eve-1; cd11817
Fifth Src homology 3 domain of ADAM-binding protein Eve-1; cd11818
Src Homology 3 domain superfamily; cl17036
Second Src homology 3 domain of ADAM-binding protein Eve-1; cd11815
Third Src homology 3 domain of ADAM-binding protein Eve-1; cd11816
Fourth Src homology 3 domain of ADAM-binding protein Eve-1; cd11817
Fifth Src homology 3 domain of ADAM-binding protein Eve-1; cd11818
Src Homology 3 domain superfamily; cl17036
Second Src homology 3 domain of ADAM-binding protein Eve-1; cd11815
Third Src homology 3 domain of ADAM-binding protein Eve-1; cd11816
Fourth Src homology 3 domain of ADAM-binding protein Eve-1; cd11817
Fifth Src homology 3 domain of ADAM-binding protein Eve-1; cd11818
First Src homology 3 domain of ADAM-binding protein Eve-1; cd11814
Second Src homology 3 domain of ADAM-binding protein Eve-1; cd11815
Third Src homology 3 domain of ADAM-binding protein Eve-1; cd11816
Fourth Src homology 3 domain of ADAM-binding protein Eve-1; cd11817
Fifth Src homology 3 domain of ADAM-binding protein Eve-1; cd11818
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Retinoic acid induced 16-like protein; pfam10257
aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; PRK05477
GatB/GatE catalytic domain; pfam02934
GatB domain; pfam02637
F-box-like; pfam12937
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
F-box-like; pfam12937
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
F-box-like; pfam12937
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Helix-turn-helix domains; cl00088
Tc5 transposase DNA-binding domain; pfam03221
DDE superfamily endonuclease; pfam03184
Centromere protein B dimerisation domain; pfam09026
Arfaptin-like domain; pfam06456
The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin; cd07660
Arfaptin-like domain; pfam06456
The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin; cd07660
Arfaptin-like domain; pfam06456
The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin; cd07660
Formin Homology 2 Domain; pfam02181
Formin Homology 2 Domain; smart00498
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
NHL repeat; pfam01436
NHL repeat; pfam01436
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
Filamin-type immunoglobulin domains; smart00557
Filamin/ABP280 repeat; pfam00630
NHL repeat; pfam01436
NHL repeat; pfam01436
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
Mnd1 family; pfam03962
Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
Mnd1 family; pfam03962
Protein of unknown function (DUF3651); pfam12371
Protein of unknown function (DUF3651); pfam12371
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Toll - interleukin 1 - resistance; smart00255
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity; cd07446
NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse...; cd03580
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin repeat-like domain; cl15786
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Fibrinogen alpha/beta chain family; pfam08702
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen alpha/beta chain family; pfam08702
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen alpha/beta chain family; pfam08702
Fibrinogen alpha C domain; pfam12160
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen alpha/beta chain family; pfam08702
Fibrinogen alpha C domain; pfam12160
Fibrinogen alpha/beta chain family; pfam08702
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibrinogen alpha/beta chain family; pfam08702
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Lecithin retinol acyltransferase; pfam04970
heterogeneous nuclear ribonucleoprotein R, Q family; TIGR01648
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Heme NO binding; cl15268
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding; cl15268
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding; cl15268
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding; cl15268
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding; cl15268
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding; cl15268
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Heme NO binding; pfam07700
Heme NO binding associated; pfam07701
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Amiloride-sensitive sodium channel; pfam00858
Tryptophan 2,3-dioxygenase; pfam03301
Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; cd02248
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor; cd06389
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor; cd06389
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
CEO family (DUF1632); pfam07857
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
7 transmembrane receptor (rhodopsin family); pfam00001
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Dehydrogenases (flavoproteins) [Energy production and conversion]; COG0644
Electron transfer flavoprotein-ubiquinone oxidoreductase; pfam05187
Ferredoxin-like protein [Energy production and conversion]; COG2440
cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; cd01926
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
TPR repeat; pfam13414
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like domain of PDZ_GEF_RA; cd01785
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins; cd05736
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins; cd05736
Uncharacterized conserved protein [Function unknown]
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins; cd05736
Uncharacterized conserved protein [Function unknown]
Gar1/Naf1 RNA binding region; pfam04410
Gar1/Naf1 RNA binding region; pfam04410
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
transketolase; Reviewed
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; cd02012
Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; cd07033
Transketolase, C-terminal domain; pfam02780
Protein of unknown function (DUF2962); pfam11176
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins; smart00744
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins; smart00744
Leucine Rich repeats (2 copies); pfam12799
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-box zinc finger; pfam00643
B-Box C-terminal domain; smart00502
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-box zinc finger; pfam00643
B-Box C-terminal domain; smart00502
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
kelch-like protein; Provisional
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
kelch-like protein; Provisional
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
Broad-Complex, Tramtrack and Bric a brac; smart00225
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
Sterol desaturase [Lipid metabolism]; COG3000
Fatty acid hydroxylase superfamily; pfam04116
Sterol desaturase [Lipid metabolism]; COG3000
Fatty acid hydroxylase superfamily; pfam04116
Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup; cd03865
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; cd11308
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins; cd04281
Astacin (Peptidase family M12A); pfam01400
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Calcium-binding EGF-like domain; smart00179
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins; cd04281
Astacin (Peptidase family M12A); pfam01400
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Superfamily II RNA helicase [DNA replication, recombination, and repair]
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
C-terminal immunoglobulin (Ig)-like domain of palladin; cd05893
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
C-terminal immunoglobulin (Ig)-like domain of palladin; cd05893
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
C-terminal immunoglobulin (Ig)-like domain of palladin; cd05893
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
C-terminal immunoglobulin (Ig)-like domain of palladin; cd05893
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
3-oxoacyl-(acyl-carrier-protein) reductase; TIGR01830
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase; cd11927
Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase; cd11930
Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase; cd11926
C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains; cd11785
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1; cd08218
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1; cd08218
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1; cd08218
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1; cd08218
Serine/Threonine protein kinases, catalytic domain; smart00220
F0F1-type ATP synthase, subunit b [Energy production and conversion]; COG0711
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 1; cd08218
Serine/Threonine protein kinases, catalytic domain; smart00220
ClC-3-like chloride channel proteins.  This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...; cd03684
Voltage gated chloride channel; pfam00654
FOG: CBS domain [General function prediction only]
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
ClC-3-like chloride channel proteins.  This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...; cd03684
Voltage gated chloride channel; pfam00654
FOG: CBS domain [General function prediction only]
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
ClC-3-like chloride channel proteins.  This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...; cd03684
Voltage gated chloride channel; pfam00654
FOG: CBS domain [General function prediction only]
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
ClC-3-like chloride channel proteins.  This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...; cd03684
Voltage gated chloride channel; pfam00654
FOG: CBS domain [General function prediction only]
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; cd04591
Uncharacterized conserved protein (DUF2228); pfam10228
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin domain; cl11960
Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; cd00609
Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; cd00609
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
Ricin-type beta-trefoil lectin domain; pfam00652
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
Ricin-type beta-trefoil lectin domain; pfam00652
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone...; cd01390
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone...; cd01390
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone...; cd01390
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
SAP30 zinc-finger; pfam13866
Sin3 binding region of histone deacetylase complex subunit SAP30; pfam13867
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
F-box-like; pfam12937
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; PRK05565
insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs; cd05323
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
Myelin proteolipid protein (PLP or lipophilin); cl02417
Myelin proteolipid protein (PLP or lipophilin); cl02417
Myelin proteolipid protein (PLP or lipophilin); pfam01275
Myelin proteolipid protein (PLP or lipophilin); pfam01275
Myelin proteolipid protein (PLP or lipophilin); cl02417
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Domain of Unknown Function (DUF1042); pfam06294
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS...; cd03724
Signal peptidase subunit; pfam04573
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3); cd08969
Formamidopyrimidine-DNA glycosylase H2TH domain; pfam06831
Zn-finger in Ran binding protein and others; pfam00641
GRF zinc finger; pfam06839
GRF zinc finger; pfam06839
Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; cd04513
Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; cd04513
Teneurin Intracellular Region; pfam06484
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Rhs family protein [Cell envelope biogenesis, outer membrane]; COG3209
RHS Repeat; cl11982
RHS repeat-associated core domain; TIGR03696
Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; cd01286
Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; cd01286
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
C2 domain found in Human protein Kibra; cd08680
PMP-22/EMP/MP20/Claudin family; cl15797
PMP-22/EMP/MP20/Claudin family; cl15797
Protein of unknown function (DUF3469); pfam11952
Inhibitor of growth proteins N-terminal histone-binding; pfam12998
PHD-finger; pfam00628
RWD domain; pfam05773
Foie gras liver health family 1; pfam11817
Gryzun, putative trafficking through Golgi; pfam07919
Gryzun, putative trafficking through Golgi; pfam07919
Gryzun, putative Golgi trafficking; pfam12742
Foie gras liver health family 1; pfam11817
Gryzun, putative trafficking through Golgi; pfam07919
Gryzun, putative trafficking through Golgi; pfam07919
Gryzun, putative Golgi trafficking; pfam12742
Winged helix Storkhead-box1 domain; pfam10264
Sulfatase; cl10460
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cd00032
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cd00032
Eukaryotic and archaeal DNA primase small subunit; pfam01896
Herpesviridae UL52/UL70 DNA primase; pfam03121
CENP-A nucleosome associated complex (NAC) subunit; pfam13097
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Hairy Orange; pfam07527
ADP/ATP transporter on adenylate translocase; Provisional
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
KIAA1430 homologue; pfam13879
PXA domain; pfam02194
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; cd08720
The phosphoinositide binding Phox Homology domain of Sorting Nexin 25; cd06878
Sorting nexin C terminal; pfam08628
FOG: TPR repeat, SEL1 subfamily [General function prediction only]
Sel1 repeat; cl02723
Sel1-like repeats; smart00671
FOG: TPR repeat, SEL1 subfamily [General function prediction only]
Sel1-like repeats; smart00671
Sel1 repeat; cl02723
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (many copies); pfam13637
Peptidase family C78; pfam07910
Myosin-like coiled-coil protein; pfam09728
Myosin-like coiled-coil protein; pfam09728
This family represents the LIM domain of ALP, actinin-associated LIM protein; cd09450
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
This family represents the LIM domain of ALP, actinin-associated LIM protein; cd09450
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
ZASP-like motif; smart00735
This family represents the LIM domain of ALP, actinin-associated LIM protein; cd09450
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
ZASP-like motif; smart00735
This family represents the LIM domain of ALP, actinin-associated LIM protein; cd09450
Sorbin homologous domain; smart00459
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Src Homology 3 domain superfamily; cl17036
Sorbin homologous domain; smart00459
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Src Homology 3 domain superfamily; cl17036
Sorbin homologous domain; smart00459
First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11920
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11917
Sorbin homologous domain; pfam02208
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Src Homology 3 domain superfamily; cl17036
Sorbin homologous domain; smart00459
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Src Homology 3 domain superfamily; cl17036
Sorbin homologous domain; smart00459
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Src Homology 3 domain superfamily; cl17036
Sorbin homologous domain; smart00459
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11917
Sorbin homologous domain; pfam02208
First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11920
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11917
Sorbin homologous domain; pfam02208
Src Homology 3 domain superfamily; cl17036
Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2); cd11923
Src Homology 3 domain superfamily; cl17036
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
TIR domain; pfam01582
Protein of unknown function (DUF3719); pfam12516
Protein of unknown function (DUF3719); pfam12516
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; cd01100
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
7 transmembrane receptor (rhodopsin family); pfam00001
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
FRG1-like family; pfam06229
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Divergent CRAL/TRIO domain; pfam13716
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology-like domain; cl00273
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Fumarate reductase flavoprotein C-term; pfam02910
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
PAS fold; pfam00989
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS fold; pfam00989
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Exocyst complex component Sec6; pfam06046
sodium/hydrogen exchanger 3; TIGR00840
Leucine rich repeat; pfam13855
p25-alpha; pfam05517
DHHC palmitoyltransferase; pfam01529
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene...; cd05513
Domain of unknown function (DUF3512); pfam12024
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; cl02556
Domain of unknown function (DUF3512); pfam12024
ATPases associated with a variety of cellular activities; smart00382
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; COG0464
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Putative binding domain; pfam13900
K-Cl cotransporter; TIGR00930
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; cd11516
glycine transporter, B0AT3; solute-binding domain; cd11517
Telomerase ribonucleoprotein complex - RNA binding domain; smart00975
TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as...; cd01648
Telomerase ribonucleoprotein complex - RNA binding domain; smart00975
TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as...; cd01648
Cleft lip and palate transmembrane protein 1 (CLPTM1); pfam05602
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; cd11514
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; COG0204
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991
EF-hand domain pair; pfam13833
Ribosomal protein L36; pfam00444
Zinc-finger domain; pfam10276
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Motif in Iroquois-class homeodomain proteins (only). Unknown function; smart00548
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
Thrombospondin type 1 repeats; smart00209
ADAM-TS Spacer 1; pfam05986
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
PLAC (protease and lacunin) domain; pfam08686
Transcription factor subunit Med10 of Mediator complex; pfam09748
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; COG0144
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
NOL1/NOP2/sun family; pfam01189
3-oxo-5-alpha-steroid 4-dehydrogenase; pfam02544
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Cid1 family poly A polymerase; pfam03828
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
Domain of Unknown Function (DUF1053); pfam06327
Adenylyl- / guanylyl cyclase, catalytic domain; smart00044
cyclase homology domain; cd07302
FAST kinase-like protein, subdomain 1; pfam06743
FAST kinase-like protein, subdomain 2; pfam08368
This domain is found in various eukaryotic species, particularly in apicomplexans; smart00952
Flavodoxin; pfam00258
FAD binding domain; pfam00667
Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred...; cd06203
Flavodoxin; pfam00258
FAD binding domain; pfam00667
Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred...; cd06203
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); cd11263
semaphorin domain; smart00630
Plexin repeat; pfam01437
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Mammalian taste receptor protein (TAS2R); pfam05296
Methyltransferase domain; pfam13659
Methyltransferase domain; pfam13659
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins; cd03339
TCP-1/cpn60 chaperonin family; pfam00118
Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]
Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; cl12031
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins; smart00744
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins; smart00744
Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains; cl02594
Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains; cl02594
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Dynein heavy chain, N-terminal region 1; pfam08385
Dynein heavy chain, N-terminal region 2; pfam08393
Hydrolytic ATP binding site of dynein motor region D1; pfam12774
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Microtubule-binding stalk of dynein motor; pfam12777
ATP-binding dynein motor region D5; pfam12781
Dynein heavy chain and region D6 of dynein motor; pfam03028
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to...; cd00170
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Trio pleckstrin homology (PH) domain; cd01232
First Src homology 3 domain of the RhoGEF kinase, Kalirin; cd11852
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Trio pleckstrin homology (PH) domain; cd01232
Second Src homology 3 domain of the RhoGEF kinase, Kalirin; cd11853
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; cl02570
OTU-like cysteine protease; cl14910
Progressive ankylosis protein (ANKH); pfam07260
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Antagonist of mitotic exit network protein 1; cl15308
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins; smart00744
Zinc-finger double-stranded RNA-binding; pfam12171
C2H2 type zinc-finger (2 copies); pfam12756
Haloacid Dehalogenase-like Hydrolases; cl11391
Myosin. Large ATPases; smart00242
Myosin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport; cd00124
Pleckstrin homology-like domain; cl00273
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Domain in Myosin and Kinesin Tails; smart00139
Band 4.1 homologues; smart00295
FERM central domain; pfam00373
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin cytoplasmic region; pfam01049
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin repeat-like domain; cl15786
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin cytoplasmic region; pfam01049
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
SSXRD motif; pfam09514
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin cytoplasmic region; pfam01049
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin cytoplasmic region; pfam01049
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin cytoplasmic region; pfam01049
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; cd00593
ribonuclease III; Reviewed; PRK00102
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; cd00593
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; cd00593
ribonuclease III; Reviewed; PRK00102
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; cd00593
Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
UPF0489 domain; pfam12640
Uncharacterized protein conserved in bacteria (DUF2336); pfam10098
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Golgi phosphoprotein 3 (GPP34); pfam05719
Myotubularin-related; pfam06602
Myotubularin Y_phosphatase-like; pfam13849
Myotubularin-associated protein; pfam12578
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
domain in DSRM or ZnF_C2H2 domain containing proteins; smart00572
Transcriptional Coactivator p15 (PC4); pfam02229
Receptor family ligand binding region; pfam01094
Type 1 periplasmic binding fold superfamily; cl10011
Ligand-binding domain of type C natriuretic peptide receptor; cd06386
Receptor family ligand binding region; pfam01094
Ligand-binding domain of type C natriuretic peptide receptor; cd06386
Receptor family ligand binding region; pfam01094
threonyl-tRNA synthetase
TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; cd01667
Threonyl and Alanyl tRNA synthetase second additional domain; smart00863
Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00771
ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00860
threonyl-tRNA synthetase
TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; cd01667
Threonyl and Alanyl tRNA synthetase second additional domain; smart00863
Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00771
ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00860
threonyl-tRNA synthetase
TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; cd01667
Threonyl and Alanyl tRNA synthetase second additional domain; smart00863
Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00771
ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00860
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
Thrombospondin type 1 repeats; smart00209
ADAM-TS Spacer 1; pfam05986
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
7 transmembrane receptor (rhodopsin family); pfam00001
GPH family sucrose/H+ symporter; TIGR01301
GPH family sucrose/H+ symporter; TIGR01301
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; COG1804
CoA-transferase family III; pfam02515
C1q domain; pfam00386
C1q domain; pfam00386
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat; pfam13424
Repair protein Rad1/Rec1/Rad17; pfam02144
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea.  These polymerase processivity factors play a role in DNA replication and repair.  PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the...; cd00577
Brix domain; cl00935
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Tumour suppressor, Mitostatin; pfam13868
DNA-binding domain; pfam13892
Zinc-finger double-stranded RNA-binding; pfam12171
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Tumour suppressor, Mitostatin; pfam13868
DNA-binding domain; pfam13892
Zinc-finger double-stranded RNA-binding; pfam12171
4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; COG0160
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; cd00610
Erythropoietin receptor, ligand binding; pfam09067
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Erythropoietin receptor, ligand binding; pfam09067
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Erythropoietin receptor, ligand binding; pfam09067
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Erythropoietin receptor, ligand binding; pfam09067
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Erythropoietin receptor, ligand binding; pfam09067
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Domain of Unknown Function (DUF1042); pfam06294
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Domain of Unknown Function (DUF1042); pfam06294
Fibronectin type III domain; pfam00041
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
EF-hand domain pair; pfam13499
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
NADPH-dependent FMN reductase; cl00438
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
UDP-glucoronosyl and UDP-glucosyl transferase; pfam00201
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; cd03784
LMBR1-like membrane protein; pfam04791
LMBR1-like membrane protein; pfam04791
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Antagonist of mitotic exit network protein 1; cl15308
Diacylglycerol kinase catalytic domain; cl01255
Diacylglycerol kinase catalytic domain; cl01255
Ran-binding domain; cd00835
Ran-binding domain; cd00835
Sodium:dicarboxylate symporter family; pfam00375
Na+/H+-dicarboxylate symporters [Energy production and conversion]; COG1301
Sodium:dicarboxylate symporter family; pfam00375
Na+/H+-dicarboxylate symporters [Energy production and conversion]; COG1301
Protein of unknown function (DUF1509); pfam07420
HEAT repeat associated with sister chromatid cohesion; pfam12765
Sister chromatid cohesion C-terminus; pfam12830
Protein of unknown function (DUF1509); pfam07420
HEAT repeat associated with sister chromatid cohesion; pfam12765
Sister chromatid cohesion C-terminus; pfam12830
Nup133 N terminal like; pfam08801
Non-repetitive/WGA-negative nucleoporin C-terminal; pfam03177
Nup133 N terminal like; pfam08801
Non-repetitive/WGA-negative nucleoporin C-terminal; pfam03177
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Transforming growth factor beta like domain; pfam00019
Transforming growth factor beta like domain; pfam00019
Transforming growth factor beta like domain; pfam00019
Transforming growth factor beta like domain; pfam00019
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cl00065
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cl00065
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type III domain; pfam00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interleukin-6 receptor alpha chain, binding; cl12153
rRNA processing/ribosome biogenesis; pfam08167
Src homology 3 domains; smart00326
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein; cd11867
Src homology 3 domains; smart00326
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein; cd11867
Src homology 3 domains; smart00326
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein; cd11867
Thrombospondin type 1 repeats; smart00209
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
membrane-attack complex / perforin; smart00457
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
7 transmembrane receptor (rhodopsin family); pfam00001
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
60S ribosomal protein L37; Provisional
Caspase activation and recruitment domain: a protein-protein interaction domain; cd01671
Thrombospondin type 1 repeats; smart00209
membrane-attack complex / perforin; smart00457
Thrombospondin type 1 repeats; smart00209
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
factor I membrane attack complex; smart00057
factor I membrane attack complex; smart00057
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 domain; pfam00090
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
membrane-attack complex / perforin; smart00457
Thrombospondin type 1 repeats; smart00209
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
factor I membrane attack complex; smart00057
factor I membrane attack complex; smart00057
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 domain; pfam00090
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112
membrane-attack complex / perforin; smart00457
Thrombospondin type 1 repeats; smart00209
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
factor I membrane attack complex; smart00057
factor I membrane attack complex; smart00057
Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1; cd08616
Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; COG1788
Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]
3-oxoacid CoA-transferase, B subunit; TIGR02428
F-box-like; pfam12937
C-terminal GTPase-like domain of F-Box Only Protein 4; cd11656
F-box-like; pfam12937
C-terminal GTPase-like domain of F-Box Only Protein 4; cd11656
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Growth hormone receptor binding; pfam12772
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Selenoprotein P, N terminal region; pfam04592
Selenoprotein P, C terminal region; pfam04593
Selenoprotein P, N terminal region; pfam04592
Selenoprotein P, C terminal region; pfam04593
Selenoprotein P, N terminal region; pfam04592
Selenoprotein P, C terminal region; pfam04593
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; TIGR01833
'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; cd00827
3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; TIGR01833
'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; cd00827
Small cytokines (intecrine/chemokine), interleukin-8 like; pfam00048
MIF4G domain; pfam02854
MIF4G domain; pfam02854
MIF4G domain; pfam02854
NAD(P) transhydrogenase subunit alpha; Provisional; PRK09424
Alanine dehydrogenase/PNT, N-terminal domain; smart01003
Alanine dehydrogenase/PNT, C-terminal domain; smart01002
Domain of unknown function (DUF3814); pfam12769
NAD(P) transhydrogenase beta subunit; pfam02233
NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; cl00566
NAD(P) transhydrogenase subunit alpha; Provisional; PRK09424
Alanine dehydrogenase/PNT, N-terminal domain; smart01003
Alanine dehydrogenase/PNT, C-terminal domain; smart01002
Domain of unknown function (DUF3814); pfam12769
NAD(P) transhydrogenase beta subunit; pfam02233
NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; cl00566
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Mitochondrial 28S ribosomal protein S30 (PDCD9); pfam07147
Ion transport protein N-terminal; pfam08412
Ion transport protein; pfam00520
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; cd01341
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; cd01341
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; cd01341
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; cd01341
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; cl00283
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; cd01341
The first LIM domain of Isl, a member of LHX protein family; cd09366
The second LIM domain of Isl, a member of LHX protein family; cd09374
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta...; cd01469
Integrin alpha (beta-propellor repeats); smart00191
Integrin alpha (beta-propellor repeats); smart00191
Family description; pfam13517
Integrin alpha; pfam08441
Predicted RNA-binding proteins [General function prediction only]; COG1537
eRF1 domain 1; pfam03463
eRF1 domain 2; pfam03464
eRF1 domain 3; pfam03465
FG-GAP repeat; cl15299
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta...; cd01469
FG-GAP repeat; cl15299
Integrin alpha (beta-propellor repeats); smart00191
Integrin alpha (beta-propellor repeats); smart00191
Family description; pfam13517
Integrin alpha (beta-propellor repeats); smart00191
Integrin alpha; pfam08441
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; cd00756
Ubiquitin domain of MoaD-like proteins; cd00754
Follistatin/Osteonectin-like EGF domain; cl11510
Kazal type serine protease inhibitors; smart00280
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cl00097
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Follistatin/Osteonectin-like EGF domain; cl11510
Kazal type serine protease inhibitors; smart00280
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cl00097
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
ETC complex I subunit conserved region; pfam04800
GTPase SAR1 and related small G proteins [General function prediction only]
Arf-like 9 (Arl9)/Arfrp2-like GTPase; cd04162
Alpha crystallin domain (ACD) found in mammalian HspB3, also known as heat-shock protein 27-like protein (HSPL27, 17-kDa) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are...; cd06477
Src Homology 3 domain of Sorting nexin 18; cd11897
The phosphoinositide binding Phox Homology domain of Sorting Nexin 18; cd07286
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18; cd07670
Src Homology 3 domain of Sorting nexin 18; cd11897
The phosphoinositide binding Phox Homology domain of Sorting Nexin 18; cd07286
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
Src Homology 3 domain of Sorting nexin 18; cd11897
The phosphoinositide binding Phox Homology domain of Sorting Nexin 18; cd07286
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
Insulin-like growth factor binding protein; cl02472
Insulin-like growth factor binding protein; cl02472
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; cd00340
Geminin; pfam07412
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cl00050
DEAD-like helicases superfamily; smart00487
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
HrpA-like helicases [DNA replication, recombination, and repair]; COG1643
Helicase associated domain (HA2); pfam04408
Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717
Superfamily II RNA helicase [DNA replication, recombination, and repair]
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
helicase superfamily c-terminal domain; smart00490
rRNA-processing arch domain; pfam13234
DSHCT (NUC185) domain; pfam08148
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the...; cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the...; cd03384
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; cl15776
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Ig-like C2-type domain; pfam06328
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Ig-like C2-type domain; pfam06328
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Ig-like C2-type domain; pfam06328
Interleukin-6 receptor alpha chain, binding; cl12153
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 1; cd06630
Serine/Threonine protein kinases, catalytic domain; smart00220
SET domain; pfam00856
ELM2 domain; pfam01448
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Myb-Like Dna-Binding Domain of MTA3 and related proteins; cd11661
Actin; pfam00022
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
POLO box duplicated region; pfam00659
POLO box duplicated region; pfam00659
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
POLO box duplicated region; pfam00659
POLO box duplicated region; pfam00659
GRB2-binding adapter (GAPT); pfam11770
Rab family protein; Provisional
Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D; cd01865
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function; cd04447
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain...; cd04405
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function; cd04447
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain...; cd04405
GNS1/SUR4 family; pfam01151
GNS1/SUR4 family; pfam01151
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
NADH ubiquinone oxidoreductase subunit NDUFA12; pfam05071
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain...; cd01367
Kinesin motor, catalytic domain. ATPase; smart00129
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain...; cd01367
Kinesin motor, catalytic domain. ATPase; smart00129
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain...; cd01367
Kinesin motor, catalytic domain. ATPase; smart00129
Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain...; cd01367
Kinesin motor, catalytic domain. ATPase; smart00129
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; COG5657
Importin-beta N-terminal domain; pfam03810
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; COG5657
Importin-beta N-terminal domain; pfam03810
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Wnt and FGF inhibitory regulator; pfam13908
Zinc knuckle; pfam13917
cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced...; cd01925
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
Thrombospondin type 1 repeats; smart00209
ADAM-TS Spacer 1; pfam05986
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
PLAC (protease and lacunin) domain; pfam08686
Centromere-associated protein K; pfam11802
Centromere-associated protein K; pfam11802
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain; cd01927
peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional
Ring finger; smart00184
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
B-Box C-terminal domain; smart00502
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
GTPase SAR1 and related small G proteins [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Ring finger; smart00184
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cl00034
B-Box C-terminal domain; smart00502
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
GTPase SAR1 and related small G proteins [General function prediction only]
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box-type zinc finger; smart00336
B-Box C-terminal domain; smart00502
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; cl02600
GTPase SAR1 and related small G proteins [General function prediction only]
(ADP-ribosylation factor domain protein 1 (ARD1); cd04158
Protein of unknown function (DUF974); pfam06159
Protein of unknown function (DUF974); pfam06159
Protein of unknown function (DUF974); pfam06159
Protein of unknown function (DUF974); pfam06159
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Zn-dependent oligopeptidases [Amino acid transport and metabolism]; COG0339
Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; cd06455
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Domain of unknown function (DUF1908); pfam08926
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; cd05609
Serine/Threonine protein kinases, catalytic domain; smart00220
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Domain of unknown function (DUF1908); pfam08926
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; cd05609
Serine/Threonine protein kinases, catalytic domain; smart00220
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Leucine rich repeat; pfam13855
Leucine Rich repeats (2 copies); pfam12799
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases; cd11910
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region...; cd04388
GTPase-activator protein for Rho-like GTPases; smart00324
N-terminal Src homology 2 (nSH2) domain found in p85; cd09942
C-terminal Src homology 2 (cSH2) domain found in p85; cd09930
N-terminal Src homology 2 (nSH2) domain found in p85; cd09942
C-terminal Src homology 2 (cSH2) domain found in p85; cd09930
N-terminal Src homology 2 (nSH2) domain found in p85; cd09942
C-terminal Src homology 2 (cSH2) domain found in p85; cd09930
Src homology 2 (SH2) domain; cl15255
C-terminal Src homology 2 (cSH2) domain found in p85; cd09930
cation diffusion facilitator family transporter; TIGR01297
Cation efflux family; pfam01545
Cyclin [Cell division and chromosome partitioning]
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Centromere protein H (CENP-H); pfam05837
cyclin-dependent protein kinase; Provisional
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; cd07841
Microtubule-associated protein Bicaudal-D; pfam09730
AAA domain; pfam13238
AAA domain; pfam13207
Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]
AAA domain; pfam13207
TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd07979
TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd07979
checkpoint protein rad24; TIGR00602
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
checkpoint protein rad24; TIGR00602
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
checkpoint protein rad24; TIGR00602
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
checkpoint protein rad24; TIGR00602
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
checkpoint protein rad24; TIGR00602
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
checkpoint protein rad24; TIGR00602
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Rad17 cell cycle checkpoint protein; pfam03215
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
checkpoint protein rad24; TIGR00602
Membrane-associating domain; pfam01284
Occludin homology domain; pfam07303
Membrane-associating domain; pfam01284
Occludin homology domain; pfam07303
Membrane-associating domain; pfam01284
Occludin homology domain; pfam07303
Membrane-associating domain; pfam01284
Occludin homology domain; pfam07303
Occludin homology domain; pfam07303
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins...; cd01453
transcription factor ssl1; TIGR00622
TFIIH C1-like domain; pfam07975
4F5 protein family; pfam04419
Survival motor neuron protein (SMN); pfam06003
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Survival motor neuron protein (SMN); pfam06003
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Survival motor neuron protein (SMN); pfam06003
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Survival motor neuron protein (SMN); pfam06003
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
4F5 protein family; pfam04419
Survival motor neuron protein (SMN); pfam06003
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Survival motor neuron protein (SMN); pfam06003
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes; cd00022
ATPases associated with a variety of cellular activities; smart00382
NACHT domain; pfam05729
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes; cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes; cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes; cd00022
ATPases associated with a variety of cellular activities; smart00382
NACHT domain; pfam05729
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins...; cd01453
transcription factor ssl1; TIGR00622
TFIIH C1-like domain; pfam07975
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cl15779
3-methylcrotonyl-CoA carboxylase, beta chain
Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; cl15772
Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; cl15772
Cocaine and amphetamine regulated transcript protein (CART); pfam06373
Mitochondrial 28S ribosomal protein S27; pfam10037
Mitochondrial 28S ribosomal protein S27; pfam10037
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Importin-beta N-terminal domain; pfam03810
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
HEAT-like repeat; pfam13513
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
HEAT-like repeat; pfam13513
Importin-beta N-terminal domain; pfam03810
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
HEAT-like repeat; pfam13513
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
HEAT-like repeat; pfam13513
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein; cd07673
mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins; cd09267
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins; cd09267
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
NAC domain; pfam01849
NAC domain; pfam01849
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
UTP15 C terminal; pfam09384
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology (PH) domain; cd00821
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology (PH) domain; cd00821
Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...; cd00029
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology (PH) domain; cd00821
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
BTB/POZ domain; pfam00651
kelch-like protein; Provisional
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
Broad-Complex, Tramtrack and Bric a brac; smart00225
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch motif; pfam01344
Glycosyl hydrolase family 20, domain 2; pfam02838
Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the...; cd06562
Glycosyl hydrolase family 20, catalytic domain; pfam00728
Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; COG0480
Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; cd01886
Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; cl02787
mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory...; cd01693
EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; cd03713
elongation factor G; Reviewed
Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; cd01886
mtEFG2_C: C-terminus of mitochondrial Elongation factor G2 (mtEFG2)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; cd04092
mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory...; cd01693
EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; cd03713
Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; cd01886
mtEFG2_C: C-terminus of mitochondrial Elongation factor G2 (mtEFG2)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; cd04092
pre-ribosomal protein NSA2 (Nop seven-associated 2); cd11381
Core-2/I-Branching enzyme; pfam02485
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGR00920
Protein export membrane protein; cl14618
Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); cd00643
3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGR00920
Protein export membrane protein; cl14618
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); cl00205
Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); cd00643
Goodpasture antigen binding protein (GPBP) Pleckstrin homology (PH) domain; cd01247
Ceramide-binding START domain of mammalian STARD11 and related domains; cd08872
Goodpasture antigen binding protein (GPBP) Pleckstrin homology (PH) domain; cd01247
Ceramide-binding START domain of mammalian STARD11 and related domains; cd08872
Goodpasture antigen binding protein (GPBP) Pleckstrin homology (PH) domain; cd01247
Ceramide-binding START domain of mammalian STARD11 and related domains; cd08872
DNA Polymerase IV/Kappa; cd03586
DNA Polymerase IV/Kappa; cd03586
Rad18-like CCHC zinc finger; smart00734
Rad18-like CCHC zinc finger; smart00734
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Death Domain: a protein-protein interaction domain; cd01670
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
synaptic vesicle protein SV2; TIGR01299
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
Calmodulin-binding motif; smart00015
IQGAP2 is a member of the IQGAP family that contains a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeat, a single WW domain, four IQ motifs which mediate interactions with calmodulin, and a Ras-GTPase-activating protein (GAP)...; cd05131
RasGAP C-terminus; pfam03836
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
S-100Z: S-100Z domain found in proteins similar to S100Z. S100Z is a member of the S100 domain family within the EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100Z group belongs, contains only S-100 EF-hand...; cd05026
Corticotropin-releasing factor binding protein (CRF-BP); pfam05428
FOG: FHA domain [Signal transduction mechanisms]
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
BED zinc finger; smart00614
PDE8 phosphodiesterase; pfam08629
Response regulator receiver domain; pfam00072
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; pfam13426
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
PDE8 phosphodiesterase; pfam08629
Response regulator receiver domain; pfam00072
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; pfam13426
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
PDE8 phosphodiesterase; pfam08629
Response regulator receiver domain; pfam00072
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
PDE8 phosphodiesterase; pfam08629
Response regulator receiver domain; pfam00072
hypothetical protein; Provisional; PHA02597
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
PDE8 phosphodiesterase; pfam08629
Response regulator receiver domain; pfam00072
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; pfam13426
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Tubulin binding cofactor A; pfam02970
Adaptin N terminal region; pfam01602
SCAMP family; pfam04144
Lipoma HMGIC fusion partner-like protein; pfam10242
Sulfatase; pfam00884
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
FAD dependent oxidoreductase; pfam01266
Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; COG0404
Sarcosine oxidase, gamma subunit family; cl01893
Glycine cleavage T-protein C-terminal barrel domain; pfam08669
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; cl14105
Homocysteine S-methyltransferase; pfam02574
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; cl14105
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; COG2040
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; cl14105
Homocysteine S-methyltransferase; pfam02574
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; cl14105
Homer type EVH1 domain; cd01206
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; cd05402
Cid1 family poly A polymerase; pfam03828
B-Box C-terminal domain; smart00502
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Domain in SPla and the RYanodine Receptor; smart00449
C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; cd03212
GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the...; cd03078
C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; cd03212
Thrombospondin N-terminal -like domains; smart00210
Cartilage oligomeric matrix protein; pfam11598
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Thrombospondin type 3 repeat; pfam02412
Thrombospondin type 3 repeat; pfam02412
Thrombospondin C-terminal region; pfam05735
Serine incorporator (Serinc); pfam03348
Serine incorporator (Serinc); pfam03348
Serine incorporator (Serinc); pfam03348
chromosome segregation protein SMC, common bacterial type; TIGR02168
Fungal specific transcription factor domain; pfam11951
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Domain of unknown function (DUF3480); pfam11979
Fungal specific transcription factor domain; pfam11951
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Domain of unknown function (DUF3480); pfam11979
Uncharacterized conserved protein (DUF2181); pfam10223
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; cd00209
Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; COG0249
MutS domain I; pfam01624
MutS domain II; pfam05188
MutS family domain IV; pfam05190
MutS domain V; pfam00488
Pleckstrin homology (PH) domain; cd00821
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
Pleckstrin homology (PH) domain; cd00821
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes; cd00716
Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes; cd00716
Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes; cd00716
universal minicircle sequence binding protein (UMSBP); Provisional
Zinc knuckle; cl15298
universal minicircle sequence binding protein (UMSBP); Provisional
Zinc knuckle; cl15298
universal minicircle sequence binding protein (UMSBP); Provisional
Zinc knuckle; cl15298
Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; cd03442
Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; cd03442
Lipid-binding START domain of mammalian STARD15 and related proteins; cd08914
Single-stranded DNA binding protein, SSDP; pfam04503
Single-stranded DNA binding protein, SSDP; pfam04503
Single-stranded DNA binding protein, SSDP; pfam04503
Single-stranded DNA binding protein, SSDP; pfam04503
Single-stranded DNA binding protein, SSDP; pfam04503
Single-stranded DNA binding protein, SSDP; pfam04503
Autophagocytosis associated protein, active-site domain; pfam03987
Autophagocytosis associated protein, active-site domain; pfam03987
S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the large and small ribosomal subunits of eukaryotes, adjacent to the decoding center. It interacts with domain III of the eukaryotic elongation factor 2 (eEF2); cd03367
Lysosome-associated membrane glycoprotein (Lamp); pfam01299
Protein of unknown function (DUF1242); pfam06842
DNA double-strand break repair and V(D)J recombination protein XRCC4; pfam06632
DNA double-strand break repair and V(D)J recombination protein XRCC4; pfam06632
DNA double-strand break repair and V(D)J recombination protein XRCC4; pfam06632
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; cd05901
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs:...; cd03517
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The...; cd03520
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins; cd03588
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; cd05901
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs:...; cd03517
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The...; cd03520
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins; cd03588
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; cd05901
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs:...; cd03517
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The...; cd03520
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins; cd03588
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; cd05901
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs:...; cd03517
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The...; cd03520
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; cl02432
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP); cd05877
Immunoglobulin V-Type; smart00406
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding...; cd03518
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a...; cd03519
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd00929
N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP); cd10353
Src Homology 3 domain of Ras GTPase-Activating Protein 1; cd11788
C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP); cd10354
RAS GTPase-activating protein (GAP) CG5898 Pleckstrin homology (PH) domain; cd01245
C2 domain present in RAS p21 protein activator 1 (RasA1); cd08400
p120GAP is a negative regulator of Ras that stimulates hydrolysis of bound GTP to GDP. Once the Ras regulator p120GAP, a member of the GAP protein family, is recruited to the membrane, it is transiently immobilized to interact with Ras-GTP. The down...; cd05391
Src homology 2 (SH2) domain; cl15255
Src Homology 3 domain of Ras GTPase-Activating Protein 1; cd11788
C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP); cd10354
RAS GTPase-activating protein (GAP) CG5898 Pleckstrin homology (PH) domain; cd01245
C2 domain present in RAS p21 protein activator 1 (RasA1); cd08400
p120GAP is a negative regulator of Ras that stimulates hydrolysis of bound GTP to GDP. Once the Ras regulator p120GAP, a member of the GAP protein family, is recruited to the membrane, it is transiently immobilized to interact with Ras-GTP. The down...; cd05391
cyclin ccl1; TIGR00569
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
cyclin ccl1; TIGR00569
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Predicted transmembrane protein 161AB; pfam10268
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265
Holliday junction regulator protein family C-terminal repeat; pfam12347
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265
Holliday junction regulator protein family C-terminal repeat; pfam12347
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265
Holliday junction regulator protein family C-terminal repeat; pfam12347
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265
Holliday junction regulator protein family C-terminal repeat; pfam12347
centrin; Provisional
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Zn-dependent hydrolases, including glyoxylases [General function prediction only]; COG0491
Metallo-beta-lactamase superfamily; smart00849
DNA-directed RNA polymerase III subunit Rpc31; pfam11705
Lysine Motif is a small domain involved in binding peptidoglycan; cd00118
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Concanavalin A-like lectin/glucanases superfamily; pfam13385
Calx-beta domain; cl02522
Calx-beta domain; pfam03160
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
EPTP domain; pfam03736
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Domains in Na-Ca exchangers and integrin-beta4; smart00237
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Calx-beta domain; cl02522
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
Arrestin (or S-antigen), N-terminal domain; pfam00339
Arrestin (or S-antigen), C-terminal domain; smart01017
DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers; cd06958
Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family; cd06948
Arb2 domain; pfam09757
Arb2 domain; pfam09757
Arb2 domain; pfam09757
Pou domain - N-terminal to homeobox domain; pfam00157
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); cd04042
C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); cd08376
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); cd08377
Plant phosphoribosyltransferase C-terminal; pfam08372
C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); cd04042
C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); cd08376
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); cd08377
Plant phosphoribosyltransferase C-terminal; pfam08372
phosphodiesterase; Provisional
Tetratricopeptide repeat; pfam13432
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
putative PEP-CTERM system TPR-repeat lipoprotein; TIGR02917
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; cl10460
Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; cd03467
Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; cd03467
Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; cd03467
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Broad-Complex, Tramtrack and Bric a brac; smart00225
Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419
Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419
Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419
Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419
RNA polymerase II elongation factor ELL; pfam10390
Occludin homology domain; pfam07303
Peptidase S8 family domain in Protein convertases; cd04059
Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; COG1404
Proprotein convertase P-domain; pfam01483
Prohormone convertase enzyme; pfam12177
Peptidase S8 family domain in Protein convertases; cd04059
Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; COG1404
Proprotein convertase P-domain; pfam01483
Prohormone convertase enzyme; pfam12177
Peptidase domain in the S8 and S53 families; cl10459
Peptidase domain in the S8 and S53 families; cl10459
Proprotein convertase P-domain; pfam01483
Prohormone convertase enzyme; pfam12177
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Calpain inhibitor; pfam00748
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
Rio2, N-terminal; pfam09202
RIO kinase family; RIO2, C-terminal catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); cd05144
RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
Rio2, N-terminal; pfam09202
RIO kinase family; RIO2, C-terminal catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); cd05144
Repulsive guidance molecule (RGM) N-terminus; pfam06535
Repulsive guidance molecule (RGM) C-terminus; pfam06534
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
SNF2 family N-terminal domain; pfam00176
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; COG0513
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Domain of unknown function (DUF4208); pfam13907
Protein of unknown function (DUF1180); pfam06679
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Glycosyltransferase family 29 (sialyltransferase); pfam00777
Organic Anion Transporter Polypeptide (OATP) family; pfam03137
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...; cd01330
Organic Anion Transporter Polypeptide (OATP) family; pfam03137
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a...; cd01330
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; pfam01082
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; pfam03712
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; pfam01082
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; pfam03712
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; pfam01082
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; pfam03712
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; pfam01082
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; pfam03712
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; pfam01082
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; pfam03712
Uncharacterized conserved protein [Function unknown]
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
NHL repeat; pfam01436
Integrase core domain; pfam00665
ATP-grasp domain; cl03087
Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cl11399
Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; cd07061
Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; cd07061
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; COG2816
NADH pyrophosphatase zinc ribbon domain; pfam09297
NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; cd03429
Receptor Binding Domain of Ephrin A; cd10425
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Antagonist of mitotic exit network protein 1; cl15308
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase; cd07686
Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins; cd10361
Protein tyrosine kinase; pfam07714
Catalytic domain of the Protein Tyrosine Kinase, Fer; cd05085
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
alpha-mannosidase
N-terminal catalytic domain of Golgi alpha-mannosidase II and similar proteins; glycoside hydrolase family 38 (GH38); cd11666
Alpha mannosidase, middle domain; smart00872
Mitochondrial carrier protein; pfam00153
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Utp21 specific WD40 associated putative domain; pfam04192
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; cl14643
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Neuronal protein 3.1 (p311); pfam11092
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
FERM adjacent (FA); pfam08736
Adenomatous polyposis coli tumour suppressor protein; pfam11414
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
APC cysteine-rich region; pfam05923
APC cysteine-rich region; pfam05923
APC cysteine-rich region; pfam05923
SAMP Motif; pfam05924
APC basic domain; pfam05956
EB-1 Binding Domain; pfam05937
Adenomatous polyposis coli tumour suppressor protein; pfam11414
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
APC cysteine-rich region; pfam05923
APC cysteine-rich region; pfam05923
APC cysteine-rich region; pfam05923
SAMP Motif; pfam05924
APC basic domain; pfam05956
EB-1 Binding Domain; pfam05937
Adenomatous polyposis coli tumour suppressor protein; pfam11414
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
APC cysteine-rich region; pfam05923
APC cysteine-rich region; pfam05923
APC cysteine-rich region; pfam05923
SAMP Motif; pfam05924
APC basic domain; pfam05956
EB-1 Binding Domain; pfam05937
SRP19 protein; pfam01922
SRP19 protein; pfam01922
SRP19 protein; pfam01922
SRP19 protein; pfam01922
TB2/DP1, HVA22 family; pfam03134
Dcp2, box A domain; pfam05026
mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical...; cd03672
Dcp2, box A domain; pfam05026
mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical...; cd03672
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
PDZ domain of MCC-2 bdg protein for Usher syndrome; pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; pfam10506
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine...; cd06007
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
HrpA-like helicases [DNA replication, recombination, and repair]; COG1643
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Helicase associated domain (HA2); pfam04408
Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717
YT521-B-like domain; pfam04146
Calcium-activated SK potassium channel; pfam03530
Ion channel; pfam07885
Calmodulin binding domain; smart01053
Ion channel; pfam07885
Calmodulin binding domain; smart01053
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
ATP synthase B/B' CF(0); pfam00430
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Domain in SPla and the RYanodine Receptor; smart00449
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones]; COG5029
Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes...; cd02895
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
emp24/gp25L/p24 family/GOLD; pfam01105
TIR domain; pfam13676
TIR domain; pfam13676
emp24/gp25L/p24 family/GOLD; pfam01105
emp24/gp25L/p24 family/GOLD; pfam01105
Cysteine dioxygenase type I; pfam05995
Ubiquitin-like domain of APG12; cd01612
Clathrin adaptor complex small chain; pfam01217
Peptidase family M1; pfam01433
Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); cd09601
Domain of unknown function (DUF3358); pfam11838
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several...; cd04758
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); cd11266
semaphorin domain; smart00630
Plexin repeat; pfam01437
DTW domain; pfam03942
RAVE protein 1 C terminal; pfam12234
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Domain of unknown function (DUF758); pfam05527
Domain of unknown function (DUF758); pfam05527
(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; cd05353
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; cl00509
enoyl-CoA hydratase
HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; cd03448
SCP-2 sterol transfer family; pfam02036
(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; cd05353
3-ketoacyl-(acyl-carrier-protein) reductase; Validated; PRK05653
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; cl00509
enoyl-CoA hydratase
HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; cd03448
SCP-2 sterol transfer family; pfam02036
(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; cd05353
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; cl00509
enoyl-CoA hydratase
HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; cd03448
SCP-2 sterol transfer family; pfam02036
eukaryotic ferritins; cd01056
Ferritin-like domain; pfam00210
BUD22; pfam09073
Lysyl oxidase; pfam01186
Lysyl oxidase; pfam01186
zinc-finger of a C2HC-type; pfam13913
zinc-finger of a C2HC-type; pfam13913
zinc-finger of a C2HC-type; pfam13913
zinc-finger of a C2HC-type; pfam13913
zinc-finger of a C2HC-type; pfam13913
zinc-finger of a C2HC-type; pfam13913
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Sorting nexin, N-terminal domain; pfam03700
The phosphoinositide binding Phox Homology domain of Sorting Nexin 2; cd07282
Vps5 C terminal like; pfam09325
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013
The phosphoinositide binding Phox Homology domain of Sorting Nexin 22; cd06880
cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; cl00197
SET domain; pfam00856
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Cep120 protein; pfam12416
Transforming acidic coiled-coil-containing protein (TACC); pfam05010
Cep120 protein; pfam12416
Transforming acidic coiled-coil-containing protein (TACC); pfam05010
putative serine/threonine kinase; Provisional
Catalytic domain of Protein Kinases; cd00180
Casein kinase 1 gamma C terminal; pfam12605
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Casein kinase 1 gamma C terminal; pfam12605
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Casein kinase 1 gamma C terminal; pfam12605
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Casein kinase 1 gamma C terminal; pfam12605
Catalytic domain of Protein Kinases; cd00180
Casein kinase 1 gamma C terminal; pfam12605
Catalytic domain of Protein Kinases; cd00180
Casein kinase 1 gamma C terminal; pfam12605
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]; COG5189
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; smart00568
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; cd07130
NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; COG1012
aldehyde dehydrogenase family 7 member
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; cd07130
aldehyde dehydrogenase family 7 member
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; cd07130
PHAX RNA-binding domain; pfam10258
Intermediate filament protein; pfam00038
Lamin Tail Domain; pfam00932
Intermediate filament protein; pfam00038
Lamin Tail Domain; pfam00932
The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins; smart00744
Glutaredoxin-like domain (DUF836); pfam05768
Glutaredoxin-like domain (DUF836); pfam05768
EMI domain; pfam07546
Laminin EGF-like (Domains III and V); pfam00053
EMI domain; pfam07546
Laminin EGF-like (Domains III and V); pfam00053
Protein of unknown function DUF84; cl00866
Cortexin of kidney; pfam11057
Cortexin of kidney; pfam11057
Amino acid permease N-terminal; pfam08403
K-Cl cotransporter; TIGR00930
Amino acid permease N-terminal; pfam08403
K-Cl cotransporter; TIGR00930
TB domain; pfam00683
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF domain; pfam07645
TB domain; pfam00683
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
TB domain; pfam00683
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
TB domain; pfam00683
TB domain; pfam00683
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain; smart00179
Complement Clr-like EGF-like; pfam12662
EGF domain; pfam12947
EGF domain; pfam12947
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
TB domain; pfam00683
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
TB domain; pfam00683
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
TB domain; pfam00683
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
TB domain; pfam00683
Calcium-binding EGF-like domain; smart00179
Complement Clr-like EGF-like; pfam12662
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
long-chain-acyl-CoA synthetase; Validated
AMP-binding enzyme; pfam00501
long-chain-acyl-CoA synthetase; Validated
AMP-binding enzyme; pfam00501
Isochorismatase family; pfam00857
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; cd01012
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
Thrombospondin type 1 repeats; smart00209
ADAM-TS Spacer 1; pfam05986
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
PLAC (protease and lacunin) domain; pfam08686
Uncharacterized protein family (UPF0258); pfam06789
Galactosyltransferase; cl09537
Chondroitin N-acetylgalactosaminyltransferase; pfam05679
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; cd01276
Complex 1 protein (LYR family); pfam05347
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; cd00132
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like proteins; cl00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like proteins; cl00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like proteins; cl00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like proteins; cl00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like proteins; cl00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Ubiquitin-like proteins; cl00155
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
long-chain acyl-CoA synthetase
AMP-binding enzyme; pfam00501
Interleukin-3; pfam02059
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine...; cd00040
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; pfam08336
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam03171
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; pfam08336
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam03171
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; pfam08336
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam03171
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; pfam08336
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam03171
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; pfam08336
Prolyl 4-hydroxylase alpha subunit homologues; smart00702
2OG-Fe(II) oxygenase superfamily; pfam03171
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interleukin 5; pfam02025
rad50; TIGR00606
The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains.  The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and...; cd03240
Rad50 zinc hook motif; pfam04423
The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains.  The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and...; cd03240
Interleukins 4 and 13; smart00190
Interleukin 4; pfam00727
Interleukin 4; pfam00727
Kinesin motor domain, kinesins II or KIF3_like proteins. Subgroup of kinesins, which form heterotrimers composed of 2 kinesins and one non-motor accessory subunit. Kinesins II play important roles in ciliary transport, and have been implicated in...; cd01371
Kinesin motor, catalytic domain. ATPase; smart00129
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
CDC/Septin GTPase family; cd01850
Septin; pfam00735
CDC/Septin GTPase family; cd01850
Septin; pfam00735
CDC/Septin GTPase family; cd01850
Septin; pfam00735
CDC/Septin GTPase family; cd01850
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Apx/Shroom domain ASD1; pfam08688
Apx/Shroom domain ASD2; pfam08687
Apx/Shroom domain ASD1; pfam08688
Apx/Shroom domain ASD2; pfam08687
Transforming growth factor-beta (TGF-beta) family; smart00204
UcrQ family; pfam02939
Liver-expressed antimicrobial peptide 2 precursor (LEAP-2); pfam07359
AF-4 proto-oncoprotein; pfam05110
AF-4 proto-oncoprotein; pfam05110
Zinc knuckle; pfam13917
Nucleotide-binding domain of HSPA4; cd11737
Hsp70 protein; pfam00012
factor I membrane attack complex; smart00057
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins; cd05736
Voltage-dependent anion channel of the outer mitochondrial membrane; cd07306
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
N-terminal CTNNB1 binding; pfam08347
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]; COG5201
Found in Skp1 protein family; smart00512
Skp1 family, dimerisation domain; pfam01466
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]; COG5201
Found in Skp1 protein family; smart00512
Skp1 family, dimerisation domain; pfam01466
serine/threonine protein phosphatase 2A; Provisional
PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; cd07846
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; cd07846
Serine/Threonine protein kinases, catalytic domain; smart00220
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Protein of unknown function (DUF3469); pfam11952
Enhancer of polycomb-like; pfam10513
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
Sar1 is an essential component of COPII vesicle coats; cd00879
GTPase SAR1 and related small G proteins [General function prediction only]
Sar1 is an essential component of COPII vesicle coats; cd00879
GTPase SAR1 and related small G proteins [General function prediction only]
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
Sec23/Sec24 zinc finger; pfam04810
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes...; cd01479
Sec23/Sec24 beta-sandwich domain; pfam08033
Sec23/Sec24 helical domain; pfam04815
Gelsolin repeat; pfam00626
Sec23/Sec24 zinc finger; pfam04810
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
DEAD-like helicases superfamily; smart00487
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
PDIa family, endoplasmic reticulum protein 44 (ERp44)-like subfamily; composed of uncharacterized PDI-like eukaryotic proteins containing only one redox active TRX (a) domain with a CXXS motif, similar to ERp44. CXXS is still a redox active motif; cd02999
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; cd00914
Ion transport protein; pfam00520
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
OAR domain; pfam03826
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; cd02904
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; cd02904
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; cd02904
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; cd02904
FHA domain; pfam00498
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Small cytokines (intecrine/chemokine), interleukin-8 like; pfam00048
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Interleukin 7/9 family; pfam01415
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
Peptidase family M23; pfam01551
EMI domain; pfam07546
Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]
Fasciclin domain; pfam02469
Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]
Fasciclin domain; pfam02469
Fasciclin domain; pfam02469
Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]
Fasciclin domain; pfam02469
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8); cd10490
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9; cd10497
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8); cd10490
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9; cd10497
N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8); cd10490
C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9; cd10497
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Ankyrin repeats (3 copies); pfam12796
Transient receptor ion channel II; pfam08344
transient-receptor-potential calcium channel protein; TIGR00870
transient-receptor-potential calcium channel protein; TIGR00870
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Transient receptor ion channel II; pfam08344
transient-receptor-potential calcium channel protein; TIGR00870
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Transient receptor ion channel II; pfam08344
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
kelch-like protein; Provisional
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
kelch-like protein; Provisional
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch domain; smart00612
Kelch domain; smart00612
Kelch motif; pfam01344
Kelch domain; smart00612
Kelch domain; smart00612
Kelch domain; smart00612
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
C-terminal immunoglobulin (Ig)-like domain of myotilin; cd05892
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
C-terminal immunoglobulin (Ig)-like domain of myotilin; cd05892
Polycystin cation channel; pfam08016
Polycystin cation channel; pfam08016
Polycystin cation channel; pfam08016
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active...; cd04393
GTPase-activator protein for Rho-like GTPases; smart00324
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active...; cd04393
GTPase-activator protein for Rho-like GTPases; smart00324
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; cl02570
found in Wnt-1; smart00097
wnt family; pfam00110
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa; cd04418
Dpy-30 motif; pfam05186
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be...; cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be...; cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be...; cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be...; cd05507
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; cl00286
Kinesin motor domain, KIF23-like subgroup. Members of this group may play a role in mitosis. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play...; cd01368
Anaphase promoting complex subunit 8 / Cdc23; pfam04049
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; pfam02351
M-phase inducer phosphatase; pfam06617
Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to...; cd01530
M-phase inducer phosphatase; pfam06617
Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to...; cd01530
A domain family that is part of the cupin metalloenzyme superfamily; smart00558
JmjC domain, hydroxylase; pfam02373
TB2/DP1, HVA22 family; pfam03134
Domain of unknown function (DUF3446); pfam11928
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Domain of unknown function (DUF3432); pfam11914
eRF1 domain 1; pfam03463
Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; COG1503
eRF1 domain 2; pfam03464
eRF1 domain 3; pfam03465
molecular chaperone DnaK; Provisional; PRK00290
Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; cd11733
Vinculin family; pfam01044
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
U1-like zinc finger; smart00451
Ataxin-2 C-terminal region; pfam07145
Ataxin-2 C-terminal region; pfam07145
Permease family; pfam00860
Permease family; pfam00860
conserved hypothetical protein YmdA/YtgF; TIGR03319
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Domain of unknown function (DUF1977); pfam09320
C-terminal domain of STING; cd12146
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
CXXC zinc finger domain; pfam02008
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171
Pleckstrin homology-like domain; cl00273
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
epidermal growth factor-like protein (EGF-like protein); Provisional
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Neuregulin family; pfam02158
Immunoglobulin I-set domain; pfam07679
Immunoglobulin (Ig)-like domain in neuregulins (NRGs); cd05750
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Neuregulin family; pfam02158
PurA ssDNA and RNA-binding protein; pfam04845
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; smart00712
Prefoldin subunit; pfam01920
EGF-like protein; Provisional
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
anion exchange protein; TIGR00834
HCO3- transporter family; pfam00955
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13637
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); pfam05456
Steroid receptor RNA activator (SRA1); pfam07304
Steroid receptor RNA activator (SRA1); pfam07304
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Pleckstrin homology-like domain; cl00273
Pleckstrin homology-like domain; cl00273
Nucleotide-sugar transporter; pfam04142
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cl02500
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; smart00916
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; smart00916
RED-like protein N-terminal region; pfam07808
RED-like protein C-terminal region; pfam07807
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
HisRS_RNA binding domain.  This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding...; cd00938
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00773
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00859
HisRS_RNA binding domain.  This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding...; cd00938
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00773
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00859
HisRS_RNA binding domain.  This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding...; cd00938
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; COG0124
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00773
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00859
HisRS_RNA binding domain.  This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding...; cd00938
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; COG0124
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00773
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00859
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; COG0124
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00773
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; cd00859
U1-like zinc finger; smart00451
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd08047
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin-like; pfam08266
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Diaphanous GTPase-binding Domain; pfam06371
Diaphanous FH3 Domain; pfam06367
Formin Homology Region 1; pfam06346
Formin Homology 2 Domain; pfam02181
Formin Homology 2 Domain; smart00498
Diaphanous GTPase-binding Domain; pfam06371
Diaphanous FH3 Domain; pfam06367
Formin Homology Region 1; pfam06346
Formin Homology 2 Domain; pfam02181
Formin Homology 2 Domain; smart00498
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; COG0123
Histone deacetylase 3 (HDAC3); cd10005
Tumour necrosis factor receptor superfamily member 19; pfam12606
Tumour necrosis factor receptor superfamily member 19; pfam12606
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 1 (FCHSD1); cd07678
First Src Homology 3 domain of FCH and double SH3 domains proteins; cd11761
Second Src Homology 3 domain of FCH and double SH3 domains protein 1; cd11895
SAM domain of Arap1,2,3 (angiotensin receptor-associated protein); cd09490
Sterile alpha motif; smart00454
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Putative GTPase activating protein for Arf; pfam01412
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their...; cd04385
GTPase-activator protein for Rho-like GTPases; smart00324
RA (Ras-associating) ubiquitin domain; cd01768
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Protocadherin; pfam08374
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Protocadherin; pfam08374
FOG: TPR repeat, SEL1 subfamily [General function prediction only]
Sel1-like repeats; smart00671
Sel1-like repeats; smart00671
FOG: TPR repeat, SEL1 subfamily [General function prediction only]
Sel1-like repeats; smart00671
Sel1-like repeats; smart00671
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
RWD domain; pfam05773
Ring finger domain; pfam13639
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
RWD domain; pfam05773
Ring finger domain; pfam13639
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
RWD domain; pfam05773
Ring finger domain; pfam13639
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
RWD domain; pfam05773
Ring finger domain; pfam13639
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
RWD domain; pfam05773
Ring finger domain; pfam13639
In Between Ring fingers; smart00647
IBR domain; pfam01485
IBR domain; pfam01485
Ring finger domain; pfam13639
In Between Ring fingers; smart00647
IBR domain; pfam01485
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; cd01399
Protein of unknown function (DUF2370); pfam10176
Sprouty protein (Spry); pfam05210
Sprouty protein (Spry); pfam05210
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cd00058
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cl00060
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate...; cl00060
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase; cd07636
Oligophrenin Pleckstrin homology (PH) domain; cd01249
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences...; cd04374
GTPase-activator protein for Rho-like GTPases; smart00324
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase; cd12064
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase; cd07636
Oligophrenin Pleckstrin homology (PH) domain; cd01249
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences...; cd04374
GTPase-activator protein for Rho-like GTPases; smart00324
Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase; cd12064
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; cl11397
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily; cd07076
Glucocorticoid receptor; pfam02155
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers; cd07172
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; cl11397
Yip1 domain; cl12048
Yip1 domain; cl12048
BTB/POZ domain; cl02518
PRELI-like family; pfam04707
PRELI-like family; pfam04707
PRELI-like family; pfam04707
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; cl00388
DnaJ central domain; pfam00684
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
First Src Homology 3 domain of SH3 domain containing ring finger 2; cd11929
Second Src Homology 3 domain of SH3 domain containing ring finger 2; cd11932
Third Src Homology 3 domain of SH3 domain containing ring finger 2; cd11784
uncharacterized Cys-rich domain; TIGR01571
aminoacyl-tRNA ligase
nucleotidyl transferase superfamily; cl00015
nucleotidyl transferase superfamily; cl00015
catalytic core domain of leucyl-tRNA synthetases; cd00812
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; cd07959
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Found in Pit-Oct-Unc transcription factors; smart00352
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
FF domain; pfam01846
FF domain; pfam01846
FF domain; pfam01846
FF domain; pfam01846
Contains two conserved F residues; smart00441
Contains two conserved F residues; smart00441
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
FF domain; pfam01846
FF domain; pfam01846
FF domain; pfam01846
FF domain; pfam01846
Contains two conserved F residues; smart00441
Contains two conserved F residues; smart00441
7 transmembrane receptor (rhodopsin family); pfam00001
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
Catalytic domain of the Protein Serine/Threonine Kinase, Yank1; cd05578
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
D-hydantoinase; TIGR02033
D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; cd01314
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
hypothetical protein; Provisional
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...; cd01327
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical...; cl11457
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...; cd01327
Kazal-type serine protease inhibitor domain; pfam07648
Kazal type serine protease inhibitors; smart00280
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal type serine protease inhibitors; smart00280
Kazal type serine protease inhibitors; smart00280
Kazal type serine protease inhibitors; smart00280
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...; cd01327
Kazal-type serine protease inhibitor domain; pfam00050
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cl00097
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam00050
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...; cd01327
Kazal-type serine protease inhibitor domain; pfam07648
Kazal type serine protease inhibitors; smart00280
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type serine protease inhibitor domain; pfam07648
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cl00097
Kazal type serine protease inhibitors; smart00280
Kazal type serine protease inhibitors; smart00280
Kazal type serine protease inhibitors; smart00280
Kazal-type serine protease inhibitor domain; pfam07648
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...; cd01327
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
Kazal-type serine protease inhibitor domain; pfam00050
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the...; cd01327
Kazal-type serine protease inhibitor domain; pfam00050
F-box domain; pfam00646
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Vomeronasal organ pheromone receptor family, V1R; cl12106
Vomeronasal organ pheromone receptor family, V1R; cl12106
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Src Homology 3 domain superfamily; cl17036
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
The first LIM domain of actin binding LIM (abLIM) proteins; cd09327
The second LIM domain on actin binding LIM (abLIM) proteins; cd09328
The third LIM domain of actin binding LIM (abLIM) proteins; cd09329
The fourth LIM domain of actin binding LIM (abLIM) proteins; cd09330
Villin headpiece domain; pfam02209
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
Pleckstrin homology (PH) domain; cd00821
GrpE; pfam01025
GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; cd00446
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
Prenylcysteine lyase; pfam07156
Interleukin-17; pfam06083
putative serine/threonine kinase; Provisional
Catalytic domain of Protein Kinases; cd00180
putative serine/threonine kinase; Provisional
Catalytic domain of Protein Kinases; cd00180
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
BAR domain; smart00721
The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein; cd07589
First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37; cd11799
Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37; cd11941
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
FOG: GAF domain [Signal transduction mechanisms]; COG2203
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; smart00065
GAF domain; pfam13185
Metal dependent phosphohydrolases with conserved 'HD' motif; cd00077
Sulfate transporter N-terminal domain with GLY motif; pfam13792
high affinity sulphate transporter 1; TIGR00815
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; cd06844
Helix-turn-helix domains; cl00088
Tc5 transposase DNA-binding domain; pfam03221
Integrase core domain; cl01316
Helix-turn-helix domains; cl00088
Tc5 transposase DNA-binding domain; pfam03221
Integrase core domain; cl01316
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; cd00084
Immunoglobulin; smart00409
Immunoglobulin domain; cd00096
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR) and similar proteins; cd04975
Immunoglobulin domain; cd00096
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; cd05106
Protein tyrosine kinase; pfam07714
Frst immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b); cd05861
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR) alpha; cd05859
Immunoglobulin domain; cl11960
Protein Kinases, catalytic domain; cl09925
Protein tyrosine kinase; pfam07714
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; cd11500
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of AGC family Protein Serine/Threonine Kinases; cd05123
Calcium/calmodulin dependent protein kinase II Association; pfam08332
Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119
Sulfatase; pfam00884
Treacher Collins syndrome protein Treacle; pfam03546
Treacher Collins syndrome protein Treacle; pfam03546
Treacher Collins syndrome protein Treacle; pfam03546
Treacher Collins syndrome protein Treacle; pfam03546
Treacher Collins syndrome protein Treacle; pfam03546
Treacher Collins syndrome protein Treacle; pfam03546
CLIP, MHC2 interacting; pfam09307
Class II MHC-associated invariant chain trimerisation domain; pfam08831
CLIP, MHC2 interacting; pfam09307
Class II MHC-associated invariant chain trimerisation domain; pfam08831
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; cd00191
CLIP, MHC2 interacting; pfam09307
40S ribosomal protein S14; Provisional
40S ribosomal protein S14; Provisional
40S ribosomal protein S14; Provisional
heparan sulfate-N-deacetylase; pfam12062
Sulfotransferase domain; pfam00685
Calcineurin-binding protein (Calsarcin); pfam05556
Calcineurin-binding protein (Calsarcin); pfam05556
zinc finger; smart00356
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Dynactin p62 family; pfam05502
Dynactin p62 family; pfam05502
Dynactin p62 family; pfam05502
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; cd00340
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Domain of unknown function (DUF4407); pfam14362
Domain of unknown function (DUF4407); pfam14362
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
Annexin; pfam00191
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...; cl00274
GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3; cd00258
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; cl15776
Transmembrane amino acid transporter protein; pfam01490
Transmembrane amino acid transporter protein; cl15776
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins...; cd01328
Secreted protein acidic and rich in cysteine Ca binding region; pfam10591
SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; cd00252
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; cd00371
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
7 transmembrane receptor (rhodopsin family); pfam00001
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor; cd06390
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor; cd06390
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Type 1 periplasmic binding fold superfamily; cl10011
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor; cd06390
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor; cd06390
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Protein of unknown function (DUF719); pfam05334
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
Predicted glycosyltransferases [General function prediction only]
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; cd02510
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
Ricin-type beta-trefoil; smart00458
SAP30 zinc-finger; pfam13866
Sin3 binding region of histone deacetylase complex subunit SAP30; pfam13867
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
La RNA-binding domain of La-related protein 1; cd08037
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function; smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function; smart00684
Sterol desaturase [Lipid metabolism]; COG3000
Fatty acid hydroxylase superfamily; pfam04116
CAF1 family ribonuclease; pfam04857
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 repeats; smart00320
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
WD40 repeats; smart00320
Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; cd00336
Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; cd00336
Kinesin motor domain, KIF4-like subfamily. Members of this group seem to perform a variety of functions, and have been implicated in neuronal organelle transport and chromosome segregation during mitosis. This catalytic (head) domain has ATPase activity...; cd01372
Kinesin motor, catalytic domain. ATPase; smart00129
Pre-SET motif; cl02622
Sarcoglycan complex subunit protein; pfam04790
Sarcoglycan complex subunit protein; pfam04790
Sarcoglycan complex subunit protein; pfam04790
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
Immunoglobulin V-Type; smart00406
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
MED7 protein; pfam05983
MED7 protein; pfam05983
Protein of unknown function (DUF3699); pfam12480
Tec pleckstrin homology (PH) domain; cd01238
Bruton's tyrosine kinase Cys-rich motif; smart00107
Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase; cd11908
Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk); cd10396
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; cd05112
Protein tyrosine kinase; pfam07714
Cytoplasmic Fragile-X interacting family; pfam05994
Cytoplasmic Fragile-X interacting family; pfam05994
Cytoplasmic Fragile-X interacting family; pfam05994
Fibronectin type 3 domain; smart00060
Magnesium transporter NIPA; pfam05653
Magnesium transporter NIPA; pfam05653
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family; cd04269
Disintegrin; pfam00200
ADAM Cysteine-Rich Domain; smart00608
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
Uncharacterized conserved protein [Function unknown]
tRNAHis guanylyltransferase; pfam04446
Thg1 C terminal domain; pfam14413
Like-Sm protein 11, middle domain; cd01739
ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated...; cd03571
ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated...; cd03571
ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated...; cd03571
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; cd11606
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved...; cd01175
helix loop helix domain; smart00353
TRC8 N-terminal domain; pfam13705
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
TRC8 N-terminal domain; pfam13705
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
TRC8 N-terminal domain; pfam13705
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
TRC8 N-terminal domain; pfam13705
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
TRC8 N-terminal domain; pfam13705
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
UBP ubiquitin processing protease; cd01813
Ubiquitin homologues; smart00213
HAD-superfamily subfamily IIID hydrolase, TIGR02245
Immunoglobulin C-2 Type; smart00408
Cytokine interleukin-12p40 C-terminus; pfam10420
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis.  In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in...; cd05835
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; pfam00061
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
C1q domain; pfam00386
Pre-mRNA splicing Prp18-interacting factor; pfam11708
Securin sister-chromatid separation inhibitor; pfam04856
E1-E2 ATPase; pfam00122
Cation transport ATPase [Inorganic ion transport and metabolism]; COG0474
Putative hydrolase of sodium-potassium ATPase alpha subunit; pfam13246
HAD-superfamily hydrolase, subfamily IIB; TIGR01484
Cation transport ATPase [Inorganic ion transport and metabolism]; COG0474
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins.  Little is known about the function of the proteins in this subgroup; cd06494
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
chromosome segregation protein SMC, primarily archaeal type; TIGR02169
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; cd05254
RmlD substrate binding domain; pfam04321
dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; cd05254
RmlD substrate binding domain; pfam04321
Teneurin Intracellular Region; pfam06484
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Plant PEC family metallothionein; pfam02068
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
RHS Repeat; pfam05593
Rhs family protein [Cell envelope biogenesis, outer membrane]; COG3209
RHS repeat-associated core domain; TIGR03696
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
C2 domain found in Human protein Kibra; cd08680
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
C2 domain found in Human protein Kibra; cd08680
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; cd00201
C2 domain found in Human protein Kibra; cd08680
Arginyl tRNA synthetase N terminal domain; pfam03485
arginine-tRNA ligase
catalytic core domain of arginyl-tRNA synthetases; cd00671
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; cl12020
Fumble; pfam03630
pantothenate kinase, eukaryotic/staphyloccocal type; TIGR00555
Leucine rich repeat N-terminal domain; smart00013
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine Rich repeats (2 copies); pfam12799
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
hypothetical protein; Provisional
Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2; cd12050
C2 domain; cl14603
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2; cd11706
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
SAM domain of SLP76 subfamily; cd09522
SAM domain (Sterile alpha motif); pfam07647
Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76); cd09929
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Calcium-activated potassium channel, beta subunit; pfam03185
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Importin-beta N-terminal domain; smart00913
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Nucleoplasmin; pfam03066
Nucleoplasmin; pfam03066
Nucleoplasmin; pfam03066
Fibroblast growth factor; pfam00167
D domain of beta-TrCP; smart01028
F-box-like; pfam12937
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
D domain of beta-TrCP; smart01028
F-box-like; pfam12937
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
D domain of beta-TrCP; smart01028
F-box-like; pfam12937
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Polo kinase kinase; pfam12474
Polo kinase kinase; pfam12474
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
dendritic cell derived ubiquitin-like protein; cd01794
Ubiquitin family; pfam00240
The phosphoinositide binding Phox Homology domain of Five SH protein; cd06888
First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains; cd12075
Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains; cd12076
Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains; cd12078
Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains; cd12018
Neuralized; cl02685
Neuralized; cl02685
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by...; cd01446
Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; cd00127
Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); pfam13850
Endoplasmic reticulum vesicle transporter; pfam07970
KOW motif; cl00354
ATP synthase subunit H; pfam05493
bZIP transcription factor; cl02576
Sec20; pfam03908
Sec20; pfam03908
Sec20; pfam03908
Sec20; pfam03908
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Stanniocalcin family; pfam03298
COMPASS (Complex proteins associated with Set1p) component shg1; pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; pfam05205
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
D1 dopamine receptor-interacting protein (calcyon); pfam06387
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
tricarboxylate carrier; TIGR00798
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Synaphin protein; pfam05835
Synaphin protein; pfam05835
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Arf-like 9 (Arl9)/Arfrp2-like GTPase; cd04162
Ribosome biogenesis protein Nop16; pfam09420
Ribosome biogenesis protein Nop16; pfam09420
Ribosome biogenesis protein Nop16; pfam09420
Hypoxia induced protein conserved region; pfam04588
Clathrin light chain; pfam01086
Clathrin light chain; pfam01086
UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology...; cd02991
Ubiquitin-like proteins; cl00155
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Cadherin tandem repeat domain; cd11304
Synuclein; pfam01387
Synuclein; pfam01387
Eukaryotic initiation factor 4E; pfam01652
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03159
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03159
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03159
Immunoglobulin domain; cl11960
Thrombospondin type 1 repeats; smart00209
Domain present in ZO-1 and Unc5-like netrin receptors; smart00218
Death domain found in Uncoordinated-5A; cd08800
hexokinase; Provisional
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Hexokinase; pfam03727
hexokinase; Provisional
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cd00012
Hexokinase; pfam03727
Zinc-finger double-stranded RNA-binding; cl09952
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; cd05099
Protein tyrosine kinase; pfam07714
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; cd05099
Protein tyrosine kinase; pfam07714
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Immunoglobulin I-set domain; pfam07679
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); cd05858
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; cd05099
Protein tyrosine kinase; pfam07714
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
PHD-finger; pfam00628
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
PHD zinc finger; smart00249
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS.   The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been...; cd05837
PHD-finger; pfam00628
PHD-finger; pfam00628
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS).  When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as...; cd05838
associated with SET domains; smart00570
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
PHD zinc finger; smart00249
Rab family protein; Provisional
Rab GTPase family 24 (Rab24); cd04118
Rab family protein; Provisional
Rab GTPase family 24 (Rab24); cd04118
PRELI-like family; pfam04707
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
VIP36 and VIPL type 1 transmembrane proteins, lectin domain; cd06901
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; cd08743
Ubiquitin domain of RGS12 and RGS14; cd01817
Raf-like Ras-binding domain; smart00455
GoLoco motif; cl12112
Phosphate:Na+ Symporter (PNaS) Family; TIGR01013
Na+/Pi-cotransporter; pfam02690
Na+/Pi-cotransporter; pfam02690
Phosphate:Na+ Symporter (PNaS) Family; TIGR01013
Na+/Pi-cotransporter; pfam02690
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the...; cd00148
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and...; cd00062
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces...; cd00061
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; cd00108
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Regulator of G protein signaling (RGS) domain superfamily; cl02565
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases; cd05605
Serine/Threonine protein kinases, catalytic domain; smart00220
Regulator of G protein signaling (RGS) domain superfamily; cl02565
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases; cd05605
Serine/Threonine protein kinases, catalytic domain; smart00220
Regulator of G protein signaling (RGS) domain superfamily; cl02565
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases; cd05605
Serine/Threonine protein kinases, catalytic domain; smart00220
ADF homology domain of drebrin and actin-binding protein 1 (abp1); cd11281
ADF homology domain of drebrin and actin-binding protein 1 (abp1); cd11281
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The first LIM domain of Enigma; cd09452
The second LIM domain of Enigma; cd09456
The third LIM domain of Enigma; cd09458
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
The first LIM domain of Enigma; cd09452
The second LIM domain of Enigma; cd09456
The third LIM domain of Enigma; cd09458
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
Pleckstrin homology-like domain; cl00273
PH domain; pfam00169
Pleckstrin homology-like domain; cl00273
PH domain; pfam00169
Downstream of tyrosine kinase  (DOK) Phosphotyrosine-binding domain; cd01203
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
emp24/gp25L/p24 family/GOLD; pfam01105
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; cd00899
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Fez1; pfam06818
LisH; cl11662
CTLH/CRA C-terminal to LisH motif domain; pfam10607
C-terminal to LisH motif; smart00668
CT11-RanBPM; smart00757
RING-type zinc-finger, LisH dimerisation motif; pfam13445
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; cl00600
CBFNT (NUC161) domain; pfam08143
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
CBFNT (NUC161) domain; pfam08143
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; COG0160
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; cd00610
Collagen triple helix repeat (20 copies); pfam01391
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
Thrombospondin type 1 repeats; smart00209
ADAM-TS Spacer 1; pfam05986
Thrombospondin type 1 domain; cl15278
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Reprolysin family propeptide; pfam01562
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that...; cd04273
RUN domain; pfam02759
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
RUN domain; pfam02759
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
RUN domain; pfam02759
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNPHF zinc finger; pfam08080
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RNPHF zinc finger; pfam08080
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; cd07429
Calreticulin family; pfam00262
Calreticulin family; pfam00262
MamL-1 domain; pfam09596
MAPEG family; pfam01124
N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region; pfam04666
N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region; pfam04666
The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which...; cd06402
Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears...; cd02340
Ubiquitin associated domain; smart00165
The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; cl02720
Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears...; cd02340
Ubiquitin associated domain; smart00165
The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; cl02720
Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears...; cd02340
Ubiquitin associated domain; smart00165
GRAM domain; pfam02893
GRAM domain; pfam02893
GTPase-activating protein [General function prediction only]
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
GRAM domain; pfam02893
GRAM domain; pfam02893
GTPase-activating protein [General function prediction only]
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cl08302
PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...; cd02122
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; cd07850
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
glucosamine:fructose-6-phosphate aminotransferase
Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; cd00714
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; cd05008
SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; cd05009
Leucine Rich repeats (2 copies); pfam12799
C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6; cd10313
Immunoglobulin I-set domain; pfam07679
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); cd05862
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3); cd05863
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Immunoglobulin C-2 Type; smart00408
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; cd05102
Protein tyrosine kinase; pfam07714
Immunoglobulin I-set domain; pfam07679
First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); cd05862
Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3); cd05863
Immunoglobulin like; smart00410
Immunoglobulin I-set domain; pfam07679
Immunoglobulin C-2 Type; smart00408
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; cd05102
Protein tyrosine kinase; pfam07714
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
GNT-I family; pfam03071
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; cd02514
GNT-I family; pfam03071
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; cd02514
GNT-I family; pfam03071
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; cd02514
GNT-I family; pfam03071
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; cd02514
GNT-I family; pfam03071
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; cd02514
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
SPRY-associated domain; cl02686
Domain in SPla and the RYanodine Receptor; smart00449
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
ATP synthase B/B' CF(0); cl07975
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; pfam13765
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; cd00127
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The...; cd00103
Interferon-regulatory factor 3; pfam10401
IPT/TIG domain; pfam01833
Hus1-like protein; pfam04005
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
GDP-mannose 4,6-dehydratase; TIGR01472
GDP-mannose 4,6 dehydratase, extended (e) SDRs; cd05260
GDP-mannose 4,6 dehydratase, extended (e) SDRs; cd05260
GDP-mannose 4,6-dehydratase; TIGR01472
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
Rad18-like CCHC zinc finger; smart00734
recombination factor protein RarA; Reviewed
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
MgsA AAA+ ATPase C terminal; pfam12002
Rad18-like CCHC zinc finger; smart00734
recombination factor protein RarA; Reviewed
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
MgsA AAA+ ATPase C terminal; pfam12002
SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; cl00137
serpin-like protein; Provisional
SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; cl00137
Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell...; cd02058
serpin-like protein; Provisional
Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell...; cd02058
serpin-like protein; Provisional
Flavodoxin-like fold; pfam02525
Protein Kinases, catalytic domain; cl09925
Protein kinase; unclassified specificity; smart00221
RIP homotypic interaction motif; pfam12721
Death Domain of Receptor-Interacting Protein 1; cd08777
Alpha/beta hydrolase family; pfam12697
tubulin beta chain; Provisional
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of...; cd02187
tubulin beta chain; Provisional
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of...; cd02187
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
cation transport protein; TIGR00898
The Phox Homology domain, a phosphoinositide binding module; cl02563
XAP5, circadian clock regulator; pfam04921
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; cd00435
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Acyl CoA binding protein; pfam00887
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Acyl CoA binding protein; pfam00887
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; cd00024
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; COG1024
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558
Ribonuclease P 40kDa (Rpp40) subunit; pfam08584
Putative phosphatase regulatory subunit; pfam03370
Complex1_LYR-like; pfam13232
Complex1_LYR-like; pfam13232
Complex1_LYR-like; pfam13232
Putative binding domain; pfam13900
phenylalanine-tRNA synthetase
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; cd00496
Ferredoxin-fold anticodon binding domain; smart00896
activation peptide
Transglutaminase family; pfam00868
Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]
Transglutaminase/protease-like homologues; smart00460
Transglutaminase family, C-terminal ig like domain; pfam00927
Transglutaminase family, C-terminal ig like domain; pfam00927
MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS); MD-2...; cd00915
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
C2H2-type zinc finger; pfam13912
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
C2H2-type zinc finger; pfam13912
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
C2H2-type zinc finger; pfam13912
Zinc-finger double domain; pfam13465
Translocon-associated protein (TRAP), alpha subunit; pfam03896
chromosome segregation protein SMC, common bacterial type; TIGR02168
chromosome segregation protein SMC, common bacterial type; TIGR02168
Protein of unknown function (DUF972); pfam06156
Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; COG1718
RIO kinase family; eukaryotic RIO1, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); cd05147
Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; COG1718
Protein Kinases, catalytic domain; cl09925
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cl02488
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; cl02531
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; cl02531
U11-48K-like CHHC zinc finger; pfam05253
TGF-beta propeptide; pfam00688
Transforming growth factor-beta (TGF-beta) family; smart00204
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in...; cd03005
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in...; cd03005
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in...; cd03005
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; cl00388
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in...; cd03005
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in...; cd03005
C-terminal, alpha helical domain of the Glutathione S-transferase family; cl02776
Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3; cd10305
UAA transporter family; pfam08449
UAA transporter family; pfam08449
UAA transporter family; pfam08449
Transcription factor AP-2; pfam03299
Transcription factor AP-2; pfam03299
Transcription factor AP-2; pfam03299
Core-2/I-Branching enzyme; pfam02485
Core-2/I-Branching enzyme; pfam02485
Core-2/I-Branching enzyme; pfam02485
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
Transmembrane proteins 14C; pfam03647
Transmembrane proteins 14C; pfam03647
Transmembrane proteins 14C; pfam03647
Transmembrane proteins 14C; pfam03647
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; cd07830
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; cd07830
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; cd07830
Serine/Threonine protein kinases, catalytic domain; smart00220
GCM motif protein; pfam03615
GNS1/SUR4 family; pfam01151
heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains; cd09851
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9; cd12002
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module; cd11550
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module; cd11570
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module; cd11550
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module; cd11570
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9; cd12002
Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module; cd11550
C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module; cd11570
Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9; cd12002
Putative transmembrane protein 170; pfam10190
FAR-17a/AIG1-like protein; pfam04750
FAR-17a/AIG1-like protein; pfam04750
Zinc-finger double domain; pfam13465
C2H2-type zinc finger; pfam13912
Zinc-finger double domain; pfam13465
Endothelin family; cl15291
Endothelin; smart00272
Endothelin family; cl15291
Endothelin; smart00272
RPEL repeat; pfam02755
RPEL repeat; pfam02755
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
RPEL repeat; pfam02755
RPEL repeat; pfam02755
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2; smart00707
Rab-GTPase-TBC domain; cl02495
Rab-GTPase-TBC domain; cl02495
Rab-GTPase-TBC domain; cl02495
Rab-GTPase-TBC domain; cl02495
Rab-GTPase-TBC domain; cl02495
Predicted dehydrogenases and related proteins [General function prediction only]; COG0673
Oxidoreductase family, NAD-binding Rossmann fold; pfam01408
Oxidoreductase family, C-terminal alpha/beta domain; cl11611
Predicted dehydrogenases and related proteins [General function prediction only]; COG0673
Oxidoreductase family, C-terminal alpha/beta domain; cl11611
Predicted dehydrogenases and related proteins [General function prediction only]; COG0673
Oxidoreductase family, C-terminal alpha/beta domain; cl11611
Oxidoreductase family, NAD-binding Rossmann fold; pfam01408
NAD-dependent deacetylase; Provisional
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; cd01412
NAD-dependent deacetylase; Provisional
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; cd01412
NAD-dependent deacetylase; Provisional
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; cd01412
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; cl00195
NUC129 domain; pfam08157
SPRY domain; pfam00622
Lissencephaly type-1-like homology motif; smart00667
C-terminal to LisH motif; smart00668
CTLH/CRA C-terminal to LisH motif domain; pfam10607
CTLH/CRA C-terminal to LisH motif domain; pfam10607
CT11-RanBPM; smart00757
Protein of unknown function (DUF1640); pfam07798
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Small domain found in the jumonji family of transcription factors; smart00545
ARID/BRIGHT DNA binding domain; pfam01388
JmjC domain, hydroxylase; pfam02373
C5HC2 zinc finger; pfam02928
Small domain found in the jumonji family of transcription factors; smart00545
ARID/BRIGHT DNA binding domain; pfam01388
JmjC domain, hydroxylase; pfam02373
C5HC2 zinc finger; pfam02928
Dysbindin (Dystrobrevin binding protein 1); pfam04440
Dysbindin (Dystrobrevin binding protein 1); pfam04440
Band 4.1 homologues; smart00295
FERM N-terminal domain; pfam09379
FERM central domain; pfam00373
FERM_C domain; cd00836
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
guanosine monophosphate reductase, eukaryotic; TIGR01305
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; cd00381
29 Q/H repeats
Capicua transcriptional repressor modulator; pfam12547
Ataxin-1 and HBP1 module (AXH); pfam08517
29 Q/H repeats
Capicua transcriptional repressor modulator; pfam12547
Ataxin-1 and HBP1 module (AXH); pfam08517
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Adenylate cyclase associated (CAP) N terminal; pfam01213
Adenylate cyclase associated (CAP) C terminal; pfam08603
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product; smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product; smart00673
RDD family; pfam06271
Nucleoporin Nup153-like; pfam08604
Zn-finger in Ran binding protein and others; pfam00641
Zn-finger in Ran binding protein and others; pfam00641
Zn-finger in Ran binding protein and others; pfam00641
Zn-finger in Ran binding protein and others; pfam00641
Retro-transposon transporting motif; pfam10599
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...; cd01365
Kinesin motor, catalytic domain. ATPase; smart00129
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Kinesin protein 1B; pfam12423
Kinesin protein; pfam12473
Kinesin protein; pfam12473
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...; cd01365
Kinesin motor, catalytic domain. ATPase; smart00129
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Kinesin protein 1B; pfam12423
Kinesin protein; pfam12473
Kinesin protein; pfam12473
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...; cd01365
Kinesin motor, catalytic domain. ATPase; smart00129
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Kinesin protein 1B; pfam12423
Kinesin protein; pfam12473
Kinesin protein; pfam12473
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity...; cd01365
Kinesin motor, catalytic domain. ATPase; smart00129
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Kinesin protein 1B; pfam12423
Kinesin protein; pfam12473
Kinesin protein; pfam12473
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; cl00286
Thiopurine S-methyltransferase (TPMT); pfam05724
CW-type Zinc Finger; pfam07496
Flavin containing amine oxidoreductase; pfam01593
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; smart00513
DEK C terminal domain; pfam08766
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; smart00513
DEK C terminal domain; pfam08766
IBR domain; pfam01485
In Between Ring fingers; smart00647
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
MBOAT, membrane-bound O-acyltransferase family; cl00738
E2F/DP family winged-helix DNA-binding domain; pfam02319
E2F/DP family winged-helix DNA-binding domain; pfam02319
2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; COG0621
Uncharacterized protein family UPF0004; pfam00919
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...; cd01388
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; cd10288
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1; cd05834
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
Ubiquitin-like domain of DCX; cd01617
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; cd12823
Zinc dependent phospholipase C; pfam00882
Integrin alpha (beta-propellor repeats); smart00191
Integrin alpha (beta-propellor repeats); smart00191
Family description; pfam13517
FG-GAP repeat; cl15299
succinic semialdehyde dehydrogenase
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; cd07103
succinic semialdehyde dehydrogenase
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; cd07103
The MANEC domain, formerly called MANSC; smart00765
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
The MANEC domain, formerly called MANSC; smart00765
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
The MANEC domain, formerly called MANSC; smart00765
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
The MANEC domain, formerly called MANSC; smart00765
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
MANEC domain; cl06508
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; cd00146
Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; cd09080
PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; cd03443
PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; cd03443
Geminin; pfam07412
Geminin; pfam07412
Geminin; pfam07412
Geminin; pfam07412
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H2B; smart00427
Na(+)-dependent inorganic phosphate cotransporter; TIGR00894
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Na(+)-dependent inorganic phosphate cotransporter; TIGR00894
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Na(+)-dependent inorganic phosphate cotransporter; TIGR00894
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
histone H3; Provisional
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
histone H3; Provisional
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H2B; smart00427
histone H3; Provisional
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
Histone H2B; smart00427
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
Histone H2B; smart00427
Histone H2B; smart00427
Histone H2B; smart00427
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
histone H3; Provisional
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H2B; smart00427
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Histone H2B; smart00427
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
histone H3; Provisional
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
histone H3; Provisional
Histone H2B; smart00427
histone H3; Provisional
Histone H2B; smart00427
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Protein of unknown function (DUF4085); pfam13315
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Protein of unknown function (DUF4085); pfam13315
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Protein of unknown function (DUF4085); pfam13315
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Protein of unknown function (DUF4085); pfam13315
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin domain; cl11960
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin domain; cl11960
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin domain; cl11960
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin domain; cl11960
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
CD80-like C2-set immunoglobulin domain; pfam08205
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Histone H2B; smart00427
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Histone H2B; smart00427
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Serine carboxypeptidase S28; pfam05577
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Histone H2B; smart00427
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
histone H3; Provisional
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H2B; smart00427
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H2B; smart00427
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; cd00073
histone H3; Provisional
Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into 'beads on a string' in...; cd00076
histone H3; Provisional
Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; cd00074
Histone H2B; smart00427
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
SCAN oligomerization domain; cd07936
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
SCAN oligomerization domain; cd07936
KRAB (Kruppel-associated box) domain -A box; cd07765
krueppel associated box; smart00349
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Ras-induced vulval development antagonist; pfam06047
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
Transposase IS4; pfam13843
SCAN oligomerization domain; cd07936
Transposase IS4; pfam13843
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SCAN oligomerization domain; cd07936
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; cd00340
Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; cd00340
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; cl00388
SCAN oligomerization domain; cd07936
Integrase core domain; pfam00665
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
7 transmembrane receptor (rhodopsin family); pfam00001
Ubiquitin homologues; smart00213
Ubiquitin-like domain of UBL; cd01769
Ubiquitin family; pfam00240
Ubiquitin-like proteins; cl00155
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; pfam13853
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); cd06366
Receptor family ligand binding region; pfam01094
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); cd06366
Receptor family ligand binding region; pfam01094
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); cd06366
Receptor family ligand binding region; pfam01094
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
krueppel associated box; smart00349
KRAB (Kruppel-associated box) domain -A box; cd07765
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; COG1594
Transcription factor S-II (TFIIS); pfam01096
DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; COG1594
Transcription factor S-II (TFIIS); pfam01096
Protein phosphatase inhibitor; pfam07491
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
SPRY-associated domain; pfam13765
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; smart00336
associated with SPRY domains; smart00589
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
associated with SPRY domains; smart00589
Domain in SPla and the RYanodine Receptor; smart00449
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
B-Box C-terminal domain; smart00502
SPRY-associated domain; pfam13765
RNAse P Rpr2/Rpp21/SNM1 subunit domain; pfam04032
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
ATP synthase B/B' CF(0); cl07975
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Zinc finger, C3HC4 type (RING finger); pfam13923
B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021
ATP synthase B/B' CF(0); cl07975
B-Box C-terminal domain; smart00502
SPRY-associated domain; pfam13765
Domain in SPla and the RYanodine Receptor; smart00449
RNAse P Rpr2/Rpp21/SNM1 subunit domain; pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; pfam04032
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
A circularly permuted subfamily of the Ras GTPases; cd01857
A circularly permuted subfamily of the Ras GTPases; cd01857
Zinc finger C-x8-C-x5-C-x3-H type (and similar); cl11592
Zinc finger C-x8-C-x5-C-x3-H type (and similar); cl11592
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; cd03221
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme; cl00146
Zinc finger C-x8-C-x5-C-x3-H type (and similar); pfam00642
Ribosomal protein S18; pfam01084
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; cd04301
Touch receptor neuron protein Mec-17; pfam05301
Uncharacterized conserved protein (DUF2358); pfam10184
Uncharacterized conserved protein (DUF2358); pfam10184
Uncharacterized conserved protein (DUF2358); pfam10184
DEAD-like helicases superfamily; smart00487
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Helicase associated domain (HA2); pfam04408
Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717
DEAD-like helicases superfamily; smart00487
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Helicase associated domain (HA2); pfam04408
Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717
PP1-regulatory protein, Phostensin N-terminal; pfam13916
Phostensin PP1-binding and SH3-binding region; pfam13914
PP1-regulatory protein, Phostensin N-terminal; pfam13916
Phostensin PP1-binding and SH3-binding region; pfam13914
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
tubulin beta chain; Provisional
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of...; cd02187
Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; cd03399
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; cd05096
Tyrosine kinase, catalytic domain; smart00219
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Protein Kinases, catalytic domain; cl09925
Tyrosine kinase, catalytic domain; smart00219
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; cd05096
Tyrosine kinase, catalytic domain; smart00219
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; cd05096
Tyrosine kinase, catalytic domain; smart00219
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Protein Kinases, catalytic domain; cl09925
Tyrosine kinase, catalytic domain; smart00219
Coagulation factor 5/8 C-terminal domain, discoidin domain; smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cd00057
Transcription factor tfb2; TIGR00625
valyl-tRNA synthetase-like protein; Provisional
nucleotidyl transferase superfamily; cl00015
catalytic core domain of valyl-tRNA synthetases; cd00817
Anticodon-binding domain of valyl tRNA synthetases; cd07962
valyl-tRNA synthetase-like protein; Provisional
nucleotidyl transferase superfamily; cl00015
catalytic core domain of valyl-tRNA synthetases; cd00817
Anticodon-binding domain of valyl tRNA synthetases; cd07962
nucleotidyl transferase superfamily; cl00015
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; COG0525
catalytic core domain of valyl-tRNA synthetases; cd00817
Anticodon-binding domain of valyl tRNA synthetases; cd07962
large tegument protein UL36; Provisional
Alpha helical coiled-coil rod protein (HCR); pfam07111
Alpha helical coiled-coil rod protein (HCR); pfam07111
Alpha helical coiled-coil rod protein (HCR); pfam07111
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
type VI secretion system FHA domain protein; TIGR03354
PHD zinc finger; smart00249
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
type VI secretion system FHA domain protein; TIGR03354
PHD zinc finger; smart00249
Found in Pit-Oct-Unc transcription factors; smart00352
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Pou domain - N-terminal to homeobox domain; cl02582
start of isoform OCT4B-164, as described in PMID:19489092
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Pou domain - N-terminal to homeobox domain; cl02582
start of isoform OCT4B-164, as described in PMID:19489092
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
Class I Histocompatibility antigen, domains alpha 1 and 2; pfam00129
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd07698
helicase 45; Provisional
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
helicase 45; Provisional
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Vacuolar (H+)-ATPase G subunit; cl03922
Vacuolar (H+)-ATPase G subunit; pfam03179
Vacuolar (H+)-ATPase G subunit; pfam03179
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; cd00184
LST-1 protein; pfam05083
LST-1 protein; pfam05083
LST-1 protein; pfam05083
LST-1 protein; pfam05083
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cd00096
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Immunoglobulin V-Type; smart00406
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
BAT2 N-terminus; pfam07001
BAT2 N-terminus; pfam07001
Ubiquitin-like domain of Scythe protein; cd01809
Ubiquitin homologues; smart00213
Domain of unknown function (DUF3538); pfam12057
Ubiquitin-like domain of Scythe protein; cd01809
Ubiquitin homologues; smart00213
Domain of unknown function (DUF3538); pfam12057
Ubiquitin-like domain of Scythe protein; cd01809
Ubiquitin homologues; smart00213
Domain of unknown function (DUF3538); pfam12057
Ubiquitin-like domain of Scythe protein; cd01809
Ubiquitin homologues; smart00213
Domain of unknown function (DUF3538); pfam12057
Ubiquitin-like domain of Scythe protein; cd01809
Ubiquitin homologues; smart00213
Domain of unknown function (DUF3538); pfam12057
Ubiquitin-like domain of Scythe protein; cd01809
Ubiquitin homologues; smart00213
Domain of unknown function (DUF3538); pfam12057
Apolipoprotein M (ApoM); pfam11032
Apolipoprotein M (ApoM); pfam11032
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
glycine rich nucleic binding domain; smart00443
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
glycine rich nucleic binding domain; smart00443
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
glycine rich nucleic binding domain; smart00443
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
glycine rich nucleic binding domain; smart00443
Ankyrin repeats (many copies); pfam13857
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
glycine rich nucleic binding domain; smart00443
Casein kinase II regulatory subunit; smart01085
Alpha/beta hydrolase family; pfam12695
Alpha/beta hydrolase family; pfam12695
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin V-set domain; pfam07686
Immunoglobulin V-set domain; pfam07686
Immunoglobulin V-set domain; pfam07686
Amidinotransferase; pfam02274
GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated...; cd03061
intracellular chloride channel protein; TIGR00862
C-terminal, alpha helical domain of Chloride Intracellular Channel 1; cd10300
DNA-binding domain of DNA mismatch repair MUTS family; smart00533
MutS family domain IV; pfam05190
MutS5 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; cd03281
DNA-binding domain of DNA mismatch repair MUTS family; smart00533
MutS family domain IV; pfam05190
MutS5 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; cd03281
DNA-binding domain of DNA mismatch repair MUTS family; smart00533
MutS family domain IV; pfam05190
MutS5 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; cd03281
DNA-binding domain of DNA mismatch repair MUTS family; smart00533
MutS family domain IV; pfam05190
MutS5 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; cd03281
Adenomatous polyposis coli tumour suppressor protein; pfam11414
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cd00198
Glutathione S-transferase C-terminal-like, alpha helical domain of vertebrate Valyl-tRNA synthetase; cd10294
valyl-tRNA synthetase-like protein; Provisional
catalytic core domain of valyl-tRNA synthetases; cd00817
Leucyl-tRNA synthetase, Domain 2; pfam13603
catalytic core domain of valyl-tRNA synthetases; cd00817
Anticodon-binding domain of valyl tRNA synthetases; cd07962
Like-Sm protein 2; cd01725
heat shock 70 kDa protein; Provisional
Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins; cd10233
heat shock 70 kDa protein; Provisional
Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins; cd10233
heat shock 70 kDa protein; Provisional
Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins; cd10233
Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; cd00260
BNR repeat-like domain; pfam13088
Plasma-membrane choline transporter; pfam04515
Plasma-membrane choline transporter; pfam04515
Plasma-membrane choline transporter; pfam04515
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Pre-SET motif; pfam05033
Proteins containing SET domain [General function prediction only]
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Pre-SET motif; pfam05033
Proteins containing SET domain [General function prediction only]
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred...; cd01470
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred...; cd01470
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); smart00032
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; cd00033
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred...; cd01470
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cd00190
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Superfamily II RNA helicase [DNA replication, recombination, and repair]
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
rRNA-processing arch domain; pfam13234
DSHCT (NUC185) domain; pfam08148
RAI1 like PD-(D/E)XK nuclease; pfam08652
Serine-threonine protein kinase 19; pfam10494
Serine-threonine protein kinase 19; pfam10494
Alpha-2-macroglobulin MG1 domain; pfam11974
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to...; cd00017
Alpha-2-macroglobulin family; pfam00207
Proteins similar to C3, C4 and C5 of vertebrate complement.  The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the...; cd02896
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical...; cd03584
Alpha-2-macroglobulin MG1 domain; pfam11974
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to...; cd00017
Alpha-2-macroglobulin family; pfam00207
Proteins similar to C3, C4 and C5 of vertebrate complement.  The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the...; cd02896
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical...; cd03584
Alpha-2-macroglobulin MG1 domain; pfam11974
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to...; cd00017
Alpha-2-macroglobulin family; pfam00207
Proteins similar to C3, C4 and C5 of vertebrate complement.  The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the...; cd02896
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical...; cd03584
Cytochrome P450; pfam00067
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; cl12078
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
EGF-like domain; pfam07974
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
EGF-like domain; pfam07974
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Furin-like cysteine rich region; pfam00757
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
EGF-like domain; pfam07974
EGF-like domain; pfam07974
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cl00065
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cl00065
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
Fibronectin type III domain; pfam00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; cd00087
basic region leucin zipper; smart00338
basic region leucin zipper; smart00338
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Interferon-induced transmembrane protein; pfam04505
Palmitoyl protein thioesterase; cl15849
Palmitoyl protein thioesterase; cl15849
Palmitoyl protein thioesterase; cl15849
EMI domain; pfam07546
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; cd07989
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; cd07989
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin like; smart00410
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin C-2 Type; smart00408
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin like; smart00410
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
CD80-like C2-set immunoglobulin domain; pfam08205
Immunoglobulin domain; cd00096
PBC domain; pfam03792
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
GoLoco motif; cl12112
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl09941
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
LNR domain; pfam00066
LNR domain; pfam00066
LNR domain; pfam00066
NOTCH protein; pfam07684
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); cd05713
Immunoglobulin V-Type; smart00406
Immunoglobulin domain; cl11960
Class II histocompatibility antigen, alpha domain; pfam00993
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, beta domain; pfam00969
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; cd05766
Class II histocompatibility antigen, beta domain; pfam00969
Immunoglobulin domain; cl11960
Class II histocompatibility antigen, alpha domain; pfam00993
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, beta domain; pfam00969
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; cd05766
Class II histocompatibility antigen, beta domain; pfam00969
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; cd05766
Class II histocompatibility antigen, alpha domain; pfam00993
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, beta domain; pfam00969
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; cd05766
Class II histocompatibility antigen, beta domain; pfam00969
Immunoglobulin domain; cl11960
ABC transporter transmembrane region; pfam00664
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
ABC transporter; pfam00005
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
ABC transporter transmembrane region; pfam00664
TAP, the Transporter Associated with Antigen Processing; TAP is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules; cd03248
Proteasome subunit beta type-5; Provisional
proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03761
Proteasome subunit beta type-5; Provisional
proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03761
Conjugate Transporter-2 (CT2) Family protein; TIGR00958
ABC transporter transmembrane region; pfam00664
TAP, the Transporter Associated with Antigen Processing; TAP is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules; cd03248
20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; COG0638
proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03762
Class II histocompatibility antigen, beta domain; pfam00969
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; cd05766
Class II histocompatibility antigen, alpha domain; smart00920
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05497
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05498
Putative binding domain; pfam13900
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05497
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05498
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05497
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05498
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05497
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino...; cd05498
Class II histocompatibility antigen, alpha domain; smart00920
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, alpha domain; pfam00993
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, alpha domain; pfam00993
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, alpha domain; pfam00993
Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain; cd05767
Class II histocompatibility antigen, beta domain; pfam00969
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; cd05766
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Collagen triple helix repeat (20 copies); pfam01391
Fibrillar collagens C-terminal domain; smart00038
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Collagen triple helix repeat (20 copies); pfam01391
Fibrillar collagens C-terminal domain; smart00038
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Collagen triple helix repeat (20 copies); pfam01391
Fibrillar collagens C-terminal domain; smart00038
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers; cd06956
The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily; cd06943
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers; cd06956
The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily; cd06943
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
ZIP Zinc transporter; pfam02535
Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]
beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; cd05333
3-ketoacyl-(acyl-carrier-protein) reductase; Validated; PRK05653
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
Vps52 / Sac2 family; pfam04129
40S ribosomal protein S18; Provisional
Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; COG0099
Galactosyltransferase; cl09537
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
BING4CT (NUC141) domain; smart01033
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl02567
BING4CT (NUC141) domain; smart01033
Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea.  Prefoldin binds and stabilizes newly synthesized polypeptides...; cd00632
Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea.  Prefoldin binds and stabilizes newly synthesized polypeptides...; cd00632
Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea.  Prefoldin binds and stabilizes newly synthesized polypeptides...; cd00632
Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea.  Prefoldin binds and stabilizes newly synthesized polypeptides...; cd00632
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Ubiquitin domain of  RalGDS-like factor (RLF) and related proteins; cd00153
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cd06224
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155
Ubiquitin domain of  RalGDS-like factor (RLF) and related proteins; cd00153
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Daxx Family; pfam03344
Daxx Family; pfam03344
Daxx Family; pfam03344
Daxx Family; pfam03344
Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins. Ncd is a spindle motor protein necessary for chromosome segregation in meiosis. KIFC2/KIFC3-like kinesins have been implicated in motility of the Golgi apparatus as well as dentritic...; cd01366
Kinesin motor, catalytic domain. ATPase; smart00129
Tudor domain; smart00333
PHD-finger; pfam00628
Polycomb-like MTF2 factor 2; pfam14061
Tudor domain; smart00333
PHD-finger; pfam00628
CutA1 divalent ion tolerance protein; pfam03091
CutA1 divalent ion tolerance protein; pfam03091
CutA1 divalent ion tolerance protein; pfam03091
CutA1 divalent ion tolerance protein; pfam03091
CutA1 divalent ion tolerance protein; pfam03091
Pleckstrin homology-like domain; cl00273
C2 domain present in Ras GTPase activating protein (GAP) family; cd04013
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP; also known as ASK-interacting protein 1 (AIP1)), is a member of the GTPase-activating proteins, down-regulates Ras-mediated...; cd05136
Domain of unknown function (DUF3498); pfam12004
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; cd06845
Inositol 1,4,5-trisphosphate/ryanodine receptor; pfam08709
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; smart00472
MIR domain; pfam02815
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; smart00472
RIH domain; pfam01365
RIH domain; pfam01365
RyR and IP3R Homology associated; pfam08454
Ion transport protein; pfam00520
Inositol polyphosphate kinase; pfam03770
Inositol polyphosphate kinase; pfam03770
in nuclear membrane-associated proteins; smart00540
Man1-Src1p-C-terminal domain; pfam09402
Man1-Src1p-C-terminal domain; pfam09402
Motilin/ghrelin; pfam04644
Motilin/ghrelin-associated peptide; pfam04643
Motilin/ghrelin; pfam04644
Motilin/ghrelin-associated peptide; pfam04643
Motilin/ghrelin; pfam04644
Motilin/ghrelin-associated peptide; pfam04643
Receptor family ligand binding region; pfam01094
Type 1 periplasmic binding fold superfamily; cl10011
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Receptor family ligand binding region; pfam01094
Type 1 periplasmic binding fold superfamily; cl10011
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
fatty oxidation complex, alpha subunit FadB; TIGR02437
fatty oxidation complex, alpha subunit FadB; TIGR02437
fatty oxidation complex, alpha subunit FadB; TIGR02437
Plectin/S10 domain; pfam03501
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; cd04666
Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; cd04666
Plectin/S10 domain; pfam03501
Plectin/S10 domain; pfam03501
Plectin/S10 domain; pfam03501
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1); cd07680
Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2; cd11998
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1); cd07680
Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2; cd11998
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; cd08532
erythroblast transformation specific domain; smart00413
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; cd08532
erythroblast transformation specific domain; smart00413
U1 zinc finger; pfam06220
N-terminal region of Chorein, a TM vesicle-mediated sorter; pfam12624
TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd08048
TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cl02176
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
SAM domain of AIDA1AB-like proteins, repeat 1; cd09499
Sterile alpha motif; smart00454
SAM domain (Sterile alpha motif); pfam07647
SAM domain of AIDA1AB-like proteins, repeat 2; cd09500
AIDA-1b Phosphotyrosine-binding (PTB) domain; cd01274
T-complex protein 11; pfam05794
T-complex protein 11; pfam05794
T-complex protein 11; pfam05794
T-complex protein 11; pfam05794
T-complex protein 11; pfam05794
T-complex protein 11; pfam05794
T-complex protein 11; pfam05794
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Plasmodium ookinete surface protein Pvs28; pfam06247
Complement Clr-like EGF-like; pfam12662
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
Calcium-binding EGF-like domain; smart00179
GCC2 and GCC3; pfam07699
GCC2 and GCC3; pfam07699
GCC2 and GCC3; pfam07699
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Pleckstrin homology (PH) domain; cd00821
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers; cd06965
The ligand binding domain of peroxisome proliferator-activated receptors; cd06932
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers; cd06965
The ligand binding domain of peroxisome proliferator-activated receptors; cd06932
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers; cd06965
The ligand binding domain of peroxisome proliferator-activated receptors; cd06932
The ligand binding domain of peroxisome proliferator-activated receptors; cd06932
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers; cd06965
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; cl11397
Fanconi anemia complementation group E protein, C-terminal domain; cd07439
Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; cd00403
TEA/ATTS domain family; pfam01285
Tub family; pfam01167
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
TPR repeat; pfam13414
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
TPR repeat; pfam13414
FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase; cl11587
Armadillo-like; pfam04826
Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation; cl03105
Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation; cd00039
Colipase, C-terminal domain; pfam02740
Colipase; smart00023
Colipase; smart00023
Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation; cd00039
Colipase; smart00023
Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation; cd00039
Lipoma HMGIC fusion partner-like protein; pfam10242
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; cl15842
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; cl00604
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; cl00604
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Sulfate transporter N-terminal domain with GLY motif; pfam13792
Sulfate transporter family; pfam00916
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; cl00604
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; cd07851
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; cd07851
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; cd07851
Serine/Threonine protein kinases, catalytic domain; smart00220
Protein Kinases, catalytic domain; cl09925
Serine/Threonine protein kinases, catalytic domain; smart00220
Enhancer of polycomb-like; pfam10513
PHD-finger; pfam13831
PHD-zinc-finger like domain; pfam13832
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl15348
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder; cd05512
The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2.   BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region.  In myeloid leukemias; cd05839
Patatin-like phospholipase domain containing protein 1; cd07219
Patatins and Phospholipases; cl11396
Patatins and Phospholipases; cl11396
Ets-domain; pfam00178
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; cd08535
Ets-domain; pfam00178
erythroblast transformation specific domain; smart00413
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; cd08535
erythroblast transformation specific domain; smart00413
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; cd08535
erythroblast transformation specific domain; smart00413
erythroblast transformation specific domain; smart00413
SAM (Sterile alpha motif ); cl15755
erythroblast transformation specific domain; smart00413
erythroblast transformation specific domain; smart00413
Broad-Complex, Tramtrack and Bric a brac; smart00225
Catalytic domain of the Protein Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; cd05628
Serine/Threonine protein kinases, catalytic domain; smart00220
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
Cyclin-dependent kinase inhibitor; pfam02234
Cyclin-dependent kinase inhibitor; pfam02234
Cyclin-dependent kinase inhibitor; pfam02234
Cyclin-dependent kinase inhibitor; pfam02234
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13833
Rab family protein; Provisional
Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); cd00154
C2 domain first repeat in Copine; cd04048
C2 domain second repeat in Copine; cd04047
VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae; cd01459
peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional
cyclophilin_SpCYP2_like: cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent...; cd01922
SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins; cd05559
SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins; cd05559
Mitochondrial carrier protein; pfam00153
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160
FGD (faciogenital dysplasia protein) pleckstrin homology (PH) domain; cd01219
FYVE zinc finger; pfam01363
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; cd00065
Pleckstrin homology (PH) domain; cd00821
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Rab-GTPase-TBC domain; pfam00566
FOG: FHA domain [Signal transduction mechanisms]
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
FOG: FHA domain [Signal transduction mechanisms]
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; cd00060
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
G-patch domain; pfam01585
FtsJ-like methyltransferase; pfam01728
Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; cl12015
Immunoglobulin like; smart00410
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Immunoglobulin domain; cd00096
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
AN1-like Zinc finger; pfam01428
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
F5/8 type C domain; pfam00754
F5/8 type C domain; pfam00754
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
F5/8 type C domain; pfam00754
F5/8 type C domain; pfam00754
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; cl12042
F5/8 type C domain; pfam00754
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
F5/8 type C domain; pfam00754
F5/8 type C domain; pfam00754
Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; cd07233
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; pfam00903
Dynein heavy chain, N-terminal region 1; pfam08385
Dynein heavy chain, N-terminal region 2; pfam08393
Hydrolytic ATP binding site of dynein motor region D1; pfam12774
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
Microtubule-binding stalk of dynein motor; pfam12777
ATP-binding dynein motor region D5; pfam12781
Dynein heavy chain and region D6 of dynein motor; pfam03028
Hormone receptor domain; pfam02793
7 transmembrane receptor (Secretin family); pfam00002
Uncharacterized conserved domain (SAYSvFN); pfam10260
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Ion channel; pfam07885
Kinesin motor domain, KIF9-like subgroup; might play a role in cell shape remodeling. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play...; cd01375
Kinesin motor, catalytic domain. ATPase; smart00129
Diaphanous GTPase-binding Domain; pfam06371
Diaphanous FH3 Domain; pfam06367
Formin Homology 2 Domain; pfam02181
Formin Homology 2 Domain; smart00498
Diaphanous GTPase-binding Domain; pfam06371
Diaphanous FH3 Domain; pfam06367
Formin Homology 2 Domain; pfam02181
Formin Homology 2 Domain; smart00498
molybdenum cofactor biosynthesis protein A; Reviewed; PRK00164
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
Molybdenum Cofactor Synthesis C; pfam06463
Molybderin biosynthesis protein CNX2
Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; cd01335
Molybdenum Cofactor Synthesis C; pfam06463
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cl11960
Fibronectin type III domain; pfam00041
ZU5 domain; pfam00791
Death domain; pfam00531
TspO/MBR family; pfam03073
TspO/MBR family; pfam03073
APOBEC-like N-terminal domain; pfam08210
Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; cd01283
APOBEC-like C-terminal domain; pfam05240
Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; cd02901
CCAAT-Binding transcription Factor; smart00521
CCAAT-Binding transcription Factor; smart00521
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin domain; cl11960
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR); cd05716
Immunoglobulin V-set domain; pfam07686
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR); cd05716
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin V-set domain; pfam07686
Immunoglobulin domain; cl11960
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR); cd05716
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR); cd05716
Immunoglobulin V-set domain; pfam07686
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR); cd05716
Immunoglobulin V-set domain; pfam07686
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Domain of unknown function (DUF3371); pfam11851
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
Domain of unknown function (DUF3371); pfam11851
A1 Propeptide; pfam07966
Gastricsins, asparate proteases produced in gastric mucosa; cd05477
Eukaryotic aspartyl protease; pfam00026
A1 Propeptide; pfam07966
Cellular and retroviral pepsin-like aspartate proteases; cl11403
Fibroblast growth factor receptor substrate 2 (FRS2/SNT1) Phosphotyrosine-binding domain; cd01202
The PET domain of overexpressed breast tumor protein (OEBT); cd09828
The first LIM domain of Testin-like family; cd09340
The second LIM domain of Testin-like family; cd09341
Zn-finger in ubiquitin-hydrolases and other protein; pfam02148
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553
TATA-binding related factor (TRF) of subunit 20 of Mediator complex; pfam08612
Bystin; pfam05291
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cl00050
Cyclin, C-terminal domain; pfam02984
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin, C-terminal domain; pfam02984
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin, C-terminal domain; pfam02984
Cyclin, C-terminal domain; pfam02984
Bromodomain associated; pfam07524
TATA Binding Protein (TBP) Associated Factor 8; cd08049
DNA polymerase III subunits gamma and tau; Provisional
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; COG5126
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Ribosomal protein S10p/S20e; pfam00338
C2H2-type zinc finger; pfam13912
ELM2 domain; pfam01448
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; smart00396
ATP-dependent Clp protease adaptor protein ClpS; pfam02617
Putative zinc finger in N-recognin (UBR box); pfam02207
ATP-dependent Clp protease adaptor protein ClpS; pfam02617
Tetraspanin family; pfam00335
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment...; cd03162
Tubulin binding cofactor C; pfam07986
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product; smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product; smart00673
60S ribosomal protein L7, eukaryotic; TIGR01310
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome.  The...; cd01657
TLR4 regulator and MIR-interacting MSAP; pfam11938
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; COG0464
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Protein phosphatase 2A regulatory B subunit (B56 family); cl03277
Protein phosphatase 2A regulatory B subunit (B56 family); pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); pfam01603
Male enhanced antigen 1 (MEA1); pfam06910
Kelch motif; pfam13964
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam07646
Kelch motif; pfam13964
Kelch motif; pfam13854
Galactose oxidase, central domain; cl02701
Domain of unknown function (DUF947); pfam06102
Mouse development and cellular proliferation protein Cullin-7; pfam11515
APC10-like DOC1 domain of CUL7, subunit of the SCF-ROC1-like E3 ubiquitin ligase complex that mediates substrate ubiquitination; cd08665
Cullin family; pfam00888
Cullin family; pfam00888
Cullin protein neddylation domain; cl11186
Mouse development and cellular proliferation protein Cullin-7; pfam11515
APC10-like DOC1 domain of CUL7, subunit of the SCF-ROC1-like E3 ubiquitin ligase complex that mediates substrate ubiquitination; cd08665
Cullin family; pfam00888
Cullin family; pfam00888
Cullin protein neddylation domain; cl11186
Ribosomal Proteins L2, RNA binding domain; pfam00181
Ribosomal Proteins L2, C-terminal domain; pfam03947
Rabaptin-like protein; pfam09311
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
Rabaptin-like protein; pfam09311
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
Rabaptin-like protein; pfam09311
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13424
Rabaptin-like protein; pfam09311
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; cd00189
Tetratricopeptide repeat; pfam13374
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4; cd05760
Immunoglobulin domain; cd00096
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin; smart00409
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; cd05046
Protein kinase; unclassified specificity; smart00221
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4; cd05760
Immunoglobulin domain; cd00096
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin domain; cl11960
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; cd05046
Protein kinase; unclassified specificity; smart00221
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4; cd05760
Immunoglobulin domain; cd00096
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin domain; cl11960
Immunoglobulin; smart00409
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; cd05046
Protein kinase; unclassified specificity; smart00221
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4; cd05760
Immunoglobulin domain; cd00096
Immunoglobulin C-2 Type; smart00408
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; cd05046
Protein kinase; unclassified specificity; smart00221
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin I-set domain; pfam07679
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4; cd05760
Immunoglobulin domain; cd00096
Immunoglobulin C-2 Type; smart00408
Immunoglobulin I-set domain; pfam07679
Immunoglobulin; smart00409
Immunoglobulin I-set domain; pfam07679
Immunoglobulin domain; cd00096
Immunoglobulin domain; cd00096
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; cd05046
Protein kinase; unclassified specificity; smart00221
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in...; cd00266
Mouse development and cellular proliferation protein Cullin-7; pfam11515
APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; cl02148
Cullin family; pfam00888
Cullin; smart00182
Cullin protein neddylation domain; smart00884
Ring finger domain; pfam13639
Zinc finger, C3HC4 type (RING finger); pfam13923
IBR domain; pfam01485
In Between Ring fingers; smart00647
IBR domain; pfam01485
In Between Ring fingers; smart00647
Nucleoside 2-deoxyribosyltransferase; pfam05014
Nucleoside 2-deoxyribosyltransferase; pfam05014
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Protein Kinases; cd00180
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The first LIM domain of thymus LIM protein (TLP); cd09476
The second LIM domain of thymus LIM protein (TLP); cd09477
U1-like zinc finger; smart00451
U1-like zinc finger; smart00451
ABC transporter transmembrane region; cl00549
Domain 1 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminas, but the function of these additional...; cd03250
putative bacteriocin export ABC transporter, lactococcin 972 group; TIGR03608
ABC transporter transmembrane region; cl00549
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
Domain 2 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional...; cd03244
ABC transporter transmembrane region; cl00549
Domain 1 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminas, but the function of these additional...; cd03250
putative bacteriocin export ABC transporter, lactococcin 972 group; TIGR03608
ABC transporter transmembrane region; cl00549
ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; COG1132
Domain 2 of the ABC subfamily C.  This family is also known as MRP (mulrtidrug resisitance-associated protein).  Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional...; cd03244
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Yip1 domain; pfam04893
AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; cd07032
RNA polymerases D; smart00662
Importin-beta N-terminal domain; smart00913
Exportin 1-like protein; pfam08389
Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; COG0389
DNA Polymerase eta; cd01702
GTPase [General function prediction only]; COG5258
GTP binding protein 1 (GTPBP1)-like family includes GTPBP2; cd04165
Domain II of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse...; cd03694
Domain III of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse...; cd03708
Mad1 and Cdc20-bound-Mad2 binding; pfam06581
Mad1 and Cdc20-bound-Mad2 binding; pfam06581
Radial spokehead-like protein; pfam04712
Ribosomal protein S18; pfam01084
Ribosomal protein S18; pfam01084
start of isoform o precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform i precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform j precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform k precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform l precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform n precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform p precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
start of isoform m precursor
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and...; cd00135
Ribosomal protein L14p/L23e; pfam00238
Late exocytosis, associated with Golgi transport; pfam13967
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; cl10015
Domain of unknown function DUF221; pfam02714
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; cd00044
Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; cd00214
EF-hand domain pair; pfam13833
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Equilibrative Nucleoside Transporter (ENT); TIGR00939
Equilibrative Nucleoside Transporter (ENT); TIGR00939
Equilibrative Nucleoside Transporter (ENT); TIGR00939
Equilibrative Nucleoside Transporter (ENT); TIGR00939
Equilibrative Nucleoside Transporter (ENT); TIGR00939
Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; cd00075
Hsp90 protein; pfam00183
UAA transporter family; pfam08449
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cd00116
alanyl-tRNA synthetase
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; cd00673
Threonyl and Alanyl tRNA synthetase second additional domain; smart00863
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; smart00717
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; cd11659
pre-mRNA splicing factor component; pfam11831
The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cd07978
The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cl02174
Runt domain; pfam00853
Runx inhibition domain; pfam08504
Runt domain; pfam00853
Runx inhibition domain; pfam08504
Runt domain; pfam00853
Runx inhibition domain; pfam08504
intracellular chloride channel protein; TIGR00862
GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated...; cd03061
C-terminal, alpha helical domain of Chloride Intracellular Channel 5; cd10297
GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated...; cd03061
intracellular chloride channel protein; TIGR00862
C-terminal, alpha helical domain of Chloride Intracellular Channel 5; cd10297
GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated...; cd03061
C-terminal, alpha helical domain of the Glutathione S-transferase family; cl02776
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663
Calcipressin; pfam04847
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); pfam13893
Calcipressin; pfam04847
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); pfam13893
Calcipressin; pfam04847
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); pfam13893
Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; COG2124
Cytochrome P450; pfam00067
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
ADP/ATP transporter on adenylate translocase; Provisional
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
ADP/ATP transporter on adenylate translocase; Provisional
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Mitochondrial carrier protein; pfam00153
Tudor domain; pfam00567
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Tudor domain; pfam00567
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; cd04508
Platelet-activating factor acetylhydrolase, isoform II; pfam03403
Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]
Platelet-activating factor acetylhydrolase, isoform II; pfam03403
Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as...; cd04282
Astacin (Peptidase family M12A); pfam01400
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; cd06263
Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits; cd03783
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
SEA domain; pfam01390
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
SEA domain; pfam01390
Immunoglobulin domain; cd00096
Immunoglobulin like; smart00410
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
SEA domain; pfam01390
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
SEA domain; cl02507
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cd00185
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; cl12111
Death domain of tumor necrosis factor receptor superfamily member 21; cd08778
First Src Homology 3 domain (SH3A) of CD2-associated protein; cd12053
Second Src Homology 3 domain (SH3B) of CD2-associated protein; cd12054
Third Src Homology 3 domain (SH3C) of CD2-associated protein; cd12056
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
Latrophilin/CL-1-like GPS domain; pfam01825
7 transmembrane receptor (Secretin family); cl12142
7 transmembrane receptor (rhodopsin family); pfam00001
Patched family; pfam02460
Protein export membrane protein; cl14618
Domain of unknown function, E. rectale Gene description (DUF3878); pfam12994
Protein export membrane protein; cl14618
methylmalonyl-CoA mutase; Reviewed
Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; cd03679
methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; cd02071
CENP-A-nucleosome distal (CAD) centromere subunit; pfam13094
Aralkyl acyl-CoA:amino acid N-acyltransferase; pfam06021
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; cl00357
Ammonium Transporter Family; pfam00909
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; cd00318
Phosphoglycerate kinase; pfam00162
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Crisp; pfam08562
SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a...; cd05383
Beta defensin; pfam13841
Beta defensin; pfam13841
Beta defensin; pfam13841
Transcription factor AP-2; pfam03299
Transcription factor AP-2; pfam03299
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; cl15674
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
G8 domain; pfam10162
Right handed beta helix region; pfam13229
G8 domain; pfam10162
Right handed beta helix region; pfam13229
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; cl15674
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
IPT/TIG domain; pfam01833
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; cd00603
G8 domain; pfam10162
Right handed beta helix region; pfam13229
G8 domain; pfam10162
Right handed beta helix region; pfam13229
Interleukin-17; pfam06083
Interleukin-17; pfam06083
minichromosome maintenance proteins; smart00350
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
minichromosome maintenance proteins; smart00350
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
Haemolysin-III related; pfam03006
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; smart00676
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; smart00676
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
TRAM1-like protein; pfam08390
TRAM, LAG1 and CLN8 homology domains; smart00724
Transmembrane proteins 14C; pfam03647
glutathione s-transferase; Provisional
GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; cd03077
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases; cd03208
glutathione s-transferase; Provisional
GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; cd03077
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases; cd03208
glutathione s-transferase; Provisional
GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; cd03077
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases; cd03208
glutathione s-transferase; Provisional
GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; cd03077
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases; cd03208
glutathione s-transferase; Provisional
GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; cd03077
C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases; cd03208
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; cd07830
Serine/Threonine protein kinases, catalytic domain; smart00220
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; cd07830
Serine/Threonine protein kinases, catalytic domain; smart00220
F-box-like; pfam12937
F-box-like; pfam12937
F-box-like; pfam12937
GCM motif protein; pfam03615
GNS1/SUR4 family; pfam01151
GNS1/SUR4 family; pfam01151
GNS1/SUR4 family; pfam01151
Glutamate-cysteine ligase; pfam03074
Glutamate-cysteine ligase; pfam03074
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; pfam07707
Kelch motif; pfam01344
Kelch motif; pfam01344
Kelch motif; pfam01344
Kelch motif; pfam01344
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; cl15309
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Leucine rich repeat; pfam13855
Somatomedin B -like domains; smart00201
von Willebrand factor type C domain; cl02515
Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620
Protein of unknown function (DUF1669); pfam07894
N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B; cd09182
7 transmembrane receptor (rhodopsin family); pfam00001
Orexin receptor type 2; pfam03827
GDNF/GAS1 domain; pfam02351
GDNF/GAS1 domain; smart00907
Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; COG0119
3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; cd07938
Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; COG0119
3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; cd07938
TGF-beta propeptide; pfam00688
Transforming growth factor-beta (TGF-beta) family; smart00204
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057
Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cl00102
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Spectrin repeats; smart00150
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
ATPase involved in DNA repair [DNA replication, recombination, and repair]; COG0419
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
EF-hand domain pair; pfam13499
Growth-Arrest-Specific Protein 2 Domain; smart00243
Spectrin repeats; smart00150
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cl02488
Chromosome segregation ATPases [Cell division and chromosome partitioning]; COG1196
Plectin repeat; pfam00681
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
Plectin repeat; smart00250
Plectin repeat; pfam00681
The BEN domain is found in diverse animal proteins; smart01025
BAG domains, present in regulator of Hsp70 proteins; smart00264
Rab GTPase family 23 (Rab23)-like; cd04106
Rab family protein; Provisional
Rab GTPase family 23 (Rab23)-like; cd04106
Rab family protein; Provisional
Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1...; cd02395
Glutamine synthetase [Amino acid transport and metabolism]; COG0174
Glutamine synthetase, beta-Grasp domain; pfam03951
Glutamine synthetase, catalytic domain; pfam00120
Glutamine synthetase, beta-Grasp domain; pfam03951
Protein-tyrosine phosphatase; pfam00102
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
PHD-finger; pfam00628
Domain in the central regions of transcription elongation factor S-II (and elsewhere); smart00510
SPOC domain; pfam07744
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Thrombospondin type 1 repeats; smart00209
Domain present in hormone receptors; smart00008
Domain of unknown function (DUF3497); pfam12003
G-protein-coupled receptor proteolytic site domain; smart00303
7 transmembrane receptor (Secretin family); pfam00002
LMBR1-like membrane protein; pfam04791
Thrombospondin N-terminal -like domains; smart00210
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Thrombospondin N-terminal -like domains; smart00210
Collagen triple helix repeat (20 copies); pfam01391
Collagen triple helix repeat (20 copies); pfam01391
Protein of unknown function (DUF3657); pfam12394
Protein of unknown function (DUF3657); pfam12394
Putative serine esterase (DUF676); pfam05057
Protein of unknown function (DUF3657); pfam12394
Protein of unknown function (DUF3657); pfam12394
Putative serine esterase (DUF676); pfam05057
Protein of unknown function (DUF3657); pfam12394
Protein of unknown function (DUF3657); pfam12394
Putative serine esterase (DUF676); pfam05057
Protein of unknown function (DUF1674); pfam07896
Putative GTPase activating protein for Arf; pfam01412
Putative GTPase activating protein for Arf; pfam01412
Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis; cd00218
Opioid growth factor receptor (OGFr) conserved region; pfam04664
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; cd00992
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins; cd04031
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins; cd04028
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
Ion transport protein; pfam00520
Ion channel; pfam07885
KCNQ voltage-gated potassium channel; pfam03520
2-oxoacid dehydrogenase subunit E1; Provisional
KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; cl00098
helicase 45; Provisional
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; cd00268
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Mab-21 protein; pfam03281
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
GidA associated domain 3; pfam13932
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
GidA associated domain 3; pfam13932
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
Rossmann-fold NAD(P)(+)-binding proteins; cl09931
GidA associated domain 3; pfam13932
elongation factor 1- alpha; Provisional
Elongation Factor 1-alpha (EF1-alpha) protein family; cd01883
EF1_alpha_II: this family represents the domain II of elongation factor 1-alpha (EF-1a) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to...; cd03693
Domain III of EF-1. Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to ribosomes. EF-1 is composed of four subunits: the alpha chain, which binds GTP and aminoacyl-tRNAs, the gamma chain that probably...; cd03705
Na(+)-dependent inorganic phosphate cotransporter; TIGR00894
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Alpha-2-macroglobulin MG1 domain; pfam11974
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Alpha-2-macroglobulin family; pfam00207
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester...; cd02897
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
Alpha-2-macroglobulin MG1 domain; pfam11974
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Alpha-2-macroglobulin family; pfam00207
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester...; cd02897
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
MG2 domain; pfam01835
Alpha-2-macroglobulin family N-terminal region; pfam07703
Alpha-2-macroglobulin family; pfam00207
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP).  Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester...; cd02897
A-macroglobulin complement component; pfam07678
A-macroglobulin receptor; pfam07677
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type III domain; pfam00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Thrombospondin N-terminal -like domains; smart00210
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type III domain; pfam00041
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different...; cd01482
Thrombospondin N-terminal -like domains; smart00210
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd00928
LEM3 (ligand-effect modulator 3) family / CDC50 family; cl02095
LEM3 (ligand-effect modulator 3) family / CDC50 family; pfam03381
LEM3 (ligand-effect modulator 3) family / CDC50 family; pfam03381
Cortactin-binding protein-2; pfam09727
Ulp1 protease family, C-terminal catalytic domain; pfam02902
Ulp1 protease family, C-terminal catalytic domain; pfam02902
Ulp1 protease family, C-terminal catalytic domain; pfam02902
Ulp1 protease family, C-terminal catalytic domain; pfam02902
Myosin. Large ATPases; smart00242
Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head)...; cd01382
SEA domain; pfam01390
SEA domain; pfam01390
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Protein of unknown function (DUF541); pfam04402
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
FOG: WD40 repeat [General function prediction only]
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional...; cd05529
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional...; cd05496
HMG14 and HMG17; pfam01101
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); cl14813
Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif; cd03030
GNS1/SUR4 family; pfam01151
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
Protein kinase domain; pfam00069
Catalytic domain of Protein Kinases; cd00180
3-methyl-2-oxobutanate dehydrogenase; Provisional
Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; cd07036
Transketolase, C-terminal domain; pfam02780
3-methyl-2-oxobutanate dehydrogenase; Provisional
Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; cd07036
Transketolase, C-terminal domain; pfam02780
Domain of unknown function (DUF1693); pfam07984
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (many copies); pfam13857
Ankyrin repeats (many copies); pfam13857
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; COG5184
Regulator of chromosome condensation (RCC1) repeat; pfam00415
Broad-Complex, Tramtrack and Bric a brac; smart00225
BTB/POZ domain; pfam00651
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Leucine rich repeat N-terminal domain; smart00013
Leucine rich repeat; pfam13855
Leucine-rich repeats, typical (most populated) subfamily; cl15310
Leucine rich repeat; pfam13855
Leucine rich repeat C-terminal domain; smart00082
Uncharacterized conserved protein (DUF2351); pfam09814
Dopey, N-terminal; pfam04118
Dopey, N-terminal; cl04407
Dopey, N-terminal; cl04407
Dopey, N-terminal; cl04407
phosphoacetylglucosamine mutase
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...; cd03086
phosphoacetylglucosamine mutase
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...; cd03086
phosphoacetylglucosamine mutase
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...; cd03086
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...; cd03086
RWD domain; pfam05773
Protein of unknown function (DUF1115); pfam06544
NADP-dependent malic enzyme; Provisional
Malic enzyme, N-terminal domain; pfam00390
NAD(P) binding domain of malic enzyme (ME), subgroup 1; cd05312
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cl00149
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; cl00149
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet...; cd03564
VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; cl02544
Cytochrome b5-like Heme/Steroid binding domain; pfam00173
p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins.  NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining...; cd06490
Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...; cd06183
chromosome segregation protein SMC, common bacterial type; TIGR02168
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA...; cd00182
5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; COG0737
CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; cd07409
5'-nucleotidase, C-terminal domain; pfam02872
5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; COG0737
CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; cd07409
5'-nucleotidase, C-terminal domain; pfam02872
PXA domain; pfam02194
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; cd08722
The phosphoinositide binding Phox Homology domain of Sorting Nexin 14; cd06877
Sorting nexin C terminal; pfam08628
PXA domain; pfam02194
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; cd08722
The phosphoinositide binding Phox Homology domain of Sorting Nexin 14; cd06877
Sorting nexin C terminal; pfam08628
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
7 transmembrane receptor (rhodopsin family); pfam00001
Protein of unknown function (DUF3353); pfam11833
Glycoprotein hormone; pfam00236
Glycoprotein hormone; pfam00236
Connexin; pfam00029
Gap junction channel protein cysteine-rich domain; smart01089
Domain of unknown function (DUF3508); pfam12018
Nucleotide-sugar transporter; pfam04142
UDP-galactose transporter; TIGR00803
Nucleotide-sugar transporter; pfam04142
EamA-like transporter family; cl01037
EamA-like transporter family; cl01037
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; COG0018
nucleotidyl transferase superfamily; cl00015
catalytic core domain of arginyl-tRNA synthetases; cd00671
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; cl12020
Origin recognition complex (ORC) subunit 3 N-terminus; pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; pfam07034
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; cl00053
Adenylation domain of GTP-dependent mRNA capping enzymes; cd07895
mRNA capping enzyme, C-terminal domain; pfam03919
RNA-binding proteins (RRM domain) [General function prediction only]
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; cd00590
M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; cd05672
amidohydrolase; TIGR01891
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Cation transporter family protein; TIGR00860
Neurotransmitter-gated ion-channel ligand binding domain; pfam02931
Neurotransmitter-gated ion-channel transmembrane region; pfam02932
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; cd00195
Gtr1/RagA G protein conserved region; pfam04670
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D; cd11385
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (many copies); pfam13637
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
Ankyrin repeat; pfam00023
Complex1_LYR-like; pfam13232
MoxR-like ATPases [General function prediction only]
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
MoxR-like ATPases [General function prediction only]
AAA domain (dynein-related subfamily); pfam07728
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
ATPases associated with a variety of cellular activities; smart00382
MoxR-like ATPases [General function prediction only]
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
P-loop containing Nucleoside Triphosphate Hydrolases; cl09099
VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The...; cd01460
Caspase 8-associated protein 2 myb-like domain; cd12202
Caspase 8-associated protein 2 myb-like domain; cd12202
Caspase 8-associated protein 2 myb-like domain; cd12202
Connexin; pfam00029
Gap junction channel protein cysteine-rich domain; pfam10582
BTB/POZ domain; pfam00651
basic region leucin zipper; smart00338
BTB/POZ domain; pfam00651
basic region leucin zipper; smart00338
Catalytic domain of Protein Tyrosine Kinases; cd00192
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Tyrosine Kinases; cd00192
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Tyrosine Kinases; cd00192
Tyrosine kinase, catalytic domain; smart00219
Catalytic domain of Protein Tyrosine Kinases; cd00192
Tyrosine kinase, catalytic domain; smart00219
Ligand Binding Domain of Ephrin type-A Receptor 7; cd10485
GCC2 and GCC3; pfam07699
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; cd05066
Protein tyrosine kinase; pfam07714
SAM domain of EPH-A7 subfamily of tyrosine kinase receptors; cd09548
SAM domain (Sterile alpha motif); pfam07647
Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase; cd11574
Glycosyltransferase family 10 (fucosyltransferase); pfam00852
Uncharacterized conserved protein (DUF2042); pfam09743
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The first LIM domain of Four and a half LIM domains protein (FHL); cd09343
The second LIM domain of Four and a half LIM domains protein 5 (FHL5); cd09428
The third LIM domain of Four and a half LIM domains protein (FHL); cd09346
The fourth LIM domain of Four and a half LIM domains protein (FHL); cd09347
LIM is a small protein-protein interaction domain, containing two zinc fingers; cl02475
The first LIM domain of Four and a half LIM domains protein (FHL); cd09343
The second LIM domain of Four and a half LIM domains protein 5 (FHL5); cd09428
The third LIM domain of Four and a half LIM domains protein (FHL); cd09346
The fourth LIM domain of Four and a half LIM domains protein (FHL); cd09347
7 transmembrane receptor (rhodopsin family); pfam00001
7 transmembrane receptor (rhodopsin family); pfam00001
Uncharacterized protein family (UPF0240); pfam06784
kelch-like protein; Provisional
BTB/POZ domain; pfam00651
BTB And C-terminal Kelch; smart00875
Kelch domain; smart00612
Kelch motif; pfam13964
Kelch motif; pfam01344
Galactose oxidase, central domain; pfam13415
Kelch motif; pfam01344
Found in Pit-Oct-Unc transcription factors; smart00352
Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086
F-box-like; pfam12937
Antagonist of mitotic exit network protein 1; cl15308
GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; cd03080
C-terminal, alpha helical domain of Metaxin and related proteins; cd03193
ubiquinone biosynthesis O-methyltransferase; TIGR01983
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Zn-finger in ubiquitin-hydrolases and other protein; pfam02148
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02667
Ubiquitin carboxyl-terminal hydrolase; pfam00443
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; cl00125
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; cd00043
SET domain; pfam00856
Zinc finger, C2H2 type; cl15478
Zinc-finger double domain; pfam13465
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Olfactory receptor; cl10458
7 transmembrane receptor (rhodopsin family); pfam00001
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers; cd00083
PAS fold; pfam00989
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; cd00130
PAS fold; pfam08447
Single-minded protein C-terminus; pfam06621
Superfamily II helicase [General function prediction only]
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Sec63 Brl domain; smart00973
Superfamily II helicase [General function prediction only]
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; cd00046
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; cd00079
Sec63 Brl domain; smart00973
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Type 1 periplasmic binding fold superfamily; cl10011
Receptor family ligand binding region; pfam01094
Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; cd00134
Ligand-gated ion channel; pfam00060
Eukaryotic homologues of bacterial periplasmic substrate binding proteins; smart00079
Ankyrin repeat; pfam00023
Ankyrin repeats (3 copies); pfam12796
ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; cd00204
Ankyrin repeats (3 copies); pfam12796
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078
Domain Homologous to E6-AP Carboxyl Terminus with; smart00119
Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; cd04458
Popeye protein conserved region; pfam04831
Popeye protein conserved region; pfam04831
Popeye protein conserved region; pfam04831
Popeye protein conserved region; pfam04831
Prolyl oligopeptidase, N-terminal beta-propeller domain; pfam02897
Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; COG1506
Prolyl oligopeptidase family; pfam00326
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; smart00317
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Autophagy protein Apg5; pfam04106
Beta/gamma crystallins; smart00247
Beta/Gamma crystallin; pfam00030
Beta/Gamma crystallin; pfam00030
Beta/Gamma crystallin; pfam00030
Beta/Gamma crystallin; pfam00030
Beta/gamma crystallins; smart00247
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; cd00161
Ricin-type beta-trefoil lectin domain; pfam00652
NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; COG0604
Human Reticulon 4 Interacting Protein 1; cd08248
Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; COG0154
aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; PRK00012
photosystem II S4 domain protein; TIGR03069
photosystem II S4 domain protein; TIGR03069
photosystem II S4 domain protein; TIGR03069
The BEN domain is found in diverse animal proteins; smart01025
The BEN domain is found in diverse animal proteins; smart01025
The BEN domain is found in diverse animal proteins; smart01025
The BEN domain is found in diverse animal proteins; smart01025
Isoprenoid Biosynthesis enzymes, Class 1; cl00210
Protein of unknown function (DUF3588); pfam12140
SAM domain of Scm proteins of Polycomb group; cd09578
Sterile alpha motif; smart00454
DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cd06257
Domain of unknown function in Sec63p, Brr2p and other proteins; smart00611
Sec63 Brl domain; smart00973
CDC45-like protein; pfam02724
Sec63 Brl domain; smart00973
Osteopetrosis-associated transmembrane protein 1 precursor; pfam09777
DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers; cd07163
The ligand binding domain of Tailless-like proteins,  orphan nuclear receptors; cd06950
The Phox Homology domain, a phosphoinositide binding module; cl02563
The phosphoinositide binding Phox Homology domain of Sorting Nexin 3 and related proteins; cd06894
Predicted ATPase [General function prediction only]
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Forkhead (FH), also known as a 'winged helix'.  FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as...; cd00059
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
PA26 p53-induced protein (sestrin); pfam04636
PA26 p53-induced protein (sestrin); pfam04636
PA26 p53-induced protein (sestrin); pfam04636
Centrosome localisation domain of Cep57; pfam14073
Centrosome microtubule-binding domain of Cep57; pfam06657
Centrosome localisation domain of Cep57; pfam14073
Centrosome microtubule-binding domain of Cep57; pfam06657
Multi-glycosylated core protein 24 (MGC-24); pfam05283
Multi-glycosylated core protein 24 (MGC-24); pfam05283
Multi-glycosylated core protein 24 (MGC-24); pfam05283
Multi-glycosylated core protein 24 (MGC-24); pfam05283
Multi-glycosylated core protein 24 (MGC-24); pfam05283
cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; cl00197
cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; cl00197
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; cl00490
NAD(P)-binding Rossmann-like domain; pfam13450
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
The LIM domain of Mical (molecule interacting with CasL) like family; cd09358
Protein of unknown function (DUF3585); pfam12130
NAD(P)-binding Rossmann-like domain; pfam13450
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; cd00014
The LIM domain of Mical (molecule interacting with CasL) like family; cd09358
Protein of unknown function (DUF3585); pfam12130
BTB/POZ domain; pfam00651
Zinc-finger double domain; pfam13465
FOG: Zn-finger [General function prediction only]
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
Zinc-finger double domain; pfam13465
BTB/POZ domain; pfam00651
Zinc finger, C2H2 type; cl15478
adenylate kinases; TIGR01351
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
AAA domain; pfam13207
Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; cl00909
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
Adenylate kinase and related kinases [Nucleotide transport and metabolism]; COG0563
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
adenylate kinases; TIGR01351
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; cd01428
AAA domain; pfam13207
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
SacI homology domain; pfam02383
7 transmembrane receptor (rhodopsin family); pfam00001
Wiskott Aldrich syndrome homology region 2; smart00246
Wiskott Aldrich syndrome homology region 2; smart00246
Wiskott Aldrich syndrome homology region 2; smart00246
Wiskott Aldrich syndrome homology region 2; smart00246
FOG: WD40 repeat [General function prediction only]
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl16911
glycine oxidase ThiO; TIGR02352
FAD dependent oxidoreductase; pfam01266
cation transport protein; TIGR00898
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; cd07867
Serine/Threonine protein kinases, catalytic domain; smart00220
Adenosylmethionine decarboxylase; pfam01536
Adenosylmethionine decarboxylase; cl03253
TFIIIC subunit; pfam10419
Brix domain; cl00935
monocarboxylate transporter 1; TIGR00892
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
Major Facilitator Superfamily; pfam07690
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; cd06174
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase; cd05778
DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production...; cd05534
DNA polymerase family B; pfam00136
C4-type zinc-finger of DNA polymerase delta; pfam14260
SEFIR domain; pfam08357
SEFIR domain; pfam08357
TIR domain; cl15770
Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases; cd12006
Src homology 2 (SH2) domain found in Fyn; cd10368
Protein tyrosine kinase; pfam07714
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; cd05034
Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases; cd12006
Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; cd09933
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; cd05034
Protein tyrosine kinase; pfam07714
Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases; cd12006
Src homology 2 (SH2) domain found in Fyn isoform a like proteins; cd10418
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; cd05034
Protein tyrosine kinase; pfam07714
Insulin-like growth factor binding protein; pfam00219
Thrombospondin type 1 domain; cl15278
Glycoprotein hormone beta chain homologues; cl00070
Insulin-like growth factor binding protein; pfam00219
Thrombospondin type 1 domain; cl15278
Glycoprotein hormone beta chain homologues; cl00070
epsilon tubulin; Provisional
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not...; cd02190
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin Domain I; pfam06008
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Uncharacterized archaeal coiled-coil protein [Function unknown]
HlyD family secretion protein; pfam00529
Laminin Domain II; pfam06009
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin Domain I; pfam06008
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Uncharacterized archaeal coiled-coil protein [Function unknown]
HlyD family secretion protein; pfam00529
Laminin Domain II; pfam06009
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin EGF-like (Domains III and V); pfam00053
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055
Laminin EGF-like (Domains III and V); pfam00053
Laminin Domain I; pfam06008
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176
Uncharacterized archaeal coiled-coil protein [Function unknown]
HlyD family secretion protein; pfam00529
Laminin Domain II; pfam06009
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110
Zinc finger, C3HC4 type (RING finger); pfam13923
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cd00162
SPRY-associated domain; cl02686
Domain in SPla and the RYanodine Receptor; smart00449
Histone deacetylase 2 (HDAC2); cd10011
Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; COG0123
Sulfotransferase domain; pfam00685
Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases; cd11845
Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk); cd10369
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; cd05068
Protein tyrosine kinase; pfam07714
HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; TIGR02244
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; cd01427
Complement component C1q domain; smart00110
Nucleosome assembly protein (NAP); pfam00956
(NAP-L) nucleosome assembly protein -L; Provisional; cl08298
Nucleosome assembly protein (NAP); pfam00956
(NAP-L) nucleosome assembly protein -L; Provisional; cl08298
Transport protein particle (TRAPP) component; pfam04051
RWD domain; pfam05773
Radial spokehead-like protein; pfam04712
Radial spokehead-like protein; pfam04712
Peptidase family C78; pfam07910
Importin beta binding domain; pfam01749
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; COG5064
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; cd00020
Protein of unknown function (DUF1075); pfam06388
Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor; cd06361
Receptor family ligand binding region; pfam01094
Nine Cysteines Domain of family 3 GPCR; pfam07562
7 transmembrane sweet-taste receptor of 3 GCPR; pfam00003
RFX DNA-binding domain; pfam02257
Vestigial/Tondu family; pfam07545
Vestigial/Tondu family; pfam07545
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063